• Participation in “Cells in Motion”

    • Research interests: cell-matrix interactions, leukocyte extravasation, blood vessels, secondary lymphoid organs
    • Spokesperson for the Cells in Motion Interfaculty Centre
    • Member of the Research and Careers Committee
    • Supervisor in the CiM-IMPRS Graduate Programme
    • Member of the Imaging Network – Microscopy

  • News & views

  • Papers in the research focus “cell dynamics and imaging”

    2024

    Dalmau Gasull A, Glavan M, Samawar SKR, Kapupara K, Kelk J, Rubio M, Fumagalli S, Sorokin L, Vivien D, Prinz M. The niche matters: origin, function and fate of CNS-associated macrophages during health and disease. Acta Neuropathol 2024;147: 37. Abstract
    Denes A, Hansen CE, Oezorhan U, Figuerola S, de Vries HE, Sorokin L, Planas AM, Engelhardt B, Schwaninger M. Endothelial cells and macrophages as allies in the healthy and diseased brain. Acta Neuropathol 2024;147: 38. Abstract
    Deshpande T, Hannocks M-J, Kapupara K, Samawar SKR, Wachsmuth L, Faber C, Smith C, Wardlaw J, Sorokin L. Microglial activation without peripheral immune cell infiltration characterises mouse and human cerebral small vessel disease. Neuropathol Appl Neurobiol 2024;50: e13015. Abstract
    Park H, Song J, Jeong H-W, Gronloh MLB, Koh BI, Bovay E, Kim K-P, Klotz L, Thistlethwaite PA, van Buul JD, Sorokin L, Adams RH. Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis. Nat Commun 2024;15: 6282. Abstract
    Sorokin L, Correa LH. Whole-Mount Imaging of Adipose Tissue Macrophages. Methods Mol Biol 2024;2713: 307-322. Abstract

    2023

    Burmeister M, Fraunenstein A, Kahms M, Arends L, Gerwien H, Deshpande T, Kuhlmann T, Gross CC, Naik VN, Wiendl H, Klingauf J, Meissner F, Sorokin L. Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function. Sci Adv 2023;9: eadg0686. Abstract
    Luik A-L, Hannocks M-J, Loismann S, Kapupara K, Cerina M, van der Stoel M, Tsytsyura Y, Glyvuk N, Nordenvall C, Klingauf J, Huveneers S, Meuth S, Jakobsson L, Sorokin L. Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication. Matrix Biol 2023;121: 56-73. Abstract
    Paul Konken C, Beutel B, Schinor B, Song J, Gerwien H, Korpos E, Burmeister M, Riemann B, Schafers M, Sorokin L, Haufe G. Influence of N-arylsulfonamido d-valine N-substituents on the selectivity and potency of matrix metalloproteinase inhibitors. Bioorg Med Chem 2023;90: 117350. Abstract
    Song J, Deshpande T, Zhang X, Hannocks M-J, Lycke N, Cardell SL, Sorokin L. The extracellular matrix of lymph node reticular fibers modulates follicle border interactions and germinal center formation. iScience 2023;26: 106753. Abstract
    Xue Y, Lin L, Li Q, Liu K, Hu M, Ye J, Cao J, Zhai J, Zheng F, Wang Y, Zhang T, Du L, Gao C, Wang G, Wang X, Qin J, Liao X, Kong X, Sorokin L, Shi Y, Wang Y. SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes. Adv Sci (Weinh) 2023;10: e2201949. Abstract

    2022

    Carmona-Rodriguez L, Martinez-Rey D, Martin-Gonzalez P, Franch M, Sorokin L, Mira E, Manes S. Superoxide Dismutase-3 Downregulates Laminin alpha5 Expression in Tumor Endothelial Cells via the Inhibition of Nuclear Factor Kappa B Signaling. Cancers (Basel) 2022;14Abstract
    Jeong H-W, Dieguez-Hurtado R, Arf H, Song J, Park H, Kruse K, Sorokin L, Adams RH. Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain. Elife 2022;11Abstract
    Kim EJY, Sorokin L, Hiiragi T. ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development 2022;149Abstract
    Siret C, van Lessen M, Bavais J, Jeong HW, Reddy Samawar SK, Kapupara K, Wang S, Simic M, de Fabritus L, Tchoghandjian A, Fallet M, Huang H, Sarrazin S, Sieweke MH, Stumm R, Sorokin L, Adams RH, Schulte-Merker S, Kiefer F, van de Pavert SA. Deciphering the heterogeneity of the Lyve1(+) perivascular macrophages in the mouse brain. Nat Commun 2022;13: 7366. Abstract

