17th CiM-IMPRS Interdisciplinary Graduate School Meeting
Cells in Action - Challenging the tango of life
25 October Online, 26th and 27th October Offline, 2023
25 October Online, 26th and 27th October Offline, 2023
Conference programme
Wednesday 25.10.2023 (Online)
9:00-9:10 Welcome Talk
9:10-10:50 Development and Cell Biology Part I
TIME
TOPICS AND SPEAKERS
9:10-9:50
Impact of lamin-A/C on cancer progression in vivo
Katharina Wolf, Radboud University Medical Center, Radboud University, Nijmegen, Netherlands9:50-10:30
A question of dynamics
Barbara di Ventura, The BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg im Breisgau, Germany10:30-10:50
Q&A and Coffee Break
10:50-12:50 Vascular Biology
10:50-11:30
Guiding Mechanotransduction in Blood Vessels
Ellie Tzima, Radcliffe Department of Medicine - Cardiovascular Medicine, University of Oxford, Oxford, UK11:30-12:10
Skeletal stem/progenitor cells: interactions within the bone vascular microenvironment and beyond
Christa Maes, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium12:10-12:50
Leukocyte breaching of blood vessel walls: Insights into the role of pericytes
Tamara Girbl, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany12:50-14:00 Lunch Break
14:00-15:50 Developmental & Cell Biology Part II
14:00-14:40
Membrane repair mechanisms and membrane integrity
Jesper Nylandsted, Cancer and Inflammation Research Unit, Danish Cancer Society Research Centre, University of Southern Denmark, Copenhagen, Denmark14:40-15:20
Cellular roadmaps: Control of cell architecture by dynamic microtubules
Anna Akhmanova, Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands15:20-15:50
Q&A and Coffee Break
15:50-17:50 Immunology & Virology
15:50-16:30
Unraveling the Molecular Architecture of the Intestinal Barrier: Insights from Spatial Transcriptomics
Eduardo Villablanca, Department of Medicine, Karolinska Institute, Stockholm, Sweden16:30-17:10
Circadian control of enteric virus infection
Julie Pfeiffer, Microbiology department, University of Texas Southwestern Medical Center, Dallas, USA17:10-17:50
Culturing Hepatitis E Virus– recent advances for basic science and drug discovery
Eike Steinmann, Department of Molecular & Medical Virology, University Bochum, Bochum, GermanyThursday 26.10.2023 (In person)
8:00-8:50 Registration
8:50-9:00 Welcome Talk
TIME
TOPICS AND SPEAKERS
9:00-9:20
Young investigator talk: Double-modified AdoMet analogues for selective targeting of methyltransferases
Mehmet Erguven, Institute of Biochemistry, WWU Münster, Germany9:20-9:40
Young investigator talk:Two-way Dispatched function in Sonic Hedgehog shedding and transfer to high-density lipoproteins
Janna Puschmann, University Hospital Münster, Germany9:40-10:00
Young investigator talk: Unexpected function of the antioxidative xCT system/Slc7a11 in systemic sclerosis
Jessica Tiemann, University Hospital Münster/ Department of Dermatology, Germany10:00-10:30
Poster Flash Talks
10:30-10:50
Q&A and Coffee Break
10:50-12:00 Non-academic Session
10:50-12:00
Career Seminar
Aishwarya Sundaram, Nature Communications editor, Berlin, Germany12:00-13:30 Lunch Break and Poster Session
13:30-16:30 Systems Biology
13:30-14:10
Mitotic rewiring on evolutionary timescales
Gautam Dey, Cell Biology and Biophysics Unit, EMBL, Heidelberg, Germany14:10-14:50
Cellular regulation in context – Integration of mathematical modeling in time and space with dedicated experiments on different scales
Edda Klipp, Institute of Biology, Humboldt University of Berlin, Berlin, Germany14:50-15:30
The EGFR/RPTPg sensory morphogenic system: a loop onto itself
Philippe Bastiaens, Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany15:30-16:10
From molecules to life: building living systems from scratch
Dora Tang, Department of Life Sciences, Saarland University, Saarbrücken, Germany16:10-16:30
Q&A and Coffee Break
16:30-17:50 Biophysics Part I
16:30-17:10
Liquid–liquid phase separation? Ask the water!
