Forschungsschwerpunkte
- Untersuchungen zur thermischen Stabilität, zur Biosynthese, zur Toxizität und zum (intestinalen) Metabolismus von Mykotoxinen.
- Entwicklung von humanen Biomonitoringmethoden (HBM) zur Expositionsabschätzung von Mykotoxinen sowie zum Nachweis von Ernährungsbiomarkern.
- Metabolomics- und Proteomics-basierte Ansätze zur Charakterisierung zellulärer Antworten auf die Exposition mit Mykotoxinen und anderen Lebensmittelinhaltsstoffen
- Transfer von Lebensmittelinhaltsstoffen an der intestinalen Barriere (Caco-2 Modell) und an der Blut-Hirn-Schranke.
- Untersuchungen zum Vorkommen und zur Bedeutung von Mykotoxinen in Innenräumen
Vita
Akademische Ausbildung
- Habilitation und Erlangung der Venia legendi im Fachgebiet "Lebensmittelchemie"
- Forschungsaufenthalt an der Emory University, Atlanta, USA, Department of Biochemistry bei Herrn Prof. Dr. A.H. Merrill
- 2. Ausbildungsphase für Lebensmittelchemiker am Landesuntersuchungsamt in Erlangen, Staatsprüfung für Lebensmittelchemiker
- Dissertation am Lehrstuhl für Lebensmittelchemie der Universität Würzburg bei Prof. Dr. P. Schreier
Beruflicher Werdegang
- Dekan des Fachbereichs Chemie und Pharmazie der Westfälischen Wilhelms-Universität Münster
- Geschäftsführender Direktor des Instituts für Lebensmittelchemie
- W3-Professur für Lebensmittelchemie an der Westfälischen Wilhelms-Universität Münster
- C3 Professur für Lebensmittelchemie an der Westfälischen Wilhelms-Universität Münster
- Wissenschaftlicher Assistent und seit 01.10.2000 Oberassistent am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
- Post-doc an der Columbia University, New York, Department of Chemistry bei Prof. Dr. K. Nakanishi
- Wissenschaftlicher Mitarbeiter am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
Preise
- Josef-Schormüller-Stipendium – Lebensmittelchemische Gesellschaft (LChG) - Fachgruppe in der Gesellschaft Deutscher
- Studienabschluss-Stipendium – Fonds der Chemischen Industrie (FCI)
- Stockmeyer Wissenschaftspreis 2002 – Heinrich-Stockmeyer-Stiftung
- Peter B. Czedik-Eysenberg-Preis – GÖCH - Gesellschaft Österreichischer Chemiker - Arbeitsgruppe Lebensmittel, Kosmetik und Gebrauchsgegenstände
Mitgliedschaften und Aktivitäten in Gremien
- Deutsche Forschungsgemeinschaft (DFG)
- Springer-Nature
- Bundesinstitut für Risikobewertung (BfR) (BfR-Kommission für Kontaminanten in der Lebensmittelkette, Mitglied)
- Gesellschaft für Mykotoxinforschung e.V.
- Wiley-VCH
- Mitglied in der der Senatskommission der Deutschen Forschungsgemeinschaft zur gesundheitlichen Bewertung von Lebensmitteln (SKLM)
- Präsident der Gesellschaft für Mykotoxinforschung e.V.
- Bundesinstitut für Risikobewertung (BFR) (Expertenkommission „Kontaminanten und andere gesundheitlich unerwünschte Stoffe in der Lebensmittelkette“, Mitglied)
- Associate Editor der Zeitschrift "Molecular Nutrition and Food-Research", Wiley-VCH
- Mitglied der Gesellschaft für Mykotoxinforschung e.V.
