Dr. Eva-Maria Niehaus, staatl. gepr. Lebensmittelchemikerin

Professur für Lebensmittelchemie (Prof. Humpf)

Corrensstraße 45
48149 Münster

  • Forschungsschwerpunkte

    • Molekulargenetische Arbeiten an Schimmelpilzen
    • Analyse von Sekundärmetaboliten

  • Lehre

    • Seminar: Institutsseminar [128231]
      (zusammen mit Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)

  • Publikationen

    • Vrabka J., Niehaus E.-M., Münsterkötter M., Proctor R.H., Brown D.W. u. a. . ‘Production and Role of Hormones During Interaction of Fusarium Species With Maize (Zea mays L.) Seedlings.’ Frontiers in Plant Science 9.
    • Niehaus E.-M., Rindermann L., Janevska S., Münsterkötter M., Güldener U., Tudzynski B. . ‘Analysis of the global regulator Lae1 uncovers a connection between Lae1 and the histone acetyltransferase HAT1 in Fusarium fujikuroi.’ Applied Microbiology and Biotechnology 102, Nr. 1: 279-295. doi: 10.1007/s00253-017-8590-0.
    • Niehaus E.-M., Kim H., Münsterkötter M., Janevska S., Arndt B. u. a. . ‘Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles.’ PLoS Pathogens 13, Nr. 10. doi: 10.1371/journal.ppat.1006670.
    • Niehaus E.-M., Schumacher J., Burkhardt I., Rabe P., Münsterkötter M. u. a. . ‘The GATA-type transcription factor Csm1 regulates conidiation and secondary metabolism in Fusarium fujikuroi.’ Frontiers in Microbiology 8, Nr. JUN. doi: 10.3389/fmicb.2017.01175.
    • Niehaus E.M., Münsterkötter M., Proctor R.H., Brown D.W., Sharon A. u. a. . ‘Comparative "omics" of the fusarium fujikuroi species complex highlights differences in genetic potential and metabolite synthesis.’ Genome Biology and Evolution 8, Nr. 11: 3574-3599. doi: 10.1093/gbe/evw259.
    • Janevska S., Arndt B., Niehaus E.-M., Burkhardt I., Rösler S. u. a. . ‘Gibepyrone biosynthesis in the rice pathogen Fusarium fujikuroi is facilitated by a small polyketide synthase gene cluster.’ Journal of Biological Chemistry 291, Nr. 53: 27403-27420. doi: 10.1074/jbc.M116.753053.
    • Studt L., Janevska S., Niehaus E.-M., Burkhardt I., Arndt B. u. a. . ‘Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi.’ Environmental Microbiology 18, Nr. 3: 936-956. doi: 10.1111/1462-2920.13150.
    • Niehaus E.-M., Studt L., Bargen K.W., Kummer W., Humpf H.-U., Reuter G., Tudzynski B. . ‘Sound of silence: The beauvericin cluster in fusarium fujikuroi is controlled by cluster-specific and global regulators mediated by H3K27 modification.’ Environmental Microbiology 18, Nr. 11: 4282-4302. doi: 10.1111/1462-2920.13576.
    • von Bargen K.W., Niehaus E.-M., Krug I., Bergander K., Würthwein E., Tudzynski B., Humpf H.-U. . ‘Isolation and Structure Elucidation of Fujikurins A-D: Products of the PKS19 Gene Cluster in Fusarium fujikuroi.’ Journal of Natural Products 78, Nr. 8: 1809-1815. doi: 10.1021/np5008137.
    • Niehaus E.-M., von Bargen K.W., Espino J.J., Pfannmüller A., Humpf H.-U., Tudzynski B. . ‘Characterization of the fusaric acid gene cluster in Fusarium fujikuroi.’ Applied microbiology and biotechnology 98, Nr. 4: 1749-62. doi: 10.1007/s00253-013-5453-1.
    • Niehaus E.-M., Janevska S., Von Bargen K.W., Sieber C.M.K., Harrer H., Humpf H.-U., Tudzynski B. . ‘Apicidin F: Characterization and genetic manipulation of a new secondary metabolite gene cluster in the rice pathogen Fusarium fujikuroi.’ PLoS ONE 9, Nr. 7. doi: 10.1371/journal.pone.0103336.
    • Studt L., Schmidt F.J., Jahn L., Sieber C.M.K., Connolly L.R. u. a. . ‘Two histone deacetylases, FfHda1 and FfHda2, are important for Fusarium fujikuroi secondary metabolism and virulence.’ Applied and environmental microbiology 79, Nr. 24: 7719-34. doi: 10.1128/AEM.01557-13.
    • von Bargen K.W., Niehaus E.-M., Bergander K., Brun R., Tudzynski B., Humpf H.-U. . ‘Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi.’ Journal of natural products 76, Nr. 11: 2136-40. doi: 10.1021/np4006053.
    • Niehaus E.-M., Kleigrewe K., Wiemann P., Studt L., Sieber C.M.K. u. a. . ‘Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the complex regulation and fusarin biosynthetic pathway.’ Chemistry & biology 20, Nr. 8: 1055-66. doi: 10.1016/j.chembiol.2013.07.004.
    • Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M. u. a. . ‘Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.’ PLoS pathogens 9, Nr. 6: e1003475. doi: 10.1371/journal.ppat.1003475.
    • Kleigrewe K., Niehaus E.-M., Wiemann P., Tudzynski B., Humpf H.-U. . ‘New approach via gene knockout and single-step chemical reaction for the synthesis of isotopically labeled fusarin c as an internal standard for the analysis of this fusarium mycotoxin in food and feed samples.’ Journal of agricultural and food chemistry 60, Nr. 34: 8350-5. doi: 10.1021/jf302534x.
    • Wiemann P., Albermann S., Niehaus E.-M., Studt L., Bargen K. u. a. . ‘The Sfp-type 4′-phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity.’ PLoS ONE 7, Nr. 5. doi: 10.1371/journal.pone.0037519.