Professor Dr. Hans-Ulrich Humpf

Professur für Lebensmittelchemie (Prof. Humpf)
Professor Dr. Hans-Ulrich Humpf

Corrensstr. 45
48149 Münster

Academic Profiles

External Profile

  • Research Foci

    • Studies on the thermal stability, biosynthesis, toxicity and (intestinal) metabolism of mycotoxins.
    • Development of human biomonitoring methods (HBM) for exposure assessment of mycotoxins and detection of nutritional biomarkers.
    • Metabolomics- and proteomics-based approaches to characterise cellular responses upon exposure to mycotoxins and other food constituents
    • transfer of food constituents across the intestinal barrier (Caco-2 model) as well as the blood-brain-barrier.
    • Studies on the occurrence and significance of mycotoxins in indoor environments
  • CV

    Academic Education

    Habilitation und Erlangung der Venia legendi im Fachgebiet "Lebensmittelchemie"
    Forschungsaufenthalt an der Emory University, Atlanta, USA, Department of Biochemistry bei Herrn Prof. Dr. A.H. Merrill
    2. Ausbildungsphase für Lebensmittelchemiker am Landesuntersuchungsamt in Erlangen, Staatsprüfung für Lebensmittelchemiker
    Dissertation am Lehrstuhl für Lebensmittelchemie der Universität Würzburg bei Prof. Dr. P. Schreier

    Positions

    Dean of the Faculty for Chemistry and Pharmacy at the Westfälischen Wilhelms-Universität Münster
    Managing Direktor of the Institute of Food Chemistry
    W3-Full-Professor for Food Chemistry and Director of the Institute of Food Chemistry at the University of Münster
    C3-Professor of Food Chemistry at the University of Münster
    Wissenschaftlicher Assistent und seit 01.10.2000 Oberassistent am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
    Post-doc an der Columbia University, New York, Department of Chemistry bei Prof. Dr. K. Nakanishi
    Wissenschaftlicher Mitarbeiter am Lehrstuhl für Lebensmittelchemie der Universität Würzburg

    Honors

    Josef-Schormüller-Stipendium – Lebensmittelchemische Gesellschaft (LChG) - Fachgruppe in der Gesellschaft Deutscher
    Studienabschluss-Stipendium – Fonds der Chemischen Industrie (FCI)
    Stockmeyer Wissenschaftspreis 2002 – Heinrich-Stockmeyer-Stiftung
    Peter B. Czedik-Eysenberg-Preis – GÖCH - Gesellschaft Österreichischer Chemiker - Arbeitsgruppe Lebensmittel, Kosmetik und Gebrauchsgegenstände

    External Functions

    German Research Foundation (DFG) (Member of the DFG Review Board "Biological Chemistry and Food Chemistry" for the subject Food Chemistry)
    Springer-Nature (Editor in Chief of the journal Mycotoxin Research)
    Federal Institute for Risk Assessment (BfR) (BfR Commission for Contaminants in the Food Chain, Member)
    Society for Mycotoxin Research (President)
    Wiley-VCH (Editor in Chief of the journal "Molecular Nutrition and Food-Research")
    Mitglied in der der Senatskommission der Deutschen Forschungsgemeinschaft zur gesundheitlichen Bewertung von Lebensmitteln (SKLM)
    Präsident der Gesellschaft für Mykotoxinforschung e.V.
    Federal Institute for Risk Assessment (BfR) (of the Expert Commission "Contaminants and other undesirable substances in the food chain", Member)
    Associate Editor der Zeitschrift "Molecular Nutrition and Food-Research", Wiley-VCH
    Mitglied der Gesellschaft für Mykotoxinforschung e.V.
    Member of the American Chemical Society
    Mitglied in der Gesellschaft Deutscher Chemiker GDCh

    Appointments

    Ruf auf eine W3-Professur für Lebensmittelchemie an der Universität Münster
    University of Münster, Lebensmittelchemie (W3) – accepted
    Ruf auf eine C4-Professur für Lebensmittelchemie, Universität Hamburg
    , Lebensmittelchemie (C4) – rejected
    Ruf auf eine C4-Professur für Lebensmittelchemie, Universität Halle-Wittenberg
    , Lebensmittelchemie (C4) – rejected
    Ruf auf eine C3-Professur für Lebensmittelchemie an der Universität Münster
    University of Münster, Lebensmittelchemie (C3) – accepted
    Ruf auf eine C3-Professur für Lebensmittelchemie, Universität Hohenheim
    , Lebensmittelchemie (C3) – rejected
  • Teaching

