Prof. Dr. Martin Dugas

Prof. Dr. Martin Dugas

Albert-Schweitzer-Campus 1
48149 Münster

  • Forschungsschwerpunkte

    • Informatik in der klinischen und translationalen Forschung
    • Single-Source-Informationssysteme
    • Integrierte Analyse von molekularen und klinischen Daten

  • Weitere Zugehörigkeit an der Universität Münster

  • Vita

    Akademische Ausbildung

    Weiterbildungsbefugnis für Medizinische Informatik der Ärztekammer Westfalen-Lippe
    Zertifikat Biometrie der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie
    Habilitation, Erlangung der Venia legendi für Medizinische Informatik an der Ludwig-Maximilians-Universität München, Habilitationsthema: "Die Analyse der Datenqualität und -komplexität in Medizinischen Datenbanken"
    Zertifikat Medizinische Informatik der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie
    Studium der Informatik an der FU Hagen
    Diplom in Informatik
    Approbation als Arzt
    Promotion zum Dr. med. an der TU München, Dissertationsthema: "Entwicklung einer computergestützten Ganzzell- und Einzelkanal-Analyse"
    Studium der Humanmedizin an der Technischen Universität München mit Auslandsaufenthalten in Zürich, London und Montpellier

    Beruflicher Werdegang

    Managing Director of the Department of Medical Informatics and Biomathematics at the University of Münster
    Mitglied der IV-Kommission an der Westfälischen Wilhelms-Universität Münster
    Leiter der Abteilung Klinische Systeme des Universitätsklinikums Münster (UKM)
    Professor für Medizinische Informatik am Institut für Medizinische Informatik und Biomathematik der Westfälischen Wilhelms-Universität Münster
    Mitarbeiter im Bereich Industrieforschung für Krankenhausinformationssysteme bei Siemens Medical Health Services, USA
    Wissenschaftlicher Mitarbeiter am Institut für Medizinische Informatik, Biometrie und Epidemiologie der Ludwig-Maximilians-Universität München
    IT-Beauftragter der Munich-Harvard Alliance for Medical Education der Ludwig-Maximilians-Universität München

    Preise

    Best Poster Award – Dachverband Reproduktionsbiologie und –medizin (DVR)

    Mitgliedschaften und Aktivitäten in Gremien

    Mitglied im Gutachtergremium im Bereich "eHealth" für die Europäischen Kommission
    Mitglied der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS)

  • Projekte

    • PRUSEARCH – FOR 2690: Translationale Pruritusforschung - TP Zentrale Informationsinfrastruktur, Zentralisierte Biomaterial und Machine Learning Analysen ( – )
      Teilprojekt in DFG-Verbund koordiniert außerhalb der Universität Münster: DFG - Forschungsgruppe | Förderkennzeichen: DU 352/15-2
    • SOLKID-GNR – Die Sicherheit des Lebendnierenspenders - das deutsche nationale Register (Realisierungsphase) ( – )
      participations in bmbf-joint project: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01GY1906
    • HiGHmed – Medizininformatik-Initiative Deutschland - Teilprojekt Münster ( – )
      participations in bmbf-joint project: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01ZZ1802V
    • PRUSEARCH – FOR 2690: Translationale Pruritusforschung - TP: Zentrale Informationsinfrastruktur, Bioinformatik und Physische Biomaterial Bank ( – )
      Teilprojekt in DFG-Verbund koordiniert außerhalb der Universität Münster: DFG - Forschungsgruppe | Förderkennzeichen: BR 5841/1-1
    • CODEX – COVID-19 Data Exchange Platform ( – )
      participations in bmbf-joint project: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01KX2021
    • COMPASS – Coordination on mobile pandemic apps best practice and solution sharing ( – )
      participations in bmbf-joint project: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01KX2021
    • Reproduction – from Genes to Molecules and Function ( – )
      Durch die Universität Münster intern gefördertes Projekt: Universität Münster-interne Förderung - Topical Programs
    • Smart Device System für Bewegungsstörungen ( – )
      Durch die Universität Münster intern gefördertes Projekt: Innovative Medizinische Forschung | Förderkennzeichen: VA 111809
    • MDM-Portal – Portal für Medizinische Datenmodelle ( – )
      Gefördertes Einzelprojekt: DFG - Sachbeihilfe/Einzelförderung | Förderkennzeichen: DU 352/11-2
    • Infektionsbedingte Mutationsprofile in pB-ALL ( – )
      Gefördertes Einzelprojekt: Deutsche Kinderkrebsstiftung e.V. | Förderkennzeichen: DKS 2016.17
    • KFO 326 - Male Germ Cells: from Genes to Function - CP: Koordination und integrierte Analyse von OMICs-Daten ( – )
      Teilprojekt in DFG-Verbund koordiniert an der Universität Münster: DFG - Klinische Forschungsgruppe | Förderkennzeichen: TU 298/5-1
    • Epigenetische Basis der Plastizitätseigenschaften und Therapieresistenz von T-Linien-abgeleiteten myeloischen Leukämiestammzellen ( – )
      Gefördertes Einzelprojekt: Deutsche Krebshilfe e.V. | Förderkennzeichen: 70112660
    • MDS-RIGHT – Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time ( – )
      EU-Projekt koordiniert außerhalb der Universität Münster: EU H2020 - Research and innovation actions | Förderkennzeichen: 634789
    • PPRC – European Prurigo Project ( – )
      Gefördertes Einzelprojekt: European Academy of Dermatology and Venereology | Förderkennzeichen: 2016012
    • PTPR – Molekulare Charakterisierung von papillären Tumoren der Pinealisregion ( – )
      Durch die Universität Münster intern gefördertes Projekt: Innovative Medizinische Forschung | Förderkennzeichen: TH 111807
    • T.I.M.E. – Telemedizinische Information bei Medizinischen Notfällen ( – )
      EU-Projekt koordiniert an der Universität Münster: EU - Europäischer Fonds für regionale Entwicklung | Förderkennzeichen: EFRE-0800196
    • Erwerbstätigkeit und Lebensqualität bei Patienten mit malignem Melanom ( – )
      Gefördertes Einzelprojekt: Deutsche Rentenversicherung Westfalen | Förderkennzeichen: 622-4012
    • Molekulargenetische Charakterisierung von lymphoblastischen T-Zell Lymphomen im Kindes- und Jugendalter ( – )
      Gefördertes Einzelprojekt: Deutsche Krebshilfe e.V. | Förderkennzeichen: 111347
    • SOLKID-GNR – Die Sicherheit des Lebendspenders - Das Deutsche Nationale Lebendspende Register - Konzeptentwicklung ( – )
      Gefördertes Einzelprojekt: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01GY1725
    • MDM-Portal – Portal für Medizinische Datenmodelle ( – )
      Gefördertes Einzelprojekt: DFG - Sachbeihilfe/Einzelförderung | Förderkennzeichen: DU 352/11-1
    • PruNet – European Network on Asessment of Severity and Burden of Pruritus ( – )
      Gefördertes Einzelprojekt: European Academy of Dermatology and Venereology | Förderkennzeichen: 2014-022
    • Role of the three-dimensional chromatin structure in expression control of the tumor suppressor gene PU.1 ( – )
      Durch die Universität Münster intern gefördertes Projekt: Interdisziplinäres Zentrum für Klinische Forschung Münster | Förderkennzeichen: Ros2/007/15
    • TRIAGE-MDS – TRIAGE-MDS: Translationale Implementierung von Genetischer Evidenz beim Management von MDS ( – )
      Gefördertes Einzelprojekt: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01KT1401
    • ADMIRE – AgenDa Medical Informatics for healthcare, Research & Education ( – )
      participations in bmbf-joint project: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01ZZ1602B
    • x4T-EDC – x4T-EDC (Exchange for Trials) (seit )
      Eigenmittelprojekt
    • Verbesserung der Diagnostik von Tumorerkrankungen durch neue DNA-Sequenzierverfahren und Algorithmen ( – )
      Gefördertes Einzelprojekt: Deutsche Krebshilfe e.V. | Förderkennzeichen: 110807; 110495
    • Eine Phase-II-Studie zur Erfassung der Effektivität einer Therapie mit ATRA und TCP bei Patienten mit Erstdiagnose einer akuten myeloischen Leukämie ( – )
      Gefördertes Einzelprojekt: Deutsche Krebshilfe e.V. | Förderkennzeichen: 110500
    • NFDM-Sprint Forschungsprojekt zur Einführung der Fachanwendung Notfalldaten-Management (NFDM) der elektronischen Gesundheitskarte (eGK). ( – )
      Eigenmittelprojekt
    • MA-RIKA – Medizinisches Akutkrankenhaus. Rettungsdienst Informations- und Kommunikationssystem für akute Notfälle im Alter ( – )
      Gefördertes Einzelprojekt: Ministerium für Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen | Förderkennzeichen: 005-GW03-114A
    • FOR 1336 - Von Monozyten bis zu Hirnmakrophagen -Einflüsse auf die Eigenschaften myeloider Zellen im Gehirn - A3: Rolle des Transkriptionsfaktors PU.1 für die Differenzierung und Funktion peripherer Makrophagen ( – )
      Teilprojekt in DFG-Verbund koordiniert außerhalb der Universität Münster: DFG - Forschungsgruppe | Förderkennzeichen: RO 2295/4-2
    • SHT-Register – Klinisches Register für Patientinnen und Patienten mit Schädelhirntrauma ( – )
      EU-Projekt koordiniert an der Universität Münster: EU - Europäischer Fonds für regionale Entwicklung | Förderkennzeichen: 005-GW02-024
    • EHR4CR – Elektronische Patientenakten-Systeme für die klinische Forschung ( – )
      EU-Projekt koordiniert außerhalb der Universität Münster: IMI Innovative Medicines Initiative
    • Identifizierung molekulargenetischer Prognosefaktoren bei TEL/AML1+ akuter lymphoblastischer Leukämie des Kindesalters ( – )
      Gefördertes Einzelprojekt: Deutsche Kinderkrebsstiftung e.V. | Förderkennzeichen: DKS2010.21
    • MoPat – MoPat (Mobile Patientenfragebögen) (seit )
      Eigenmittelprojekt
    • EuGESMA – European Genomics and Epigenomics - Translating Genomic and epigenetic Studies of MDS and AML ( – )
      EU-Projekt koordiniert außerhalb der Universität Münster: EU - COST Actions | Förderkennzeichen: BM0801
    • Integrierte klinische Informationssysteme nach dem Single-Source-Konzept ( – )
      Gefördertes Einzelprojekt: DFG - Sachbeihilfe/Einzelförderung | Förderkennzeichen: DU 352/5-1
    • Telematische Unterstützung der Schwerverletztenversorgung ( – )
      participations in bmbf-joint project: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 005-GW01-128A
    • Leukemia Gene Atlas - ein integriertes System für molekulare und klinische Daten zur Unterstützung der translationalen Leukämieforschung ( – )
      Gefördertes Einzelprojekt: José Carreras Leukämie-Stiftung | Förderkennzeichen: DJCLS H 09/04
    • Verbund: KIS-basierte Unterstützung der Patientenrekrutierung in klinischen Studien - Teilprojekt der Uni Münster ( – )
      participations in bmbf-joint project: Bundesministerium für Bildung und Forschung | Förderkennzeichen: 01EZ0941A
    • EUROPEAN LEUKEMIANET – Strengthen and develop scientific and technological excellence in research and therapy of leukemia (CML, AML, ALL, CLL, MDS, CMPD) by integration of the leading national leukemia networks and their interdisciplinary partner groups in Europe ( – )
      EU-Projekt koordiniert außerhalb der Universität Münster: EU FP 6 - Networks of Excellence | Förderkennzeichen: 503216