- Mitglied in der American Chemical Society
- Mitglied in der Gesellschaft Deutscher Chemiker GDCh
Rufe
- WWU Münster, Lebensmittelchemie (W3) – angenommen
- Universität Hamburg, Lebensmittelchemie (C4) – abgelehnt
- Martin-Luther-Universität Halle-Wittenberg, Lebensmittelchemie (C4) – abgelehnt
- WWU Münster, Lebensmittelchemie (C3) – angenommen
- Universität Hohenheim, Lebensmittelchemie (C3) – abgelehnt
Lehre
- Vorlesung: Spezielle Lebensmittelchemie [128216]
[ - | | wöchentlich | Mi | LC 1 | Prof. Dr. Hans-Ulrich Humpf] - Vorlesung: Biochemie der Ernährung [128219]
(zusammen mit Dr. Svetlana Kalinina, Prof. Dr. Melanie Esselen)
[ - | | wöchentlich | Di | LC 1 | Dr. Svetlana Kalinina]
[ - | | wöchentlich | Do | LC 1 | Dr. Svetlana Kalinina] - Seminar: Institutsseminar [128233]
(zusammen mit Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ | wöchentlich | Do | Dr. Benedikt Cramer] - Seminar: Seminar Isotopen- und Enantiomerenanalytik [128217]
[ - | | wöchentlich | Fr | LC 1 | Prof. Dr. Hans-Ulrich Humpf] - Seminar: Aktuelle Forschung [128229]
(zusammen mit Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ - | | wöchentlich | Do | LC 3 | Dr. Benedikt Cramer] - Anleitung zum wissenschaftlichen Arbeiten: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Humpf [128231]
[n. V. | Prof. Dr. Hans-Ulrich Humpf] - Literaturseminar für Doktoranden [128232]
(zusammen mit Prof. Dr. Melanie Esselen)
[n. V. | Prof. Dr. Hans-Ulrich Humpf] - Vorlesung: Spezielle Lebensmittelchemie [126221]
- Seminar: Aktuelle Forschung [126230]
(zusammen mit Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Seminar: Institutsseminar [126233]
(zusammen mit Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Anleitung zum wissenschaftlichen Arbeiten: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Humpf [126232]
- Vortrag: Vortrag zur Bachelorarbeit [126220]
(zusammen mit Dr. Benedikt Cramer, Dr. Michael Lange-Aperdannier, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Literaturseminar für Doktoranden [126233]
(zusammen mit Prof. Dr. Melanie Esselen)
- Vorlesung: Spezielle Lebensmittelchemie [128216]
Publikationen
- 10.1038/s41598-024-55920-x. . ‘Antagonistic properties against Fusarium sporotrichioides and glycosylation of HT-2 and T-2 toxins by selected Trichoderma strains.’ Scientific Reports 14, Nr. 1. doi:
- 10.1007/s00204-024-03688-4. . ‘Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.’ Archives of Toxicology 98, Nr. 4: 1081–1093. doi:
- 10.1021/acs.jafc.3c07465. . ‘Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.’ Journal of Agricultural and Food Chemistry 72, Nr. 6: 3150–3159. doi:
- 10.1007/s00204-024-03726-1. . ‘Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food.’ Archives of Toxicology 98, Nr. 6. doi:
- . . ‘Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.’ Journal of Agricultural and Food Chemistry 72, Nr. 6. doi: 10.1021/acs.jafc.3c07465.
- . . ‘Human Intervention Study: Alkylresorcinol Metabolites as Potential Biomarkers for Grain Intake and the Occurrence of Alkylresorcinols in Commonly Consumed Foods in the German Retail Sector.’ ACS Omega 9, Nr. 22. doi: 10.1021/acsomega.4c00733.
- . . ‘Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi.’ Epigenetics and Chromatin 17, Nr. 1. doi: 10.1186/s13072-024-00532-y.
- . . ‘Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.’ Archives of Toxicology 1. doi: 10.1007/s00204-024-03688-4.
- . . ‘Role of albumin in the metabolism and excretion of ochratoxin A.’ Mycotoxin Research 1. doi: 10.1007/s12550-024-00538-1.
- . . ‘Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells.’ Molecular Nutrition and Food Research 68, Nr. 6. doi: 10.1002/mnfr.202300639.
- . . ‘Surface Display and Engineering of Laccase CotA for Increased Growth of Pseudomonas putida on Lignin.’ ChemCatChem 16, Nr. 4. doi: 10.1002/cctc.202301055.
- 10.1016/j.fgb.2024.103892. . ‘Tools to make Stachybotrys chartarum genetically amendable: Key to unlocking cryptic biosynthetic gene clusters.’ Fungal Genetics and Biology 172. doi:
- . . ‘Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.’ Molecular Nutrition and Food Research 67, Nr. 21: e2300052. doi: 10.1002/mnfr.202300052.
- 10.1111/bjh.18939. . ‘Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.’ British Journal of Haematology 202, Nr. 5: 1033–1048. doi:
- contributed to the DPhG Annual Meeting, Tübingen, . „Role of stabilizers in protein adsorption patterns of PLGA nanoparticles.“
- . . ‘Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.’ Archives of Toxicology 97, Nr. 12: 3179–3196. doi: 10.1007/s00204-023-03607-z.