  • Publications

    • , , , , , , , , and . “Antagonistic properties against Fusarium sporotrichioides and glycosylation of HT-2 and T-2 toxins by selected Trichoderma strains.Scientific Reports, 14 (1) doi: 10.1038/s41598-024-55920-x.
    • , , , , , , , , , , , , , , and . “Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.Archives of Toxicology, 98 (4): 10811093. doi: 10.1007/s00204-024-03688-4.
    • , , , , and . “Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.Journal of Agricultural and Food Chemistry, 72 (6): 31503159. doi: 10.1021/acs.jafc.3c07465.
    • , , , , , , , , , , , , , , , , , , , , , , and . “Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food.Archives of Toxicology, 98 (6) doi: 10.1007/s00204-024-03726-1.
    • , , , , and . . “Co-occurrence of T-2 and HT-2 Mycotoxins and α and <i>β</i> Anomers of Their Glucosides in Wheat and Oat Grains.Journal of Agricultural and Food Chemistry, 72 (6) doi: 10.1021/acs.jafc.3c07465.
    • , , , and . . “Human Intervention Study: Alkylresorcinol Metabolites as Potential Biomarkers for Grain Intake and the Occurrence of Alkylresorcinols in Commonly Consumed Foods in the German Retail Sector.ACS Omega, 9 (22) doi: 10.1021/acsomega.4c00733.
    • , , , , , , , and . . “Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in <i>Fusarium fujikuroi</i>.Epigenetics and Chromatin, 17 (1) doi: 10.1186/s13072-024-00532-y.
    • , , , , , , , , , , , , , , and . . “Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.Archives of Toxicology, 1 doi: 10.1007/s00204-024-03688-4.
    • , , , , , , , , , and . . “Role of albumin in the metabolism and excretion of ochratoxin A.Mycotoxin Research, 1 doi: 10.1007/s12550-024-00538-1.
    • , , , , , and . . “Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells.Molecular Nutrition and Food Research, 68 (6) doi: 10.1002/mnfr.202300639.
    • , , , , , and . . “Surface Display and Engineering of Laccase CotA for Increased Growth of <i>Pseudomonas putida</i> on Lignin.ChemCatChem, 16 (4) doi: 10.1002/cctc.202301055.
    • , , , , , , , and . “Tools to make Stachybotrys chartarum genetically amendable: Key to unlocking cryptic biosynthetic gene clusters.Fungal Genetics and Biology, 172 doi: 10.1016/j.fgb.2024.103892.
    • , , , , and . “Are stabilizers, located at the surface of PLGA nanoparticles, able to modify the protein adsorption pattern?” contributed to the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Wien
    • , , , , , and . “Impact of the protein corona on nanoparticle uptake by macrophages.” contributed to the DPhG Annual Meeting (2024), Münster

    • , , , , , , , , , , , , , , , , , , , , , , , and . “Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.British Journal of Haematology, 202 (5): 10331048. doi: 10.1111/bjh.18939.
    • , , , , , and . “Role of stabilizers in protein adsorption patterns of PLGA nanoparticles.” contribution to the DPhG Annual Meeting, Tübingen
    • , , , , , , , , , , and . . “Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.Archives of Toxicology, 97 (12): 31793196. doi: 10.1007/s00204-023-03607-z.
    • , , , , and . “Degradation products of aflatoxin M1 (AFM1) formed by high voltage atmospheric cold plasma (HVACP) treatment.Toxicon, 230 doi: 10.1016/j.toxicon.2023.107160.
    • , , , , and . “Determination of furan and alkylfuran in breakfast cereals from the European market and their correlation with acrylamide levels.European Food Research and Technology, 2023 doi: 10.1007/s00217-023-04374-y.
    • , , , , , and . “Maternal exposure to multiple mycotoxins and adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh.Archives of Toxicology, 97 (6): 17951812. doi: 10.1007/s00204-023-03491-7.
    • , , , , and . . “Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.Molecular Nutrition and Food Research, 67 (21): e2300052e2300052. doi: 10.1002/mnfr.202300052.
    • , , , , , , , , , , , , , , , and . . “Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.PLoS Pathogens, 19 (7): e1010986e1010986. doi: 10.1371/journal.ppat.1010986.