  • Publikationen

    • , , , , , , , , , , , , , , , , und . . „Raising the standards of patient-centered outcomes research in myelodysplastic syndromes: Clinical utility and validation of the subscales of the QUALMS from the MDS-RIGHT project.“ Cancer medicine, Nr. 12 (6): 7529–7539. doi: 10.1002/cam4.5487.
    • . . „ODM-DQA-Reporter: A Generic Approach to Assess and Monitor Basic Data Quality of Medical Research Data in Operational Data Model (ODM) Format.“ Studies in Health Technology and Informatics, Nr. 290: 983–984. doi: 10.3233/SHTI220229.
    • , , , , , , , , , , , , und . „Symptom monitoring based on digital data collection during inpatient treatment of schizophrenia spectrum disorders – A feasibility study.“ Psychiatry Research, Nr. 316 doi: 10.1016/j.psychres.2022.114773.
    • , , , , , , , , , , , , , , und . „Limitations of Nasal Nitric Oxide Measurement for Diagnosis of Primary Ciliary Dyskinesia with Normal Ultrastructure.“ Annals of the American Thoracic Society, Nr. 19 (8): 1275–1284. doi: 10.1513/AnnalsATS.202106-728OC.
    • , , , , , , , , , , , , , , , , , , , , , , , , und . . „PRIMORDIAL GERM CELLS IDENTIFIED AS ONE POTENTIAL CELL OF ORIGIN OF MYC RHABDOID TUMORS.“ Neuro-Oncology, Nr. 24 Suppl 1: 6–6. doi: 10.1093/neuonc/noac079.014.
    • , , und . . „InterCellar enables interactive analysis and exploration of cell-cell communication in single-cell transcriptomic data.“ Communications biology, Nr. 5 (1): 21–21. doi: 10.1038/s42003-021-02986-2.
    • , , , , , , , , , , und . . „Benchmarking atlas-level data integration in single-cell genomics.“ Nature Methods, Nr. 19 (1): 41–50. doi: 10.1038/s41592-021-01336-8.
    • , , , , , , , , , , , , , , und . . „Limitations of Nasal Nitric Oxide Measurement for Diagnosis of Primary Ciliary Dyskinesia with Normal Ultrastructure.“ Annals of the American Thoracic Society, Nr. 19 (8): 1275–1284. doi: 10.1513/AnnalsATS.202106-728OC.
    • , , , , , , , , , und . . „Design of a targeted next-generation DNA sequencing panel for pediatric T-cell lymphoblastic lymphoma to unravel biology and optimize treatment.“ Genes, Chromosomes and Cancer, Nr. 61 (8): 459–470. doi: 10.1002/gcc.23037.
    • , , , , , , , , , , , , und . . „Symptom monitoring based on digital data collection during inpatient treatment of schizophrenia spectrum disorders - A feasibility study.“ Psychiatry Research, Nr. 316: 114773–114773. doi: 10.1016/j.psychres.2022.114773.
    • , , , , , , , , , und . . „Chronic pruritus patients reveal distinct expression signatures in chronically scratched skin.“ Experimental Dermatology, Nr. 31 (2): E87–E88.
    • , , , , , und . . „ELaPro, a LOINC-mapped core dataset for top laboratory procedures of eligibility screening for clinical trials.“ BMC Medical Research Methodology, Nr. 22 (1): 141–141. doi: 10.1186/s12874-022-01611-y.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma.“ International Journal of Molecular Sciences (IJMS), Nr. 23 (9) doi: 10.3390/ijms23095174.
    • , , , , , , , , , , , , , , , , und . . „Raising the standards of patient-centered outcomes research in myelodysplastic syndromes: Clinical utility and validation of the subscales of the QUALMS from the MDS-RIGHT project.“ Cancer medicine, Nr. 12 (6): 7529–7539. doi: 10.1002/cam4.5487.
    • . . „Transcriptomic, Epigenomic, and Neuroanatomic Signatures Differ in Chronic Prurigo, Atopic Dermatitis, and Brachioradial Pruritus.“ Journal of Investigative Dermatology, Nr. 143 (2): 264–272.e3. doi: 10.1016/j.jid.2022.08.042.
    • . . „Altered resting‐state functional connectivity of default mode network in brachioradial pruritus.“ Journal of the European Academy of Dermatology and Venereology, Nr. 2022 (11): 2214–2223. doi: 10.1111/jdv.18411.
    • , , , , , , , , , , , , , , , , , , , , , , , und . . „Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.“ Nature Communications, Nr. 13 (1): 1544–1544. doi: 10.1038/s41467-022-29152-4.
    • , , , , , , , , , , und . . „A GWAS in idiopathic/unexplained infertile men detects a genomic region determining Follicle-stimulating hormone levels.“ Journal of Clinical Endocrinology and Metabolism, Nr. 107 (8): 2350–2361. doi: 10.1210/clinem/dgac165.
    • , , , , , und . „MainzelHandler: A Library for a Simple Integration and Usage of the Mainzelliste.“ In Public Health and Informatics, Bd. 281 aus Studies in Health Technology and Informatics, herausgegeben von Mantas John, Stoicu-Tivadar Lăcrămioara, Chronaki Catherine, Hasman Arie, Weber Patrick, Gallos Parisis, Crişan-Vida Mihaela, Zoulias Emmanouil und Chirila Oana Sorina. Bristol: IOP Publishing. doi: 10.3233/SHTI210155.
    • , , , , , , , und . . „Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1).“ International Journal of Infectious Diseases, Nr. 105: 304–306. doi: 10.1016/j.ijid.2021.02.085.
    • , , , , , , , und . . „The burden in chronic prurigo: patients with chronic prurigo suffer more than patients with chronic pruritus on non-lesional skin: A comparative, retrospective, explorative statistical analysis of 4,484 patients in a real-world cohort.“ Journal of the European Academy of Dermatology and Venereology, Nr. 35 (3) doi: 10.1111/jdv.16929.
    • , , , , , , , , , , , , , , , , , , , , , , , und . . „Pruritus Intensity Scales across Europe: a prospective validation study.“ Journal of the European Academy of Dermatology and Venereology, Nr. 35 (5): 1176–1185. doi: 10.1111/jdv.17111.
    • , , , , , , , und . . „The burden in chronic prurigo: patients with chronic prurigo suffer more than patients with chronic pruritus on non-lesional skin A comparative, retrospective, explorative statistical analysis of 4,484 patients in a real-world cohort.“ Journal of the European Academy of Dermatology and Venereology, Nr. 35 (3): 738–743. doi: 10.1111/jdv.16929.
    • , , , , , , , , , , , und . „Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes.“ Clinical Epigenetics, Nr. 13 (1) doi: 10.1186/s13148-021-01144-z.
    • , , , und . „A seamless pseudonymization and randomization workflow for REDCap.“ In Public Health and Informatics: Proceedings of MIE 2021, herausgegeben von J. Mantas, L. Stoicu-Tivadar, C. Chronaki, A. Hasman, P. Weber, P. Gallos, M. Crișan – Vida, E. Zoulias und O.S. Chirila. Amsterdam: IOS Press. doi: 10.3233/SHTI210319.
    • , , , , , , , , , , , , , , , , , , und . . „Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.“ Frontiers in immunology, Nr. 12: 595390–595390. doi: 10.3389/fimmu.2021.595390.
    • , , , , , , und . . „Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men.“ Journal of Endocrinological Investigation, Nr. 44 (11): 2465–2474. doi: 10.1007/s40618-021-01561-0.
    • , , , , , , , und . . „Die Sicherheit des Lebendnierenspenders -- Das Deutsche Lebendspende Register SOLKID-GNR -- Entstehung und Struktur eines nationalen Registers in der Versorgungsforschung.“ Gesundheitswesen, Supplement, Nr. 83 (S 01): S33–S38. doi: 10.1055/a-1547-7114.
    • , , , , , , , , , , , , , , und . . „Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer.“ European Journal of Human Genetics, Nr. 29 (8): 1301–1311. doi: 10.1038/s41431-021-00878-x.
    • , , , und . . „Reliable Measurement of chronic Pruritus in Routine clinical Practice.“ Journal der Deutschen Dermatologischen Gesellschaft, Nr. 19 (Suppl 2): 107–107.
    • , , , und . . „A Seamless Pseudonymization and Randomization Workflow for REDCap.“ Studies in Health Technology and Informatics, Nr. 281: 952–956. doi: 10.3233/SHTI210319.
    • , , und . . „An Open-Source, Standard-Compliant, and Mobile Electronic Data Capture System for Medical Research (OpenEDC): Design and Evaluation Study.“ JMIR medical informatics, Nr. 9 (11): e29176–e29176. doi: 10.2196/29176.
    • , , , , , , , , , , , , , und . . „Pragmatic MDR: a metadata repository with bottom-up standardization of medical metadata through reuse.“ BMC Medical Informatics and Decision Making, Nr. 21 (1): 160–160. doi: 10.1186/s12911-021-01524-8.
    • , , , , , , und . . „Portal of Medical Data Models: Stakeholder Feedback and Requirements.“ Studies in Health Technology and Informatics, Nr. 281: 488–489. doi: 10.3233/SHTI210208.
    • , , , , , und . . „FhirExtinguisher: A FHIR Resource Flattening Tool Using FHIRPath.“ Studies in Health Technology and Informatics, Nr. 281: 1112–1113. doi: 10.3233/SHTI210369.
    • , , , , , , , , , , , , , , und . . „The international primary ciliary dyskinesia (PCD) registry reports genotype/phenotype-correlations.“ In Monitoring airway disease, herausgegeben von European Respiratory Journal. online: European Respiratory Society. doi: 10.1183/13993003.congress-2021.PA2233.
    • , , und . . „Comparing SDTM and FHIR® for Real World Data from Electronic Health Records for Clinical Trial Submissions.“ Studies in Health Technology and Informatics, Nr. 281: 585–589. doi: 10.3233/SHTI210238.
    • , , , und . . „Comparison of Open-access Databases for Clinical Variant Interpretation in Cancer: A Case Study of MDS/AML.“ Cancer Genomics and Proteomics, Nr. 18 (2): 157–166. doi: 10.21873/cgp.20250.
    • , , , , , , , , , und . . „Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status.“ Cancer medicine, Nr. 10 (4): 1347–1356. doi: 10.1002/cam4.3741.
    • , , , , , , , , , , , , und . . „Publisher Correction: Reconstructing clonal evolution in relapsed and non-relapsed Burkitt lymphoma.“ Leukemia, Nr. 35 (12): 3630–3630. doi: 10.1038/s41375-021-01359-2.
    • , , und . . „SimFFPE and FilterFFPE: improving structural variant calling in FFPE samples.“ GigaScience, Nr. 10 (9) doi: 10.1093/gigascience/giab065.
    • , , , , und . . „Design and Implementation of an Informatics Infrastructure for Standardized Data Acquisition, Transfer, Storage, and Export in Psychiatric Clinical Routine: Feasibility Study.“ JMIR Mental Health, Nr. 8 (6): e26681–e26681. doi: 10.2196/26681.
    • , , , , , , , , , , , , , , und . . „Validation of the Qualms Questionnaire to Assess Health-Related Quality of Life in European and Israeli Patients with Myelodysplastic Syndromes: Results from the MDS-Right Project.“ Blood, Nr. 138 (Supplement 1): 1982–1982. doi: 10.1182/blood-2021-147176.
    • , , , , , , , , , , , , , , , , , , und . . „Immunophenotyping in pemphigus reveals a TH17/TFH17 cell-dominated immune response promoting desmoglein1/3-specific autoantibody production.“ Journal of Allergy and Clinical Immunology, Nr. 147 (6): 2358–2369. doi: 10.1016/j.jaci.2020.11.008.
    • , , , , , , , , , , , , , , , , , , , und . . „Type 17 T follicular helper cells promote desmoglein 1/3-specific autoantibody production in pemphigus.“ Experimental Dermatology, Nr. 30 (3): 65–65.
    • , , , , , , , , und . . „Persistent symptoms and lab abnormalities in patients who recovered from COVID-19.“ Scientific Reports, Nr. 11 (1): 12775–12775. doi: 10.1038/s41598-021-91270-8.
    • , , , , , , , , , und . . „Novel Germline POT1 Variant Predisposes to Childhood Acute Myeloid Leukemia.“ Blood, Nr. 138 (Supplement 1): 3449–3449. doi: 10.1182/blood-2021-150456.