Martina Havenith-Newen, Center of Molecular Spectroscopy and Simulation of Solvent Controlled Processes, Ruhr University Bochum, Bochum, Germany17:10-17:50
Modulation of the Slo potassium channel by small molecules and auxiliary proteins
Dr. Tobias Raisch, Structural Biochemistry of Membrane Proteins, Max Planck Institute of Molecular Physiology, Dortmund, Germany18:00 onwards Social Event: Get together & Pub Quiz
Friday 27.10.2023 (In person)
9:45-10:00 Registration
10:00-10:10 Welcome Talk
10:10-14:40 Neuroscience
TIME
TOPICS AND SPEAKERS
10:10-10:50
Interactions of Tau protein condensates
Susanne Wegmann, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, Germany10:50-11:30
Programming cell fate and age for neuronal disease modeling and repair
Oliver Brüstle, Institut für Rekonstruktive Neurobiologie, Universitätsklinikum Bonn, Bonn, Germany11:30-12:30
KEYNOTE: Synaptic vesicles – key organelles in synaptic transmission
Reinhard Jahn, Max Planck Institute for Multidisciplinary Sciences,
University of Göttingen, Göttingen, Germany12:30-14:00 Poster Sessions and Lunch Break
14:00-14:40
Single-cell delineation of lineage and genetic identity in the mouse brain
Christian Mayer, Max Planck Institute for Biological Intelligence, LMU Munich, Martinsried, Munich, Germany14:40-16:00 Biophysics Part II
14:40-15:20
Cytoskeletal fibres as building blocks for life
Franziska Lautenschläger, Center for Biophysics, Saarland University, Saarbrücken, Germany15:20-16:00
Cellular cartography: mapping cytoskeletal organization and intracellular transport in neurons
Lukas Kapitein, Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands16:00-16:30 Poster Awards & Closing Ceremony
16th Interdisciplinary Graduate School Meeting
Through the lens of science - Insights into molecular mechanisms
19 October to 21 October, 2022
19 October to 21 October, 2022
Conference programme
Wednesday 19.10.2022
9:00-9:30 Welcome talk
9:30-12:45 Session: Development and Regeneration
Time Topics and speakers 9:30-10:30 KEYNOTE: Coping with mechanical stress: tissue dynamics during development, homeostasis and repair
Yanlan Mao, Laboratory for Molecular Cell Biology, University College London, London, UK10:30-11:00 Deep learning in developmental biology
Patrick Müller, Chair of Developmental Biology at the University of Konstanz, Konstanz, Germany11:00-11:30 Q&A and coffee break 11:30-12:00 Young investigator talk: Early endosomes act as local exocytosis hubs to repair endothelial membrane damage
Nikita Raj, Institute of Medical Biochemistry (ZMBE), WWU Münster, Germany12:00-12:30 How to engineer human pluripotent stem cells to understand human development and disease
Nuria Monteserrat, Institute of Bioengineering of Catalonia (IBEC), Barcelona, Spain12:30-12:45 Q&A 12:45-13:30 Lunch break
13:30-16:45 Session: Neurobiology
13:30-14:30 KEYNOTE: Me and my Markov blanket: Sentience and the Free Energy Principle
Karl Friston, Institute of Neurology, University College London, London, UK14:30-15:00 Mechanisms of Axon Growth and Regeneration
Frank Bradke, DZNE, Bonn, Germany15:00-15:30 Q&A and coffee break 15:30-16:00 Young investigator talk: Synaptic retrograde regulation of the PKA-induced SNAP-25 and Synapsin-1 phosphorylation
Aleksandra Polishchuk, Rovira i Virgili University, Spain16:00-16:30 The CeNGEN project: neurogenomics at single-cell resolution across an entire nervous system
Marc Hammarlund, Yale School of Medicine, New Haven, USA16:30-16:45 Q&A 16:45-17:15 Coffee break
17:45-18:45 Session: Career
17:45-18:15 Julia Eckhoff, freelance medical writer (Eckcomms Ltd), former Nature Communications editor, London, UK 18:15-18:45 Michael Spiegelmacher, BionautLabs, Los Angeles, CA, USA Thursday 20.10.2022
9:00-12:15 Session: Vascular Biology
Time Topics and speakers 9:00-10:00 KEYNOTE: Neutrophil breaching of venular walls: Novel concepts and pathophysiological regulation
Sussan Nourshargh, Queen Mary University of London, London, UK10:00-10:30 How leukocytes breach the vessel wall: Searching for the ideal transmigration hotspot
Jaap van Buul, Swammerdam Institute for Life Sciences (SILS) at University of Amsterdam, Amsterdam, the Netherlands10:30-11:00 Q&A and coffee break 11:00-11:30 Young investigator talk: The role of nuclear envelope structure in response to shear stress in Endothelial cells
Parisa Ghanbari, Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany11:30-12:00 Young investigator talk: The effect of hydrogen peroxide on the permeability of the blood-brain barrier in vitro
Margarita Shuvalova, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia12:00-12:15 Q&A 12:15-14:15 Poster and lunch break
14:15-17:30 Session: Viruses and anti-viral agents
Time Topics and speakers 14:15-15:15 KEYNOTE: Synthetic metal complexes for in-cell catalysis
Peter Sadler, Department of Chemistry, University of Warwick, Coventry, UK15:15-15:45 Learning from viruses for EV functionalization
Kenneth Witwer, John Hopkins University School of Medicine, Baltimore, USA15:45-16:15 Q&A and coffee break 16:15-16:45 Junctional mechanotransduction in angiogenesis