    • , , , , , , and . . “Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro.PloS one, 17 (6): e0269486e0269486. doi: 10.1371/journal.pone.0269486.
    • , , , , , , , , and . . “Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.Food and Chemical Toxicology, 164: 113006. doi: 10.1016/j.fct.2022.113006.
    • , , , , , and . . “Mycotoxins in Serum and 24-h Urine of Vegans and Omnivores from the Risks and Benefits of a Vegan Diet (RBVD) Study.Molecular Nutrition and Food Research, 66 (6) doi: 10.1002/mnfr.202100874.
    • , , , and . . “Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.Analytical Chemistry, 94 (10): 42094217. doi: 10.1021/acs.analchem.1c04254.
    • , , , , and . . “In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.Metabolites, 12: 88. doi: 10.3390/metabo12010088.
    • , , , , , , and . “Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles.Biomaterials and Biosystems, 5: 100032. doi: 10.1016/j.bbiosy.2021.100032.
    • , , , , , , , , , , , , , , , , , , , , and . . “Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.Archives of Toxicology, 96 (11): 29672981. doi: 10.1007/s00204-022-03361-8.
    • , , , , , , , , , , , , , and . . “Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.Archives of Toxicology, 96 (12): 33493361. doi: 10.1007/s00204-022-03395-y.
    • , , , , and . “In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.Metabolites, 12 (1): 88. doi: 10.3390/metabo12010088.
    • , , , and . . “Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.Archives of Toxicology, 96 (11): 29832998. doi: 10.1007/s00204-022-03348-5.
    • , , , , and . “Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh.Archives of Toxicology, 96 (7): 21232138. doi: 10.1007/s00204-022-03288-0.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and . . “Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.Archives of Toxicology, 96 (6): 19051914. doi: 10.1007/s00204-022-03296-0.
    • , , , , , and . . “Analysis of mold and mycotoxins in naturally infested indoor building materials.Mycotoxin Research, 2022 doi: 10.1007/s12550-022-00461-3.
    • , , , and . “From the laboratory bench to the lecture hall: latest findings from mycotoxin research presented at the 43rd Mycotoxin Workshop.Mycotoxin Research, 2022 doi: 10.1007/s12550-022-00462-2.
    • , , and . . “C Lignin in the Pig Cecum Model.Journal of Agricultural and Food Chemistry, 70 (27): 83178325. doi: 10.1021/acs.jafc.2c02836.
    • , , , , and . . “.In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys.Toxins, 14 (6): 395. doi: 10.3390/toxins14060395.
    • , , , and . . “Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.Analytical Chemistry, 94 (10): 42094217. doi: 10.1021/acs.analchem.1c04254.
    • , , , , , and . . “Can the presence of additives result in false positive errors for microplastics in infant feeding bottles?Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 39 (1): 185197. doi: 10.1080/19440049.2021.1989498.

    • , , and . . “Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).Mycotoxin Research, 37 (4): 275278. doi: 10.1007/s12550-021-00439-7.
    • , , , , , and . “Studies on the formation of a protein corona on colloidal drug carriers.” contribution to the EMBO practical course – targeted proteomics: Experimental design and data analysis., CRG – Centre de Regulació Genòmica, online
    • , , , , and . “Nanoparticle matrix and incubation medium – main influencer of the protein corona?” contribution to the DPhG Annual Meeting, Leipzig online
    • , , , , , , and . . “Determination of urinary mycotoxin biomarkers using a sensitive online solid phase extraction‐uhplc‐ms/ms method.Toxins, 13 (6) doi: 10.3390/toxins13060418.
    • , , , , and . “Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.European journal of pharmaceutics and biopharmaceutics, 163: 212222.
    • , , , , and . . “Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine.Mycotoxin Research, 37 (2): 129140. doi: 10.1007/s12550-021-00423-1.
    • , , , , , , , , , , , , , , and . . “Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney.Archives of Toxicology, 95 (6): 21632177. doi: 10.1007/s00204-021-03073-5.
    • , , , , , , , , , , and . “Chemoenzymatic synthesis of 2,6-disubsttuted tetrahydropyrans with high 1 receptor affinity, antitumor and analgesic activity.European Journal of Medicinal Chemistry, 219: 113443. doi: 10.1016/j.ejmech.2021.113443.
    • , , and . . “Natural Compounds Isolated from <i>Stachybotrys chartarum</i> Are Potent Inhibitors of Human Protein Kinase CK2.Molecules, 26 (15): 4453. doi: 10.3390/molecules26154453.
    • , , , , , , , , , and . . “Insights into Ergochromes of the Plant Pathogen <i>Claviceps purpurea</i>.Journal of Natural Products, 84 (10): 26302643. doi: 10.1021/acs.jnatprod.1c00264.
    • , , , , , , and . . “Primary Human Colon Epithelial Cells (pHCoEpiCs) Do Express the Shiga Toxin (Stx) Receptor Glycosphingolipids Gb3Cer and Gb4Cer and Are Largely Refractory but Not Resistant towards Stx.International Journal of Molecular Sciences (IJMS), 22 (18): 10002. doi: 10.3390/ijms221810002.
    • , , , , , , , and . . “Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains.Toxins, 13 (8): 529.
    • , , , and . . “Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone.Toxins, 13 (5): 327. doi: 10.3390/toxins13050327.
    • , , , , , , , and . . “Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity.Toxins, 13 (2): 139. doi: 10.3390/toxins13020139.

