Forschungsschwerpunkte
- Evolutionary molecular design: Escape from adaptative conflicts via multifunctionality in Proteins and RNA
- Modular evolution of proteins: Dynamics and adaptive benefits of domain rearrangements
- Genome evolution: Rearrangements and emergence of novel genes in development
- Regulatory network evolution: Molecular causes and phenotypic consequences for diseases
- Bioinformatics
Vita
Akademische Ausbildung
- PhD in Theoretical Biochemistry (Institute for Theoratical Chemistry, University of Vienna, Austria)
- Diploma (equivalent to MSc) in Biochemistry, University of Vienna, Austria
- Studies in Biochemistry, Physics and Mathematics, University of Vienna, Austria
Beruflicher Werdegang
- Gastprofessur Université Lyon 1, Claude Bernard, Laboratoire de Biométrie et Biologie Évolutive
- Gastwissenschaftler EBI, Thornton Group "The Spices", Cambridge
- Full Professor of Molecular Evolution and Bioinformatics, University of Münster, Germany
- Senior Lecturer in Bioinformatics, School of Biological Sciences, The University of Manchester, UK
- Project Manager EML Ltd. (Heidelberg, Germany)
- Postdoctoral Research Associate (Cancer Research Centre Heidelberg, Germany)
- Assistant Professor in Mathematics (Univ. Ass., Institute for Mathematics, University of Vienna, Austria)
Publikationen
- . . ‘Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning .’ F1000Research eCollection 2023. doi: 10.12688/f1000research.130443.1.
- 10.1038/s41586-024-07473-2. . ‘The complete sequence and comparative analysis of ape sex chromosomes.’ Nature 630, Nr. 8015. doi:
- . . ‘DNA Transposons Favor De Novo Transcript Emergence Through Enrichment of Transcription Factor Binding Motifs.’ Genome Biology and Evolution 16, Nr. 7. doi: 10.1093/gbe/evae134.
- . . ‘How antisense transcripts can evolve to encode novel proteins.’ Nature Communications 15, Nr. 1. doi: 10.1038/s41467-024-50550-3.
- . . ‘Modeling Length Changes in De Novo Open Reading Frames during Neutral Evolution.’ Genome Biology and Evolution 16, Nr. 7. doi: 10.1093/gbe/evae129.
- . . ‘Quantification and modeling of turnover dynamics of de novo transcripts in Drosophila melanogaster.’ Nucleic Acids Research 52, Nr. 1. doi: 10.1093/nar/gkad1079.
- . . ‘High-throughput Selection of Human de novo-emerged sORFs with High Folding Potential.’ Genome Biology and Evolution 16, Nr. 4: evae069. doi: 10.1093/gbe/evae069.
- . . ‘Experimental characterization of de novo proteins and their unevolved random-sequence counterparts.’ Nature Ecology and Evolution 7, Nr. 4. doi: 10.1038/s41559-023-02010-2.
- . . ‘Introducing creative destruction as a mechanism in protein evolution.’ Proceedings of the National Academy of Sciences of the United States of America 120, Nr. 6. doi: 10.1073/pnas.2220460120.
- . . ‘Population genomics reveals mechanisms and dynamics of de novo expressed open reading frame emergence in Drosophila melanogaster.’ Genome Research 33. doi: 10.1101/gr.277482.122.
- 10.1016/j.isci.2023.107832. . ‘Live-bearing cockroach genome reveals convergent evolutionary mechanisms linked to viviparity in insects and beyond.’ iScience 26, Nr. 10. doi:
- . . ‘Origin matters: Using a local reference genome improves measures in population genomics.’ Molecular Ecology Resources 23, Nr. 7. doi: 10.1111/1755-0998.13838.
- . . ‘Neutral Models of De Novo Gene Emergence Suggest that Gene Evolution has a Preferred Trajectory.’ Molecular Biology and Evolution 40, Nr. 4. doi: 10.1093/molbev/msad079.
- . . ‘Heterologous expression of naturally evolved putative de novo proteins with chaperones.’ Protein Science 31, Nr. 8. doi: 10.1002/pro.4371.
- 10.1111/mec.16753. . ‘More effective transposon regulation in fertile, long-lived termite queens than in sterile workers.’ Molecular Ecology 32, Nr. 2. doi:
- . . ‘Eusocial Transition in Blattodea: Transposable Elements and Shifts of Gene Expression.’ Genes 13, Nr. 11. doi: 10.3390/genes13111948.