- 10.1016/j.toxicon.2023.107160. . ‘Degradation products of aflatoxin M1 (AFM1) formed by high voltage atmospheric cold plasma (HVACP) treatment.’ Toxicon 230. doi:
- 10.1007/s00217-023-04374-y. . ‘Determination of furan and alkylfuran in breakfast cereals from the European market and their correlation with acrylamide levels.’ European Food Research and Technology 2023. doi:
- 10.1007/s00204-023-03491-7. . ‘Maternal exposure to multiple mycotoxins and adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh.’ Archives of Toxicology 97, Nr. 6: 1795–1812. doi:
- . . ‘Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.’ PLoS Pathogens 19, Nr. 7: e1010986. doi: 10.1371/journal.ppat.1010986.
- . . ‘Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro.’ PloS one 17, Nr. 6: e0269486. doi: 10.1371/journal.pone.0269486.
- . . ‘Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.’ Archives of Toxicology 96, Nr. 11: 2983–2998. doi: 10.1007/s00204-022-03348-5.
- . . ‘Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.’ Food and Chemical Toxicology 164: 113006. doi: 10.1016/j.fct.2022.113006.
- . . ‘Mycotoxins in Serum and 24-h Urine of Vegans and Omnivores from the Risks and Benefits of a Vegan Diet (RBVD) Study.’ Molecular Nutrition and Food Research 66, Nr. 6. doi: 10.1002/mnfr.202100874.
- . . ‘Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.’ Analytical Chemistry 94, Nr. 10: 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- . . ‘In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.’ Metabolites 12: 88. doi: 10.3390/metabo12010088.
- 10.1016/j.bbiosy.2021.100032. . ‘Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles.’ Biomaterials and Biosystems 5: 100032. doi:
- 10.1007/s00204-022-03361-8. . ‘Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.’ Archives of Toxicology 96, Nr. 11: 2967–2981. doi:
- 10.1007/s00204-022-03395-y. . ‘Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.’ Archives of Toxicology 96, Nr. 12: 3349–3361. doi:
- . . ‘In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.’ Metabolites 12, Nr. 1: 88. doi: 10.3390/metabo12010088.
- 10.1007/s00204-022-03288-0. . ‘Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh.’ Archives of Toxicology 96, Nr. 7: 2123–2138. doi:
- . . ‘Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.’ Archives of Toxicology 96, Nr. 6: 1905–1914. doi: 10.1007/s00204-022-03296-0.
- . . ‘Analysis of mold and mycotoxins in naturally infested indoor building materials.’ Mycotoxin Research 2022. doi: 10.1007/s12550-022-00461-3.
- 10.1007/s12550-022-00462-2. . ‘From the laboratory bench to the lecture hall: latest findings from mycotoxin research presented at the 43rd Mycotoxin Workshop.’ Mycotoxin Research 2022. doi:
- . . ‘C Lignin in the Pig Cecum Model.’ Journal of Agricultural and Food Chemistry 70, Nr. 27: 8317–8325. doi: 10.1021/acs.jafc.2c02836.
- . . ‘.In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys.’ Toxins 14, Nr. 6: 395. doi: 10.3390/toxins14060395.
- . . ‘Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.’ Analytical Chemistry 94, Nr. 10: 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- . . ‘Can the presence of additives result in false positive errors for microplastics in infant feeding bottles?’ Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 39, Nr. 1: 185–197. doi: 10.1080/19440049.2021.1989498.
- . . ‘Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).’ Mycotoxin Research 37, Nr. 4: 275–278. doi: 10.1007/s12550-021-00439-7.
- contributed to the EMBO practical course – targeted proteomics: Experimental design and data analysis., CRG – Centre de Regulació Genòmica, online, . „Studies on the formation of a protein corona on colloidal drug carriers.“
- contributed to the DPhG Annual Meeting, Leipzig online, . „Nanoparticle matrix and incubation medium – main influencer of the protein corona?“
- . . ‘Determination of urinary mycotoxin biomarkers using a sensitive online solid phase extraction‐uhplc‐ms/ms method.’ Toxins 13, Nr. 6. doi: 10.3390/toxins13060418.
- . ‘Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.’ European journal of pharmaceutics and biopharmaceutics 163: 212–222.
- . . ‘Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine.’ Mycotoxin Research 37, Nr. 2: 129–140. doi: 10.1007/s12550-021-00423-1.