    • , , , , , , , , und . . „A Genome Wide Association Study in men with unexplained infertility identifies nine SNPs at the FSHB locus to be associated with Follicle Stimulating Hormone level.“ Human Reproduction, Nr. 36 (Suppl 1): 10–11. doi: 10.1093/humrep/deab125.019.
    • , , , , , , , , und . . „Identifying a genomic region at Chromosome 11p.14.1 that is associated to FSH serum level in men with unexplained male infertility.“ European Urology, Nr. 79 (Suppl 1): S691–S691. doi: 10.1016/S0302-2838(21)00883-6.
    • , , , , , , , , , und . . „Dexamethasone-mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells.“ British Journal of Haematology, Nr. 196 (4): 995–1006. doi: 10.1111/bjh.17940.
    • , , , , , , , , , , , , , , und . . „Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis.“ Cell Reports Medicine, Nr. 2 (9) doi: 10.1016/j.xcrm.2021.100395.
    • , , , , , , , , , , , , , , , , , , , und . . „Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19.“ Journal of Clinical Virology, Nr. 139 doi: 10.1016/j.jcv.2021.104847.
    • , , , , , , , , , , , , , , , , , , , , und . . „Integrative genomic analysis of pediatric T- cell lymphoblastic lymphoma reveals candidates of clinical significance.“ Blood, Nr. 2020 doi: 10.1182/blood.2020005381.
    • , , , , , , , , , , , , , und . . „Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation.“ Blood, Nr. 135 (23): 2059–2070. doi: 10.1182/blood.2019004121.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study.“ Journal of the European Academy of Dermatology and Venereology, Nr. 34 (10): 2373–2383. doi: 10.1111/jdv.16309.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction.“ Acta dermato-venereologica, Nr. 2020 doi: 10.2340/00015555-3726.
    • , , , und . . „Assessing and Improving the Usability of the Medical Data Models Portal.“ Studies in Health Technology and Informatics, Nr. 271: 199–206.
    • , , , , , , , , , , , , , , , , , , und . . „Immunophenotyping in pemphigus reveals a T17/T17 cell-dominated immune response promoting desmoglein1/3-specific autoantibody production.“ Journal of Allergy and Clinical Immunology, Nr. 2020 doi: 10.1016/j.jaci.2020.11.008.
    • , , , , , , , , , , , , und . . „Reconstructing clonal evolution in relapsed and non-relapsed Burkitt lymphoma.“ Leukemia, Nr. 2020
    • , und . . „Conceptual Design, Implementation, and Evaluation of Generic and Standard-Compliant Data Transfer into Electronic Health Records.“ Applied Clinical Informatics, Nr. 11 (3): 374–386.
    • , , , , , und . . „Patient-reported outcomes on familial amyloid polyneuropathy (FAP).“ Orphanet Journal of Rare Diseases, Nr. 15 (1): 287. doi: 10.1186/s13023-020-01575-6.
    • , , , , , , , und . . „Association of contact to small children with a mild course of COVID-19.“ International Journal of Infectious Diseases, Nr. 100: 314–315. doi: 10.1016/j.ijid.2020.09.003.
    • , , , , , , , , und . . „Repeated Digitized Assessment of Risk and Symptom Profiles During Inpatient Treatment of Affective Disorder: Observational Study.“ JMIR Mental Health, Nr. 7 (12): e24066. doi: 10.2196/24066.
    • , , , , , , , und . . „The burden in chronic prurigo: patients with chronic prurigo suffer more than patients with chronic pruritus on non-lesional skin: A comparative, retrospective, explorative statistical analysis of 4,484 patients in a real-world cohort.“ Journal of the European Academy of Dermatology and Venereology, Nr. 2020 doi: 10.1111/jdv.16929.
    • , , , , , , , , , und . . „Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study.“ Journal of Clinical Medicine, Nr. 9 (4) doi: 10.3390/jcm9041006.
    • , , , , und . . „The Smart Device System for Movement Disorders: Preliminary Evaluation of Diagnostic Accuracy in a Prospective Study.“ Studies in Health Technology and Informatics, Nr. 270: 889–893.
    • , , , , , , , , , , , , , , , , , , , , , , , und . . „A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy.“ Leukemia, Nr. 2020 doi: 10.1038/s41375-020-0892-z.
    • , , , und . . „AMLVaran: a software approach to implement variant analysis of targeted NGS sequencing data in an oncological care setting.“ BMC Medical Genomics, Nr. 13 (1): 17.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility.“ American Journal of Human Genetics, Nr. 107 (2): 342–351. doi: 10.1016/j.ajhg.2020.06.010.
    • , , , , , , , , , , , , , , und . . „Multicenter Next-Generation Sequencing Studies Between Theory and Practice: Harmonization of Data Analysis Using Real-World Myelodysplastic Syndrome Data.“ Journal of Molecular Diagnostics, Nr. 2020 doi: 10.1016/j.jmoldx.2020.12.001.
    • , , , , , und . . „CopyDetective: Detection threshold-aware copy number variant calling in whole-exome sequencing data.“ GigaScience, Nr. 9 (11) doi: 10.1093/gigascience/giaa118.
    • , , , , , , , , und . . „Does the FSHB c.-211G{\textgreater}T polymorphism impact Sertoli cell number and the spermatogenic potential in infertile patients?“ Andrology, Nr. 8 (5): 1030–1037. doi: 10.1111/andr.12777.
    • , , und . . „[Medical apps-possibilities for pruritus].“ Der Hautarzt, Nr. 71 (7): 528–534.
    • , , , , , und . . „Evaluation of openEHR Repositories Regarding Standard Compliance.“ Studies in Health Technology and Informatics, Nr. 270: 592–596.
    • , , , , , , , , und . . „Repeated digitised assessment of risk and symptom profiles during inpatient treatment for affective disorders: Observational study.“ JMIR Mental Health, Nr. 7
    • , , , , und . . „The Smart Device System for Movement Disorders: Preliminary Evaluation of Diagnostic Accuracy in a Prospective Study.“ Studies in Health technologies and informatics, Nr. 270
    • , , , , , , , , und . . „Repeated digitised assessment of risk and symptom profiles during inpatient treatment for affective disorders: Observational study.“ JMIR Mental Health, Nr. 7
    • , , , , , und . . „The Male Fertility Gene Atlas: a web tool for collecting and integrating OMICS data in the context of male infertility.“ Human Reproduction, Nr. 35 (9) doi: 10.1093/humrep/deaa155.
    • , , , , , und . . „The Male Fertility Gene Atlas: a web tool for collecting and integrating OMICs data in the context of male infertility.“ Human Reproduction, Nr. 35 (9): 1983–1990. doi: 10.1093/humrep/deaa155.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Bi-allelic mutations in M1AP are a frequent cause of meiotic arrest and severely impaired spermatogenesis leading to male infertility.“ American Journal of Human Genetics, Nr. 107 (2): 342–351. doi: 10.1016/j.ajhg.2020.06.010.
    • , , , , , , , und . . „The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis.“ Clinical Epigenetics, Nr. 121 (1): 61. doi: 10.1186/s13148-020-00854-0.
    • , , , und . . „Benchmarking of 4C-seq pipelines based on real and simulated data.“ Bioinformatics, Nr. 35 (23)
    • , , , , , , , , , , , , , , und . . „Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.“ Nature Immunology, Nr. Mar 25
    • , , , und . . „Core Data Elements in Acute Myeloid Leukemia: A Unified Medical Language System-Based Semantic Analysis and Experts' Review.“ JMIR Med Inf, Nr. 7 (3): e13554. doi: 10.2196/13554.
    • , , , , , , , , , und . . „Genetic alterations in human papillomavirus-associated oropharyngeal squamous cell carcinoma of patients with treatment failure.“ Oral Oncology, Nr. 93: 59–65. doi: 10.1016/j.oraloncology.2019.04.013.
    • , , , , und . . „Common Data Elements for Acute Coronary Syndrome: Analysis Based on the Unified Medical Language System.“ JMIR medical informatics, Nr. 7 (3): e14107. doi: 10.2196/14107.
    • , , , , , , und . . „Compatible Data Models at Design Stage of Medical Information Systems: Leveraging Related Data Elements from the MDM Portal.“ Studies in Health Technology and Informatics, Nr. 264: 113–117.
    • , , und . . „StudyPortal - Geovisualization of Study Research Networks.“ Journal of Medical Systems, Nr. 44 (1): 22.
    • , , und . . „StudyPortal - A Novel Method to Visualize Study Research Networks.“ Studies in Health Technology and Informatics, Nr. 258: 163.
    • , , , , , , und . . „A Smart Device System to Identify New Phenotypical Characteristics in Movement Disorders.“ Frontiers in Neurology, Nr. 10: 48. doi: 10.3389/fneur.2019.00048.
    • , , , und . . „Interoperability Improvement of Mobile Patient Survey (MoPat) Implementing Fast Health Interoperability Resources (FHIR).“ Studies in Health Technology and Informatics, Nr. 258: 141–145.
    • , , , , , , und . . „Portal of Medical Data Models: Status 2018.“ Studies in Health Technology and Informatics, Nr. 258: 239–240.
    • , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID.“ Nature Communications, Nr. 10 (1): 5563.
    • , , , , , , , , , , , , , und . . „Genetic analysis of 24 candidate genes validates TEX14, TEX11, NR5A1 and DMRT1 as clinically relevant for non-obstructive azoospermia.“ European Journal of Human Genetics, Nr. 27 2: 1191.
    • , , , , und . . „Reviving 30 Year Old Technology: Lessons Learned from Transferring Patient Data Using Data Matrix Codes.“ Studies in Health Technology and Informatics, Nr. 258: 90–94.
    • , , , , , , , , und . . „EMR-integrated minimal core dataset for routine health care and multiple research settings: A case study for neuroinflammatory demyelinating diseases.“ PloS one, Nr. 14 (10): e0223886.
    • , , , , , , , , und . . „Adverse events in brain tumor surgery: incidence, type, and impact on current quality metrics.“ Acta Neurochirurgica, Nr. 161 (2): 287–306. doi: 10.1007/s00701-018-03790-4.
    • , , , , , , , , , , und . . „Establishing risk-adjusted quality indicators in surgery using administrative data-an example from neurosurgery.“ Acta Neurochirurgica, Nr. 161 (6): 1057–1065. doi: 10.1007/s00701-018-03792-2.
    • , , , , , , , , , , , , , und . . „appreci8: a pipeline for precise variant calling integrating 8 tools.“ Bioinformatics, Nr. 2018/24/34 doi: 10.1093/bioinformatics/bty518.
    • , , , , , , , , , , , , , , , , , , und . . „Temporal auto-regulation during human PU.1 locus SubTAD formation.“ Blood, Nr. 132
    • , , , , , , , , , , , , , , , , , , , , und . . „Loss of Pax5 Exploits Sca1-BCR-ABL Susceptibility to Confer the Metabolic Shift Essential for pB-ALL.“ Cancer Research, Nr. 78 (10): 2669–2679.
    • , , , , , , , , , , , und . . „Mutational spectrum of relapse in pediatric and adolescent patients with T-LBL.“ British Journal of Haematology, Nr. 182 1: 20.
    • , , , , , , , und . . „Compatibility Between Metadata Standards: Import Pipeline of CDISC ODM to the Samply.MDR.“ Studies in Health Technology and Informatics, Nr. 247: 221–225.
    • , , , , , , und . . „Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.“ European Journal of Pediatrics, Nr. 177 (1): 53–60.
    • , , , , , , und . . „Correction to: Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.“ European Journal of Pediatrics, Nr. 177 (1): 61.