Stephan Huveneers, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands16:45-17:15 SARS-CoV-2 adaptation to effective transmission and its replication in airway epithelia
Raul Andino, UCSF, San Francisco, USA17:15-17:30 Q&A Friday 21.10.2022
9:00-11:00 Session: Computational Biology
Time Topics and speakers 9:00-09:30 Generative models of brain function: Inference, mechanisms, and psychedelics
Adeel Razi, Institute for Brain and Mental Health, the School of Psychological Sciences, Monash University, Melbourne, Australia9:30-10:00 Formatting Biological Big Data to Enable (Personalized) Systems Pharmacology
Patrick Aloy, Structural Bioinformatics and Network Biology, IRB, Barcelona, Spain10:00-10:30 Solving 3D puzzles of biomolecular assemblies by integrative modelling
Alexandre Bonvin, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands10:30-11:00 Q&A and coffee break 11:00-16:00 Session: Light for Life
11:00-11:30 Controlling receptor activity with photoswitchable drugs: basic research and future therapies
Pau Gorostiza, ICREA, BIST, CIBER, IBEC, Barcelona, Spain11:30-12:00 How to Quantify A Zebrafish: Research Software for Image-Driven Biomedical Studies
Elisabeth Kugler, University College London, London, UK12:00-12:15 Q&A 12:15-14:00 Lunch break & poster session 14:00-15:00 KEYNOTE: Advanced optical microscopy studies of molecular membrane organizations
Christian Eggeling, Friedrich-Schiller Universität Jena, Jena, Germany15:00-15:30 Young investigator talk: CryoEM structure of the peroxisomal AAA-complex Pex1/Pex6 processing a substrate
Maximilian Rüttermann, CryoEM of Complex Nanosystems, Institute for Medical Physics and Biophysics, WWU Münster, Germany15:30-16:00 Q&A and coffee break 16:00-17:15 Session: Lipid Metabolism
Time Topics and speakers 16:00-16:30 Lipid transport at contact sites by tube-forming lipid transport proteins
William Prinz, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, Maryland, USA16:30-17:00 Dissecting the biophysical phase properties of cellular lipid storage
Mike Henne, Department of Cell Biology, UTSW Medical Center, UT Southwestern, Dallas, USA17:00-17:15 Q&A 17:15-17:30 Poster awards & Closing ceremony
15th Interdisciplinary Graduate School Meeting
Beyond the Barriers: New Perspectives and Advances in Life Science
20 October to 22 October, 2021
20 October to 22 October, 2021
Conference programme
Wednesday 20.10.2021
13:00-13:30 Welcome
13:30-17:30 Session: cell & molecular biology
Time Topics and speakers 13:30-14:30 Keynote: The systemic vasculature as guardian of health and longevity
Hellmut Augustin, Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany14:30-15:00 Modeling human brain disorders in vitro with patient-derived induced pluripotent stem cells
Cedric Bardy, Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute, Adelaide, Australia15:00-15:30 Q&A 15:30-16:00 Heterogeneity of myeloid cells in the brain
Marco Prinz, Institute of Neuropathology, University Hospital Freiburg, Freiburg, Germany16:00-16:30 Metabolic guidance of vascular growth and differentiation
Michael Potente, Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany16:30-17:00 Young investigator talk: Deciphering the role of Nicastrin in the egress of influenza A virus
Swathi Sukumar, Center for Molecular Biology of Inflammation (ZMBE) Institute of Virology with Prof. Stefan Ludwig, University of Münster, Münster, Germany17:00-17:30 Q&A Thursday 21.10.2021
10:00-11:45 Session: cell metabolism 1
Time Topics and speakers 10:00-10:30 Mechanisms of hepatocyte polarization and liver tissue morphogenesis
Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany10:30-11:00 Keeping the good ones: intracellular selection of mitochondrial DNA
Christof Osman, Cell and Developmental Biology, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany11:00-11:30 Young investigator talk: CHIMs - A class of versatile cholesterol analogs with unique properties
Anna Lívia Linard Matos, Center for Molecular Biology of Inflammation (ZMBE) Institute of Medical Biochemistry with Prof. Volker Gerke, Münster, Germany11:30-11:45 Q&A 11:45-12:30 Lunch break
12:30-13:00 Poster session
13:00-15:00 Session: cell metabolism 2
Time Topics and speakers 13:00-14:00 Keynote: Molecular architecture as a critical determinant of metabolism
Gökhan S. Hotamisligil, Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Harvard University, Boston, USA14:00-14:30 The impact of adipose tissues in cancer cells and macrophage immunometabolism
Kelly Grace Magalhães, Laboratory of Immunology and Inflammation, Departament of Cell Biology, University of Brasilia, Brasilia, Brasil14:30-15:00 Q&A 15:00-19:00 Session: cell architecture visualization
Time Topics and speakers 15:00-16:00 Keynote: Light, CRISPR and DNA repair
Taekjip Ha, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, USA16:00-16:30 Young investigator talk: Potential neuroprotective, immunomodulatory and antiviral effects of omega-3 (DHA) in neuronal and microglial ZIKV infection
Heloísa Antoniella Braz de Melo, Laboratory of Immunology and Inflammation – University of Brasília (UnB)16:30-17:00 Q&A 17:00-17:30 Cryo-ET reveals sarcomere structures at molecular resolution