- . . ‘Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney.’ Archives of Toxicology 95, Nr. 6: 2163–2177. doi: 10.1007/s00204-021-03073-5.
- . . ‘Chemoenzymatic synthesis of 2,6-disubsttuted tetrahydropyrans with high 1 receptor affinity, antitumor and analgesic activity.’ European Journal of Medicinal Chemistry 219: 113443. doi: 10.1016/j.ejmech.2021.113443.
- . . ‘Natural Compounds Isolated from Stachybotrys chartarum Are Potent Inhibitors of Human Protein Kinase CK2.’ Molecules 26, Nr. 15: 4453. doi: 10.3390/molecules26154453.
- . . ‘Insights into Ergochromes of the Plant Pathogen Claviceps purpurea.’ Journal of Natural Products 84, Nr. 10: 2630–2643. doi: 10.1021/acs.jnatprod.1c00264.
- . . ‘Primary Human Colon Epithelial Cells (pHCoEpiCs) Do Express the Shiga Toxin (Stx) Receptor Glycosphingolipids Gb3Cer and Gb4Cer and Are Largely Refractory but Not Resistant towards Stx.’ International Journal of Molecular Sciences (IJMS) 22, Nr. 18: 10002. doi: 10.3390/ijms221810002.
- . . ‘Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains.’ Toxins 13, Nr. 8: 529.
- . . ‘Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone.’ Toxins 13, Nr. 5: 327. doi: 10.3390/toxins13050327.
- . . ‘Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity.’ Toxins 13, Nr. 2: 139. doi: 10.3390/toxins13020139.
- . . ‘Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics.’ Mycotoxin Research 36, Nr. 2: 193–206. doi: 10.1007/s12550-019-00381-9.
- . . ‘Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.’ Journal of Medicinal Chemistry 63, Nr. 21: 13159–13186. doi: 10.1021/acs.jmedchem.0c01635.
- . . ‘Govaniadine Evaluation of Cytotoxicity and Permeability in Cell Culture.’ Revista Brasileira de Farmacognosia 30, Nr. 3: 374–380. doi: 10.1007/s43450-020-00066-w.
- . . ‘Mass Spectrometry–Based Analysis of Urinary Biomarkers for Dietary Tomato Intake.’ Molecular Nutrition & Food Research 64.
- . . ‘Identification of a novel N-caprylhistamine-β-glucoside from tomato fruits and LC-MS/MS-based food screening for imidazole alkaloids.’ Food Chemistry 312.
- . . ‘Artificial vs natural Stachybotrys infestation—Comparison of mycotoxin production on various building materials.’ Indoor Air 30, Nr. 6: 1268–1282. doi: 10.1111/ina.12705.
- . . ‘Metabolomics Study on Pathogenic and Non-pathogenic E. coli with Closely Related Genomes with a Focus on Yersiniabactin and Its Known and Novel Derivatives.’ Metabolites 10, Nr. 6: 221. doi: 10.3390/metabo10060221.
- . . ‘Intestinal Metabolism of α- and β‑Glucosylated Modified Mycotoxins T‑2 and HT‑2 Toxin in the Pig Cecum Model.’ Journal of Agricultural and Food Chemistry 68, Nr. 19. doi: 10.1021/acs.jafc.0c00576.
- . . ‘Real-time interaction analysis of Shiga toxins and membrane microdomains of primary human brain microvascular endothelial cells.’ Glycobiology 30, Nr. 3: 174–185. doi: 10.1093/glycob/cwz091.
- . . ‘Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles.’ Microorganisms 7, Nr. 11: 582. doi: 10.3390/microorganisms7110582.
- . . ‘Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.’ Molecules 24, Nr. 7: 1328. doi: 10.3390/molecules24071328.
- . ‘Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles.’ Eur. J. Pharm. Biopharm. 2019: 70–80.
- . ‘Serum type and concentration both affecting the protein corona composition of PLGA nanoparticles.’ Beilstein J. Nanotechnol. 10: 1002–1015.
- . . ‘Occurrence of the ochratoxin A degradation product 2′R-ochratoxin a in coffee and other food: An update.’ Toxins 11, Nr. 6: 329. doi: 10.3390/toxins11060329.
- . . ‘Matrix binding of T-2 toxin: structure elucidation of reaction products and indications on the fate of a relevant food-borne toxin during heating.’ Mycotoxin Research 35, Nr. 3: 261–270. doi: 10.1007/s12550-019-00350-2.
