Inflammation & Imaging Lecture

• GD2IL18CART – First-in-human study of a novel CAR T cell product (CRC 1450 PEP-2022-09)
  Claudia Rössig, Department of Pediatric Hematology and Oncology, UKM
• MRI single cell tracking for early detection of inflammation (CRC 1009 Z02)
  Enrica Wilken, Department of Radiology, UKM
• Model-based GlucoCEST MRI (CRC 1450 C05)
  Chris Lippe, Translational Research Imaging Center, UKM

• Adult skull bone marrow is an expanding and resilient hematopoietic reservoir (CRC 1009 A10)
  Bong-Ihn Koh, MPI for Molecular Biomedicine, Münster
• The role of the scavenger receptor MARCO in the organ-specific regulation of efferocytosis (CRC 1450 C02) Irene Aranda Pardos, Institute of Immunology, University of Münster
• Multimodal chemical imaging of tissue samples (CRC 1450 B02) Lena Hiddeßen, Institute of Inorganic and Analytical Chemistry, University of Münster

• Collagen density determines MMP14 activity in cancer cell invadopodia (CRC 1009 A09)
  Stephan Niland, Institute of Physiological Chemistry and Pathobiochemistry, University of Münster
• Metabolic targeting of bacteria through complex carbohydrates (CRC 1450 A04)
  Andreas Faust, European Institute for Molecular Imaging, University of Münster and Silke Niemann, Institute of Medical Microbiology, UKM

Flashlight Talks

• Imaging of inflammatory and regulatory mechanisms in arthritis (CRC 1450 C03)
  Jan Bobrowski, Institute of Immunology, University of Münster
• Integrin activation by two independently regulated calcium mediated pathways is required for neutrophil recruitment (CRC 1009 A05)
  Anika Cappenberg, Department of Anesthesiology and Critical Care Medicine, UKM
• Dynamic imaging and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum (CRC 1450 C04)
  Julian Malchow and Lydia Sorokin, Institute of Physiological Chemistry and Pathobiochemistry, University of Münster

• Molecular organization of the epithelial barrier at tricellular junctions (CRC 1009 A04)
  Raphael Schleutker, Institute of Integrative Cell Biology and Physiology, University of Münster
• Chemiluminescent activation of optogenetic proteins for the targeting sites of inflammation (CRC 1450 PEP12)
  Seraphine Wegner, Institute of Physiological Chemistry and Pathobiochemistry, University of Münster
• Developing amphiphilic aza-BODIPY nanostructures for multimodal imaging (CRC 1450 B01)
  Antonia Albers, Institute for Organic Chemistry, University of Münster
  Shivadharshini Kuberasivakumaran, Department of Radiology, UKM

• Mutation of S100A9 (N70A) in immune cells (CRC 1009 B08)
  Jonas Petersen, Institute of Immunology, University of Münster
• Improving intravital microscopy of inflammatory cell response by active motion compensation with controlled adaptive optics (CRC 1450 A06)
  Manuel Kunisch, Biomolecular Photonics, University of Bielefeld
  Sascha Beutler, Institute for Analysis and Numerics, University of Münster
• Metabolic priminig of monocytes in innate immune memory (CRC 1450 C01)
  Ricarda Jürgens, Institute of Immunology, University of Münster

• The impact of VE-cadherin phospho-regulation on endothelial junction integrity (CRC 1009 A01)
  Leonie Holtermann, MPI for Molecular Biomedicine
• Interactive and computational analysis of large multiscale imaging data (CRC 1450 Z01)
  Robin Rexeisen und Hennes Rave, Institute of Computer Science, University of Münster

• Proteomic-based identification and validation of novel candidate mediators for damage and refurbishment of the endothelial glycocalyx in bacterial sepsis and COVID-19 (CRU 342 PP3)
  Carolin Drost, Medical Clinic D, UKM
• Analyzing the association of the unique STEC subtilase cytotoxin with OMVs and its impact on host cells (CRC 1009 B04)
  Alexander Kehl, Institute of Hygiene, UKM
• Targeting immune cell dynamics by longitudinal whole-body imaging and mathematical modelling (CRC 1450 A05)
  Nils Marquardt, European Institute for Molecular Imaging, University of Münster & Marco Mauritz, Institute for Analysis and Numerics, University of Münster

• Nanocapsules as reporters and for drug delivery (CRC 1450 C06)
  Katharina Landfester, MPI for Polymer Research, Mainz
• The role of heat shock protein 27 in immune tolerance (CRC 1009 B09)
  Judith Austermann, Institute of Immunology, University of Münster
• Investigating renal recovery from acute kidney injury in critically ill patients with inflammatory syndromes – a machine learning guided approach (CRU 342 PP4)
  Thilo von Groote, Department of Anaesthesiology, Intensive Care and Pain Medicine, UKM