- . . ‘Evidence for a conserved queen-worker genetic toolkit across slave-making ants and their ant hosts.’ Molecular Ecology 31, Nr. 19. doi: 10.1111/mec.16639.
- . . ‘Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite.’ Communications biology 5, Nr. 44. doi: 10.1038/s42003-021-02974-6.
- . . ‘Vector Redesign and In-Droplet Cell-Growth Improves Enrichment and Recovery in live Escherichia coli.’ Microbial Biotechnology 15, Nr. 11. doi: 10.1111/1751-7915.14144.
- . . ‘Domain Evolution of Vertebrate Blood Coagulation Cascade Proteins.’ Journal of Molecular Evolution 90: 418–428. doi: 10.1007/s00239-022-10071-3.
- . . ‘Ancestral sequences of a large promiscuous enzyme family correspond to bridges in sequence space in a network representation.’ Interface 18, Nr. 184. doi: 10.1098/rsif.2021.0389.
- 10.1371/journal.pgen.1009787. . ‘A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster.’ PLOS GENETICS 17, Nr. 9. doi:
- . . ‘Convergent Loss of Chemoreceptors across Independent Origins of Slave-Making in Ants.’ Molecular Biology and Evolution 39, Nr. 1. doi: 10.1093/molbev/msab305.
- . . ‘Gene Coexpression Network Reveals Highly Conserved, Well-Regulated Anti-Ageing Mechanisms in Old Ant Queens.’ Genome Biology and Evolution 13, Nr. 6. doi: 10.1093/gbe/evab093.
- . . ‘Structural and functional characterization of a putative de novo gene in Drosophila.’ Nature Communications 12, Nr. 1. doi: 10.1038/s41467-021-21667-6.
- . . ‘Structure and function of naturally evolved de novo proteins.’ Current Opinion in Structural Biology 68. doi: 10.1016/j.sbi.2020.11.010.
- . . ‘A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy.’ RNA Biology 18, Nr. sup1: 409–415. doi: 10.1080/15476286.2021.1952756.
- . . ‘Author Correction: Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme.’ Nature Chemical Biology 16: 930. doi: 10.1038/s41589-020-0588-8.
- . . ‘Gene content evolution in the arthropods.’ Genome Biology 21, Nr. 15. doi: 10.1186/s13059-019-1925-7.
- . . ‘Stochastic Gain and Loss of Novel Transcribed Open Reading Frames in the Human Lineage.’ Genome Biology and Evolution 12, Nr. 11. doi: 10.1093/gbe/evaa194.
- . . ‘Comparative analyses of caste, sex, and developmental stage-specific transcriptomes in two Temnothorax ants.’ Ecology and Evolution 10, Nr. 10. doi: 10.1002/ece3.6187.
- . . ‘The modular nature of protein evolution: domain rearrangement rates across eukaryotic life.’ BMC Evolutionary Biology 20, Nr. 1: 30. doi: 10.1186/s12862-020-1591-0.
- . . ‘Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme.’ Nature Chemical Biology 15: 1120–1128. doi: 10.1038/s41589-019-0386-3.
- . . ‘Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme (vol 51, pg 831, 2020).’ Nature Chemical Biology 16, Nr. 8. doi: 10.1038/s41589-020-0588-8.
- . . ‘Becoming a de novo gene.’ Nature Ecology and Evolution 3, Nr. 4: 524–525. doi: 10.1038.
- . . ‘Ant behaviour and brain gene expression of defending hosts depend on the ecological success of the intruding social parasite.’ Philosophical Transactions of the Royal Society B: Biological Sciences 374, Nr. 1769: 20180192. doi: 10.1098/rstb.2018.0192.
- . . ‘Genome-wide genotype-expression relationships reveal both copy number and single nucleotide differentiation contribute to differential gene expression between stickleback ecotypes.’ Genome Biology and Evolution n.a. doi: 10.1093/gbe/evz148.
- . . ‘A Roadmap to Domain Based Proteomics.’ In Computational Methods in Protein Evolution, edited by , 287–300. doi: 10.1007/978-1-4939-8736-8_16.
- . . ‘DOGMA: a web server for proteome and transcriptome quality assessment.’ Nucleic Acids Research 47, Nr. W1. doi: 10.1093/nar/gkz366.