- . . ‘Human Study on the Kinetics of 2′R-Ochratoxin A in the Blood of Coffee Drinkers.’ Molecular Nutrition and Food Research 63, Nr. 4: 1801026. doi: 10.1002/mnfr.201801026.
- . . Thermal reactions and the formation of degradation products of T-2 and HT-2 toxin during processing of oats. 0. Aufl. Washington, D.C.: American Chemical Society. doi: 10.1021/bk-2019-1306.ch007.
- . . ‘Identification of ochratoxin-N-acetyl-L-cysteine as a new ochratoxin A metabolite and potential biomarker in human urine.’ Mycotoxin Research 2020, Nr. 36: 1–10. doi: 10.1007/s12550-019-00360-0.
- . . ‘Exploring secondary metabolite profiles of stachybotrys spp. By LC-MS/MS.’ Toxins 11, Nr. 3: 133. doi: 10.3390/toxins11030133.
- . . ‘Large-Scale Screening of Foods for Glucose-Derived β-Carboline Alkaloids by Stable Isotope Dilution LC–MS/MS.’ Journal of Agricultural and Food Chemistry 67: 3890–3899.
- . . ‘Detection of Novel Cytotoxic Imidazole Alkaloids in Tomato Products by LC-MS/MS.’ Journal of Agricultural and Food Chemistry 67: 3670–3678.
- . . ‘Identification of potential human urinary biomarkers for tomato juice intake by mass spectrometry-based metabolomics.’ European Journal of Nutrition 59: 685–697.
- . . ‘Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells.’ Toxins 10, Nr. 9: 353. doi: 10.3390/toxins10090353.
- 10.3390/toxins10070256. . ‘Interaction of Ochratoxin A and Its Thermal Degradation Product 2′R-Ochratoxin A with Human Serum Albumin.’ Toxins 10, Nr. 7: 256. doi:
- . ‘Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp.’ Mycotoxin Res. 34: 179–185.
- 10.1371/journal.pone.0197406. . ‘Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.’ PloS one 13(5). doi:
- . . ‘Interaction of ochratoxin A and its thermal degradation product 2'R-ochratoxin A with human serum albumin.’ Toxins 10, Nr. 7. doi: 10.3390/toxins10070256.
- . . ‘Glucosylation of T-2 and HT-2 toxins using biotransformation and chemical synthesis: Preparation, stereochemistry, and stability.’ Mycotoxin Research 34, Nr. 3: 159–172. doi: 10.1007/s12550-018-0310-9.
- . . ‘Detection of the Cytotoxic Penitrems A-F in Cheese from the European Single Market by HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 66, Nr. 5: 1264–1269. doi: 10.1021/acs.jafc.7b06001.
- . . ‘Interaction of 2'R-ochratoxin A with serum albumins: Binding site, effects of site markers, thermodynamics, species differences of albumin-binding, and influence of albumin on its toxicity in MDCK cells.’ Toxins 10, Nr. 9. doi: 10.3390/toxins10090353.
- . . ‘Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants.’ Journal of Agricultural and Food Chemistry 66, Nr. 1: 315–322. doi: 10.1021/acs.jafc.7b05580.
- 10.1016/j.enzmictec.2017.08.005. . ‘In vitro biosynthesis of 3-mercaptolactate by lactate dehydrogenases.’ Enzyme and Microbial Technology 108, Nr. null: 1–10. doi:
- 10.1007/s12550-017-0302-1. . ‘Enniatin B and ochratoxin A in the blood serum of workers from the waste management setting.’ Mycotoxin Research 34, Nr. 2: 85–90. doi:
- 10.1007/s00204-016-1799-3. . ‘Structure–activity relationship of ochratoxin A and synthesized derivatives: importance of amino acid and halogen moiety for cytotoxicity.’ Archives of Toxicology 91, Nr. 3: 1461–1471. doi:
- 10.1002/mnfr.201600629. . ‘Short-term biomarkers of apple consumption.’ Molecular Nutrition and Food Research 61, Nr. 3. doi:
- 10.1093/glycob/cww090. . ‘Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood-brain barrier endothelial cells.’ Glycobiology 27, Nr. 1: 99–109. doi:
- 10.1007/s12550-016-0263-9. . ‘Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study.’ Mycotoxin Research 33, Nr. 1: 79–91. doi:
- 10.1007/s12550-016-0261-y. . ‘Evidence of ochratoxin A conjugates in urine samples from infants and adults.’ Mycotoxin Research 33, Nr. 1: 39–47. doi:
- 10.1007/s00216-016-0047-2. . ‘Localization of ergot alkaloids in sclerotia of Claviceps purpurea by matrix-assisted laser desorption/ionization mass spectrometry imaging.’ Analytical and Bioanalytical Chemistry 409, Nr. 5: 1221–1230. doi:
- 10.1007/s12550-017-0290-1. . ‘Alternaria toxins in South African sunflower seeds: cooperative study.’ Mycotoxin Research 33, Nr. 4: 309–321. doi:
- In Chemical Contaminants and Residues in Food: Second Edition, edited by , 51–66. 0. Aufl. Amsterdam: Elsevier. doi: 10.1016/B978-0-08-100674-0.00003-5. . ‘Applications of High-Performance Liquid Chromatography-Mass Spectrometry Techniques for the Analysis of Chemical Contaminants and Residues in Food.’
