Dr. Matthias Lechtenberg
Institut für Pharmazeutische Biologie und Phytochemie, Corrensstraße 48, 48149 Münster
Tel.: +49 251 83 34670
Raum: A 120.229
Forschungsprofile
Lebenslauf
1985- 1990 Studium der Lebensmittelchemie an der Westfälischen Wilhelms-Universität, Münster
1990 1. Staatsexamen Lebensmittelchemie; 1990-1991 Praktisches Jahr im ChLUA, Münster
1991 2. Staatsexamen Lebensmittelchemie
Feb. 1992 - Feb. 1996 Promotion (bei Prof. A. Nahrstedt), Universität Münster, Institut für Pharmazeutische Biologie und Phytochemie: Cyanogene Glykoside in Rosaceae
März - Mai 1996 Sertürner Arzneimittel, Gütersloh
seit Juni 1996 akademischer Rat am Institut für Pharmazeutische Biologie und Phytochemie
seit 2002 akadem. Oberrat am Institut für Pharmazeutische Biologie und Phytochemie.
Forschung
Qualitätsbeurteilung von Nahrungsergänzungsmitteln
Naturstoffanalytik (DC, CE, U(H)PLC, HPLC, GC, FCPC etc.); speziell: Cyanogene Glykoside
Extraktion, Fraktionierung, Isolierung, Strukturaufklärung, Quantifizierung
Lehre
Modul "Biologie der Nutzpflanzen und Bioaktivität" B.Sc. Lebensmittelchemie
Praktikum Pharmazeutische Biologie III (Biologische und Phytochemische Untersuchungen) für Pharmazeuten
Betreuung von Bachelor- und Masterarbeiten (B.Sc. / M.Sc. Lebensmittelchemie, M.Sc. Arzneimitelwissenschaften)
Publikationen
- . . „Glucoraphanin in Keimsaaten.“ Zeitschrift für Phytotherapie 44, Nr. 06: 257–267. doi: 10.1055/a-2179-8902.
- . . „Nahrungsergänzungsmittel auf Basis von Safran – wie sieht die Qualitätssituation aus?“ Zeitschrift für Phytotherapie 43, Nr. 4: 178–185. doi: 10.1055/a-1716-9696.
- . . ‘Cyanogenesis in Aralia spinosa (Araliaceae).’ Planta Medica 88, Nr. 13: 1209–1222. doi: 10.1055/a-1671-5525.
- . . ‘Mannose-enthaltende Nahrungsergänzungsmittel – wie sieht die Qualitätssituation aus?’ Zeitschrift für Phytotherapie 43, Nr. 5: 204–208. doi: 10.1055/a-1857-9517.
- . . „Nahrungsergänzungsmittel auf Basis von Heidelbeeren - Wie sieht die Qualitätssituation aus?“ Zeitschrift für Phytotherapie 42: 69–81. doi: 10.1055/a-1336-6346.
- . . ‘Quality Assessment of Bilberry Fruits (Vaccinium myrtillus) and Bilberry-Containing Dietary Supplements.’ J. Agric. Food Chem. 2021. doi: 10.1021/acs.jafc.0c07784.
- . . Cyanogenic Glycosides and Biogenetically Related Compounds in Higher Plants and Animals. doi: 10.1002/9780470015902.a0029316.
- . . ‘An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β-D-glucosyl-9-O-(6′′-deoxysaccharosyl)olivil in Valerian Root.’ Planta Medica 2020. doi: 10.1055/a-1078-5195.
- . . „Nahrungsergänzungsmittel auf Brokkolibasis – wie sieht die Qualitätssituation aus?“ Zeitschrift für Phytotherapie 41(3): 113–122. doi: 10.1055/a-1126-9287.
- . . „Baldrian: Auf der Suche nach dem "Schlaflignan".“ phytotherapie.at 14, Nr. 6: 23.
- . . „Nahrungsergänzungsmittel auf Brokkolibasis – eine Frage der Qualität!“ Z Phytother [Kongressbeitrag] 40, Nr. S1: 19–20. doi: 10.1055/s-0039-1697283.