- . . ‘Tribolium castaneum gene expression changes after Paranosema whitei infection.’ Journal of Invertebrate Pathology 153. doi: 10.1016/j.jip.2018.02.009.
- . . ‘The first cockroach genome and its significance for understanding development and the evolution of insect eusociality.’ Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 330, Nr. 5. doi: 10.1002/jez.b.22826.
- . . ‘Origins and structural properties of novel and de novo protein domains during insect evolution.’ The FEBS Journal 285, Nr. 14: 2605–2625. doi: 10.1111/febs.14504.
- . . ‘Hemimetabolous genomes reveal molecular basis of termite eusociality.’ Nature Ecology and Evolution 2, Nr. 3: 557–566. doi: 10.1038/s41559-017-0459-1DO-10.1038/s41559-017-0459-1.
- . . ‘Evolutionary Potential of Cis-Regulatory Mutations to Cause Rapid Changes in Transcription Factor Binding.’ Genome Biology and Evolution 11, Nr. 2: 406–414. doi: 10.1093/gbe/evy269.
- . . ‘Remodeling of the juvenile hormone pathway through caste-biased gene expression and positive selection along a gradient of termite eusociality.’ Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 330, Nr. 5: 296–304. doi: 10.1002/jez.b.22805.
- . . ‘Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest.’ J. Exp. Zool. B Mol. Dev. Evol. 330, Nr. 5: 254–264. doi: 10.1002/jez.b.22824.
- 10.1093/molbev/msx057. . ‘The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen de Novo.’ Molecular Biology and Evolution 34, Nr. 5: 1066–1082. doi:
- 10.12688/f1000research.10079.1. . ‘Fact or fiction: Updates on how protein-coding genes might emerge de novo from previously non-coding DNA.’ F1000Research 6, Nr. null. doi:
- 10.1186/s12862-017-0985-0. . ‘Comparative analysis of lincRNA in insect species.’ BMC Evolutionary Biology 17, Nr. 1. doi:
- . . ‘Enzyme sub-functionalization driven by regulation.’ EMBO Reports 18: 1043–1045. doi: 10.15252/embr.201744383.
- . . ‘Evolution of Protein Domain Repeats in Metazoa.’ Molecular Biology and Evolution 33. [accepted / in Press (not yet published)]
- . „DOGMA: Domain-Based Transcriptome and Proteome Quality Assessment.“ contributed to the German Conference on Bioinformatics, Berlin, .
- 10.1111/mec.13829. . ‘Phylogeographic differentiation versus transcriptomic adaptation to warm temperatures in Zostera marina, a globally important seagrass.’ Molecular Ecology 25, Nr. 21: 5396–5411. doi:
- . „Domain World.“ contributed to the GCB 2016, Berlin, Deutschland, .
- 10.1093/nar/gkw492. . ‘Mechanisms of transcription factor evolution in Metazoa.’ Nucleic Acids Research 44, Nr. 13: 6287–6297. doi:
- 10.1093/bioinformatics/btw231. . ‘DOGMA: Domain-based transcriptome and proteome quality assessment.’ Bioinformatics 32, Nr. 17: 2577–2581. doi:
- 10.1016/j.cois.2016.05.016. . ‘Chapter 6. Comparative genomic approaches to investigate molecular traits specific to social insects.’ Current Opinion in Insect Science 16, Nr. null: 87–94. doi:
- . ‘The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea.’ Nature doi: 10.1038/nature16548.
- 10.1016/j.zool.2016.05.005. . ‘Comparative transcriptomics of stickleback immune gene responses upon infection by two helminth parasites, Diplostomum pseudospathaceum and Schistocephalus solidus.’ Zoology (Jena) 2016, Nr. 119(4): 307–313. doi:
- . . ‘Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks.’ Molecular Ecology 2016, Nr. 25(4): 943–958. doi: 10.1111/mec.13520.
- 10.1016/j.dci.2015.09.008. . ‘Immunity comes first: the effect of parasite genotypes on adaptive immunity and immunization in three-spined sticklebacks.’ Developmental and Comparative Immunology 54, Nr. 1: 137–144. doi:
- . . ‘Detection of orphan domains in Drosophila using "hydrophobic cluster analysis".’ Biochimie 119. doi: 10.1016/j.biochi.2015.02.019.