Stefan Raunser, Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany17:30-18:00 Power at the nanoscale: speed, strength and efficiency in biological motors
Carlos Bustamante, Single Molecule Biophysics, University of California, Berkeley, USA18:00-18:30 Mechano-genomics of cell-state transitions
G.V. Shivashankar, Department of Health Sciences and Technology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland18:30-19:00 Q&A Friday 22.10.2021
09:00-12:45 Session: tissue engineering
Time Topics and speakers 09:00-10:00 Keynote: Organoids to model human disease
Hans Clevers, Hubrecht Institute for Developmental Biology and Stem Cell Research, Princess Máxima Center for Pedriatic Oncology, Utrecht, the Netherlands10:00-10:30 Engineering organoids-on-a-chip
Matthias Lutolf, Laboratory of Stem Cell Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland10:30-11:00 Q&A 11:00-11:30 Engineering pancreas organogenesis: from self-organization to understanding diabetes
Anne Grapin-Botton, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany11:30-12:00 Young investigator talk: The vertebrate RNA-binding protein Dead end controls the access of nanos RNA to ribosome-rich areas at the periphery of germ granules
Kim Westerich, Center for Molecular Biology of Inflammation (ZMBE) Institute of Cell Biology with Prof. Erez Raz Münster, Germany12:00-12:30 Tissue-specific vascular models – modelling human disease at the microscale
Kristina Haase, Tissue Biology and Disease Modelling, European Molecular Biology Laboratory Barcelona, Barcelona, Spain12:30-12:45 Q&A 12:45-13:30 Lunch break
13:30-14:00 Poster session
14:00-17:30 Session: systems biology
Time Topics and speakers 14:00-15:00 Keynote: Synthetic biology: life redesigned
James Collins, Massachusetts Institute of Technology, Massachusetts, USA15:00-15:30 Image analysis and AI in microscopy-based life science research
Carolina Wählby, Department of Information Technology, Uppsala University, Uppsala, Sweden15:30-16:00 Q&A 16:00-16:30 Towards reconstructing petabyte-scale lightsheet microscopy acquisitions
Stephan Preibisch, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA16:30-17:00 Computational approaches for analysis of single-cell multi-modal data
Laleh Haghverdi, Computational Methodologies and Omic Analytics, Max Delbrück Center for Molecular Medicine, Berlin, Germany17:00-17:15 Q&A 17:15-17:30 Closing activities
14th Interdisciplinary Graduate School Meeting
Breaking the Frontiers: Modern Perspectives in Life Science
30 September to 2 October, 2020
30 September to 2 October, 2020
Conference programme
Wednesday 30.09.2020
14:00-14:30 Welcome
14:30-19:00 Session 1 – Biology
Time Topics and speakers 14:30-15:30 Keynote: Molecular Mechanism of Cytokinesis
Prof. Thomas D. Pollard, Department of Molecular Cellular and Developmental Biology, Yale University, USA15:30-16:00 Blastoids – Blastocyst-like Structures Generated Solely From Stem Cells
Dr. Nicolas Rivron, Austrian Academy of Sciences, IMBA - Institute of Molecular Biotechnology, Austria16:00-16:30 Q&A Session & Coffee Break 16:30-17:00 Dynamizing Nuclear Actin Filaments in Cell Division
Prof. Robert Grosse, Experimental and clinical pharmacology and toxicology, Freiburg University, Germany17:00-17:30 Young Investigator Talk: Excluding Oct4 From Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs
Sergiy Velychko from Professor Dr. Hans R. Schöler's lab, Max Planck Institute for Molecular Biomedicine, Germany17:30-18:00 Identifying Chromatin Regulators at Specific Genomic Loci
Prof. Sylvia Erhardt, Center for Molecular Biology, Heidelberg University, Germany18:00-18:30 Q&A Session 18:30-19:00 Closing Remarks for the Day Thursday 01.10.2020
09:00-13:00 Session 2 – Biology
Time Topics and speakers 09:00-10:00 Keynote: The Vascular Barrier – What We Know and Why It’s Important
Prof. Lena Claesson-Welsh, Vascular Biology, Uppsala University, Sweden10:00-10:30 Quantifying Material Properties of Living Matter and How These Relate to Biological Function
Prof. Lene B Oddershede, Optical Tweezers Group, Niels Bohr Institute, University of Copenhagen, Denmark10:30-11:00 Q&A Session & Coffee Break 11:00-11:30 Young Investigator Talk: Master Mitotic Kinases Regulate HPV16 Nuclear Delivery During Mitosis
Matteo Rizzato from Prof. Dr. Mario Schelhaas's lab, Institute for Cellular Virology, Münster University, Germany11:00-11:30 Young Investigator Talk: Master Mitotic Kinases Regulate HPV16 Nuclear Delivery During Mitosis
Matteo Rizzato from Prof. Dr. Mario Schelhaas's lab, Institute for Cellular Virology, Münster University, Germany11:30-12:00 Young Investigator Talk: PECAM-1 Mediates Leukocyte Diapedesis by Triggering Dephosphorylation of VE-Cadherin-Y731
Nida Arif from Prof. Dr. Dietmar Vestweber's lab, Max Planck Institute for Molecular Biomedicine, Germany12:00-12:30 Tolerance to Aneuploidy
Prof. René Medema, Cell division and Cancer, Netherlands Cancer Institute, Netherlands12:30-13:00 Q&A Session 13:00-14:00 Lunch Break
14:00-19:00 Session 3 – Biophysics
Time Topics and speakers 14:00-15:00 Keynote: Engineering 3D Cultures of Physiology and Disease – How Simple is Complex Enough?
