Dr. Jens Köhler
wissenschaftlicher Mitarbeiter

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Kontakt

PharmaCampus der Universität Münster
Institut für Pharmazeutische und Medizinische Chemie
Corrensstraße 48
48149 Münster

Tel.: +49 (0)251 83-32274
Raum: A 120.204
E-Mail

 

Tätigkeiten am Institut

Lehraufgaben/ Praktikumsbetreuung

Forschungsschwerpunkte

  • Lipasen – katalytische und regulatorische Eigenschaften
Publikationen
 
Dissertation
  • Lipasen zur asymmetrischen Synthese enantiomerenreiner NMDA-Rezeptor-Antagonisten mit 1,3-Dioxan-Struktur und Untersuchung der Reaktionskinetik (2007)

Veröffentlichungen

  • Köhler J., Bergander K., Fabian J., Schepmann D., Wünsch B. Enantiomerically Pure 1,3-Dioxanes as Highly Selective NMDA and σ1 Receptor Ligands. Journal of Medicinal Chemistry 2012, 55, 8953–8957.
    doi: 10.1021/jm301166m
  • Sarkar S., Schepmann D., Köhler J., Fröhlich R., Wünsch B. Asymmetric Synthesis of Potent and Selective σ1 Receptor Ligands with Tetrahydro-3-benzazepine Scaffold. European Journal of Medicinal Chemistry 2012, 30, 5980–5990.
    doi: 10.1002/ejoc.201200927
  • Köhler J., Erlenkamp G., Eberlin A., Rumpf T., Slynko I., Metzger E., Schüle R., Sippl W., Jung M. Lestaurtinib Inhibits Histone Phosphorylation and Androgen-Dependent Gene Expression in Prostate Cancer Cells. PLoS ONE 2012, 7:e34973.
    doi: 10.1371/journal.pone.0034973
  • Köhler J., Wünsch B. Conversion of a pentane-1,3,5-triol derivative using lipases as chiral catalysts and possible function of the lid for the regulation of substrate selectivity and enantioselectivity. Biocatalysis and Biotransformation 2012, 30, 217-225.
    doi: 10.3109/10242422.2012.661726
  • Utech T., Köhler J., Wünsch B. Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists. European Journal of Medicinal Chemistry 2011, 46, 2157-2169.
    doi: 10.1016/j.ejmech.2011.02.070
  • Utech T., Köhler J., Buschmann H., Holenz J., Vela J., Wünsch B., Synthesis and Pharmacological Evaluation of a Potent and Selective σ1 Receptor Antagonist with High Antiallodynic Activity. Archiv der Pharmazie 2011, 344, 415-421
    doi:10.1002/ardp.201000365
  • Banerjee A., Schepmann D., Köhler J., Würthwein E.-U., Wünsch B. Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists. Bioorganic and Medicinal Chemistry 2010, 18, 7855-7867.
    doi: 10.1016/j.bmc.2010.09.047
  • Köhler J., Wünsch B. The allosteric modulation of lipases and its possible biological relevance. Theoretical Biology and Medical Modelling 2007, 4:34.
    doi:10.1186/1742-4682-4-34
  • Köhler J., Wünsch B. Computer simulation of asymmetric transformations. Tetrahedron: Asymmetry 2006, 17, 3100-3110.
    doi:10.1016/j.tetasy.2006.11.040
    Supplemental Excel Spreadsheets for the article.
  • Köhler J., Wünsch B. Lipase catalyzed enantioselective desymmetrization of a prochiral pentane-1,3,5-triol derivative. Tetrahedron: Asymmetry 2006, 17, 3091-3099.
    doi:10.1016/j.tetasy.2006.10.043

Tagungsbeiträge

  • Köhler J.; Mathias U.; Orth J.; Jank T.; Aktories K.; Sippl W.; Jung M. A homogeneous fluorimetric assay for inhibitors of the ADP-ribosylating enzyme MTX. EMBL Conference on Chemical Biology, 8th – 11th October 2008, Heidelberg. (Poster)
  • Köhler J., Zelenka C., Wünsch B. Lipase catalyzed enantioselective acetylation of a prochiral pentane-1,3,5-triol derivative. IRTG Tagung am 4. - 5. September 2006, Münster. (Poster)

Patentanmeldung

  • Köhler J., Wünsch B. Lipasenmodulation (DE) vom 23.06.2005, offengelegt im Patentblatt 2006, 126, 40759.