- . „Evolution of enzyme specificity in the alkaline phosphatase superfamily.“ contributed to the SMBE, Vienna, Austria, . [accepted / in Press (not yet published)]
- . „The Origins of Life's Molecular Diversity: Does Modularity Epitomize the Evolvability of Early Functional Units .“ contributed to the Volkswagen Stiftung Kick-off Conference: Life? - A New Funding Initiative Introduces Itself, Schloss Herrenhausen, Hannover, Germany, . [accepted / in Press (not yet published)]
- . „Functional Transitions in Enzyme Evolution: Balancing Stability, Folding and Catalytic Specificity.“ contributed to the The annual meeting of the Society for Molecular Biology and Evolution, Hofburg Palace, Vienna, Austria, . [accepted / in Press (not yet published)]
- contributed to the Society of Molecular Biology and Evolution, Wien, . „Detecting convergent molecular evolution in eusocial insects.“
- 10.1016/j.biochi.2015.02.019. . ‘Detection of orphan domains in Drosophila using "hydrophobic cluster analysis".’ Biochimie 119: 244–253. doi:
- 10.1111/nph.13211. . ‘Protein domain evolution is associated with reproductive diversification and adaptive radiation in the genus Eucalyptus.’ New Phytologist 206: 1328–1336. doi:
- 10.1186/s13059-015-0623-3. . ‘The genomes of two key bumblebee species with primitive eusocial organization.’ Genome Biol. 16. doi:
- 10.1093/molbev/msv165. . ‘How do genomes create novel phenotypes Insights from the loss of the worker caste in ant social parasites.’ Molecular Biology and Evolution 32, Nr. 11: 2919–2931. doi:
- 10.1186/s12859-015-0570-8. . ‘Domain similarity based orthology detection.’ BMC Bioinformatics 16, Nr. 1. doi:
- . . ‘The Rise and Fall of TRP-N, an Ancient Family of Mechanogated Ion Channels, in Metazoa.’ Genome Biol. Evol. 7, Nr. 6: 1713–1727. doi: 10.1093/gbe/evv091.
- . . ‘MDAT - Aligning multiple domain arrangements.’ BMC Bioinformatics 16. doi: 10.1186/s12859-014-0442-7.
- . . ‘Emergence of de novo proteins from 'dark genomic matter' by 'grow slow and moult'.’ Biochem Soc Trans. 43(5): 867–873. doi: 10.1042/BST20150089.
- 10.1371/journal.pgen.1004966. . ‘Genomics of Divergence along a Continuum of Parapatric Population Differentiation.’ PLoS Genetics 2015. doi:
- . . ‘Host-Pathogen Coevolution: The Selective Advantage of Bacillus thuringiensis Virulence and Its Cry Toxin Genes.’ PLoS Biology 13, Nr. 6: e1002169. doi: 10.1371/journal.pbio.1002169.
- . . ‘Infection routes matter in population-specific responses of the red flour beetle to the entomopathogen Bacillus thuringiensis.’ BMC Genomics 15. doi: 10.1186/1471-2164-15-445.
- . . ‘Infection routes matter in population-specific responses of the red flour beetle to the entomopathogen Bacillus thuringiensis.’ BMC Genomics 16, Nr. 1: 445.
- . . ‘Genomic divergence between nine- and three -spined sticklebacks .’ BMC Genomics 14.
- . . ‘Molecular traces of alternative social organization in a termite genome .’ Nature Communications 5.
- . . ‘Specific gene expression responses to parasite genotypes reveal redundancy of innate immunity in vertebrates.’ PloS one 9, Nr. 9. doi: 10.1371/journal.pone.0108001.
- . . ‘The genome of Eucalyptus grandis.’ Nature 510, Nr. 7505: 362. doi: 10.1038/nature13308.
- . . ‘Rapid similarity search of proteins using alignments of domain arrangements.’ Bioinformatics 30, Nr. 2: 281. doi: 10.1093/bioinformatics/btt379.
- . . ‘Protein family analysis at the domain-level.’ Lecture Notes in Informatics (LNI), Proceedings - Series of the Gesellschaft fur Informatik (GI) P-235: 26.
- . . ‘Genome-wide transcriptomic responses of the seagrasses Zostera marina and Nanozostera noltii under a simulated heatwave confirm functional types.’ Marine Genomics 15: 73. doi: 10.1016/j.margen.2014.03.004.
- . . ‘DoMosaics: Software for domain arrangement visualization and domain-centric analysis of proteins.’ Bioinformatics 30, Nr. 2: 283. doi: 10.1093/bioinformatics/btt640.