    • , , , , , und . . „A Web Service to Suggest Semantic Codes Based on the MDM-Portal.“ Studies in Health Technology and Informatics, Nr. 253: 35–39.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Lmo2 expression defines tumor cell identity during T-cell leukemogenesis.“ EMBO Journal, Nr. 37 (14)
    • , , , , , , , , , , und . . „The mutational spectrum of relapsed Burkitt lymphoma in children and adolescents.“ British Journal of Haematology, Nr. 182 1 (SI): 80.
    • , , , , und . . „CDEGenerator: an online platform to learn from existing data models to build model registries.“ Clinical Epidemiology, Nr. 10: 961–970. doi: 10.2147/CLEP.S170075.
    • , , und . . „Web-Based Information Infrastructure Increases the Interrater Reliability of Medical Coders: Quasi-Experimental Study.“ Journal of medical Internet research, Nr. 20 (10): e274.
    • , , , , , , , , , , , und . . „Targeted panel for pediatric T-LBL.“ British Journal of Haematology, Nr. 182 1: 52.
    • , , , , , , , , , , , , , , , , , , und . . „Temporal autoregulation during human PU.1 locus SubTAD formation.“ Blood, Nr. 132 (25): 2643–2655. doi: 10.1182/blood-2018-02-834721.
    • , , , , und . . „Gene expression profiling in chronic prurigo of nodular type.“ Experimental Dermatology, Nr. 27 (3): E79–E80.
    • , , , , und . . „Connecting healthcare and clinical research: Workflow optimizations through seamless integration of EHR, pseudonymization services and EDC systems.“ International Journal of Medical Informatics, Nr. 119: 103–108. doi: 10.1016/j.ijmedinf.2018.09.007.
    • , , , , , , , , und . . „ADVERSE EVENTS IN BRAIN TUMOR SURGERY: INCIDENCE, TYPE AND IMPACT ON CURRENT QUALITY METRICS.“ Neuro-Oncology, Nr. 20 6: 120. doi: 10.1093/neuonc/noy148.502.
    • , , , , , , , , und . . „Standardising the Development of ODM Converters: The ODMToolBox.“ Studies in Health Technology and Informatics, Nr. 247: 231–235.
    • , , , , , , und . . „Correction to: Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.Y - 2018.“ European Journal of Pediatrics, Nr. 177 (1): 61.
    • , , , , , , und . . „Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.Y - 2018.“ European Journal of Pediatrics, Nr. 177 (1): 53–60.
    • , und . . „REST-based annotation and filtering of Next-Generation Sequencing variant lists with integration into standard office tools.“ Beitrag präsentiert auf der European Conference on Computational Biology (ECCB), Athen doi: 10.7490/f1000research.1116119.1.
    • , , , und . . „MOPAT@HOME: Electronic Patient Reported Outcomes Filled Out at Home, Evaluated at the Hospital.“ Studies in Health Technology and Informatics, Nr. 244: 101.
    • , , , , und . . „Automated Transformation of CDISC ODM to OpenClinica.“ Studies in Health Technology and Informatics, Nr. 243: 95–99.
    • , , , , , und . . „Automatic Conversion of Metadata from the Study of Health in Pomerania to ODM.“ Studies in Health Technology and Informatics, Nr. 236: 88–96.
    • , , , , und . . „Effects of computerized decision support system implementations on patient outcomes in inpatient care: a systematic review.“ Journal of the American Medical Informatics Association, Nr. 2017
    • , , , , , , , und . . „EUROPEAN EADV NETWORK ON ASSESSMENT OF SEVERITY AND BURDEN OF PRURITUS (PRUNET): VALIDATION OF INSTRUMENTS FOR ITCH INTENSITY ITCH-IMPAIRED QUALITY OF LIFE IN PRURITIC DERMATOSES IN EUROPE.“ Acta dermato-venereologica, Nr. 97 (8): 1025–1025.
    • , , , , , , , , und . . „Cancer Predisposition in Childhood Cancer -The Duesseldorf Experience in Comprehensive Clinical Evaluation and Trio Whole Exome Sequencing of Families.“ Pediatric Blood and Cancer, Nr. 64 3: S154–S155.
    • , , , , , , , und . . „Initiative PruNet: Validation of Instruments for the Measurement of Pruritus Intensity and Quality of Life in itchy Dermatoses in Europe.“ Journal der Deutschen Dermatologischen Gesellschaft, Nr. 15: 186–187.
    • , , , , , , und . . „APPRECI8: A PIPELINE FOR PRECISE VARIANT CALLING INTEGRATING 8 TOOLS.“ Haematologica, Nr. 102 2: 492–492.
    • , , , , und . . „GLOBAL GENE EXPRESSION PROFILING IN PRURIGO NODULARIS.“ Acta dermato-venereologica, Nr. 97 (8): 1037–1037.
    • , , , , , , , und . . „EUROPEAN EADV NETWORK ON ASSESSMENT OF SEVERITY AND BURDEN OF PRURITUS (PRUNET): VALIDATION OF INSTRUMENTS FOR ITCH INTENSITY ITCH-IMPAIRED QUALITY OF LIFE IN PRURITIC DERMATOSES IN EUROPE.“ Acta dermato-venereologica, Nr. 97 (8): 1025–1025.
    • , , , , , , , , , , , , , , , , , , , , , , und . . „Clonal evolution in myelodysplastic syndromes.“ Nature Communications, Nr. 8: 15099.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.“ Nature Cell Biology, Nr. 19 (7): 844–855.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases.“ Cancer Research, Nr. 77 (16): 4365–4377.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation.“ Biology of Blood and Marrow Transplantation, Nr. 23 (7): 1095–1101.
    • , , , , , , , , , , , , , , und . . „Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing.“ Haematologica, Nr. 102 (5): e179–e183.
    • , , , , , , , und . . „Leveraging the EHR4CR platform to support patient inclusion in academic studies: challenges and lessons learned.“ BMC Medical Research Methodology, Nr. 17 (1): 36.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.“ Nature Medicine, Nr. 23 (1): 69–78.
    • , und . „S2O - A software tool for integrating research data from general purpose statistic software into electronic data capture systems.“ BMC Medical Informatics and Decision Making, Nr. 17 (1) doi: 10.1186/s12911-016-0402-4.
    • , , und . . „BBCAnalyzer: a visual approach to facilitate variant calling.“ BMC Bioinformatics, Nr. 18 doi: 10.1186/s12859-017-1549-4.
    • , , , , und . „GLM-based optimization of NGS data analysis: A case study of Roche 454, ion torrent PGM and Illumina NextSeq sequencing data.“ PloS one, Nr. 12 (2) doi: 10.1371/journal.pone.0171983.
    • , , , , , , und . „Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data.“ Scientific Reports, Nr. 7 (null) doi: 10.1038/srep43169.
    • , , , , , , , und . „Chronic pruritus: evaluation of patient needs and treatment goals with a special regard to differences according to pruritus classification and sex.“ British Journal of Dermatology, Nr. 176 (2): 363–370. doi: 10.1111/bjd.14910.
    • , und . . „European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo.“ Journal of the European Academy of Dermatology and Venereology, Nr. n/a doi: 10.1111/jdv.14570.
    • , , , , und . . „Integrating x4T-EDC into an Image-Portal to Establish an Ophthalmic Reading Center.“ Studies in Health Technology and Informatics, Nr. 245: 1254.
    • , , , , und . . „Medical Effect of Venous Thromboembolism Prophylaxis Systems and Common Input Categories: Preliminary Findings from a Systematic Review.“ Studies in Health Technology and Informatics, Nr. 245: 1175–1179.
    • , , , , , , , , und . . „The Portal of Medical Data Models: Where Have We Been and Where Are We Going?“ Studies in Health Technology and Informatics, Nr. 245: 858–862.
    • , , , und . . „What Information Does Your EHR Contain? Automatic Generation of a Clinical Metadata Warehouse (CMDW) to Support Identification and Data Access Within Distributed Clinical Research Networks.“ Studies in Health Technology and Informatics, Nr. 245: 313–317.
    • , , , , , , , und . . „A Secure Architecture to Provide a Medical Emergency Dataset for Patients in Germany and Abroad.“ Studies in Health Technology and Informatics, Nr. 245: 230–234.
    • , , und . . „Operational Data Model Conversion to ResearchKit.“ Studies in Health Technology and Informatics, Nr. 245: 225–229.
    • , , , und . . „AML-Varan – a generic approach to integrate a multi-tool-combination based NGS variant calling pipeline into a web-based diagnostics platform.“ Beitrag präsentiert auf der Intelligent Systems for Molecular Biology (ISMB), Prag doi: 10.7490/f1000research.1114839.1.
    • , , , , , , und . „Portal of medical data models: Information infrastructure for medical research and healthcare.“ Database: The Journal of Biological Databases and Curation, Nr. 2016 (null) doi: 10.1093/database/bav121.
    • , , , , , , , , und . „Common data elements for secondary use of electronic health record data for clinical trial execution and serious adverse event reporting.“ BMC Medical Research Methodology, Nr. 16 (1) doi: 10.1186/s12874-016-0259-3.
    • , , , , , , , , , , , , , , , , , , , , , und . „Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors.“ EMBO Journal, Nr. 35 (22): 2399–2416. doi: 10.15252/embj.201693927.
    • , , , , , , , , , , , , , , , , , und . „Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.“ Blood, Nr. 127 (12): 1575–1586. doi: 10.1182/blood-2015-07-655928.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „European EADV network on assessment of severity and burden of Pruritus (PruNet): first meeting on outcome tools.“ Journal of the European Academy of Dermatology and Venereology, Nr. 30 (7): 1144–1147. doi: 10.1111/jdv.13296.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . „Azacitidine in combination with intensive induction chemotherapy in older patients with acute myeloid leukemia: The AML-AZA trial of the study alliance leukemia.“ Leukemia, Nr. 30 (3): 555–561. doi: 10.1038/leu.2015.306.
    • , , und . . „Converting ODM Metadata to FHIR Questionnaire Resources.“ Studies in Health Technology and Informatics, Nr. 228: 456–60.
    • , , und . . „Implementation of an ODM and HL7 Compliant Electronic Patient-Reported Outcome System.“ Studies in Health Technology and Informatics, Nr. 228: 421–5.
    • , , , , , , , , , , , , , , , , und . . „Key Data Elements in Myeloid Leukemia.“ Studies in Health Technology and Informatics, Nr. 228: 282–6.
    • . . „Design of case report forms based on a public metadata registry: re-use of data elements to improve compatibility of data.“ Trials, Nr. 17 (1): 566.
    • , , und . . „ODMSummary: A Tool for Automatic Structured Comparison of Multiple Medical Forms Based on Semantic Annotation with the Unified Medical Language System.“ PloS one, Nr. 11 (10): e0164569.
    • . . „Sharing clinical trial data.“ Lancet, Nr. 387 (10035): 2287.
    • , , , , , und . . „Chronic pruritus : Care in daily practice.“ Der Hautarzt, Nr. 67 (8): 640–7.
    • , , , , und . . „Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes.“ Cell Reports, Nr. 15 (2): 310–22.
    • , , , , und . . „ODMedit: uniform semantic annotation for data integration in medicine based on a public metadata repository.“ BMC Medical Research Methodology, Nr. 16: 65.
    • , , , , , , , , , , , , , , , , , , , und . . „Leukemia research in Germany: the Competence Network Acute and Chronic Leukemias.“ Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Nr. 59 (4): 444–453.