    2021

    Gan Y, Zhang T, Chen X, Cao W, Lin L, Du L, Wang Y, Zhou F, He X, He Y, Gan J, Sheng H, Sorokin L, Shi Y, Wang Y. Steroids Enable Mesenchymal Stromal Cells to Promote CD8(+) T Cell Proliferation Via VEGF-C. Adv Sci (Weinh) 2021;8: 2003712. Abstract
    Hartlehnert M, Borsch A-L, Li X, Burmeister M, Gerwien H, Schafflick D, Heming M, Lu I-N, Narayanan V, Strecker J-K, Kolz A, Peters A, Wu GF, Wiendl H, Sorokin L, Meyer Zu Horste G. Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation. Proc Natl Acad Sci U S A 2021;118Abstract
    Korpos E, Kadri N, Loismann S, Findeisen CR, Arfuso F, Burke GW 3rd, Richardson SJ, Morgan NG, Bogdani M, Pugliese A, Sorokin L. Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes. Diabetologia 2021;64: 1626-1641. Abstract
    Liu J, Long H, Zeuschner D, Rader AFB, Polacheck WJ, Kessler H, Sorokin L, Trappmann B. Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting. Nat Commun 2021;12: 3402. Abstract

    2020

    Betterman KL, Sutton DL, Secker GA, Kazenwadel J, Oszmiana A, Lim L, Miura N, Sorokin L, Hogan BM, Kahn ML, McNeill H, Harvey NL. Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. J Clin Invest 2020;130: 3315-3328. Abstract
    Hallmann R, Hannocks M-J, Song J, Zhang X, Di Russo J, Luik A-L, Burmeister M, Gerwien H, Sorokin L. The role of basement membrane laminins in vascular function. Int J Biochem Cell Biol 2020;127: 105823. Abstract
    Li L, Song J, Chuquisana O, Hannocks M-J, Loismann S, Vogl T, Roth J, Hallmann R, Sorokin L. Endothelial Basement Membrane Laminins as an Environmental Cue in Monocyte Differentiation to Macrophages. Front Immunol 2020;11: 584229. Abstract
    Polisetti N, Giessl A, Li S, Sorokin L, Kruse FE, Schlotzer-Schrehardt U. Laminin-511-E8 promotes efficient in vitro expansion of human limbal melanocytes. Sci Rep 2020;10: 11074. Abstract
    Samus M, Li Y-T, Sorokin L, Rottner K, Vestweber D. Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System. J Neurosci 2020;40: 1389-1404. Abstract
    Zhang X, Wang Y, Song J, Gerwien H, Chuquisana O, Chashchina A, Denz C, Sorokin L. The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain. J Exp Med 2020;217: e20191339. Abstract

    2019

    Hannocks M-J, Zhang X, Gerwien H, Chashchina A, Burmeister M, Korpos E, Song J, Sorokin L. The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes. Matrix Biol 2019;75-76: 102-113. Abstract
    Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Ergun S, Henke E, Nieswandt B. Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood 2019;133: 2696-2706. Abstract

    2018

    Beutel B, Song J, Konken CP, Korpos E, Schinor B, Gerwien H, Vidyadharan R, Burmeister M, Li L, Haufe G, Sorokin L. New in Vivo Compatible Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitors. Bioconjug Chem 2018;29: 3715-3725. Abstract
    Breuer J, Korpos E, Hannocks M-J, Schneider-Hohendorf T, Song J, Zondler L, Herich S, Flanagan K, Korn T, Zarbock A, Kuhlmann T, Sorokin L, Wiendl H, Schwab N. Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus. J Neuroinflammation 2018;15: 236. Abstract
    Hannocks M-J, Pizzo ME, Huppert J, Deshpande T, Abbott NJ, Thorne RG, Sorokin L. Molecular characterization of perivascular drainage pathways in the murine brain. J Cereb Blood Flow Metab 2018;38: 669-686. Abstract
    Masthoff M, Gran S, Zhang X, Wachsmuth L, Bietenbeck M, Helfen A, Heindel W, Sorokin L, Roth J, Eisenblätter M, Wildgruber M, Faber C. Temporal window for detection of inflammatory disease using dynamic cell tracking with time-lapse MRI. Sci Rep 2018;8: 9563. Abstract
    Nascimento MA, Sorokin L, Coelho-Sampaio T. Fractone Bulbs Derive from Ependymal Cells and Their Laminin Composition Influence the Stem Cell Niche in the Subventricular Zone. J Neurosci 2018;38: 3880-3889. Abstract
    Pizzo ME, Wolak DJ, Kumar NN, Brunette E, Brunnquell CL, Hannocks M-J, Abbott NJ, Meyerand ME, Sorokin L, Stanimirovic DB, Thorne RG. Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery. J Physiol 2018;596: 445-475. Abstract
    Samus M, Seelige R, Schafer K, Sorokin L, Vestweber D. CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. J Leukoc Biol 2018;104: 787-797. Abstract
    Susek KH, Korpos E, Huppert J, Wu C, Savelyeva I, Rosenbauer F, Muller-Tidow C, Koschmieder S, Sorokin L. Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow. Matrix Biol 2018;67: 47-62. Abstract
    Tuchscherr L, Korpos E, van de Vyver H, Findeisen C, Kherkheulidze S, Siegmund A, Deinhardt-Emmer S, Bach O, Rindert M, Mellmann A, Sunderkotter C, Peters G, Sorokin L, Löffler B. Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts. Int J Med Microbiol 2018;308: 761-769. Abstract

