• Participation in “Cells in Motion”

    • Research interests: morphogenesis of tubular organs, cellular and molecular mechanisms that control epithelial tube size and shape, cell behaviour and tissue mechanics in cylindrical epithelia, dynamics of intracellular membrane and protein trafficking, structure and function of epithelial tricellular junctions, roles of hypoxia in development
    • Cells in Motion Professor of Tubular Morphogenesis
    • Executive Board member of the Cells in Motion Interfaculty Centre
    • Supervisor in the CiM-IMPRS Graduate Programme
    • Member of the Imaging Network – Microscopy

  • News & views

  • Papers in the research focus “cell dynamics and imaging”

    2022

    Camelo C, Korte A, Jacobs T, Luschnig S. Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies. J Cell Sci 2022;135Abstract
    Gass MM, Borkowsky S, Lotz M-L, Siwek R, Schroter R, Nedvetsky P, Luschnig S, Rohlmann A, Missler M, Krahn MP. PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. Cell Mol Life Sci 2022;79: 248. Abstract
    Labbaf Z, Petratou K, Ermlich L, Backer W, Tarbashevich K, Reichman-Fried M, Luschnig S, Schulte-Merker S, Raz E. A robust and tunable system for targeted cell ablation in developing embryos. Dev Cell 2022;57: 2026-2040.e5. Abstract

    2021

    Camelo C, Luschnig S. Cells into tubes: Molecular and physical principles underlying lumen formation in tubular organs. Curr Top Dev Biol 2021;143: 37-74. Abstract
    Isasti-Sanchez J, Munz-Zeise F, Lancino M, Luschnig S. Transient opening of tricellular vertices controls paracellular transport through the follicle epithelium during Drosophila oogenesis. Dev Cell 2021;56: 1083-1099.e5. Abstract

    2020

    Gross-Thebing S, Truszkowski L, Tenbrinck D, Sanchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Huwel J, Gaede F, Sasse R, Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Munoz A, Burger M, Raz E. Using migrating cells as probes to illuminate features in live embryonic tissues. Sci Adv 2020;6: eabc5546. Abstract
    Wittek A, Hollmann M, Schleutker R, Luschnig S. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila. Curr Biol 2020;30: 4254-4262.e5. Abstract

    2019

    Sauerwald J, Backer W, Matzat T, Schnorrer F, Luschnig S. Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles. Elife 2019;8: e48857. Abstract

    2018

    Beati H, Peek I, Hordowska P, Honemann-Capito M, Glashauser J, Renschler FA, Kakanj P, Ramrath A, Leptin M, Luschnig S, Wiesner S, Wodarz A. The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. J Cell Biol 2018;217: 1079-1095. Abstract
    Loison O, Weitkunat M, Kaya-Copur A, Nascimento Alves C, Matzat T, Spletter ML, Luschnig S, Brasselet S, Lenne P-F, Schnorrer F. Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation. PLoS Biol 2018;16: e2004718. Abstract
    Nelson JO, Forster D, Frizzell KA, Luschnig S, Metzstein MM. Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Genetics 2018;209: 1073-1084. Abstract

    2017

    Caviglia S, Flores-Benitez D, Lattner J, Luschnig S, Brankatschk M. Rabs on the fly: Functions of Rab GTPases during development. Small GTPases 2017: 1-10. Abstract
    Misra T, Baccino-Calace M, Meyenhofer F, Rodriguez-Crespo D, Akarsu H, Armenta-Calderon R, Gorr TA, Frei C, Cantera R, Egger B, Luschnig S. A genetically encoded biosensor for visualising hypoxia responses in vivo. Biol Open 2017;6: 296-304. Abstract
    Sauerwald J, Soneson C, Robinson MD, Luschnig S. Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila. Development 2017;144: 657-663. Abstract

    2016

    Caviglia S, Brankatschk M, Fischer EJ, Eaton S, Luschnig S. Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis. Nat Cell Biol 2016;18: 727-739. Abstract
    De Lella Ezcurra AL, Bertolin AP, Kim K, Katz MJ, Gandara L, Misra T, Luschnig S, Perrimon N, Melani M, Wappner P. miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga. PLoS Genet 2016;12: e1006073. Abstract

    2015

    Byri S, Misra T, Syed ZA, Batz T, Shah J, Boril L, Glashauser J, Aegerter-Wilmsen T, Matzat T, Moussian B, Uv A, Luschnig S. The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Dev Cell 2015;33: 535-548. Abstract