    • , , , , , , , , , , , , , , , , , , , , und . . „A NOVEL EPIGENETIC RESISTANCE MECHANISM TO THE FLT3 INHIBITOR PKC412 INDUCES CROSS-RESISTANCE TO STANDARD CHEMOTHERAPY IN ACUTE MYELOID LEUKEMIA (AML).“ Haematologica, Nr. 101 1: 166–166.
    • , und . . „Robust and exact structural variation detection with paired-end and soft-clipped alignments: SoftSV compared with eight algorithms.“ Briefings in Bioinformatics, Nr. 17 (1): 51–62.
    • , , , und . . „AML-Varan - a web-based platform to display and analyze genomic variants from targeted NGS sequencing data.“ Beitrag präsentiert auf der European Conference on Computational Biology (ECCB), Den Haag doi: 10.7490/f1000research.1113145.1.
    • , , , , , , , und . „Efficiency and effectiveness evaluation of an automated multi-country patient count cohort system study design.“ BMC Medical Research Methodology, Nr. 15 (1) doi: 10.1186/s12874-015-0035-9.
    • , , , , , , , und . „Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity.“ Dermatology, Nr. 231: 253–259.
    • , , , und . . „Basic4Cseq: an R/Bioconductor package for analyzing 4C-seq data.“ Bioinformatics, Nr. 30 (22): 3268–3269. doi: 10.1093/bioinformatics/btu497.
    • , und . „Transformations between CDISC ODM and openEHR Archetypes.“ In Bd. 205 aus Studies in Health Technology and Informatics Bristol: IOP Publishing. doi: 10.3233/978-1-61499-432-9-1225.
    • , , , , , , , , , , , , , , , , , , , , und . „Mutations in the cohesin complex in acute myeloid leukemia: Clinical and prognostic implications.“ Blood, Nr. 123 (6): 914–920. doi: 10.1182/blood-2013-07-518746.
    • , , , , , , , , , , , , , , , , , und . „Genetic characterization of acquired aplastic anemia by targeted sequencing.“ Haematologica, Nr. 99 (9) doi: 10.3324/haematol.2013.101642.
    • , , , , , , , , , , , , , , , , , , , und . . „DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding.“ Blood, Nr. 121 (1): 178–187.
    • , , , , und . . „Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review.“ Briefings in Bioinformatics, Nr. 14 (1): 27–35.
    • , , , , , , , , , , , , , , und . . „COMPETENCE CENTER CHRONIC PRURITUS AT THE UNIVERSITY HOSPITAL OF MUNSTER: A DEDICATED CENTER WITH A DECADE OF EXPERIENCE IN MULTIDISCIPLINARY MEDICAL CARE.“ Acta dermato-venereologica, Nr. 93 (5): 634.
    • , , , , und . . „Semantic enrichment of medical forms - semi-automated coding of ODM-elements via web services.“ Studies in Health Technology and Informatics, Nr. 180: 1102–1104.
    • , , , , und . . „Semantic enrichment of medical forms - semi-automated coding of ODM-elements via web services.“ Studies in Health Technology and Informatics, Nr. 180: 1102–1104.
    • , , , , , , , , , und . . „Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements.“ Journal of Toxicology and Environmental Health, Part A: Current Issues, Nr. 75 (8-10): 461–470.
    • , , , und . . „Interoperability in clinical research: from metadata registries to semantically annotated CDISC ODM.“ Studies in Health Technology and Informatics, Nr. 180: 564–568. doi: 10.3233/978-1-61499-101-4-564.
    • , , , , , , , , , und . . „DNMT3B overexpression is associated with prolonged survival in myeloid leukemic mouse model.“ Onkologie, Nr. 35 6: 100–100.
    • , , , , , , , , , und . . „Next-generation sequencing reveals complex molecular rearrangements in MLLT10/MLL childhood AML.“ European Journal of Pediatrics, Nr. 171 (9): 1426–1426.
    • , , , , , , , , , , , , , , , , und . . „Acquisitions of Pruritus: Curremt Standards and Implications for Practice (vol 63, pg 521, 2012).“ Der Hautarzt, Nr. 63 (9): 723–723.
    • , , , , , , , und . . „Homeobox protein HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells.“ Journal of Biological Chemistry, Nr. 287 (48): 40703–49712.
    • , , , , , , , , , , , und . . „CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL.“ Haematologica, Nr. 97 (9): 1304–1311.
    • , , , , , , , , , , und . . „EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia.“ British Journal of Haematology, Nr. 157 (3): 387–390.
    • , , , , , , und . . „Multilingual medical data models in ODM format--a novel form-based approach to semantic interoperability between routine health-care and clinical research.“ Appl Clin Inf, Nr. 3: 276–289. doi: 10.4338/ACI-2012-03-RA-0011.
    • , , , , , , , , , , , , , , , , und . . „Assessment of pruritus - current standards and implications for clinical practice : Consensus paper of the Action Group Pruritus Parameter of the International Working Group on Pruritus Research (AGP).“ Der Hautarzt, Nr. 63 (7): 521–531.
    • , , , , , , , , , , , , , , , , , , , und . . „Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.“ Nature Medicine, Nr. 18 (4): 605–611.
    • , , , , und . . „Qualitative and quantitative evaluation of EHR-integrated mobile patient questionnaires regarding usability and cost-efficiency.“ International Journal of Medical Informatics, Nr. 81 (5): 303–313. doi: 10.1016/j.ijmedinf.2011.12.008.
    • , , , , und . . „Mobile Capture of the DLQI (Dermatology Life Quality Index) for medical Care and Research in Dermatology.“ Experimental Dermatology, Nr. 21 (3): e49–e49.
    • , und . . „A generic method to monitor completeness and speed of medical documentation processes.“ Methods of Information in Medicine, Nr. 51 (3): 252–257.
    • , , , , , , , , , , , , , , , , , , , , und . . „Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival.“ Leukemia Research, Nr. 35 (5): 620–625. doi: 10.1016/j.leukres.2010.11.006.
    • , , , , und . . „Concept and implementation of a computer-based reminder system to increase completeness in clinical documentation.“ International Journal of Medical Informatics, Nr. 80 (5): 351–358.
    • , , , , , , , , , , und . . „Whole Genome Amplification with Subsequent High Throughput Sequencing Allows Comprehensive Genome-Wide Analysis of Single Leukemic Cells.“ Blood, Nr. 118 (21): 624–624.
    • , , , , , , , , , , , , und . . „Somatic Structural Variations in Pediatric High Hyperdiploid Acute Lymphoblastic Leukemia Revealed by Paired-End Parallel Sequencing.“ Blood, Nr. 118 (21): 184–184.
    • , , , , , , , , und . . „Histone H3 Methylation Mediates All-Trans-Retinoic Acid Responsiveness in Acute Myeloid Leukemia.“ Blood, Nr. 118 (21): 103–103.
    • , , , , , , , , , , , , , , , und . . „Identification of the PML-RAR alpha Associated DNA Methylome Using Reduced Representation Bisulfite Sequencing in Primary Patient Samples.“ Blood, Nr. 118 (21): 1046–1047.
    • , und . . „Single source information systems can improve data completeness in clinical studies: an example from nuclear medicine.“ Studies in Health Technology and Informatics, Nr. 169: 872–876.
    • , , , , , , , und . . „Populating the i2b2 database with heterogeneous EMR data: a semantic network approach.“ Studies in Health Technology and Informatics, Nr. 169: 502–506.
    • , , , , , , , , , und . . „Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology.“ Journal of Molecular Diagnostics, Nr. 13 (2): 129–136.
    • , , , , , , und . . „Psychooncological interventions -what do cancer patients aged 60 years or older wish for?“ Journal of Psychosomatic Research, Nr. 70 (6): 612–613.
    • , , , , und . . „CORRELATION OF ITCH INTENSITY WITH QUALITY OF LIFE, ANXIETY AND DEPRESSION.“ Acta dermato-venereologica, Nr. 91 (5): 636–637.
    • , , , , , , und . . „MEDICAL CARE OF CHRONIC PRURITUS PATIENTS: HOW TO EFFICIENTLY COLLECT PATIENT REPORTED OUTCOMES.“ Acta dermato-venereologica, Nr. 91 (5): 636–636.
    • , , , , und . . „CIS-based registration of quality of life in a single source approach.“ BMC Medical Informatics and Decision Making, Nr. 11: 26. doi: 10.1186/1472-6947-11-26.
    • , , , und . . „Mapping turnaround times (TAT) to a generic timeline: a systematic review of TAT definitions in clinical domains.“ BMC Medical Informatics and Decision Making, Nr. 11: 34. doi: 10.1186/1472-6947-11-34.
    • , , , , und . . „HIS-based Kaplan-Meier plots--a single source approach for documenting and reusing routine survival information.“ BMC Medical Informatics and Decision Making, Nr. 11: 11. doi: 10.1186/1472-6947-11-11.
    • , , , , , , und . . „[Psychooncological interventions - what do cancer patients aged 60 years or older wish for?].“ Zeitschrift für Psychosomatische Medizin und Psychotherapie, Nr. 57 (3): 223–232.
    • , , , , , , , , und . . „Prognosis in patients with MDS or AML and bone marrow blasts between 10% and 30% is not associated with blast counts but depends on cytogenetic and molecular genetic characteristics.“ Leukemia, Nr. 25 (8): 1361–1364.
    • , , , , , , , , , und . . „Targeted next-generation sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure.“ Leukemia, Nr. 25 (4): 671–680.
    • , , , , , , , , , , , , , , , , , , und . . „AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.“ Blood, Nr. 117 (16): 4328–4337. doi: 10.1182/blood-2009-09-242545.
    • , , , , , , und . . „R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data.“ Bioinformatics, Nr. 27 (8): 1162–1163.
    • , , , , , , , und . . „The Single Source Architecture x4T to Connect Medical Documentation and Clinical Research.“ In User Centred Networked Health Care - Proceedings of MIE 2011, Bd. 169 aus Studies in Health Technology and Informatics, herausgegeben von Andersen Stig Kjær Moen Anne und Hurlen Petter Aarts Jos. Bristol: IOP Publishing. doi: 10.3233/978-1-60750-806-9-902.
    • , , , , und . . „Concept and implementation of a single source information system in nuclear medicine for myocardial scintigraphy (SPECT-CT data).“ Applied Clinical Informatics, Nr. 2010 (1): 50–67. doi: 10.4338/ACI-2009-12-RA-0017.
    • , , , , , , , , , , , , und . . „Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia.“ Haematologica, Nr. 95 (9)
    • , , , , , , , , , , , , und . . „Low SMC1A protein expression predicts poor survival in acute myeloid leukemia.“ Oncol Rep, Nr. 24 (1): 47–56.
    • , , , , , , , , , , , , , , , , , , , , , , und . . „Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.“ Blood, Nr. 116: 3564–3571. doi: 10.1182/blood-2009-09-240978.
    • , , , , , , und . . „Serum concentration of baseline mast cell tryptase: evidence for a decline during long-term immunotherapy for Hymenoptera venom allergy.“ Clin Exp Allergy
    • , , , , und . . „Single-Source-Ansätze am Universitätsklinikum Münster.“ mdi, Nr. 2010 (2): 57–59.
    • , , , , und . . „Using routine data from hospital information systems to facilitate recruitment in clinical research.“ Clinical Trials, Nr. 7 (2): 183–189.
    • , , , , und . . „Routine data from hospital information systems can support patient recruitment for clinical studies.“ Clinical Trials, Nr. 7 (2): 183–189. doi: 10.1177/1740774510363013.
    • , , , , , , , , , , , , und . . „Low SMC1A protein expression predicts poor survival in acute myeloid leukemia.“ Oncology Reports, Nr. 24 (1): 47–56.
