Dr. Anna Ziegler

Brain lipid metabolism

 

The figure shows a fruit fly larva with ppk::CD4GFP labeled c4da neurons (top). The bottom part shows tracings of c4da neuronal dendrites of a wildtype neuron (left) and neurons in which toxic lipids accumulate with increasing concentration.
© Anna Ziegler

Neurobiology
Physiology     
Lipid metabolism
Drosophila

The brain is our most lipid enriched organ. However, especially neurons are very vulnerable to alterations in lipid metabolism. We study how a failure in lipid metabolic pathways is affecting neuronal development and maintenance and focus mainly on human disease related alleles which we bring into Drosophila to study how they affect specific subsets of neurons. In the lab we use molecular biology, genetics, histology, in vivo imaging, and behavioral analysis.

Dr. Anna Ziegler
Dr. Anna Ziegler
Westfälische Wilhelms-Universität Münster
Multiscale Imaging Centre (MIC)
Röntgenstraße 16
48149 Münster
T: +49 (0) 251- 83- 23 891
anna.ziegler@uni-muenster.de

Vita

  • 2002 - 2010       Studies in Biology and PhD studies in Chemistry and Biochemistry at the
                                  Ruhr-university Bochum, Germany
  • 2010 - 2015       Postdoctoral studies at the CNRS in Dijon, France
  • 2015 – 2021      Senior Postdoc at the German Center for Neurodegenerative Disorders (DZNE)
                                  Bonn, Germany
  • Since 2021        Junior group leader at the University of Münster

Selected references

Ziegler AB, Thiele C, Tenedini F, Richard M, Leyendecker P, Hoermann A, Soba P, Tavosanis G: Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty acid synthesis regulator SREBP. Cell reports. 2017 Dec 19;21(12):3346-3353. doi:10.1016/j.celrep.2017.11.069

Maniére G *, Ziegler AB *, Geillon F, Featherstone DE, Grosjean Y: Direct sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells. Cell Reports. 2016 Sep 27;17(1):137-148. doi: 10.1016/j.celrep.2016.08.093. *equal contribution

Ziegler AB# and Tavisanis G: Glycerophospholipids - Emerging players in neuronal dendrite branching and outgrowth. Dev Biol. 2018 Dec 18. pii: S0012-1606(18)30341-5. doi: 10.1016/j.ydbio.2018.12.009.

Ziegler AB#, Menage C, Garcia T, Ferveur J-F, Bretillon L, Grosjean Y#: PUFAs are necessary and required for synapse function in the Drosophila visual system.
PLoS One. 2015 Aug 26;10(8):e0135353. doi: 10.1371/journal.pone.0135353. #corresponding authors

Ziegler AB, Augustin H, Clark N, Berthelot-Grosjean M, Simonnet M, Steinert JR, Geillon F, Maniére G, Featherstone DE, Grosjean Y: JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Regulates Locomotor Activity in Drosophila Larvae.
Scientific Reports. 2016 Jan 25;6:19692. doi: 10.1038/srep19692

Links

Ziegler lab

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