Dr. Jörg Fabian
Apotheker

© Dziemba

Kontakt

PharmaCampus der Universität Münster
Institut für Pharmazeutische und Medizinische Chemie
Corrensstraße 48, 48149 Münster, Germany

Tel.: +49 (0)251 83-33326
Raum: A 120.217
E-Mail: jfabian[@]wwu[dot]de

ORCID-ID: 0000-0001-9673-5527



Tätigkeiten am Institut

Lehraufgaben/ Praktikumsbetreuung

wissenschaftliche Verwaltungsaufgaben

  • Abteilungsleiter Massenspektrometrie

nichtwissenschaftliche Verwaltungsaufgaben

  • Bibliotheksbeauftragter
  • Campusmanagementbeauftragter


Forschungsschwerpunkte

  • Präklinische Pharmakokinetik
    • metabolische Stabilität von potenziellen Wirkstoffen
    • Bestimmung der CYP P450 Enzym-Spezifitäten
    • Strukturaufklärung von Metaboliten mittels LC-MSn
    • LogP/LogD-Wert Bestimmung
    • Dialyse
  • Mikrosomale Prostaglandin E2 Synthase (mPGES-1) - Synthese und Screening potenzieller Inhibitoren
  • Entwicklung und Etablierung von LC-MSn Methoden zur qualitativen und quantitativen Bestimmung von Analyten in biologischen Matrices
  • automatisierte Probenvorbereitung
  • Entwicklung von innovativen Methoden zum Therapeutischen Drug Monitoring mit DBS
  • Entwicklung von innovativen Methoden zum Biomarker-Screening

Publikationen

 Dissertation

  • Regioselektive Synthese von Furo[2,3-c]-, Pyrrolo[2,3-c]- und Pyridazino[4,5-c]chinolinen
    Dissertation, Universität Braunschweig, 2000

Veröffentlichungen

  • Gorlitzer, K.; Fabian, J.; Jones, P. G.; Frohberg, P.; Drutkowski, G. Furo[2,3-c]quinolines and furo[3,4-c]quinolones--synthesis and investigation of lipoxygenase inhibition. Pharmazie 2002, 57, 159-168.

  • Gorlitzer, K.; Fabian, J.; Frohberg, P.; Drutkowski, G. Pyrrolo[2,3-c]quinolines and pyrrolo[3,4-c]quinolines--synthesis and investigation of lipoxygenase inhibition. Pharmazie 2002, 57, 243-249.

  • Gorlitzer, K.; Fabian, J.; Jones, P. G.; Frohberg, P.; Drutkowski, G. Pyridazino[3,4-c]quinolines and pyridazino[4,5-c]quinolines--synthesis and investigation of lipoxygenase inhibition. Pharmazie 2002, 57, 362-371.

  • Gorlitzer, K.; Fabian, J.; Jones, P. G. Cleavage of a dithioacetalmonosulfoxide. Pharmazie 2002, 57, 453-5.

  • Gorlitzer, K.; Fabian, J.; Trittmacher, J., Dimers from o-nitrobenzylidene acetoacetic esters. Pharmazie 2005, 60, 571-3.

  • Fabian, J.; Lehr, M. Normal-phase HPLC and HPLC-MS studies of the metabolism of a cytosolic phospholipase A2alpha inhibitor with activated ketone group by rat liver microsomes. J Pharm Biomed Anal 2007, 43(2), 601-5.

  • Fritsche, A.; Elfringhoff, A. S.; Fabian, J.; Lehr, M. 1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility. Bioorg Med Chem. 2008,  16(7),  3489-500.

  • Schmolke, M.; Fabian, J.; Lehr, M. High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C. Anal Biochem 2008, 375, 291-8.