    • , , und . . „Sorting chromosomes as a software-based exercise.“ Medical Education, Nr. 44 (11): 1127. doi: 10.1111/j.1365-2923.2010.03845.x.
    • , , , , , , und . . „Serum concentration of baseline mast cell tryptase: evidence for a decline during long-term immunotherapy for Hymenoptera venom allergy.“ Clinical and Experimental Allergy, Nr. 40 (4): 643–649. doi: 10.1111/j.1365-2222.2009.03436.x.
    • , , , , und . . „Comparative study of unsupervised dimension reduction techniques for the visualization of microarray gene expression data.“ Trials, Nr. 11: 567–577. doi: 10.1186/1471-2105-11-567.
    • , , , , , , , , , , , , und . . „Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia.“ Haematologica, Nr. 95 (9): 1481–1488. doi: 10.3324/haematol.2009.011114.
    • , , , , , , , , und . . „Clinical map document based on XML (cMDX): document architecture with mapping feature for reporting and analysing prostate cancer in radical prostatectomy specimens.“ BMC Medical Informatics and Decision Making, Nr. 10: 71. doi: 10.1186/1472-6947-10-71.
    • , , , , , , , , , , und . . „Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways.“ Leukemia, Nr. 24 (6): 1216–1220. doi: 10.1038/leu.2010.73.
    • , , , , , , , und . . „PROGNOSTIC FACTORS FOR AND PREVALENCE OF BK-VIRUS INFECTION IN A CAUCASIAN RENAL TRANSPLANT POPULATION.“ Transplant International, Nr. 23 Suppl.: 0112 –.
    • , , , und . . „Steps towards single source--collecting data about quality of life within clinical information systems.“ Studies in Health Technology and Informatics, Nr. 160 (Pt 1): 188–192.
    • , , , und . . „Multidisciplinary education in medical informatics--a course for medical and informatics students.“ Studies in Health Technology and Informatics, Nr. 160 (Pt 1): 581–584.
    • , , und . . „HIS-based electronic documentation can significantly reduce the time from biopsy to final report for prostate tumours and supports quality management as well as clinical research.“ BMC Med Inform Decis Mak., Nr. 9 (1): 5–5.
    • , , , und . . „LOINC® Codes for Hospital Information System documents - a case study.“ J Am Med Inform Assoc, Nr. 16 (3): 400–403.
    • , und . . „Transferring HIS data to population-based cancer registries - concept and first implementations.“ Studies in Health Technology and Informatics, Nr. 150: 86–90.
    • , , , , , , , , , , , , und . . „The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.“ Blood, Nr. 114 (22): 526–527.
    • , , , , und . . „Single Source Information Systems to Connect Patient Care and Clinical Research.“ In Medical Informatics in a United and Healthy Europe - Proceedings of MIE 2009 – The XXIInd International Congress of the European Federation for Medical Informatics, Bd. 150 aus Studies in Health Technology and Informatics, herausgegeben von Bernd Blobel Klaus-Peter Adlassnig und Izet Masic John Mantas. Bristol: IOP Publishing. doi: 10.3233/978-1-60750-044-5-61.
    • , , , , , , , , , , , , , , , , und . . „S100A2 induces metastasis in non-small cell lung cancer.“ Clinical Cancer Research, Nr. 15 (1): 22–29. doi: 10.1158/1078-0432.CCR-08-0953.
    • , , , , , , und . . „Cyclin A1 regulates WT1 expression in acute myeloid leukemia cells.“ International Journal of Oncology, Nr. 34 (1): 129–136.
    • , , , , , , , , , , , , und . . „Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.“ Haematologica, Nr. 94 (2): 213–223. doi: 10.3324/haematol.13024.
    • , , , , , , , , , , , , , , und . . „High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray.“ Molecular Cancer Research, Nr. 7 (5): 665–677. doi: 10.1158/1541-7786.MCR-08-0270.
    • , , , , , und . . „Estimation of patient accrual rates in clinical trials based on routine data from hospital information systems.“ Methods of Information in Medicine, Nr. 48 (3): 263–266. doi: 10.3414/ME0582.
    • , , , , , , , , , , und . . „AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features.“ Leukemia, Nr. 23 (5): 934–943. doi: 10.1038/leu.2008.388.
    • , , , , , , , , , , , , , , , , und . . „Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.“ Haematologica, Nr. 94 (9): 1301–1306. doi: 10.3324/haematol.2009.005744.
    • , , , , , und . . „Integrated analysis of copy number alterations and gene expression: a bivariate assessment of equally directed abnormalities.“ Bioinformatics, Nr. 25 (24): 3228–3235. doi: 10.1093/bioinformatics/btp592.
    • , , , , und . . „Single Source Informationssysteme - Nutzung von Routinedaten für die klinische Forschung.“ Beitrag präsentiert auf der 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS), Essen Essen. doi: 10.3205/09gmds287.
    • , , , und . . „Workflow to improve patient recruitment for clinical trials within hospital information systems - a case-study.“ Trials, Nr. 9: 2. doi: 10.1186/1745-6215-9-2.
    • , , , , , und . . „Analysis of factors influencing the ultrasonic fetal weight estimation.“ Fetal Diagnosis and Therapy, Nr. 23 (3): 204–210. doi: 10.1159/000116742.
    • , , , , , , , , , , und . . „ChIP-Chip in Primary AML Blasts Identifies Peroxiredoxin-II as An Epigenetically Silenced Tumor Suppressor.“ Blood, Nr. 112 (11): 1150–1151.
    • , , , , , , , , , und . . „Gene Expression Profiling in AML with Normal Karyotype: A Multicenter Study Investigating Molecular Markers in 252 Cases.“ Blood, Nr. 112 (11): 278–279.
    • , und . . „Application of microarray technology for the analysis of gene expression in veterinary medicine.“ Berl. Münch. Tierärztl. Wochenschr: 179–188.
    • , und . . „ChIP- chip microarrays to study the epigenome in leukemia.“ European Leukemia Network of Excellence, Information Letter Nr. 5.
    • , , , , , , , , , , , und . . „Identification of acute myeloid leukaemia associated microRNA expression patterns.“ British Journal of Haematology, Nr. 140 (2): 153–161.
    • , , und . . „Benchmarking of hospital information systems: monitoring of discharge letters and scheduling can reveal heterogeneities and time trends.“ BMC Medical Informatics and Decision Making, Nr. 8: 15. doi: 10.1186/1472-6947-8-15.
    • , , , , , , , und . . „Translocation t(14;19)(q32;q13) Is a Rare Abnormality in CLL and Associated with Trisomy 12, an Unmutated IgVH Status and a Distinct Gene Expression Profile.“ Beitrag präsentiert auf der ASH 2007
    • , , , , , , , , und . . „Combined Analysis of Valproic Acid Induced MicroRNA and Gene Expression Changes in Acute Myeloid Leukemia.“ Beitrag präsentiert auf der ASH 2007
    • , , , , , , und . . „An Approach to Virtual Karyotyping for Unbalanced Rearrangements Based on Gene Expression Data.“ Beitrag präsentiert auf der ASH 2007
    • , , , , , , , , , , , und . . „Numerous Genomic Abnormalities in AML with Normal Karyotype.“ Beitrag präsentiert auf der ASH 2007
    • , , , , , , , und . . „Gain of the Short Arm of Chromosome 2 Is a New Recurring Chromosome Aberration in CLL Which Is Significantly Associated with an Unmutated IgGVH Status and a Complex Aberrant Karyotype and Leads to a Higher Expression of Genes Located on 2P.“ Beitrag präsentiert auf der ASH 2007
    • , , , , , , , und . . „Microarray Analysis Detects Unique Expression Pattern for NPM1-Mutated AML with Normal Karyotype and Reveals Pathobiological Insights.“ Beitrag präsentiert auf der ASH 2007
    • , , , , , , und . . „An approach to virtual karyotyping for unbalanced rearrangements based on gene expression data.“ Blood, Nr. 110 (11): 885.
    • , , , , , , , , , und . . „Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential.“ Blood, Nr. 110 (2): 686–694. doi: 10.1182/blood-2006-10-053181.
    • , , , , , , , und . . „Gain of the short arm of chromosome 2 is a new recurring chromosome aberration in CLL which is significantly associated with an unmutated IgGVH status and a complex aberrant karyotype and leads to a higher expression of genes located on 2P.“ Blood, Nr. 110 (11): 2075.
    • , , , , , , , und . . „Microarray analysis detects unique expression pattern for NPM1-mutated AML with normal karyotype and reveals pathobiological insights.“ Blood, Nr. 110 (11): 2382.
    • , , , , , , , , , , , und . . „Numerous genomic abnormalities in AML with normal karyotype.“ Blood, Nr. 110 (11): 1811.
    • , , , , , , , und . . „Translocation t(14;19)(q32;q13) is a rare abnormality in CLL and associated with trisomy 12, an unmutated IgVH status and a distinct gene expression profile.“ Blood, Nr. 110 (11): 4703.
    • , , , , und . . „A Generic Concept for Large-scale Microarray Analysis Dedicated to Medical Diagnostics.“ Methods Inf Med, Nr. 45 (2): 146–152.
    • , , , , , und . . „Impact of trisomy 8 on expression of genes located on chromosome 8 in different AML subgroups.“ Genes Chromosomes Cancer, Nr. 45 (12): 1164–1168.
    • , , , , , , , , , , und . . „Distinct expression patterns of human microRNAs in myeloid differentiation and acute myeloid leukemia.“ Blood, Nr. 108 (11): 632A–632A.
    • , und . . „Hospital Information Systems.“ In Imaging Systems for Medical Diagnostics N/A: Sonstiger Verlag / other publisher.
    • , , , , , , , , , , , und . . „Alpha-gluthathione S-transferase as an early marker of hepatic ischemia/reperfusion injury after liver resection.“ World J Surg, Nr. 29 (4): 528–534.
    • , , , , , , und . . „AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes.“ Genes Chromosomes Cancer, Nr. 43 (2): 113–127.
    • , , , , , und . . „Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus.“ J Dtsch Dermatol Ges, Nr. 3 (5): 343–347.
    • , , , , , , , , , und . . „Digital teaching file Concept, implementation, and experiences in a university setting.“ Radiologe, Nr. 45 (8): 724–734.
    • , , , , , , und . . „Genomic gains and losses influence expression levels of genes located within the affected regions: a study on acute myeloid leukemias with trisomy 8, 11, or 13, monosomy 7, or deletion 5q.“ Leukemia, Nr. 19 (7): 1224–1228.
    • , , , , , , und . . „Global approach to the diagnosis of leukemia using gene expression profiling.“ Blood, Nr. 106 (4): 1189–1198.
    • , , , , , , und . . „New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes.“ Leukemia, Nr. 19 (6): 953–964.
    • , , , , , , , und . . „Pattern robustness of diagnostic gene expression signatures in leukemia.“ Genes Chromosomes Cancer, Nr. 42 (3): 299–307.
    • , , , , , , , , , , , , , , und . . „Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature.“ Circ Res, Nr. 96 (9): 1022–1029.
    • , , , , , , , , , , , und . . „Effects of Pringle manoeuvre and ischaemic preconditioning on haemodynamic stability in patients undergoing elective hepatectomy: a randomized trial.“ Br J Anaesth, Nr. 93 (2): 204–211.
    • , , , , , , , , , , und . . „Estimation of liver size for liver transplantation: the impact of age and gender.“ Liver Transpl, Nr. 10 (5): 678–685.
    • , , , , , , , , , , , , und . . „Global gene expression in human myocardium-oligonucleotide microarray analysis of regional diversity and transcriptional regulation in heart failure.“ J Mol Med, Nr. 82 (5): 308–316.