Prof. Christopher Chen, Tissue Microfabrication Lab, Boston University & Harvard University, USA15:00-15:30 Young Investigator Talk: Synthetic Extracellular Matrices With Tailored Properties Support Lumen Formation During Angiogenic Sprouting
Jifeng Liu from Dr. Britta Trappmann's lab, Max Planck Institute for Molecular Biomedicine, Germany15:30-16:00 Active Cell Deformation Through Actin Assembly, and How We May Infer Nucleus Deformation
Dr. Cécile Sykes, Institute Curie PSL Paris, Sorbonne University, France16:00-17:00 Coffee Break & Poster Session 17:00-17:30 Intravascular Tracking of Tumor Metastasis
Dr. Jacky Goetz, Lab for Tumor Biomechanics, INSERM Institut d’Hématologie et d’Immunologie Strasbourg, France17:30-18:00 Deep Learning-Based Point-Scanning Super-Resolution Microscopy
Prof. Uri Manor, Biophotonics Core Facility, Salk Institute for Biological Studies, USA18:00-18:30 Q&A Session 18:30-19:00 Closing Remarks for the Day Friday 02.10.2020
10:00-13:00 Session 4 – Biochemistry
Time Topics and speakers 10:00-11:00 Keynote: Synthetic Protobiology – The Chemistry of Life-like Objects
Prof. Stephen Mann, Bristol Centre for Functional Nanomaterials, University of Bristol, UK11:00-11:30 Spatiotemporal Control Over Adhesions in Synthetic Cells Using Light
Prof. Seraphine Wegner, Institute for Physiological Chemistry and Pathobiochemistry, Münster University, Germany11:30-12:00 Phthalocyanine-Based Photosensitizers and Their (Soft) Nanostructures for Photo-Antimicrobial Applications
Dr. Anzhela Galstyan, Center for Soft Nanoscience, Münster University, Germany12:00-12:30 Molecularly Engineered Nanobiomaterials to Understand and Control Biology
Dr. Helena Azevedo, School of Engineering and Materials Science and Institute of Bioengineering, Queen Mary University of London, UK12:30-13:00 Q&A Session 13:00-14:00 Lunch Break
14:00-16:30 Session 5 – Bioinformatics/Mathematics
Time Topics and speakers 14:00-14:30 Prediction and Design of Biological Sequences with Neural Machines
Prof. Debora Marks, Department of Systems Biology, Harvard Medical School, USA14:30-15:00 Modeling Cellular Response in Time and Space
Prof. Fabian Theis, Institute of Computational Biology, Helmholtz Zentrum München, Germany15:00-15:30 Suggestions From Mathematics for the Functioning of Flatworm Regeneration
Prof. Angela Stevens, Institute for Applied Mathematics: Analysis and Numerics, Münster University, Germany15:30-16:00 Q&A Session 16:00-16:30 Final Closing Remarks Speakers
- Prof. Thomas D. Pollard’s research focuses on understanding cell motility through the study of actin filaments and myosin motors. His lab uses a combination of biochemistry, biophysics, microscopy and fission yeast genetics to investigate the molecular basis of cellular motility and cytokinesis.
- Dr. Nicolas Rivron’s lab is seeking to understand the general principles underlying the organization of stem cells in the early developmental phase of organisms. To study these principles, they use model organisms (Blastoids) that were created by harnessing the intrinsic potential of stem cells to self-organize which allows to systematically modulate and analyse their behavior. Their main focus is to generate more such embryo models for drug and genetic screens, biochemistry and genomic analysis.
- Prof. Robert Grosse investigates the role of cytoskeletal proteins such as formin in cell motility, tumor progression and metastasis. His lab is also interested in discovering how actin network formation and organization drives cellular behaviors, such as polarization, invasion, mitotic spindle formation, chromosome congression and the effect of intracellular signaling on cellular morphology and dynamics.
- Prof. Sylvia Erhardt’s research focuses on understanding the epigenetic mechanisms specifying centromere identity and aims to elucidate how these mechanisms are linked to chromosome segregation and cell cycle progression.
- Prof. Lena Claesson-Welsh’s research focus lies in the molecular mechanisms of endothelial cell biology, particularly angiogenesis and its link to cancer metastasis, VEGF signal transduction, vessel permeability and tissue homeostasis.
- Prof. Lene B Oddershede’s lab investigates physical properties of biological systems at levels ranging from the single molecule to the whole cell with a particular interest in stem cells. Her lab uses single particle tracking, fluorescence, sub-diffraction techniques and their state-of-the-art force-scope optical tweezers to study nanoparticle plasmonics.
- Dr. Alex Bird’s group investigates the function and regulation of microtubule networks in context to mitosis, migration and neuritogenesis. One of the major aims of his research is to uncover the regulatory mechanisms and pathways that guide the formation function of the mitotic spindle to ensure genome stability.
- Prof. René Medema studies the molecular mechanisms of cell division. His lab works on understanding cell recovery from DNA damage and aims to use this knowledge in designing efficient anti-cancer drugs. They are also interested in studying the role of establishment of the correct balance of forces during bipolar spindle assembly, which is required to segregate chromosomes during cell division.
- Prof. Christopher Chen is interested in cellular interactions, especially the cooperation between mechanical and biochemical signaling in the regulation of angiogenesis and stem cell biology. His lab studies tissue vascularization, connective tissues and cancer using micro- and nanofabrication tools.
- Prof. Cécile Sykes studies Biomimetism of cell movement and approaches the biological problems using the principles of soft matter physics. Her team focuses mainly on the underlying mechanisms of cell division and motility that would expand the knowledge about cancer invasion and metastasis. With a combination of in-vitro biomimetic systems and in-vivo cellular and animal models ranging from nematode worms to mouse oocytes, her research provides answers to many physical and biochemical mechanisms governing cell shape change and movement.
- Having developed the unique intravital CLEM (Correlative Light and Electron Microscopy) technology, Dr. Jacky Goetz’s lab tracks intravascular tumor metastasis and are keen on understanding the molecular and cellular mechanisms driving metastasis formation. They are also examining the role of mechanical forces in tumor invasion and the fate and function of tumor exosomes on local and distant microenvironment during the priming of metastatic niches.
- The primary focus of Prof. Uri Manor is the integration and application of optical and charged particle detection technologies to investigate problems of critical biological significance. He is focused on developing deep learning-based computational approaches to increase the resolution, sensitivity and speed of next generation microscopes, as well as designing nanoprobes for high spatiotemporal resolution imaging of subcellular dynamics. His main biological interests are organelle-organelle contacts, cytoskeletal dynamics, mitochondria, sensorineural hearing loss and neurodegeneration.
- Prof. Stephen Mann is the founder of biomimetic chemistry and is distinguished for his contributions to biomineralization, bioinspired materials chemistry, self-assembly of functional nanostructures and hybrid nanoscale objects. His current research focus includes, the chemical synthesis, characterization and emergence of complex organized matter, including models of protocell assembly.