    2017

    Di Russo J, Hannocks M-J, Luik A-L, Song J, Zhang X, Yousif L, Aspite G, Hallmann R, Sorokin L. Vascular laminins in physiology and pathology. Matrix Biol 2017;57-58: 140-148. Abstract
    Di Russo J, Luik A-L, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker E NTP, Hellstrand P, Bhattachariya A, Albinsson S, Pincet F, Hallmann R, Sorokin L. Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J 2017;36: 183-201. Abstract
    Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol 2017;19: 189-201. Abstract
    Polisetti N, Sorokin L, Okumura N, Koizumi N, Kinoshita S, Kruse FE, Schlotzer-Schrehardt U. Laminin-511 and -521-based matrices for efficient ex vivo-expansion of human limbal epithelial progenitor cells. Sci Rep 2017;7: 5152. Abstract
    Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lütke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L. Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration. Cell Rep 2017;18: 1256-1269. Abstract

    2016

    Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lütke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J. Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun 2016;7: 10828. Abstract
    Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen Z-L, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol 2016;56: 42-56. Abstract
    Gerwien H, Hermann S, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer N, Opdenakker G, Wiendl H, Schäfers M, Sorokin L. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med 2016;8: 364ra152. Abstract
    Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L. Laminin alpha5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol 2016;56: 24-41. Abstract

    2015

    Hallmann R, Zhang X, Di Russo J, Li L, Song J, Hannocks M-J, Sorokin L. The regulation of immune cell trafficking by the extracellular matrix. Curr Opin Cell Biol 2015;36: 54-61. Abstract
    Liu Z, Xu Y, Zhang X, Song J, Sorokin L, Bahler M. The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J Neuroimmunol 2015;282: 25-32. Abstract
    Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schafers M, Korner H, Opdenakker G, Hallmann R, Sorokin L. Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Cell Rep 2015;10: 1040-1054. Abstract
    Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz H-J, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab 2015;35: 1711-1721. Abstract

    2014

    Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN. Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep 2014;14: 552. Abstract
    Deak F, Mates L, Korpos E, Zvara A, Szenasi T, Kiricsi M, Mendler L, Keller-Pinter A, Ozsvari B, Juhasz H, Sorokin L, Dux L, Mermod N, Puskas LG, Kiss I. Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration. J Cell Sci 2014;127: 3240-3256. Abstract
    Schneider-Hohendorf T, Rossaint J, Mohan H, Boning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med 2014;211: 1833-1846. Abstract
    Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L. Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nat Cell Biol 2014;16: 931-941. Abstract
    Spenle C, Lefebvre O, Lacroute J, Mechine-Neuville A, Barreau F, Blottiere HM, Duclos B, Arnold C, Hussenet T, Hemmerle J, Gullberg D, Kedinger M, Sorokin L, Orend G, Simon-Assmann P. The laminin response in inflammatory bowel disease: protection or malignancy?. PLoS One 2014;9: e111336. Abstract

    2013

    Enzmann G, Mysiorek C, Gorina R, Cheng Y-J, Ghavampour S, Hannocks M-J, Prinz V, Dirnagl U, Endres M, Prinz M, Beschorner R, Harter PN, Mittelbronn M, Engelhardt B, Sorokin L. The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol 2013;125: 395-412. Abstract
    Korpos E, Kadri N, Kappelhoff R, Wegner J, Overall CM, Weber E, Holmberg D, Cardell S, Sorokin L. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013;62: 531-542. Abstract
    Song J, Wu C, Zhang X, Sorokin LM. In Vivo Processing of CXCL5 (LIX) by Matrix Metalloproteinase (MMP)-2 and MMP-9 Promotes Early Neutrophil Recruitment in IL-1beta-Induced Peritonitis. J Immunol 2013;190: 401-410. Abstract
    Yousif L, Di Russo J, Sorokin L. Laminin isoforms in endothelial and perivascular basement membranes. Cell Adh Migr 2013;7: 101-110. Abstract
    Zhang X, Wu C, Song J, Gotte M, Sorokin L. Syndecan-1, a Cell Surface Proteoglycan, Negatively Regulates Initial Leukocyte Recruitment to the Brain across the Choroid Plexus in Murine Experimental Autoimmune Encephalomyelitis. J Immunol 2013;191: 4551-4561. Abstract

    2012

    Steiner E, Enzmann GU, Lin S, Ghavampour S, Hannocks M-J, Zuber B, Ruegg MA, Sorokin L, Engelhardt B. Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia 2012;60: 1646-1659. Abstract

    2006

    Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L, Nourshargh S. Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J Exp Med 2006;203: 1519-1532. Abstract