    • , , , , , , , und . . „Identification of differentially expressed genes in scrapie-infected mouse brains by using global gene expression technology.“ J Virol, Nr. 78 (20): 11051–11060.
    • , , , und . . „mdclust - Exploratory Microarray Analysis by Multidimensional Clustering.“ Bioinformatics, Nr. 20 (6): 931–936.
    • , , , , , , und . . „Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients.“ Leukemia, Nr. 18 (1): 63–71.
    • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , und . . „Synergy between medical informatics and bioinformatics: facilitating genomic medicine for future health care.“ Journal of Biomedical Informatics, Nr. 37 (1): 30–42.
    • , , , , und . . „Ultrasound training: the virtual patient.“ Ultrasound Obstet Gynecol, Nr. 24 (4): 440–444.
    • , , , , , und . . „Bioinformatics for Medical Diagnostics: Assessment of Microarray Data in the Context of Clinical Databases.“ Beitrag präsentiert auf der AMIA 2003 Annual Symposium
    • , , , , , und . . „Acute myeloid leukemia with recurring chromosome abnormalities as defined by the WHO-classification: incidence of subgroups, additional genetic abnormalities, FAB subtypes and age distribution in an unselected series of 1,897 patients with acute myeloid leukemia.“ Haematologica, Nr. 88 (3): 351–352.
    • , , , , und . . „Design and implementation of a common drug information database for a university hospital.“ Pharm World Sci, Nr. 25 (4): 156–161.
    • , , , und . . „Developmental markers of B cells are superior to those of T cells for identification of stages with distinct gene expression profiles.“ J Leukoc Biol, Nr. 74 (4): 602–610. doi: 10.1189/jlb.0203085.
    • , , , , , , und . . „Electroanatomic mapping of endocardial right ventricular activation as a guide for catheter ablation in patients with arrhythmogenic right ventricular dysplasia.“ Pacing Clin Electrophysiol, Nr. 26 (6): 1308–1316.
    • , , , , , , , , , , , , , , , und . . „Interleukin 4-therapy of psoriasis induces Th2-responses and improves human autoimmune disease.“ Nature Medicine, Nr. 9 (1): 40–46. doi: 10.1038/nm804.
    • , , , , , , und . . „Molecular characterization of acute leukemias by use of microarray technology.“ Genes, Chromosomes and Cancer, Nr. 37: 396–405.
    • , , , , , , und . . „Radiofrequency catheter ablation: different cooled and noncooled electrode systems induce specific lesion geometries and adverse effects profiles.“ Pacing Clin Electrophysiol: 1438–1445.
    • , , , , , , , und . . „Risk factors for recurrence of atrial fibrillation in patients undergoing hybrid therapy for antiarrhythmic drug-induced atrial flutter.“ Eur Heart J, Nr. 24 (13): 1264–1272.
    • , , , , , , und . . „T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients.“ Br J Haematol, Nr. 122 (5): 795–801.
    • , , , , , , , , , und . . „The German Multicentre Study Group for Adult ALL (GMALL): Recruitment in comparison to ALL incidence and its impact on study results.“ Annals of Hematology, Nr. 82: 83–87.
    • , , , , , , , , , , und . . „Transvenous defibrillation leads: high incidence of failure during long-term follow-up.“ J Cardiovasc Electrophysiol, Nr. 14 (1): 38–43.
    • , , , , und . . „Web-based training in occupational medicine.“ International Archives of Occupational and Environmental Health, Nr. 76: 50–54.
    • , , , , , , und . . „Molecular characterization of acute leukemias by use of microarray technology.“ Genes, Chromosomes and Cancer, Nr. 37 (4): 396–405.
    • . . „Datenerhebung im Internet - Potential, Probleme und Perspektiven.“ In Moderne Gesundheitskommunikation - Von der Arzt-Patient-Interaktion zur E-Health Bern: Hans Huber Verlag.
    • , und . . „XML-based Knowledge Management for Teleteaching and Telelearning in Medicine.“ Beitrag präsentiert auf der 7th International Conference on the Medical Aspects of Telemedicine: Integration of Health Telematics into Medical Practice
    • , , , , , , , , , , , und . . „Analysis of FLT3 length mutations in 1003 patients with AML: relation to cytogenetics, fab subtype, and prognosis in the AMLCG-study and usefullness as a marker for detection of minimal residual disease.“ Blood, Nr. 100 (1): 59–66.
    • , , , , , , , , , und . . „Complexity of Biomedical Data Models in Cardiology: The Intranet-based Atrial Fibrillation Registry.“ Computer Methods and Programs in Biomedicine, Nr. 68: 49–61.
    • , , , , , , , , und . . „Detection of Malignant Hepatic Lesions Before Orthotopic Liver Transplantation: Accuracy of Ferumoxides-Enhanced MR Imaging.“ Am J Roentgenol, Nr. 179 (4): 1045–1051.
    • , , , , , , , , , , , , , und . . „Heterogeneous Expression of MAGE-A Genes in Occult Disseminated Tumor Cells: A novel multimarker RT-PCR for diagnosis of micrometastatic disease.“ Cancer Research, Nr. 62: 251–261.
    • , , , , , , und . . „Impact of integrating clinical and genetic information.“ Silico Biology
    • , , , und . . „Interactive decision support in hepatic surgery.“ BMC Med Inform Decis Mak, Nr. 2 (1)
    • , , , , , , , , und . . „Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: A detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH.“ Genes Chromosomes Cancer, Nr. 35: 20–29.
    • , , und . . „Profound effect of normalization on detection of differentially expressed genes in oligonucleotide microarray data analysis.“ Genome Biology, Nr. 3 (7) doi: 10.1186/gb-2002-3-7-research0033.
    • , , , , , , , , , , , und . . „Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease.“ Blood, Nr. 100 (1): 59–66.
    • . . „Perspektiven für ein patientenorientiertes Informations- und Kommunikationsmanagement durch das Computerbasierte Patientendossier.“ Beitrag präsentiert auf der Schweizerischen Gesellschaft für Medizinische Informatik, Basel
    • , , , , , , und . . „Impact of integrating clinical and genetic information.“ Beitrag präsentiert auf der German Conference on Bioinformatics (GCB 2001)
    • , , , , und . . „Interactive Computer-Based-Training in Medicine - an example from Emergency Medicine.“ Beitrag präsentiert auf der Proceedings of the Slice of Life 2001 & Computers in Healthcare Symposium, Berlin Berlin: Logos Verlag.
    • , , , , , und . . „Vorstellung des computerunterstützten Lernprogramms „Co-LAB“ für das Fach Arbeitsmedizin.“ Beitrag präsentiert auf der 41. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V.
    • , , , , , , , und . . „A comprehensive leukemia database: Integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunphenotyping.“ Leukemia, Nr. 15: 1805–1810.
    • , , , , , , , , , , und . . „Case-oriented computer-based-training in radiology: concept, implementation and evaluation.“ BMC Medical Education
    • , , , , , , und . . „Dependence of age-specific incidence of acute myeloid leukemia on karyotype.“ Blood, Nr. 98: 3500.
    • , , , und . . „Intranet Database for a University Hospital Drug Information Center.“ American Journal of Health-System Pharmacy, Nr. 58: 799–802.
    • , , , und . . „XML-based visualization of design and completeness in medical databases.“ Medical Informatics and the Internet in Medicine, Nr. 26: 237–250.
    • , , , , , und . . „XML-based Visual Data Mining in Medicine.“ Medinfo, Nr. 10 (2): 1324–1328.
    • , und . . „An Intranet Tool for XML-based Data Modelling in Medicine.“ Medical Infobahn for Europe, Nr. 2000 (77): 983–987.
    • , , und . . „Online-Kurs Notfallmedizin: Kurrikulare Integration von Computer-Based-Training.“ Der Anaesthesist, Nr. 2000 (49): 881–886.
    • , und . . „Intranet Based Clinical Workstations.“ In Medical Informatics, Biostatistics and Epidemiology for Efficient Health Care and Medical Research München: Urban und Vogel.
    • , , , und . . „Intranet-Anwendungen am Universitätsklinikum Köln.“ In Herausforderungen in der Informationsverarbeitung an den Universitäten des Landes NRW Düren: Shaker Verlag.
    • , , und . . „An Intranet-Based System for Quality Assurance in Surgery.“ J Med Syst, Nr. 23 (1): 13–19.
    • , und . . „Computer-Based-Training in der Neurologie mit Intranet-Technik am Beispiel Epilepsie. Biomedical Journal 1999, 53(1), 27-29.“ Biomedical Journal, Nr. 53 (1): 27–29.
    • , , , und . . „Intranet-based multi-purpose medical records in Orthopedics.“ Medical Informatics, Nr. 24 (4): 269–275.
    • , , und . . „Mr. Lewis on the web - how to convert learning resources for intranet-technology.“ Medical Education, Nr. 33 (1): 42–46.
    • , , und . . „Innovative Lösungen für eine transparente Nutzerführung zu Online- und Offline-Angeboten an Lernstationen für Studenten.“ In Computer Based Training in der Medizin Technik - Evaluation-Implementation Düren: Shaker Verlag.
    • . . „An intranet-based information system for nurses.“ MD Computing, Nr. 15 (3): 158–161.
    • , und . . „Intranet-Technologie für die Medizinische Ausbildung am Beispiel Klinische Chemie.“ Medizinische Ausbildung : Forum zur Erforschung der ärztlichen Aus-, Weiter- und Fortbildung, Nr. 1998 (60): 27–30.
    • , , , , , , , , , , , , und . . „Correlation between student use of computer-based instruction and high exam scores in pathology.“ Journal of Medical Education Technologies, Nr. 1998 (6): 20–25.
    • , und . . Pflegeinformationen per Computer,
    • . . „HTML-Anwendungen im Intranet - Erfahrungen im Klinikum Großhadern.“ In Kongreßband der XII. Jahrestagung der SGMI/SSIM. Klinikinformationssysteme von der Theorie zur Praxis Zürich.
    • . . „Clinical applications of Intranet-Technology.“ In New Technologies in Hospital Information Systems Amsterdam: IOS Press.
    • , und . . „Bereitstellung und Nutzung medizinischer Inhalte mit einem universellen Klinikinformationsserver des IBE - Erfahrungen auf 50 Stationen im Klinikum Großhadern.“ In Medizinische Informatik, Biometrie und Epidemiologie München: MM Medizin + Medien Verlag.
    • . . „Kommunikation im Gesundheitswesen: HTML-Anwendungen im Intranet.“ In Medizinische Dokumentation und Information
    • , , und . . „CBT in der Medizin mit Intranet-Technologie - Erfahrungen im Klinikum Großhadern.“ In CBT in der Medizin Aachen.
    • , , und . . „Mutually Exclusive Action of Cationic Veratridine and Cevadine at an Intracellular Site of the Cardiac Sodium Channel.“ J Gen Physiol, Nr. 1992 (99): 699–720.
    • , , und . . „Relation between Veratridine Reaction Dynamics and Macroscopic Na Current in Single Cardiac Cells.“ J Gen Physiol, Nr. 1992 (99): 683–697.
    • , , , und . . „Interaction between DPI 201-106 Enantiomers at the Cardiac Sodium Channel.“ Molecular Pharmacology, Nr. 1990 (37): 17–24.
    • , , , und . . „Sodium Channel Comodification with Full Activator reveals Veratridine Reaction Dynamics.“ Molecular Pharmacology, Nr. 1990 (37): 144–148.
    • , , und . . „Tetrodotoxin block of single germitrine-activated sodium channels in cultured rat cardiac cells.“ J Physiol, Nr. 1989 (411): 611–626.