- Prof. Seraphine Wegner is interested in light-controlled systems, especially the spatiotemporal control of cell-material and cell-cell interactions and associated processes in natural and synthetic minimal cells by using visible light. Her lab focuses on addressing questions in cell biology to better engineer new synthetic minimal cells, which reduces the complexity despite retaining the key features of a cell, allowing to quantify and correlate cell behavior with their molecular information.
- Dr. Helena Azevedo engineers molecules for biomedical application. She uses supramolecular chemistry to program macromolecules to self-assemble into biologically active structures to understand the energy pathways required for this self-assembly.
- Prof. Debora Marks and her lab develop computational methods for interpreting genetic variation with a focus on biomedical applications. To this end they have developed tools to predict 3D structures of RNAs, RNA-protein complexes and proteins from genomic sequence data. The current focus of her lab lies in developing methods in deep learning to address a wide range of biological challenges including the prediction of the effects of genetic variation and sequence design for biosynthetic applications.
- The research focus of Prof. Fabian Theis’s lab includes using computational methods for analyzing and modelling single cell heterogeneities with a focus on machine learning approaches and predictive algorithms applied to biological and biomedical questions. This includes the development of tools for scRNA-Seq Analysis, predicting perturbation effects in scRNA-Seq data and analysing and interpreting RNA Velocity.
- Prof. Angela Stevens is particularly interested in mathematical modelling in biology and medicine, where she analyses developmental processes and cell motility. Her work combines rigorous mathematical research with challenging problems in the life sciences.
13th Interdisciplinary Graduate School Meeting
Horizons in biology: beyond the biological borders
Münster, 24–26 April 2019
Münster, 24–26 April 2019
Conference programme
Wednesday, 24.04.2019
09:00 Registration 11:30 Lunch 12:15 Opening remarks Morphogenesis session
12:30 Keynote: Phase segregation of ooplasm and yolk granules in zebrafish oocytes is mediated
by periodic bulk actin polymerization waves
Carl-Philipp Heisenberg, Klosterneuburg/Austria13:30 Imaging How Cells Choose their Fate, Shape and Position to Form the
Mammalian Embryo
Nicolas Plachta, Singapore14:10 Coffee break Morphogenesis session
14:40 Connections for vision
Iris Salecker, London/UK15:20 Investigating neuronal cell fate in vivo in the developing vertebrate retina
Leanne Godinho, Munich/GermanyPoster session
16:00 Students will present their projects in form of posters. Chemistry session
17:00 DNA origami tools to explore biological processes
Barbara Sacca, Essen/GermanyEvening Program
18:45 Dinner and city tour Thursday, 25.04.2019
Cell biology session
9:00 Frank Edenhofer, Innsbruck/Austria 9:40 Binding of surface-associated antigen causes plasma membrane wounding
and repair in B lymphocytes, a process that promotes BCR activation
Norma Andrews, College Park/USA10:20 The Impact of organelle size control on a physiological function: Weibel-Palade Bodies and
Haemostasis
Daniel Cutler, London/UK11:00 Coffee break Cell biology session
11:30 Information content of intracellular patterns
Wu Min, Singapore12:10 Molecular control of actomyosin contractility and morphogenesis in epithelia
Andreas Wodarz, Cologne/Germany12:50 Lunch Cell dynamics session
13:50 The conserved Myosin 1D controls multiscale chirality in Drosophila
Stephane Noselli, Nice/France14:30 Leukocyte transendothelial migration: the endothelium in control
Jaap van Buul, Amsterdam/Netherlands15:10 Dynamics and mechanics of collective cancer cell migration
Andrew Clark, Paris/France15:50 Coffee break Cell dynamics & biophysics session
16:20 Keynote: Mechanosensing Depletion Drives Regeneration and Cancer
Michael Sheetz, Singapore17:20 Mechanosensitivity and microtubule-dependent regulation of integrin-mediated adhesions
Alexander D. Bershadsky, Singapore18:00 Reconstitution of the steady state of dynamic actin networks
Laurent Blanchoin, Grenoble/France18:40 Physics of epithelial flows and folds
Guillaume Salbreux, London/UKEvening Program
20:15 Social event Friday, 26.04.2019
Chemistry session
8:20 Regulation of lipid droplet - endoplasmic reticulum membrane contacts by seipin
Elina Ikonen, Helsinki/FinlandGenomics session
9:00 Mass spectrometry for cell signaling: from global maps to new biological insights
Chuna Ram Choudhary, Copenhagen/Denmark9:40 Christoph Lippert, Berlin/Germany 10:20 Keynote: Tracing genomic regulatory programs at single-cell resolution
Stein Aerts, Leuven/BelgiumPoster session
11:20 Students will present their projects in form of posters. Young investigator's session
12:20 Simulating the binding of Pioneer Transcription Factors to the nucleosome
Jan Huertas, University of Münster/Max-Planck Institute for Molecular Biomedicine12:40 Cell surface functionality is triggered by endolysosomal calcium release
Nicole Heitzig, University of Münster/Institute of Medical Biochemistry13:00 Endothelial Basement Membrane Laminins Affect Shear Response in Resistance Arteries by Modulating Communication between Endothelium and Smooth Muscle
