• Participation in “Cells in Motion”

    • Research interests: membrane trafficking and signal transduction, regulatory protein complexes of small GTPases, mechanisms of membrane targeting, protein structure analysis, protein engineering and inhibitor design
    • Supervisor in the CiM-IMPRS Graduate Programme

  • News & views

  • Papers in the research focus “cell dynamics and imaging”

    2022

    Klink BU, Herrmann E, Antoni C, Langemeyer L, Kiontke S, Gatsogiannis C, Ungermann C, Raunser S, Kümmel D. Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation. Proc Natl Acad Sci USA 2022;119: e2121494119. Abstract
    Peters A, Herrmann E, Cornelissen NV, Klocker N, Kummel D, Rentmeister A. Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases. Chembiochem 2022;23: e202100437. Abstract

    2021

    Fitzian K, Bruckner A, Brohee L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kummel D. TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol Cell 2021;81: 2705-2721.e8. Abstract
    Michailidou F, Klocker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kummel D, Rentmeister A. Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew Chem Int Ed Engl 2021;60: 480-485. Abstract

    2020

    Hansmann P, Bruckner A, Kiontke S, Berkenfeld B, Seebohm G, Brouillard P, Vikkula M, Jansen FE, Nellist M, Oeckinghaus A, Kummel D. Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. Structure 2020;28: 933-942.e4. Abstract

    2017

    Kiontke S, Langemeyer L, Kuhlee A, Schuback S, Raunser S, Ungermann C, Kummel D. Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1. Nat Commun 2017;8: 14034. Abstract