    • , , , , and . . “Mass Spectrometry–Based Analysis of Urinary Biomarkers for Dietary Tomato Intake.Molecular Nutrition & Food Research, 64
    • , , , and . . “Identification of a novel N-caprylhistamine-β-glucoside from tomato fruits and LC-MS/MS-based food screening for imidazole alkaloids.Food Chemistry, 312
    • , , , , , , and . . “Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics.Mycotoxin Research, 36 (2): 193206. doi: 10.1007/s12550-019-00381-9.
    • , , , , , , , , , , , , , , , , , , and . . “Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.Journal of Medicinal Chemistry, 63 (21): 1315913186. doi: 10.1021/acs.jmedchem.0c01635.
    • , , , , , , , and . . “Govaniadine Evaluation of Cytotoxicity and Permeability in Cell Culture.Revista Brasileira de Farmacognosia, 30 (3): 374380. doi: 10.1007/s43450-020-00066-w.
    • , , , , , , and . . “Artificial vs natural Stachybotrys infestation—Comparison of mycotoxin production on various building materials.Indoor Air, 30 (6): 12681282. doi: 10.1111/ina.12705.
    • , , , , , , and . . “Metabolomics Study on Pathogenic and Non-pathogenic E. coli with Closely Related Genomes with a Focus on Yersiniabactin and Its Known and Novel Derivatives.Metabolites, 10 (6): 221. doi: 10.3390/metabo10060221.
    • , , , , , and . . “Intestinal Metabolism of α- and β‑Glucosylated Modified Mycotoxins T‑2 and HT‑2 Toxin in the Pig Cecum Model.Journal of Agricultural and Food Chemistry, 68 (19) doi: 10.1021/acs.jafc.0c00576.
    • , , , , , , , and . . “Real-time interaction analysis of Shiga toxins and membrane microdomains of primary human brain microvascular endothelial cells.Glycobiology, 30 (3): 174185. doi: 10.1093/glycob/cwz091.

    • , , , and . . “Large-Scale Screening of Foods for Glucose-Derived β-Carboline Alkaloids by Stable Isotope Dilution LC–MS/MS.Journal of Agricultural and Food Chemistry, 67: 38903899.
    • , , , and . . “Detection of Novel Cytotoxic Imidazole Alkaloids in Tomato Products by LC-MS/MS.Journal of Agricultural and Food Chemistry, 67: 36703678.
    • , , , , and . . “Identification of potential human urinary biomarkers for tomato juice intake by mass spectrometry-based metabolomics.European Journal of Nutrition, 59: 685697.
    • , , , , , , and . . “Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.Molecules, 24 (7): 1328. doi: 10.3390/molecules24071328.
    • , , , , , , and . “Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles.Eur. J. Pharm. Biopharm., 2019: 7080.
    • , , , , and . “Serum type and concentration both affecting the protein corona composition of PLGA nanoparticles.Beilstein J. Nanotechnol., 10: 10021015.
    • , , , , , and . . “Occurrence of the ochratoxin A degradation product 2′R-ochratoxin a in coffee and other food: An update.Toxins, 11 (6): 329. doi: 10.3390/toxins11060329.
    • , , and . . “Matrix binding of T-2 toxin: structure elucidation of reaction products and indications on the fate of a relevant food-borne toxin during heating.Mycotoxin Research, 35 (3): 261270. doi: 10.1007/s12550-019-00350-2.
    • , , , and . . “Human Study on the Kinetics of 2′R-Ochratoxin A in the Blood of Coffee Drinkers.Molecular Nutrition and Food Research, 63 (4): 1801026. doi: 10.1002/mnfr.201801026.
    • , , , , and . . ACS Symposium Series, Vol.1306, Thermal reactions and the formation of degradation products of T-2 and HT-2 toxin during processing of oats, Washington, D.C.: American Chemical Society. doi: 10.1021/bk-2019-1306.ch007.
    • , , , and . . “Identification of ochratoxin-N-acetyl-L-cysteine as a new ochratoxin A metabolite and potential biomarker in human urine.Mycotoxin Research, 2020 (36): 110. doi: 10.1007/s12550-019-00360-0.
    • , , , , , , , and . . “Exploring secondary metabolite profiles of stachybotrys spp. By LC-MS/MS.Toxins, 11 (3): 133. doi: 10.3390/toxins11030133.
    • , , , , , , , and . . “Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles.Microorganisms, 7 (11): 582. doi: 10.3390/microorganisms7110582.