Anna-Liisa Luik, University of Münster/Institute for Physiological Chemistry and Pathobiochemistry13:20 Novel routes to holey (carbon) support films
Philipp Selenschik, University of Münster/Institute of Medical Physics and BiophysicsClosing ceremony
13:40 Closing remarks and poster awards 13:50 Lunch
12th Interdisciplinary Graduate School Meeting
From molecules to life: a multiscale perspective of cell cynamics
Münster, 25–27 April 2018
Münster, 25–27 April 2018
Conference programme
Wednesday, 25.04.2018
09:00 Registration 13:00 Opening Session 1: Cytoskeleton
13:15 Reconstitution of (parts of) cell division
Andrea Musacchio, Dortmund - Germany13:55 Comparative approach to understanding mitotic division
Snezhana Oliferenko, London - UK14:35 Coffee break Session 2: Cell trafficking
15:05 T-/B-cell interaction promoting CNS autoimmunity
Alexander Flügel, Göttingen - Germany15:45 VE-cadherin endocytosis regulates cell polarity, collective cell migration, and angiogenesis during development
Andrew P. Kowalczyk, Atlanta - USAPoster Session
16:25 Students will present their projects in form of posters. Session 3: Ion channels
17:25 Open Sesame...Close Sesame: Ion Channels - Key to stomatal gating
Kavitha Sankaranarayanan, Chennai - India18:05 Structure and Biology of NMDA receptors
Hiro Furukawa, New York - USAEvening Program
18:45 Dinner and social event Thursday, 26.04.2018
Session 4: Biomechanics
09:20 Cell mechanoadaptation and tissue stiffening in health and disease
Miguel Ángel del Pozo, Madrid - Spain10:00 Structural organisation, liquid disorder, jamming, and glassy dynamics in king penguin colonies
Ben Fabry, Erlangen - Germany10:40 Real-time deformability cytometry: Mechanical phenotyping for translational applications
Fabian Czerwinski, Greifswald - Germany11:20 Coffee break Session 5: Biochemistry
11:50 Protein TAILS Tell Remarkable Tales: Proteomic Untangling of the Protease Web in Immunity
Christopher Overall, Vancouver - Canada12:30 Circadian rhythms in immune cell trafficking and function
Christoph Scheiermann, Munich - GermanySession 6: Chemistry
14:10 Allosteric inhibitors of flaviviral NS3/NS2B proteases
Tanja Schirmeister, Mainz - Germany14:50 The molecular dynamics of potassium channel permeation, selectivity and gating
Bert de Groot, Göttingen - Germany15:30 Young investigator talk
Imtiaz AliPoster Session
15:50 Students will present their projects in form of posters. Session 7: RNA and DNA biology
16:50 Simulating chromatin
Modesto Orozco, Barcelona - Spain17:30 Sensing the environment through tRNA modifications: T. brucei dynamically alters Queuosine levels in response to nutrient changes
Juan Alfonzo, Columbus - USA18:10 Young investigator talk
Sergiy VelychkoEvening Program
18:30 City tour and dinner (for speakers only) Friday, 27.04.2018
Session 8: Imaging
09:00 Collective cancer cell invasion: plasticity and interconversions
Peter Friedl, Nijmegen - The Netherlands10:00 Endocytic control of mechanics, collective motion and cancer progression
Giorgio Scita, Milan - Italy10:40 Coffee break Session 9: Imaging
11:10 Actin regulation in healthy and diseased brain
Pirta Hotulainen, Helsinki - FinlandClosing Ceremony
11:50 Closing remarks and poster awards Career Talks & Workshop
13:20 Career talk 14:30 Workshop: Huygens post-processing: the fastest road to TRUE analysis of your microscopic data 16:30 End
11th Interdisciplinary Graduate School Meeting
From cells to organisms: insights into biomolecular mechanisms
Münster, 26–28 April 2017
Conference programme
Wednesday, 26.04.2017
10:00 Registration 12:00 Lunch (for speakers only) 12:45 Opening remarks Session 1: Vasculature
13:00 Endothelial cells in motion
Holger Gerhardt, Berlin - Germany13:40 Vascular malformations: From human genetic mosaicism towards clinical trials
Miikka Vikkula, Brussels - Belgium14:20 Cell mechanoadaptation: Caveolae mechanobiology and tissue biomechanics
Miguel Ángel del Pozo Barriuso, Madrid - Spain15:00 Coffee break Session 2: Physiology
15:30 How to use atomic-scale manipulations to study function & pharmacology of ion channels
Stephan Pless, Copenhagen - Denmark16:10 The Quantum Robin: Magnetoreception in migratory birds
Henrik Mouritsen, Oldenburg - Germany16:50 Optical control of synaptic signaling proteins: Photoswitchable ligands to study the function of glutamate receptors
Andreas Reiner, Bochum - GermanyEvening Program
18:45 City tour and dinner (for speakers only) Thursday, 27.04.2017
Session 3: Imaging and Detection Tools
09:00 Labeling proteins on-demand with fl uorogenic probes
Arnaud Gautier, Paris - France09:40 Bioelectronics: Building connections between DNA, proteins, neurons and electronics
Andreas Offenhäusser, Jülich - Germany10:20 Molecular tracers for neuroinfl ammation: From synthesis to animal imaging
Andrew Sutherland, Glasgow - UK11:00 Coffee break Session 4: Cell Migration
11:30 Dynamic interplay between mitochondria, ER and actin filaments during mitochondrial fission
Henry Higgs, Dartmouth - USA12:10 Rho GTPases: signalling in cell adhesion and migration
Anne Ridley, London - UK12:50 Studying the mechanics and molecules underlying in vivo tissue invasion
Daria Siekhaus, Klosterneuburg - Austria13:30 Lunch (for speakers only) Session 5: Biophysics
14:30 Synthetic morphogenesis in naïve embryonic tissues
Stefano De Renzis, Heidelberg - Germany15:10 A new perspective on nanoscale structure and dynamics with ultrasensitive optical microscopy