- 10.1021/acs.jafc.7b01484. . ‘Impact of Mechanical and Thermal Energies on the Degradation of T-2 and HT-2 Toxins during Extrusion Cooking of Oat Flour.’ Journal of Agricultural and Food Chemistry 65, Nr. 20: 4177–4183. doi:
- 10.3390/toxins9070210. . ‘Influence of environmental factors on the production of penitrems A–F by Penicillium crustosum.’ Toxins 9, Nr. 7. doi:
- 10.1007/s00216-017-0279-9. . ‘Multi-mycotoxin analysis using dried blood spots and dried serum spots.’ Analytical and Bioanalytical Chemistry 409, Nr. 13: 3369–3382. doi:
- 10.1002/cbic.201600691. . ‘A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.’ ChemBioChem 18, Nr. 10: 899–904. doi:
- 10.1093/glycob/cwx048. . ‘Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors.’ Glycobiology 27, Nr. 10: 947–965. doi:
- 10.1007/s00204-016-1855-z. . ‘Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase.’ Archives of Toxicology 91, Nr. 4: 2007–2016. doi:
- 10.3390/toxins9040126. . ‘Establishment of the inducible Tet-on system for the activation of the silent trichosetin gene cluster in Fusarium fujikuroi.’ Toxins 9, Nr. 4. doi:
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- 10.3390/toxins9110338. . ‘Shiga toxin glycosphingolipid receptors in human Caco-2 and HCT-8 colon epithelial cell lines.’ Toxins 9, Nr. 11. doi:
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Betreute Promotionen
Lins, Anika Untersuchungen zur Proteincorona an kolloidalen Arzneistoffträgern. Laabs, Moritz Entwicklung, Charakterisierung und Testung von Lecithin-gecoateten Nanopartikeln zur Überwindung der Blut-Hirn-Schranke. Franziska Michaela Jürgens Untersuchungen pharmakokinetischer Eigenschaften von antileishmanialen Sesquiterpenlactonen aus Arnica montana L. Wünsch, Angelika Imitation von Lipoproteinen als nanopartikuläre Arzneistoffträgersysteme Dr. Krug, Isabel Doris In vitro-Untersuchungen zu den Effekten ausgewählter Mykotoxine und mariner Biotoxine an der Blut-Hirn-Schranke Dr. Sueck, Franziska Vorkommen, Proteinaffinität, Metabolismus und biologische Halbwertszeit der Mykotoxine 2’R-Ochratoxin A und Ochratoxin A beim Menschen Dr. Wagner (geb. Ferse), Ines Isolierung und Strukturaufklärung neuer Monascus-Sekundärmetabolite in Rotschimmelreis sowie Synthese von Ochratoxin A-Derivaten zur Untersuchung der StrukturWirkungs-Beziehung Dr. Kuchenbuch (geb. Schmidt), Henning Sören Investigations on the stability and degradation of T-2 toxin during thermal food processing Dr. Hickert, Sebastian Rudolf Investigation on Alternaria mycotoxins with focus on tenuazonic acid and studies oin the potential of micro-HPLC-MS/MS and MALDI-Imaging mass spectrometry for mycotoxin analysis Dr. Saenger (geb. Kemme), Theresa Studien zum Nachweis ernährungsbedingter Biomarker im Humanurin Kalinina Svetlana Penicillium spp. as a Source of Secondary Metabolites: Structure Elucidation, Occurrence in Food, Cytotoxicity, and Biological Activity Dr. Bergmann, Dominik Stabilisotopenmarkierte Darstellung des Mykotoxins Citrinin und seines Hauptmetaboliten Dihydrocitrinon sowie Synthese von Aminoglykosid-Derivaten Dr. Uebel, Thomas Beeinflussung des zellulären Redoxstatus durch Asaronisomere und der Beitrag zur DNA-Integrität Dr. Rottkord, Ulrike Struktur-Wirkungs-Beziehungen zur Toxizität von Ochratoxin A und kombinatorische Effekte mit Citrinin Dr. Arndt, Birgit Untersuchungen zum Sekundärmetabolismus von Fusarium