Dr. Eva-Maria Niehaus, staatl. gepr. Lebensmittelchemikerin

Professur für Lebensmittelchemie (Prof. Humpf)

Corrensstraße 45
48149 Münster

  • Forschungsschwerpunkte

    • Molekulargenetische Arbeiten an Schimmelpilzen
    • Analyse von Sekundärmetaboliten

  • Lehre

    • Seminar: Institutsseminar [128231]
      (zusammen mit Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)

  • Publikationen

    • Vrabka J., Niehaus E.-M., Münsterkötter M., Proctor R.H., Brown D.W., Novák O., Pěnčik A., Tarkowská D., Hromadová K., Hradilová M., Oklešt'ková J., Oren-Young L., Idan Y., Sharon A., Maymon M., Elazar M., Freeman S., Güldener U., Tudzynski B., Galuszka P., Bergougnoux V. . ‘Production and Role of Hormones During Interaction of Fusarium Species With Maize (Zea mays L.) Seedlings.’ Frontiers in Plant Science 9.
    • Niehaus E.-M., Rindermann L., Janevska S., Münsterkötter M., Güldener U., Tudzynski B. . ‘Analysis of the global regulator Lae1 uncovers a connection between Lae1 and the histone acetyltransferase HAT1 in Fusarium fujikuroi.’ Applied Microbiology and Biotechnology 102, Nr. 1: 279-295. doi: 10.1007/s00253-017-8590-0.
    • Niehaus E.-M., Kim H., Münsterkötter M., Janevska S., Arndt B., Kalinina S., Houterman P., Ahn I., Alberti I., Tonti S., Kim D., Sieber C.M.K., Humpf H.-U., Yun S., Güldener U., Tudzynski B. . ‘Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles.’ PLoS Pathogens 13, Nr. 10. doi: 10.1371/journal.ppat.1006670.
    • Niehaus E.-M., Schumacher J., Burkhardt I., Rabe P., Münsterkötter M., Güldener U., Sieber C.M.K., Dickschat J., Tudzynski B. . ‘The GATA-type transcription factor Csm1 regulates conidiation and secondary metabolism in Fusarium fujikuroi.’ Frontiers in Microbiology 8, Nr. JUN. doi: 10.3389/fmicb.2017.01175.
    • Niehaus E.M., Münsterkötter M., Proctor R.H., Brown D.W., Sharon A., Idan Y., Oren-Young L., Sieber C.M.K., Novák O., Pěnčík A., Tarkowská D., Hromadová K., Freeman S., Maymon M., Elazar M., Youssef S., El-Shabrawy E., Shalaby A., Houterman P., Brock N., Burkhardt I., Tsavkelova E., Dickschat J., Galuszka P., Güldener U., Tudzynski B. . ‘Comparative "omics" of the fusarium fujikuroi species complex highlights differences in genetic potential and metabolite synthesis.’ Genome Biology and Evolution 8, Nr. 11: 3574-3599. doi: 10.1093/gbe/evw259.
    • Janevska S., Arndt B., Niehaus E.-M., Burkhardt I., Rösler S., Brock N., Humpf H.-U., Dickschat J., Tudzynski B. . ‘Gibepyrone biosynthesis in the rice pathogen Fusarium fujikuroi is facilitated by a small polyketide synthase gene cluster.’ Journal of Biological Chemistry 291, Nr. 53: 27403-27420. doi: 10.1074/jbc.M116.753053.
    • Studt L., Janevska S., Niehaus E.-M., Burkhardt I., Arndt B., Sieber C.M.K., Humpf H.-U., Dickschat J., Tudzynski B. . ‘Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi.’ Environmental Microbiology 18, Nr. 3: 936-956. doi: 10.1111/1462-2920.13150.
    • Niehaus E.-M., Studt L., Bargen K.W., Kummer W., Humpf H.-U., Reuter G., Tudzynski B. . ‘Sound of silence: The beauvericin cluster in fusarium fujikuroi is controlled by cluster-specific and global regulators mediated by H3K27 modification.’ Environmental Microbiology 18, Nr. 11: 4282-4302. doi: 10.1111/1462-2920.13576.
    • von Bargen K.W., Niehaus E.-M., Krug I., Bergander K., Würthwein E., Tudzynski B., Humpf H.-U. . ‘Isolation and Structure Elucidation of Fujikurins A-D: Products of the PKS19 Gene Cluster in Fusarium fujikuroi.’ Journal of Natural Products 78, Nr. 8: 1809-1815. doi: 10.1021/np5008137.
    • Niehaus E.-M., von Bargen K.W., Espino J.J., Pfannmüller A., Humpf H.-U., Tudzynski B. . ‘Characterization of the fusaric acid gene cluster in Fusarium fujikuroi.’ Applied microbiology and biotechnology 98, Nr. 4: 1749-62. doi: 10.1007/s00253-013-5453-1.
    • Niehaus E.-M., Janevska S., Von Bargen K.W., Sieber C.M.K., Harrer H., Humpf H.-U., Tudzynski B. . ‘Apicidin F: Characterization and genetic manipulation of a new secondary metabolite gene cluster in the rice pathogen Fusarium fujikuroi.’ PLoS ONE 9, Nr. 7. doi: 10.1371/journal.pone.0103336.
    • Studt L., Schmidt F.J., Jahn L., Sieber C.M.K., Connolly L.R., Niehaus E.-M., Freitag M., Humpf H.-U., Tudzynski B. . ‘Two histone deacetylases, FfHda1 and FfHda2, are important for Fusarium fujikuroi secondary metabolism and virulence.’ Applied and environmental microbiology 79, Nr. 24: 7719-34. doi: 10.1128/AEM.01557-13.
    • von Bargen K.W., Niehaus E.-M., Bergander K., Brun R., Tudzynski B., Humpf H.-U. . ‘Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi.’ Journal of natural products 76, Nr. 11: 2136-40. doi: 10.1021/np4006053.
    • Niehaus E.-M., Kleigrewe K., Wiemann P., Studt L., Sieber C.M.K., Connolly L.R., Freitag M., Güldener U., Tudzynski B., Humpf H.-U. . ‘Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the complex regulation and fusarin biosynthetic pathway.’ Chemistry & biology 20, Nr. 8: 1055-66. doi: 10.1016/j.chembiol.2013.07.004.
    • Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M., Espino J.J., Huß K., Michielse C.B., Albermann S., Wagner D., Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T., Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W., Proctor R.H., Münsterkötter M., Freitag M., Humpf H.-U., Güldener U., Tudzynski B. . ‘Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.’ PLoS pathogens 9, Nr. 6: e1003475. doi: 10.1371/journal.ppat.1003475.
    • Kleigrewe K., Niehaus E.-M., Wiemann P., Tudzynski B., Humpf H.-U. . ‘New approach via gene knockout and single-step chemical reaction for the synthesis of isotopically labeled fusarin c as an internal standard for the analysis of this fusarium mycotoxin in food and feed samples.’ Journal of agricultural and food chemistry 60, Nr. 34: 8350-5. doi: 10.1021/jf302534x.
    • Wiemann P., Albermann S., Niehaus E.-M., Studt L., Bargen K., Brock N., Humpf H.-U., Dickschat J., Tudzynski B. . ‘The Sfp-type 4′-phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity.’ PLoS ONE 7, Nr. 5. doi: 10.1371/journal.pone.0037519.