Philipp Kukura, Oxford - UK15:50 From ancient lipids to synthetic life
James Sáenz, Dresden - GermanyPoster Session
16:45 Students present their projects in a form of poster. Evening Program
18:30 Dinner 19:30 Social event Friday, 28.04.2017
Session 6: Dynamics of the Cytoskeleton
09:30 Forces controlling endothelial adhesion dynamics within the vasculature
Stephan Huveneers, Amsterdam - Netherlands10:10 Cellular level chemotaxis and haptotaxis
Nikolaos Sfakianakis, Mainz - Germany10:50 Molecular mechanisms for making tubes: anisotropies and cytoskeletal crosstalk
Katja Röper, Cambridge - UK11:30 Lunch (for speakers only) Career Talks
12:30 The industrial path: Insights into industrial careers 13:00 The academical path: overview of grant application procedures and the career path Closing Remarks
13:30 Closing remarks and poster awards
10th Interdisciplinary Graduate School Meeting
Insights into molecular and cellular dynamics
Münster, 11-13 May 2016
Conference programme
Wednesday, 11.05.2016
9:00 Registration 10:45 Welcome Remarks Session 1: Immunology
11:00 NETs - the second function of chromatin
Arturo Zychlinsky (Max Planck Institute for Infection Biology)11:30 Retroviruses, envelopes, receptors and metabolic markers
Marc Sitbon (The Institute of Molecular Genetics of Montpellier)12:00 Mammalian sterile 20-like kinase 1: an important player for neutrophil transmigration
Markus Sperandio (Ludwig-Maximilians-Universität Munich)12:30 Lunch Session 2: Cell Biology
14:00 Establishing new tools for manipulating alternative model organisms in the study of the evolution of developmental processes
Cassandra G. Extavour (Department of Molecular and Cellular Biology, Harvard University)14:30 Extracellular matrix and its role in biomedical research
Katja Schenke-Layland (Fraunhofer Institute for Interfacial Engineering and Biotechnology)15:00 Deconstructing cell migration
Matthieu Piel (Institut Curie)15:30 Innate immune cell dynamics at sites of inflammation and infection
Tim Lämmermann (Max Planck Institute of Immunobiology and Epigenetics)16:00 Coffee break Session 3: Young Scientist Talks
16:30 Wound-induced signals and positional cues cooperate to initiate regeneration in the planarian s. mediterranea
Suthira Owlarn (Münster, Germany)16:50 Regulation of bone vascularization and osteogenesis during mouse development
Urs H. Langen (Münster, Germany)17:10 A nanotechnological approach reveals the role of alpha 2 beta 1 integrin in collagen-induced platelet aggregation
Augusto Martins Lima (Münster, Germany)17:30 Plasma membrane organization in zebrafish primordial germ cells (PGCs) bleb
Mohammad Goudarzi (Münster, Germany)Evening Program
18:30 Guided City Tour 19:30 Dinner Thursday, 12.05.2016
Session 4: Developmental Biology
09:00 Regeneration of hematopoietic stem cells from endothelial cells
Dhvanit Shah (Harvard Medical School)09:30 Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
Victoria L. Bautch (University of North Carolina at Chapel Hill)10:00 Molecular regulation of endothelial barrier properties in the central nervous system
Stefan Liebner (Goethe University Frankfurt)10:30 CNS neuronal progenitors regulate vascular patterning in adjacent mesodermal tissues
Didier Stainier (Max Planck Institute for Heart and Lung Research)11:00 Coffee break Keynote lecture
11:30 The development of colour patterns in fishes - Towards an understanding of the evolution of beauty
Christiane Nüsslein-Volhard (Max Planck Institute for Developmental Biology)12:30 Lunch Session 5: Applied Mathematics
14:00 Aspects of cell swimming motility
Eamonn Gaffney (University of Oxford)14:30 Mathematical modeling of mechano-chemical pattern formation
Anna Marciniak-Czochra (University of Heidelberg)15:00 Identification of mammary stem cells and their dynamics during branching morphogenesis
Edouard Hannezo (University of Cambridge)15:30 Coffee break Poster Session
16:00 to 18:00 Evening Program
18:30 Dinner 19:30 Party Friday, 13.05.2016
Session 6: Genomics and Systems Biology
09:00 Towards a true isoform biology: deep long read sequencing reveals molecular co-association of distant splicing events in the human brain
Hagen Tilgner (Stanford University)09:30 Epigenomic establishment of macrophage tolerance and trained immunity
Henk Stunnenberg (Radboud Institute for Molecular Life Sciences)10:00 Establishment and maintenance of mammalian heterochromatin
Thomas Jenuwein (Max Planck Institute of Immunobiology and Epigenetics)10:30 Coffee break Session 7: Drug Design
11:00 Controlling biological activity with photopharmacology
Dirk Trauner (Ludwig-Maximilians-Universität Munich)11:30 Tools to probe the epigenetic code
Manfred Jung (University of Freiburg)12:00 Highly selective JAK3-inhibitors with a covalent-reversible binding mode targeting a nitrile induced arginine pocket
Stefan Laufer (University of Tübingen)12:30 Lunch Session 8: Neuroscience
14:00 Large protein and nanoparticle transport across the blood-brain barrier (BBB),with implications for drug delivery
N. Joan Abbott (King's College London)14:30 Glial glycogen and brain energy metabolism: new insights
Bruce R. Ransom (University of Washington)15:00 The interaction of genes and epigenes – A chromatin loop conferring an increased risk to develop Alzheimer’s disease
Johannes Gräff (École polytechnique fédérale de Lausanne)Fare-Well
15:30 Closing remarks and poster prize