PhD Student
Computational Drug Discovery

M.Sc. Chemistry

E-Mail: friederike.fuesser@uni-muenster.de
Institute of Pharmaceutical and Medicinal Chemistry
Corrensstr. 48
48149 Münster

 

 

 

 

Research Topic

My project is related to the development of a lead candidate molecule for the treatment of tuberculosis. I am responsible for the biochemical and biophysical characterisation of the underlying inhibitor of the M. tuberculosis thioredoxin reductase. For this purpose, I combine biochemical laboratory work with computer-based methods. This includes protein expression, analysis of the interactions and crystallography to obtain a crystal structure of the protein-inhibitor complex, crystallographic fragment screening and the computer-based methods of molecular design to optimise the inhibitor.

Publications

Isaak, A., Dobelmann, C., Füsser, F. T., Erlitz, K. S., Koch, O. Junker, A. Unveiling the Structure-Activity Relationships at the Orthosteric Binding Site of P2X Ion Channels: The Route to Selectivity. Journal of medicinal chemistry, 2022, [Online]. https://doi.org/10.1021/acs.jmedchem.2c00812

Marchetti, G. M., Füsser, F., Singh, R. K., Brummel, M., Koch, O., Kümmel, D., Hippler, M. Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii. Journal of structural biology 2022, 214 (1), 107829. https://doi.org/10.1016/j.jsb.2021.107829

PDB: Fuesser, F., Kuemmel, D. (2021), Chlamydomonas reinhardtii NADPH Dependent Thioredoxin Reductase 1 domain CS mutant. http://doi.org/10.2210/pdb7P9E/pdb

Patberg, M., Isaak, A., Füsser, F., Ortiz Zacarías, N. V., Vinnenberg, L., Schulte, J., Michetti, L., Grey, L., van der Horst, C., Hundehege, P., Koch, O., Heitman, L. H., Budde, T., Junker, A. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. European journal of medicinal chemistry 2021, 226, 113838. https://doi.org/10.1016/j.ejmech.2021.113838

Bhagawati, M., Terhorst, T. M. E., Füsser, F., Hoffmann, S., Pasch, T., Pietrokovski, S., Mootz, H. D. A mesophilic cysteine-less split intein for protein trans-splicing applications under oxidizing conditions. Proceedings of the National Academy of Sciences of the United States of America 2019, 116 (44), 22164–22172. https://doi.org/10.1073/pnas.1909825116