    • , , , , , and . . “Detection of the Cytotoxic Penitrems A-F in Cheese from the European Single Market by HPLC-MS/MS.Journal of Agricultural and Food Chemistry, 66 (5): 12641269. doi: 10.1021/acs.jafc.7b06001.
    • , , , , , , , , , , , and . . “Interaction of 2'R-ochratoxin A with serum albumins: Binding site, effects of site markers, thermodynamics, species differences of albumin-binding, and influence of albumin on its toxicity in MDCK cells.Toxins, 10 (9) doi: 10.3390/toxins10090353.
    • , , , , , and . . “Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants.Journal of Agricultural and Food Chemistry, 66 (1): 315322. doi: 10.1021/acs.jafc.7b05580.
    • , , , , , and . . “Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells.Toxins, 10 (9): 353. doi: 10.3390/toxins10090353.
    • , , , , , , , , and . “Interaction of Ochratoxin A and Its Thermal Degradation Product 2′<i>R</i>-Ochratoxin A with Human Serum Albumin.Toxins, 10 (7): 256. doi: 10.3390/toxins10070256.
    • , , , , , , and . “Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp.Mycotoxin Res., 34: 179185.
    • , , , and . “Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.PloS one, 13(5) doi: 10.1371/journal.pone.0197406.
    • , , , , , , , , and . . “Interaction of ochratoxin A and its thermal degradation product 2'R-ochratoxin A with human serum albumin.Toxins, 10 (7) doi: 10.3390/toxins10070256.
    • , , , , , and . . “Glucosylation of T-2 and HT-2 toxins using biotransformation and chemical synthesis: Preparation, stereochemistry, and stability.Mycotoxin Research, 34 (3): 159172. doi: 10.1007/s12550-018-0310-9.
    • , , , , and . “In vitro biosynthesis of 3-mercaptolactate by lactate dehydrogenases.Enzyme and Microbial Technology, 108 (null): 110. doi: 10.1016/j.enzmictec.2017.08.005.
    • , , , , , and . “Enniatin B and ochratoxin A in the blood serum of workers from the waste management setting.Mycotoxin Research, 34 (2): 8590. doi: 10.1007/s12550-017-0302-1.

    • , , , , , , , and . “Structure–activity relationship of ochratoxin A and synthesized derivatives: importance of amino acid and halogen moiety for cytotoxicity.Archives of Toxicology, 91 (3): 14611471. doi: 10.1007/s00204-016-1799-3.
    • , , and . “Short-term biomarkers of apple consumption.Molecular Nutrition and Food Research, 61 (3) doi: 10.1002/mnfr.201600629.
    • , , , , , and . “Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood-brain barrier endothelial cells.Glycobiology, 27 (1): 99109. doi: 10.1093/glycob/cww090.
    • , , , , and . “Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study.Mycotoxin Research, 33 (1): 7991. doi: 10.1007/s12550-016-0263-9.
    • , , , , and . “Evidence of ochratoxin A conjugates in urine samples from infants and adults.Mycotoxin Research, 33 (1): 3947. doi: 10.1007/s12550-016-0261-y.
    • , , , , , , and . “Localization of ergot alkaloids in sclerotia of Claviceps purpurea by matrix-assisted laser desorption/ionization mass spectrometry imaging.Analytical and Bioanalytical Chemistry, 409 (5): 12211230. doi: 10.1007/s00216-016-0047-2.
    • , , , , , , , and . “Alternaria toxins in South African sunflower seeds: cooperative study.Mycotoxin Research, 33 (4): 309321. doi: 10.1007/s12550-017-0290-1.
    • , , and . “Applications of High-Performance Liquid Chromatography-Mass Spectrometry Techniques for the Analysis of Chemical Contaminants and Residues in Food.” in Chemical Contaminants and Residues in Food: Second Edition, Vol.null , edited by D Schrenk. Amsterdam: Elsevier. doi: 10.1016/B978-0-08-100674-0.00003-5.
    • , , , and . “Impact of Mechanical and Thermal Energies on the Degradation of T-2 and HT-2 Toxins during Extrusion Cooking of Oat Flour.Journal of Agricultural and Food Chemistry, 65 (20): 41774183. doi: 10.1021/acs.jafc.7b01484.
    • , , , , and . “Influence of environmental factors on the production of penitrems A–F by Penicillium crustosum.Toxins, 9 (7) doi: 10.3390/toxins9070210.
    • , , , and . “Multi-mycotoxin analysis using dried blood spots and dried serum spots.Analytical and Bioanalytical Chemistry, 409 (13): 33693382. doi: 10.1007/s00216-017-0279-9.
    • , , , , , and . “A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.ChemBioChem, 18 (10): 899904. doi: 10.1002/cbic.201600691.
    • , , , , , , and . “Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors.Glycobiology, 27 (10): 947965. doi: 10.1093/glycob/cwx048.
    • , , , , , , , and . “Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase.Archives of Toxicology, 91 (4): 20072016. doi: 10.1007/s00204-016-1855-z.
    • , , , , , , and . “Establishment of the inducible Tet-on system for the activation of the silent trichosetin gene cluster in Fusarium fujikuroi.Toxins, 9 (4) doi: 10.3390/toxins9040126.
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    • , , , , and . . “Absolute stereochemistry of natural 3,4-Dihydroxy-β-ionone glycosides by the cd exciton chirality method.Journal of Natural Products, 57: 17621765. doi: 10.1021/np50114a027.