• The gut ↔ skin axis: How commensals shape cutaneous immunity (CRC 1009 B11)
  Verena Raker, Department of Dermatology, UKM
• A biased view on formyl peptide receptor activation (CRC 1009 A06)
  Ursula Rescher, Institute of Medical Biochemistry, ZMBE
• Functional analysis of cardiac resident hematopoietic cells during post-injury recovery in zebrafish (CRC 1450 PEP05)
  Felix Gunawan, Institute of Cell Biology, ZMBE

• Alarmin S100A8/A9 regulates platelet-neutrophil interaction during acute inflammation (CRU 342 P05)
  Julian Revenstorff, Institute of Immunology, WWU
• Interactions of macrophages and endothelial cells at lymphoid barriers (CRC 1009 A12)
  Cindy Pamela Ulloa Guerrero, Institute of Immunology, WWU
• Cell-type-specific labelling of HoxB8 cells through bioorthogonal tagging in vivo (CRC 1450 A01)
  Jonas Schöning & Kristian Friedla, Institute of Biochemistry, WWU

• The role of bacteria-derived outer-membrane-vesicles (OMVs) in the induction of systemic inflammation and organ damage (CRU 342 P10)
  Andreas Margraf, Department of Anaesthesiology, Intensive Care and Pain Medicine, UKM
• Generation of iPSC-derived brain endothelial cells (CRC 1009 A03)
  Dominik Krüger, Department of Neurology, UKM
• The role of tyrosine and lysine residues for VE-cadherin endocytosis (CRC 1450 B03)
  Markus Wilkens, Max Planck Institute for Molecular Biomedicine

• Photofunctional contrast agents for multiscale-multimodal imaging (CRC 1450 A02)
  Sidharth Thulaseedharan Nair Sailaja, Institute of Inorganic and Analytical Chemistry, WWU
• The role of RANK/RANKL signaling for skin homeostasis and barrier function during anti-microbial immune responses (CRC 1009 B07)
  Karin Loser, Institute of Immunology, University Oldenburg

• Adaptation and bacterium-host interaction during long-term bladder colonization (CRC 1009 B05)
  Ulrich Dobrindt, Institute of Hygiene, UKM
• The polymerase of HPAIV as a determinant of cytokine storm induction and systemic replication (CRU 342 P06)
  Josua Janowski, Institute of Molecular Virology, ZMBE, WWU
• The regulatory role of CD163 in inflammatory response (CRU 342 P03)
  Bruna Caroline Véras de Carvalho, Institute of Immunology, WWU

• Mechanisms of monocyte tolerance in systemic inflammation (CRU 342 Z)
  Judith Austermann, Institute of Immunology, WWU
• Mechanical and biochemical signals from the endothelial basement membrane (CRC 1009 A02)
  Adan Olguin Olguin, Institute of Physiological Chemistry and Pathobiochemistry, WWU
• Multiscale visualisation and analysis of innate immune cell migration at sites of hypoxic inflammation in vivo (CRC 1450 B04)
  Nadine Bauer, European Institute for Molecular Imaging, WWU
  Daniel Beckmann, Institute for Geoinformatics, WWU

• Generation of human kidney organoids for developmental biology studies, disease modeling and therapeutic discovery (CRU 342 P07)
  Markus Döser, Medical Clinic D, UKM
• Novel virulence factor functions of an enteric pathogen manipulating host cells and barriers (CRC 1009 B12)
  Petra Dersch, Institute of Infectiology, ZMBE, WWU
• Preclinical PET-MRI: the road towards dual kinetic modelling (CRC 1450 B06)
  Juela Cufe, Department of Nuclear Medicine, UKM & European Institute for Molecular Imaging, WWU

• Mechanisms of pathogen evasion from NETs during pulmonary inflammation (CRC 1450 B05)
  Helena Block, Department of Anaesthesiology, Intensive Care and Pain Medicine, UKM
• The MEK-inhibitor ATR-002 as a potential antibacterial compound (CRC 1009 B02)
  Jasmin Jacob, Institute of Virology, ZMBE, WWU
• The polymerase of HPAIV as a determinant of cytokine storm induction and systemic replication (CRU 342 P06)
  Josua Janowski, Institute of Virology, ZMBE, WWU