  • Fabian, J. Determination of PGE2 by on-line solid-phase extraction-liquid chromatography with ultraviolet detection for microsomal prostaglandin E2 synthase-1 inhibitor screening, J Chromatogr B Analyt Technol Biomed Life Sci. 2008; 875 (2): 557-561

  • Drews, A.; Bovens, S.; Roebrock, K.; Sunderkotter, C.; Reinhardt, D.; Schafers, M.; van der Velde, A.; Schulze Elfringhoff, A.; Fabian, J.; Lehr, M. 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. J Med Chem 2010, 53, 5165-78

  • Wiegard, A.; Hanekamp, W.; Griessbach, K.; Fabian, J.; Lehr, M. Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E(2) synthase-1. Eur J Med Chem 2012, 48, 153-63

  • Kohler, J.; Bergander, K.; Fabian, J.; Schepmann, D.; Wunsch, B. Enantiomerically pure 1,3-dioxanes as highly selective NMDA and sigma(1) receptor ligands. J Med Chem 2012, 55, 8953-7.

  • Fabian, J.; Hanekamp, W.; Thomas, M. H.; Olivier, J. L.; Lehr, M., Investigations on the metabolic stability of cytosolic phospholipase A2alpha inhibitors with 1-indolylpropan-2-one structure. Chem Biol Interact 2013, 206 (2), 356-63

  • Sundermann, T.; Fabian, J.; Hanekamp, W.; Lehr, M.
    1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2a and fatty acid amide hydrolase: Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability
    Bioorg. Med. Chem. 2015, 23, 2579-2592

  • Lehr, M.; Fabian, J.; Hanekamp, W.
    Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones.
    Biopharm. Drug Dispos. 2015, 36, 398-404.

 

  • Stein, Nora C.; Mulac, Dennis; Fabian, Jörg; Herrmann, Fabian C.; Langer, Klaus (2020): Nanoparticle albumin-bound mTHPC for photodynamic therapy: Preparation and comprehensive characterization of a promising drug delivery system. In: International journal of pharmaceutics 582, S. 119347. DOI: 10.1016/j.ijpharm.2020.119347.

  • Fabian, Jörg; Mergemeier, Kira; Lehr, Matthias (2021): Evaluation of inhibitors of the arachidonic acid cascade with intact platelets using an on-line dilution and on-line solid phase extraction HPLC-MS method. In: Prostaglandins & other lipid mediators 155, S. 106551. DOI: 10.1016/j.prostaglandins.2021.106551

  • Liu, Yang; Chen, Qi; Han, Dong; Schoeler, Hans; Fabian, Jörg; Stehling, Martin et al. (2021): Dopamine signaling regulates hematopoietic stem and progenitor cell function. Blood, DOI: 10.1182/blood.2020010419

  • Ke, L., Wang, Y., Schäfer, M., Städler, T., Zeng, R., Fabian, J., Pulido, H., De Moraes, C. M., Song, Y., & Xu, S. (2021). Transcriptomic Profiling Reveals Shared Signalling Networks Between Flower Development and Herbivory-Induced Responses in Tomato. Frontiers in plant science, 12, 722810. https://doi.org/10.3389/fpls.2021.722810


Tagungsbeiträge

  • J. Fabian, K. Görlitzer; Furo[2,3-c]-, Pyrrolo[2,3-c]- and Pyridazino[4,5-c]-quinolines (Poster)
    17th International Congress of Heterocyclic Chemistry, Wien, 1.-7. August 1999.
  • J. Fabian, M. Lehr; Metabolism of a cytosolic Phospholipase A2α Inhibitor with an activated ketone group by rat liver microsomes (Poster)
    Jahrestagung der DPhG 2005 in Mainz
  • J. Fabian, M. Lehr; Characterization of human cytochrome P450 enzymes involved in the metabolism of cPLA2α inhibitors with 1-Indol-1-ylpropan-2-one skeleton (Poster), Jahrestagung der DPhG 2007 in Erlangen
  • M. Schmolke, J. Fabian, M. Lehr; HPLC-UV assay for evaluation of inhibitors of phosphatidylinositol-specific phopholipase C, Jahrestagung der DPhG 2007 in Erlangen
  • M. Siebelmann, G. Miesner, J. Fabian, E.J. Verspohl, The angiotensin generating system in the insulinoma cell line INS-1 (Poster), Jahrestagung der DPhG 2007 in Erlangen