fujikuroi Korte, Robin Analysis and Characterization of Food Allergens: A Mass Spectrometric Approach Haupenthal, Sabrina Beeinflussung der DNA-Integrität durch Metaboliten natürlicher kanzerogener Phenylpropanoide. Dr. Dopstadt, Julian Das Potential des Mutterkornpilzes Claviceps purpurea zur Produktion neuer Sekundärmetaboliten Dr. Rösler, Sarah M. Complex Regulation of Secondary Metabolism in the Phytopathogenic Fungus Fusarium fujikuroi Dr. Lichtenwald, Marina Molecular and phenotypical analysis of biofilm formation of enterohaemorrhagiuc Eschericia coli Meyer, Sören Instrumentelle Analytik (LC/ICPMS/MS) und toxikologische Charakterisierung von Arsenolipiden Dr. Gerding, Johannes Biomarkerbasierte Abschätzung der humanen Mykotoxinexposition und Untersuchung des Metabolismus ausgewählter Mykotoxine Schnieders, Annika Untersuchung von Naturstoffen als MHC-II Beladungskatalysatoren am Beispiel des HLA-DR Serotyps Kunsmann, Lisa Charakterisierung von Membranvesikeln enterohämorrhagischer Escherichia coli Dr. Hummel, Marlene Allergene Proteine in Gewürzen: Massenspektro-metrische Identifizierung und Charakterisierung von 2S Albuminen aus Senf und Sesam Bittner, Andrea Matrix-gebundene Ochratoxin A-Rückstände in thermisch behandelten Lebensmitteln: Strukturaufklärung, Analytik und Bioverfügbarkeit Bittner, Katharina Studien zum Vorkommen, zur systemischen Absorption und zum Metabolismus von Polyphenolen Dr. von Bargen, Katharina Walburga Identifizierung und Strukturaufklärung neuer Sekundärmetaboliten aus Fusarium fujikuroi sowie Untersuchungen zur Biosynthese und Analytik Bargen, Christoph Authentifizierung und Strukturaufklärung von Lebensmittelinhaltsstoffen mittels massenspektrometrischer Methoden am Beispiel von Proteinen und Polyphenolen Unterberg, Marlies Etablierung eines LC/FTMS basierten Testsystems zur Quantifizierung der epigenetische Effekte von Arsenverbindungen Hemmersbach, Sarah Intestinal absorption of flavonoids and metabolites in the Caco-2 model Pieper, Imke Organoquecksilberspezies und der zelluläre DNA-Schadensresponse Lepski, Silke Charakterisierung und massenspektrometrische Nachweis von Nussallergenen Weiss, André Funktionale Charakterisierung der Serinprotease-Autotransporter EspPα und Espl aus enterohämorrhagischen Escherichia coli Weidner, Maria Untersuchungen zur Toxizität und zum Metabolismus von Fusarium-Mykotoxinen in humanen Primärzellen Studt, Lena Effects of biotic and abiotic factors on the production of Fusarium-mycotoxins by phytophathogenic Fusarium-isolates Leffers, Larissa Bioverfügbarkeit, Metabolismus und Toxizität von Arsenozuckern Dr. Brezina, Ulrike Determination of zearalenone, deoxynivalenol and their metabolites in physiological samples of pigs with LC-MS/MS: Development of multi-mycotoxin methods and verification through a dose-response feeding study Lohrey, Lilia Darstellung der stabilisotopenmarkierten Mykotoxine Moniliformin und Tenuazonsäure sowie Synthese von bioaktiven Arylthiazolen mittels direkter Fusarin-Analoga Engemann, Anna Intestinaler Metabolismus von Lebensmittelinhaltsstoffen im Schweine-Caecum-Modell Dr. Havermann, Susannah Aktivierung des ARE durch Flavonole und Hydroxyzimtsäurederivate: Untersuchungen in Zellkultursystemen und C. elegans Kleigrewe, Karin Vorkommen von Fusarin-C-Mykotoxinen in Lebensmitteln und Strukturaufklärung neuer Fusarin-Analoga Dr. Diederich, Johannes Manganspeziation