- . . ‘Extensive Copy-Number Variation of Young Genes across Stickleback Populations.’ PLoS Genetics 10, Nr. 12. doi: 10.1371/journal.pgen.1004830.
- . . ‘Mechanisms and Dynamics of Orphan Gene Emergence in Insect Genomes.’ Genome Biology and Evolution 5, Nr. 2: 439–455. doi: 10.1093/gbe/evt009.
- 10.1016/j.bbapap.2013.01.007. . ‘Quantification and functional analysis of modular protein evolution in a dense phylogenetic tree.’ Biochimica et Biophysica Acta - Proteins and Proteomics 1834, Nr. 5: 898–907. doi:
- . . ‘Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality.’ Genome Research 23, Nr. 8: 1247. doi: 10.1101/gr.155408.113.
- . . ‘Dynamics and adaptive benefits of modular protein evolution.’ Current Opinion in Structural Biology 23, Nr. 3: 459. doi: 10.1016/j.sbi.2013.02.012.
- . . ‘Genome-wide patterns of standing genetic variation in a marine population of three-spined sticklebacks.’ Molecular Ecology 22, Nr. 3: 649. doi: 10.1111/j.1365-294X.2012.05680.x.
- . . ‘Evaluating characteristics of de novo assembly software on 454 transcriptome data: a simulation approach.’ PloS one 7, Nr. 2: e31410. doi: 10.1371/journal.pone.0031410.
- . . ‘Dynamics and adaptive benefits of protein domain emergence and arrangements during plant genome evolution.’ Genome Biology and Evolution 4, Nr. 3: 316. doi: 10.1093/gbe/evs004.
- . . ‘Proteome of Hydra Nematocyst.’ Journal of Biological Chemistry 287, Nr. 13. doi: 10.1074/jbc.M111.328203.
- . . ‘Evolutionary dynamics of simple sequence repeats across long evolutionary time in genus Drosphila.’ Trends in Evolutionary Biology 4, Nr. 1.
- . . ‘Fast Homology Search Using Domain-Architecture Alignment.’ JOBIM, Conference proceedings 1.
- 10.1093/molbev/msr250. . ‘The dynamics and evolutionary potential of domain loss and emergence.’ Molecular Biology and Evolution 29, Nr. 2: 787–796. doi:
- . . ‘Evolutionary Dynamics on Protein Bi-stability Landscapes can Potentially Resolve Adaptive Conflicts.’ PLoS Computational Biology 8, Nr. 9: e1002659. doi: 10.1371/journal.pcbi.1002659.
- . . ‘Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustness.’ Proceedings of the National Academy of Sciences of the United States of America 109, Nr. 37. doi: 10.1073/pnas.1115620109.
- . . ‘The interface of protein structure, protein biophysics, and molecular evolution.’ Protein Science 21, Nr. 6: 769. doi: 10.1002/pro.2071.
- . . ‘Genomic and Morphological Evidence Converge to Resolve the Enigma of Strepsiptera.’ Current biology 22, Nr. 14: 1309–1313. doi: 10.1016/j.cub.2012.05.018.
- . . ‘Identifying core features of adaptive metabolic mechanisms for chronic heat stress attenuation contributing to systems robustness.’ Integrative Biology 4, Nr. 5: 480. doi: 10.1039/c2ib00109h.
- . . ‘Proteome of Hydra nematocyst.’ Journal of Biological Chemistry 287, Nr. 13: 9672. doi: 10.1074/jbc.M111.328203.
- . . ‘The genome sequence of the leaf-cutter ant Atta cephalotes reveals insights into its obligate symbiotic lifestyle.’ PLoS Genetics 7, Nr. 2: e1002007. doi: 10.1371/journal.pgen.1002007.
- . . ‘Back to the sea twice: identifying candidate plant genes for molecular evolution to marine life.’ BMC Evolutionary Biology 11: 8. doi: 10.1186/1471-2148-11-8.
- . . ‘The evolution of protein interaction networks.’ Methods in Molecular Biology 696: 273. doi: 10.1007/978-1-60761-987-1_17.
- . . ‘Transcriptomic resilience to global warming in the seagrass Zostera marina, a marine foundation species.’ Proceedings of the National Academy of Sciences of the United States of America 108, Nr. 48: –81. doi: 10.1073/pnas.1107680108.