  • Betreute Arbeiten

    Promotionen

    Planung und Analyse adaptiv-sequentieller klinischer Studien mit multiplen, korrelierten Ereigniszeit-Endpunkten
    Kerschke, Laura JuleNew Test Procedures for the Comparison of Survival Curves, Theory and Application to Complex Trial Designs
    Krenz, HenrikeKonzeption, Implementierung und Evaluation des Male Fertility Gene Atlas
    Niemeyer, SinaDokumentation der chronischen Prurigo
    Blitz, RogerioRogerio BlitzGenerischer, standardkonformer Metadaten und Datentransfer in die elektronische Patientenakte
    Wünsch, ChristianAMLVaran: a software approach to implement variant analysis of targeted NGS sequencing data in an oncological care setting
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    Holz, ChristianCommon Data Element Analysis & Harmonization for Acute Myeloid Leukemia
    Kentgen, MarkusCommon Data Element Analysis & Harmonization for Acute Coronary Syndrome
    Walter, CarolinAnalyse von NGS-und 4C-seq-Daten
    Suilmann, Theresa AntoniaUsability of validated sleep-assessment questionnaires in patients with chronic pruritus
    Multilinguale Validierung von Fragebögen zur Erfassung von Pruritus in Deutschland, Polen und der Türkei
    Winter, TanjaPruNet Teilprojekt: Vergleich der Dermatosen anhand der Lebensqualität in Frankreich/Russland
    Vietmeier, Friederike ElisabethPruNet Teilprojekt: Validierung und Anwendung von Fragebögen zur Intensität und Lebensqualität bei chronischen Pruritus in zwei europäischen Kollektiven
    Funke, JuliaPruNet Teilprojekt
    Sandmann, SarahEvaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data
    Mozar, JulianPruNet Teilprojekt: Validierung von zwei Pruritus-spezifischen Fragebögen zur Erfassung der Lebensqualität in Österreich
    Riepe, ClaudiaBestimmung der minimal klinisch relevanten Differenz auf Intensitätsskalen für chronischen Pruritus
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    "Mobile Health als Teil der modernen Medizin Anforderungen aus Sicht der Bevölkerung"
    Soto Rey, IñakiEfficiency and effectiveness evaluation of an automated multi-country patient count cohort system
    Warlich, BenjaminHealth-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity
    Tilahun, BinyamElectronic medical record system framework for low resource setting hospitals
    Butz, OlafEvaluation des Bilddatenaustausches im Traumanetzwerk NordWest Einflüsse auf Prozesse in der Notaufnahme
    Neuhaus, PhilippCharacterization of Image Transfer Patterns in a Regional Trauma Network
    Bruland, PhilippDoes single-source create an added value? Evaluating the impact of introducing x4T into the clinical routine on workflow modifications, data quality and cost-benefit.
    Frequency analysis of medical concepts in clinical trials and their coverage in MeSH and SNOMED-CT
    Bartenhagen, ChristophRobuste und genaue Detektion struktureller Varianten mit Paired-End- und Soft-Clip-Alignments: SoftSV im Vergleich mit acht Algorithmen
    Heide, TobiasResearch Portals - Knowledge Access, Content Design, and Quality Management
    Trinczek, BenjaminDesign and multicentric implementation of a generic software architecture for patient recruitment systems re-using existing HIS tools and routine patient data
    Doods, JustinA European inventory of common electronic health record data elements for clinical trial feasibility
    Krumm, RainerThe need for harmonized structured documentation and chances of secondary use
    Does single-source create an added value? Evaluating the impact of introducing x4T into the clinical routine on workflow modifications, data quality and cost-benefit.
    Bayesianische Verfahren in pädiatrischen Studien Extrapolation historischer Informationen aus klinischen Studien an Erwachsenen und Kindern: Ergebnisse, Limitationen und Erweiterungen eines meta-analytisch prädiktiven Ansatzes
    Hebestreit, KatjaDetection of significantly differentially methylated regions in targeted bisulfite sequencing data
    Fritz, FleurQualitative and quantitative evaluation of EHR-integrated mobile patient questionnaires regarding usability and cost-efficiency
    Breil, BernhardKIS-basierte Kaplan-Meier Kurven - Ein Single-Source Ansatz für die Dokumentation und Wiederverwendung von Überlebenszeitdaten
    Klein, Hans-UlrichQuantitative comparison of microarray experiments with published leukemia related gene expression signatures
    Herzberg, SusanneKonzept und Implementierung eines Single Source Informationssystems in der Nuklearmedizin
    Eminaga, OkyazClinical map document based on XML (cMDX) - document architecture with mapping feature for reporting and analysing prostate cancer in radical prostatectomy specimens

    Habilitationen

    Semantische Analysen und Entscheidungsunterstützungssysteme in der Medizin
    Konfirmatorische adaptive Designs für Phase II Studien mit Überlebenszeitendpunkt
    Software Engineering für mobile Endgeräte
    Reitz, ChristianeVascular Disease and Cognitive Impairment