    • , , and . . “Natural Precursor of Isomeric Vitispiranes from Plant Tissues: 3,4-Dihydroxy-7,8-dihydro-β-ionol β-D-glucoside.” in Progress in Flavour Precursor Studies, edited by P Schreier and P Winterhalter. N/A: Sonstiger Verlag / other publisher.

    • , , and . . “3,4-dhydroxy-7,8-dihydro-β-ionol β-D-gucopyranoside: Natural precursor of isomeric vitispiranes from gooseberry (Ribes uva crispa L.) and whitebeam (Sorbus aria) leaves.Journal of Agricultural and Food Chemistry, 40 (11): 20602062. doi: 10.1021/jf00023a006.
    • , and . . “3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-hydroxy-7,8-dihydro-β-ionol β-d-glucopyranoside: New C13 norisoprenoid glucoconjugates from sloe tree (prunus spinosa l.) leaves.Journal of Agricultural and Food Chemistry, 40 (10): 18981901. doi: 10.1021/jf00022a034.
    • , and . . “3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-Hydroxy-7,8-dihydro-β-ionol β-D-Glucopyranoside: New C13 Norisoprenoid Glucoconjugates from Sloe Tree (Prunus spinosa L.) Leaves.Journal of Agricultural and Food Chemistry, 40: 18981901. doi: 10.1021/jf00022a034.

    • , , and . . “3,4-Dihydroxy-7,8-dihydro-β-ionone β-d-glucopyranoside: natural precursor of 2,2,6,8-tetramethyl-7,l 1-dioxatricyclote.[6.2.1.0]-ene (Riesling Acetal) and l,l,6-trimethyl-l,2-dihydronaphthalene in red currant (Ribes rubrum L.) leaves.Journal of Agricultural and Food Chemistry, 39 (10): 18331835. doi: 10.1021/jf00010a029.
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  • Supervised Doctoral Studies