• Yersinia pseudotuberculosis is a modulator of neutrophil effector functions (CRC 1450 project C07)
  Ann-Kathrin Wienkamp, Department of Anaesthesiology, Intensive Care and Pain Medicine, UKM
• Modulation of signaling responses by autopenetrating Shigella effector protein IpaH7.8 (CRC 1009, B03)
  Theresa Meyer, Institute of Infectiology, ZMBE
• Molecular approaches to the common clinical problem of capillary leakage syndrome (CRU 342, P01)
  Laura Brabenec, Department of Anaesthesiology, Intensive Care and Pain Medicine, UKM

• The role of intracellular calcium regulators in integrin activation and leukocyte recruitment (CRC 1009 project A05)
  Marina Kardell, Department of Anaesthesiology, Intensive Care and Pain Medicine, UKM
• Mural cell differentiation and arterialization in the central nervous system (CRC 1009 project A10)
  Rodrigo Diéguez-Hurtado, MPI for Molecular Biomedicine

• Interplay of cell adhesion and matrix proteolysis in barrier-breaking invadopodia of tumor cells (CRC 1009 project A09)
  Stephan Niland, Institute of Physiological Chemistry and Pathobiochemistry, WWU
• Death eaters – tissue specific cell clearance by macrophages (CRC 1450 project C02)
  Achmed Imam Chasan, Institute of Immunology, WWU
• Targeting S100A8/A9 for imaging of inflammatory disorders (CRC 1450 project A03)
  Andreas Faust, European Institute for Molecular Imaging, WWU and Günter Fritz, Department of Cellular Microbiology, University of Hohenheim

• Modelling relaxation processes of contrast-enhanced quantitative MRI for cellular imaging (CRC 1450 project B02)
  Lauritz Klünder, Department of Radiology, UKM
• Multiparametric MRI in sepsis induced acute kidney injury (CRC 1450 project C05)
  Verena Hörr, Department of Radiology, UKM
• Mechanistic insights into the basis of disease – harnessing the power of quantitative cell biology (CRC 1009 project B10)
  Roland Wedlich-Söldner, Institute of Cell Dynamics and Imaging, WWU

• How to build tight contacts between three cells - Molecular organization of tricellular occluding junctions in Drosophila epithelia (CRC 1009 project A04) Raphael Schleutker, Institute for Neurobiology

• The role of VE-PTP in Schlemms canal function (CRC 1009 project A01)
  Sarthak Mishra, Max Planck Institute Molecular Biomedicine
• The role of myeloid-derived suppressor cells (MDSCs) in arthritis (CRC 1450 project C03)
  Thomas Vogl, Institute of Immunology
• Analysis of the S100A9-N70A mutation in mice (CRC 1009 project B08)
  Jonas Petersen, Institute of Immunology

Flashlight talks

• Towards the assessment of endothelial permeability through self-assembled BODIPY nanostructures (CRC 1450 project B01)
  Jonas Matern, Institute for Organic Chemistry, WWU
• The gut-skin axis - how microbiota shape cutaneous immunity (CRC 1009 project B11)
  Verena K. Raker, Department of Dermatology, UKM
• Specific PET-imaging of bacterial infections - complex carbohydrates and glycosylated siderophores (CRC 1450 project A04)
  Andreas Faust, European Institute for Molecular Imaging (EIMI), UKM
  Silke Niemann, Institute of Medical Microbiology, UKM

• Improving intravital microscopy of inflammatory cell response by active motion compensation with controlled adaptive optics (CRC 1450 project A06)
  Benedikt Wirth, Institute for Applied Mathematics, WWU
  Thomas Huser, Physics Faculty, Bielefeld University
• Jupyterhub - A data science platform for visualization and analysis (CRC 1450 project INF)
  Jonathan Radas, WWU IT
• Biased perspectives on formyl peptide receptors (CRC 1009 project A06)
  Ursula Rescher, Institute of Medical Biochemistry, WWU

• Chromatin remodeling in immune tolerance of monocytes (CRC 1009 project B09)
  Judith Austermann, Institute of Immunology
• Metabolic priming of monocytes during inflammation in vivo (CRC 1450 project C01)
  Nadine Heiden, Department of Nuclear Medicine & European Institute for Molecular Imaging
  Ricarda Jürgens, Institute of Immunology
• Dynamic imaging and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum (CRC 1450 project C04)
  Jian Song, Institute of Physiological Chemistry and Pathobiochemistry

• The bacterial secreted combinome: Synergistic host injury by exotoxins of enterohemorrhagic Escherichia coli (CRC 1009 project B04) Alexander Kehl, Institute of Hygiene
• PET reconstruction models for targeting immune cells (CRC 1450 project A05) Marco Mauritz, Institute for Analysis and Numerics
• Interactive and computational analysis of large multiscale imaging data (CRC 1450 project Z01) Adrian Derstroff, Dominik Drees, Simon Leistikow, Department of Computer Science