- . . ‘Comprehensive transcriptome analysis of the highly complex Pisum sativum genome using next generation sequencing.’ BMC Genomics 12, Nr. 1: 227. doi: 10.1186/1471-2164-12-227.
- . . ‘Evolutionary divergence and limits of conserved non-coding sequence detection in plant genomes.’ Nucleic Acids Research . doi: 10.1093/nar/gkr179.
- . . ‘The sieve element occlusion gene family in dicotyledonous plants.’ Plant Signaling and Behavior 6, Nr. 1: 151. doi: 10.4161/psb.6.1.14308.
- . . ‘Signals: tinkering with domains.’ Science Signaling 3, Nr. 139: pe31. doi: 10.1126/scisignal.3139pe31.
- . . ‘Functional and evolutionary insights from the genomes of three parasitoid nasonia species.’ Science 327, Nr. 5963: 343–348. doi: 10.1126/science.1178028.
- . . ‘How do new proteins arise?’ Current Opinion in Structural Biology 20, Nr. 3. doi: 10.1016/j.sbi.2010.02.005.
- 10.1016/j.bpj.2010.02.046. . ‘EvoIvability and single-genotype fluctuation in phenotypic properties: A simple heteropolymer model.’ Biophysical Journal 98, Nr. 11: 2487–2496. doi:
- . . ‘Evolution after and before gene duplication?’ In Evolution after Gene Duplication, edited by , e. New York City: John Wiley & Sons. doi: 10.1002/9780470619902.ch6.
- . . ‘Molecular and phylogenetic characterization of the sieve element occlusion gene family in Fabaceae and non-Fabaceae plants.’ BMC Plant Biology 10. doi: 10.1186/1471-2229-10-219.
- . . ‘Protein Domains as Evolutionary Units.’ In Evolutionary Genomics and System Biology, edited by , 213–230. N/A: unbekannt / n.a. / unknown. doi: 10.1002/9780470570418.ch12.
- . . ‘How do new proteins arise?’ Current Opinion in Structural Biology 20, Nr. 3: 390. doi: 10.1016/j.sbi.2010.02.005.
- . . ‘Robustness versus evolvability: a paradigm revisited.’ HFSP Journal 4, Nr. 3-4: 105. doi: 10.2976/1.3404403.
- . . ‘Evolvability and single-genotype fluctuation in phenotypic properties: a simple heteropolymer model.’ Biophysical Journal 98, Nr. 11: 2487. doi: 10.1016/j.bpj.2010.02.046.
- . . ‘Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs.’ Database: The Journal of Biological Databases and Curation 2009: bap009. doi: 10.1093/database/bap009.
- . . ‘Just how versatile are domains?’ BMC Evolutionary Biology 8: 285. doi: 10.1186/1471-2148-8-285.
- . . ‘Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans.’ Immunobiology 213, Nr. 3-4: 237. doi: 10.1016/j.imbio.2007.12.004.
- . . ‘The look-ahead effect of phenotypic mutations.’ Biology Direct 3: 18. doi: 10.1186/1745-6150-3-18.
- . . ‘The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction network.’ Journal of Molecular Medicine 86, Nr. 4: 423–432. doi: 10.1007/s00109-008-0307-5.
- 10.1007/s00792-008-0138-x. . ‘Metabolism of halophilic archaea.’ Extremophiles 12, Nr. 2: 177–196. doi:
- . . ‘Arrangements in the modular evolution of proteins.’ Trends in Biochemical Sciences 33, Nr. 9: 444. doi: 10.1016/j.tibs.2008.05.008.
- . . ‘Comparative analysis of expressed sequence tag (EST) libraries in the seagrass Zostera marina subjected to temperature stress.’ Marine Biotechnology 10, Nr. 3: 297–309. doi: 10.1007/s10126-007-9065-6.
- . . ‘A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network.’ BMC Systems Biology 1: 34. doi: 10.1186/1752-0509-1-34.
- . . ‘A structural model of latent evolutionary potentials underlying neutral networks in proteins.’ HFSP J. 1: 79–87.
- . . ‘Automated Improvement of Domain ANnotations using context analysis of domain arrangements (AIDAN).’ Bioinformatics 23, Nr. 14: 1834. doi: 10.1093/bioinformatics/btm240.