    Untersuchungen zur Proteincorona an kolloidalen Arzneistoffträgern.
    Entwicklung, Charakterisierung und Testung von Lecithin-gecoateten Nanopartikeln zur Überwindung der Blut-Hirn-Schranke.
    Franziska Michaela JürgensInvestigation of pharmacokinetic properties of antileishmanial Sesquiterpene lactones from Arnica montana L. (Thesis written in German)
    Wünsch, AngelikaImitation von Lipoproteinen als nanopartikuläre Arzneistoffträgersysteme
    Dr. Krug, Isabel DorisIn vitro-Untersuchungen zu den Effekten ausgewählter Mykotoxine und mariner Biotoxine an der Blut-Hirn-Schranke
    Dr. Sueck, FranziskaVorkommen, Proteinaffinität, Metabolismus und biologische Halbwertszeit der Mykotoxine 2’R-Ochratoxin A und Ochratoxin A beim Menschen
    Dr. Wagner (geb. Ferse), InesIsolierung und Strukturaufklärung neuer Monascus-Sekundärmetabolite in Rotschimmelreis sowie Synthese von Ochratoxin A-Derivaten zur Untersuchung der StrukturWirkungs-Beziehung
    Dr. Kuchenbuch (geb. Schmidt), Henning SörenInvestigations on the stability and degradation of T-2 toxin during thermal food processing
    Dr. Hickert, Sebastian RudolfInvestigation on Alternaria mycotoxins with focus on tenuazonic acid and studies oin the potential of micro-HPLC-MS/MS and MALDI-Imaging mass spectrometry for mycotoxin analysis
    Dr. Saenger (geb. Kemme), TheresaStudien zum Nachweis ernährungsbedingter Biomarker im Humanurin
    Kalinina SvetlanaPenicillium spp. as a Source of Secondary Metabolites: Structure Elucidation, Occurrence in Food, Cytotoxicity, and Biological Activity
    Dr. Bergmann, DominikStabilisotopenmarkierte Darstellung des Mykotoxins Citrinin und seines Hauptmetaboliten Dihydrocitrinon sowie Synthese von Aminoglykosid-Derivaten
    Dr. Uebel, ThomasImpact of aserone isomers on cellular redox status and the onset of DNA-integrity
    Dr. Rottkord, UlrikeStruktur-Wirkungs-Beziehungen zur Toxizität von Ochratoxin A und kombinatorische Effekte mit Citrinin
    Dr. Arndt, BirgitStudies on the secondary metabolism of Fusarium fujikuroi
    Analysis and Characterization of Food Allergens: A Mass Spectrometric Approach
    Haupenthal, SabrinaBeeinflussung der DNA-Integrität durch Metaboliten natürlicher kanzerogener Phenylpropanoide.
    Dr. Dopstadt, JulianDas Potential des Mutterkornpilzes Claviceps purpurea zur Produktion neuer Sekundärmetaboliten
    Dr. Rösler, Sarah M.Complex Regulation of Secondary Metabolism in the Phytopathogenic Fungus Fusarium fujikuroi
    Dr. Lichtenwald, MarinaMolecular and phenotypical analysis of biofilm formation of enterohaemorrhagiuc Eschericia coli
    Instrumentelle Analytik (LC/ICPMS/MS) und toxikologische Charakterisierung von Arsenolipiden
    Dr. Gerding, JohannesBiomarkerbasierte Abschätzung der humanen Mykotoxinexposition und Untersuchung des Metabolismus ausgewählter Mykotoxine
    Investigation of natural products as MHC-II loading enhancers with the HLA-DR1 serotype as an example (Thesis written in German)
    Kunsmann, LisaCharakterisierung von Membranvesikeln enterohämorrhagischer Escherichia coli
    Dr. Hummel, MarleneAllergene Proteine in Gewürzen: Massenspektro-metrische Identifizierung und Charakterisierung von 2S Albuminen aus Senf und Sesam
    Matrix-gebundene Ochratoxin A-Rückstände in thermisch behandelten Lebensmitteln: Strukturaufklärung, Analytik und Bioverfügbarkeit
    Studien zum Vorkommen, zur systemischen Absorption und zum Metabolismus von Polyphenolen
    Dr. von Bargen, Katharina WalburgaIdentifizierung und Strukturaufklärung neuer Sekundärmetaboliten aus Fusarium fujikuroi sowie Untersuchungen zur Biosynthese und Analytik
    Authentifizierung und Strukturaufklärung von Lebensmittelinhaltsstoffen mittels massenspektrometrischer Methoden am Beispiel von Proteinen und Polyphenolen
    Etablierung eines LC/FTMS basierten Testsystems zur Quantifizierung der epigenetische Effekte von Arsenverbindungen
    Intestinal absorption of flavonoids and metabolites in the Caco-2 model
    Organoquecksilberspezies und der zelluläre DNA-Schadensresponse
    Charakterisierung und massenspektrometrische Nachweis von Nussallergenen
    Funktionale Charakterisierung der Serinprotease-Autotransporter EspPα und Espl aus enterohämorrhagischen Escherichia coli