Flashlight talks

• Interactions of perivascular macrophages with endothelial barriers in the lymphoid organs (CRC 1009 project A12) Noelia Alonso Gonzalez, Institute of Immunology
• Myeloid contribution to autoimmunity: intervention strategies (CRC 1450 project C06) Verena Raker, Department of Dermatology
• Effects of the alarmin S100A8/A9 on the platelet and neutrophil response during pulmonary inflammation (CRU 342 project P5) Julian Revenstorff, Institute of Immunology

• Enhanced pathogenicity of Th17 cells due to natalizumab treatment-implications for MS disease rebound (CRC 1009 project A03)
  Luisa Klotz, Department of Neurology
• Cell-specific labeling of immune cells using bioorthogonal tagging (CRC 1450 project A01)
  Henning Mootz, Institute of Biochemistry
  Andrea Rentmeister, Institute of Biochemistry
• Csk strengthens endothelial barrier functions (CRU 342 project P2)
  Rebekka Stegmeyer, Max Planck Institute for Molecular Biomedicine - Vascular Cell Biology

• Time-lapse MRI: single cell tracking of patrolling immune cells (CRC 1009 project Z02)
  Enrica Wilken, TRIC, Clinic of Radiology
• RANK/RANKL signaling and its impact on skin barrier integrity in response to external stimuli (CRC 1009 project B07)
  Karin Loser, Institute for Immunology (Oldenburg)
• The role of glutamine in acute kidney injury (CRU 342 project P8)
  Katharina Thomas, Department of Anaesthesiology
  Daniel Hescheler, Department of Nuclear Medicine

• One more thing on hypoxia imaging and analysis (CRC 1450 project B04)
  Friedemann Kiefer, European Institute for Molecular Imaging (EIMI)
  Benjamin Risse, Institute of Computer Science

• Mechanical and biochemical signals from the endothelial basement membrane that affect leukocyte extravasation
  (CRC 1009 project A02)
  Adán Olguin-Olguin, Institute of Physiological Chemistry and Pathobiochemistry

• Effects of albumin on endothelial S1P signaling in sepsis (CRU 342 project PP1)
  Alexandros Rovas, Medical Clinic D

• Myeloid differentiation and the regulation of systemic inflammatory processes (CRU 342 project P3)
  Katarzyna Barczyk-Kahlert, Institute of Immunology
• Cellular changes under experimental septic conditions (CRU 342 project P4)
  Kari vom Werth, Institute of Hygiene
• Differential modulation of host gene expression by uropathogenic Escherichia coli (CRC 1009 project B05)
  Ulrich Dobrindt, Institute of Hygiene

• Role of the CNFY toxin for Yersinia pseudotuberculosis-mediated inflammation (CRC 1009 project B12)
  Petra Dersch, Institute of Infectiology
• Photofunctional coordination compounds addressing bacterial targets (CRC 1450 project A02)
  Cristian Strassert, Institute of Inorganic and Analytical Chemistry

• New light on old buddys: Facts, effects and mechanisms of the sepsis biomarker procalcitonin (CRU 342 project P1)
  Nana-Maria Wagner, Department of Anaesthesiology and Intensive Care Medicine

• Phagocyte tolerance in systemic inflammation (CRU 342 project Z)
  Johannes Roth, Institute of Immunology

• Global kinase activity profiling of THP1-macrophages after treatment with the bacterial cell-penetrating effector protein IpaH7.8 (CRC 1009 project B03)
  Ivan Ngueya Yango, Institute of Infectiology

• Plasticity of the leukocyte transmigration route in different tissues (CRC 1450 project B03)
  Min Xia, Department of Vascular Cell Biology, MPI Münster
• Signal transduction inhibitors for anti-infective therapy (CRC 1009 project B02)
  Stephan Ludwig, Institute of Molecular Virology
• Therapeutic potential of repurposed MAPK p38 inhibitors against COVID-19 (CRU 342 project P6)
  Linda Brunotte, Institute of Molecular Virology

• Introduction to the new Inflammation & Imaging Lecture and other joint activities
  Johannes Roth (CRC 1009), Michael Schäfers (CRC 1450), Jan Rossaint (CRU 342)
• The long road to hybrid parametric imaging in PET/MRI: Methodological challenges and implications for imaging of inflammation (CRC 1450 project B06)
  Florian Büther, European Institute for Molecular Imaging (EIMI)
• Effects of different doses of remote ischemic preconditioning on kidney damage among patients undergoing cardiac surgery: a single-center mechanistic randomized controlled trial (CRU 342 project P7)
  Mira Küllmar, Department of Anaesthesiology and Intensive Care Medicine