- . . ‘The AtGenExpress global stress expression data set: protocols, evaluation and model data analysis of UV-B light, drought and cold stress responses.’ The Plant journal 50, Nr. 2: 347. doi: 10.1111/j.1365-313X.2007.03052.x.
- . . ‘Evidence of interaction network evolution by whole-genome duplications: a case study in MADS-box proteins.’ Molecular Biology and Evolution 24, Nr. 3: 670. doi: 10.1093/molbev/msl197.
- . . ‘One billion years of bZIP transcription factor evolution: conservation and change in dimerization and DNA-binding site specificity.’ Molecular Biology and Evolution 24, Nr. 3: 827. doi: 10.1093/molbev/msl211.
- . . ‘Reduction/oxidation-phosphorylation control of DNA binding in the bZIP dimerization network.’ BMC Genomics 7: 107. doi: 10.1186/1471-2164-7-107.
- . . ‘Finding common protein interaction patterns across organisms.’ Evolutionary Bioinformatics 2: 45–52.
- . . ‘Domain deletions and substitutions in the modular protein evolution.’ The FEBS Journal 273, Nr. 9: 2037. doi: 10.1111/j.1742-4658.2006.05220.x.
- . . ‘Evolution of circular permutations in multidomain proteins.’ Molecular Biology and Evolution 23, Nr. 4: 734. doi: 10.1093/molbev/msj091.
- . . Transcriptional networking. 6. Aufl. . doi: 10.1186/gb-2005-6-9-344.
- . . ‘Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex.’ Phytochemistry 66, Nr. 11: 1296–1311. doi: 10.1016/j.phytochem.2005.04.012.
- . . ‘Rapid motif-based prediction of circular permutations in multi-domain proteins.’ Bioinformatics 21, Nr. 7: 932. doi: 10.1093/bioinformatics/bti085.
- . . ‘Phylogenetic profiling of protein interaction networks in eukaryotic transcription factors reveals focal proteins being ancestral to hubs.’ Gene 347, Nr. 2: 247–253. doi: 10.1016/j.gene.2004.12.031.
- . . ‘The evolution of domain arrangements in proteins and interaction networks.’ Cellular and Molecular Life Sciences 62, Nr. 4: 435. doi: 10.1007/s00018-004-4416-1.
- . . ‘Comparing folding codes in simple heteropolymer models of protein evolutionary landscape: robustness of the superfunnel paradigm.’ Biophysical Journal 88, Nr. 1: 118–131. doi: 10.1529/biophysj.104.050369.
- . . ‘The evolution of protein interaction networks in regulatory proteins.’ Comparative and Functional Genomics 5, Nr. 1: 79–84. doi: 10.1002/cfg.365.
- . ‘Inference of Aspergillus fumigatus pathways by computational genome analysis: Tricarboxylic acic cycle (TCA) and glyoxylate shunt.’ Journal of microbiology and biotechnology 14, Nr. 1: 74–80.
- . . ‘Convergent evolution of gene networks by single-gene duplications in higher eukaryotes.’ EMBO Reports 5, Nr. 3: 274. doi: 10.1038/sj.embor.7400096.
- . . ‘CADRE: the Central Aspergillus Data REpository.’ Nucleic Acids Research 32, Nr. Database issue: –5. doi: 10.1093/nar/gkh009.
- . . A putative transcription factor inducing mobility in Mycoplasma pneumoniae..
- . . ‘BioMiner--modeling, analyzing, and visualizing biochemical pathways and networks.’ Bioinformatics 18 Suppl 2: –30. doi: 10.1093/bioinformatics/18.suppl_2.S219.
- . . ‘Perspectives on protein evolution from simple exact models.’ Applied Bioinformatics 1, Nr. 3: 121.
- . . ‘Recombinatoric exploration of novel folded structures: A heteropolymer-based model of protein evolutionary landscapes.’ Proc. Natl. Acad. Sci. 99: 809–814. doi: 10.1073/pnas.022240299.
- . . ‘Conceptual data modelling for bioinformatics.’ Briefings in Bioinformatics 3, Nr. 2: 166. doi: 10.1093/bib/3.2.166.
- . . ‘TreeWiz: interactive exploration of huge trees.’ Bioinformatics 18, Nr. 1: 109. doi: 10.1093/bioinformatics/18.1.109.
- . . ‘Switching from simple to complex oscillations in calcium signaling.’ Biophysical Journal 79, Nr. 3: 1188. doi: 10.1016/S0006-3495(00)76373-9.
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