in biologischen Proben Fraske, Andrea Studien zur systemischen Absorption und zum Metabolismus von Anthocyanen im Tiermodell Schwein Dr. Riedel, Sylvia Modulation of lipid metabolism as a possible tool to prevent carcinoigenoic effects of fumonisin B1 Dr. Ehlers, Susan Analytik von Perfluoralkylsäuren in verschiedenen Matrices zur Klärung der Toxikokinetik in Tierarten die der Lebensmittelgewinnung dienen Dr. Bevanda-Franjic, Marijane In vitro-Studien von Anthocyanen im Caco-2-Modellsystem Rzeppa, Sebastian Isolierung, Strukturaufklärung und Analytik von Procyanidinen sowie Kinetikstudien im Tiermodell am Schwein Blaas, Nina Untersuchungen zur massenspektrometrischen Charakterisierung von Sphingophospholipiden in humaner Milch und pflanzlichen Lebensmitteln Mulac, Dennis Zellkulturstudien zur Cytotoxizität, zur Aufnahme und zum Transportmechanismus von Mutterkornalkaloiden Hübner, Florian Darstellung der stabilisotopen-markierten Mykotoxine Fumonisin B1 und Alternariol Dr. Betz, Josefine Struktur-Funktions-Analysen von Shiga Toxin-Rezeptoren mikro- und makrovaskulärer humaner Endothelzellen Dr. Neue, Kristina Elucidation of N-glycosylation by unspecific proteolysis in combination with ZIC-HILIC SPE and de novo sequencing of IgG primary structures by use of direct nanoESI Q-Tof mass spectrometry Dr. Harrer, Henning Uwe Michael Die Bedeutung des Sphingolipidstoffwechsels für die toxikologische Wirkungsweise der Fumonisin-Mykotoxine Dr. Franzmann, Carolin Untersuchungen zum Vorkommen, zur Stabilität und zum thermischen Abbau von Mutterkornalkaloiden in Roggen und Roggenprodukten Dr. Nollen, Maike Cora Untersuchungen zur indirekten Genotoxizität von Arsenit und seinem Metabolit monomethylarsonige Säure Wiemann, Philipp Regulation des sekundär Metabolismus in phytopathogenen Fusarium spp. Dr. van 't Slot, Gordon Untersuchungen zum intestinalen Metabolismus von pflanzlichen Lebensmittelinhaltsstoffen Dr. Fischbeck, Anne Vorkommen von Sphingomyelin in der menschlichen Ernährung und seine Bedeutung bei entzündlichen Darmerkrankungen im Tiermodell Dr. Trebstein, Anke Analytik von Mykotoxinen der Gattung Fusarium mittels Hochleistungsflüssigchromatographie mit Fluoreszenzdetektion und Tandem-Massenspektrometrie Dr. Beyer, Marita Produktion, Analytik und Abbau bedeutender Trichothecen-Mykotoxine Brockmeyer, Jens Structure and function of the plasmid-encoded bacterial serine protease autotransporter EspP from Shiga toxin-producing Escherichia coli Dr. Aldick, Thomas Stabilität und Aktivität von freiem und vesikulärem Hämolysin aus enterohämorrhagischen Escherichia coli Cramer, Benedikt Thermischer Abbau und Analytik der Mykotoxine Ochratoxin A und Zearalenon Dr. Königs, Maika Untersuchungen zur Cytotoxizität und zum Metabolismus von Fusarientoxinen in humanen Primärzellen Dr. Rose, Ina Katrin Metabolismus von Flavonoiden durch die intestinale Mikroflora im Schweine-Caecum-Modell Dr. Klötzel, Marianna Entwicklung von Analyseverfahren zur empfindlichen Bestimmung von Fusarientoxinen in Lebensmitteln Dr. Bartke, Nana Untersuchungen zum Vorkommen von Sphingolipiden in pflanzlichen Lebensmitteln Dr. Knecht, Anja Monascus-Sekundärmetabolite: Neue Verbindungen und Untersuchungen zur biologischen Aktivität Dr. Bretz, Michael Ewald Produktion, Analytik und Abbau ausgewählter Fusarientoxine
Professor Dr. Hans-Ulrich Humpf
Professur für Lebensmittelchemie (Prof. Humpf)