    Untersuchungen zur Toxizität und zum Metabolismus von Fusarium-Mykotoxinen in humanen Primärzellen
    Effects of biotic and abiotic factors on the production of Fusarium-mycotoxins by phytophathogenic Fusarium-isolates
    Bioverfügbarkeit, Metabolismus und Toxizität von Arsenozuckern
    Dr. Brezina, UlrikeDetermination of zearalenone, deoxynivalenol and their metabolites in physiological samples of pigs with LC-MS/MS: Development of multi-mycotoxin methods and verification through a dose-response feeding study
    Darstellung der stabilisotopenmarkierten Mykotoxine Moniliformin und Tenuazonsäure sowie Synthese von bioaktiven Arylthiazolen mittels direkter Fusarin-Analoga
    Intestinaler Metabolismus von Lebensmittelinhaltsstoffen im Schweine-Caecum-Modell
    Dr. Havermann, SusannahAktivierung des ARE durch Flavonole und Hydroxyzimtsäurederivate: Untersuchungen in Zellkultursystemen und C. elegans
    Vorkommen von Fusarin-C-Mykotoxinen in Lebensmitteln und Strukturaufklärung neuer Fusarin-Analoga
    Dr. Diederich, JohannesManganspeziation in biologischen Proben
    Studien zur systemischen Absorption und zum Metabolismus von Anthocyanen im Tiermodell Schwein
    Dr. Riedel, SylviaModulation of lipid metabolism as a possible tool to prevent carcinoigenoic effects of fumonisin B1
    Dr. Ehlers, SusanAnalytik von Perfluoralkylsäuren in verschiedenen Matrices zur Klärung der Toxikokinetik in Tierarten die der Lebensmittelgewinnung dienen
    Dr. Bevanda-Franjic, MarijaneIn vitro-Studien von Anthocyanen im Caco-2-Modellsystem
    Isolierung, Strukturaufklärung und Analytik von Procyanidinen sowie Kinetikstudien im Tiermodell am Schwein
    Untersuchungen zur massenspektrometrischen Charakterisierung von Sphingophospholipiden in humaner Milch und pflanzlichen Lebensmitteln
    Zellkulturstudien zur Cytotoxizität, zur Aufnahme und zum Transportmechanismus von Mutterkornalkaloiden
    Darstellung der stabilisotopen-markierten Mykotoxine Fumonisin B1 und Alternariol
    Dr. Betz, JosefineStruktur-Funktions-Analysen von Shiga Toxin-Rezeptoren mikro- und makrovaskulärer humaner Endothelzellen
    Dr. Neue, KristinaElucidation of N-glycosylation by unspecific proteolysis in combination with ZIC-HILIC SPE and de novo sequencing of IgG primary structures by use of direct nanoESI Q-Tof mass spectrometry
    Dr. Harrer, Henning Uwe MichaelDie Bedeutung des Sphingolipidstoffwechsels für die toxikologische Wirkungsweise der Fumonisin-Mykotoxine
    Dr. Franzmann, CarolinUntersuchungen zum Vorkommen, zur Stabilität und zum thermischen Abbau von Mutterkornalkaloiden in Roggen und Roggenprodukten
    Dr. Nollen, Maike CoraUntersuchungen zur indirekten Genotoxizität von Arsenit und seinem Metabolit monomethylarsonige Säure
    Regulation of secondary metabolism in phytophathogenic Fusarium spp.
    Dr. van 't Slot, GordonUntersuchungen zum intestinalen Metabolismus von pflanzlichen Lebensmittelinhaltsstoffen
    Dr. Fischbeck, AnneVorkommen von Sphingomyelin in der menschlichen Ernährung und seine Bedeutung bei entzündlichen Darmerkrankungen im Tiermodell
    Dr. Trebstein, AnkeAnalytik von Mykotoxinen der Gattung Fusarium mittels Hochleistungsflüssigchromatographie mit Fluoreszenzdetektion und Tandem-Massenspektrometrie
    Dr. Beyer, MaritaProduktion, Analytik und Abbau bedeutender Trichothecen-Mykotoxine
    Structure and function of the plasmid-encoded bacterial serine protease autotransporter EspP from Shiga toxin-producing Escherichia coli
    Dr. Aldick, ThomasStabilität und Aktivität von freiem und vesikulärem Hämolysin aus enterohämorrhagischen Escherichia coli
    Thermischer Abbau und Analytik der Mykotoxine Ochratoxin A und Zearalenon
    Dr. Königs, MaikaUntersuchungen zur Cytotoxizität und zum Metabolismus von Fusarientoxinen in humanen Primärzellen
    Dr. Rose, Ina KatrinMetabolismus von Flavonoiden durch die intestinale Mikroflora im Schweine-Caecum-Modell
    Dr. Klötzel, MariannaEntwicklung von Analyseverfahren zur empfindlichen Bestimmung von Fusarientoxinen in Lebensmitteln
    Dr. Bartke, NanaUntersuchungen zum Vorkommen von Sphingolipiden in pflanzlichen Lebensmitteln
    Dr. Knecht, AnjaMonascus-Sekundärmetabolite: Neue Verbindungen und Untersuchungen zur biologischen Aktivität
    Dr. Bretz, Michael EwaldProduktion, Analytik und Abbau ausgewählter Fusarientoxine