- . „Baldrianwurzel – Auf der Suche nach dem Schlaflignan.“ präsentiert auf der Phytotherapiekongress 2019, Münster, . doi: 10.1055/s-0039-1697322.
- . . ‘Determination of glucosinolates in broccoli-based dietary supplements by cyclodextrin-mediated capillary zone electrophoresis.’ Journal of Food Composition and Analysis 78: 138–149. doi: 10.1016/j.jfca.2019.02.007.
- . . „Hepatotoxisch und karzinogen - Pyrrolizidinalkaloide in Arznei- und Lebensmitteln sorgen für Probleme.“ Deutsche Apotheker Zeitung 31, Nr. 157: 32–40.
- ‘Flavan-3-ols and proanthocyanidins from Limonium brasiliense inhibit the adhesion of Porphyromonas gingivalis to epithelial host cells by interaction with gingipains.’ Fitoterapia 118, Nr. null: 87–93. doi: 10.1016/j.fitote.2017.03.002. .
- . . ‘Aqueous extract from Orthosiphon stamineus leaves prevents bladder and kidney infection in mice.’ Phytomedicine 28. doi: 10.1016/j.phymed.2017.02.009.
- „Von der Ethnopharmakologie zur rationalen Phytotherapie: Phytochemische Charakterisierung und präklinische Untersuchungen zur potenziellen Wundheilungsaktivität von Extrakten aus Combretum mucronatum Schum& Thonn.“ Zeitschrift für Phytotherapie 37, Nr. 2: 59–65. doi: 10.1055/s-0042-104378. .
- „Uncomplicated urinary tract infections: The efficacy of extracts from corn silk (Zea mays L.) against uropathogenic E. coli.“ Zeitschrift für Phytotherapie 37, Nr. 1: 9–15. doi: 10.1055/s-0042-102715. .
- „Safran gegen Depressionen.“ Deutsche Apotheker-Zeitung 156, Nr. 25. .
- . . „Nachweis und quantitative Bestimmung von Piperin in Cayennepfeffer, Chillipulver und Rosenpaprika – Sind Verunreinigungen mit echtem Pfeffer technisch unvermeidbar? .“ Lebensmittelchemie 70: 81–112. doi: 10.1002/lemi.201690028.
- . . „Unkomplizierte Harnwegsinfektionen: Extrakte aus Maisgriffeln (Zea mays L.) wirken gegen uropathogene E. coli.“ Zeitschrift für Phytotherapie 37: 9–12.
- ‘From Ethnopharmacological Field Study to Phytochemistry and Preclinical Research: The Example of Ghanaian Medicinal Plants for Improved Wound Healing.’ In Ethnopharmacology, edited by , 179–196. Chichester: John Wiley & Sons. .
- ‘Isolation and Quantification of Oligomeric and Polymeric Procyanidins in the Aerial Parts of St John' Wort (Hypericum perforatum).’ Planta Medica 81, Nr. null: 1175–1181. doi: 10.1055/s-0035-1545916. .
- . . ‘Phytochemical characterization and in vitro wound healing activity of leaf extracts from Combretum mucronatum Schum. & Thonn.: Oligomeric procyanidins as strong inductors of cellular differentiation.’ Journal of Ethnopharmacology 174: 628–636. doi: 10.1016/j.jep.2015.06.008.
- . . ‘Traditionally used medicinal plants against uncomplicated urinary tract infections: Are unusual, flavan-4-ol- and derhamnosylmaysin derivatives responsible for the antiadhesive activity of extracts obtained from stigmata of Zea mays L. against uropathogenic E. coli and Benzethonium chloride as frequent contaminant faking potential antibacterial activities?’ Fitoterapia 105, Nr. null: 246–253. doi: 10.1016/j.fitote.2015.07.014.
- . . ‘Isolation and quantification of oligomeric and polymeric procyanidins in leaves and flowers of Hawthorn (Crataegus spp.).’ Fitoterapia 104, Nr. null: 14–22. doi: 10.1016/j.fitote.2015.04.010.
- . . ‘Concentrated green tea extract induces severe acute hepatitis in a 63-year-old woman--a case report with pharmaceutical analysis.’ Journal of Ethnopharmacology 155, Nr. 1: 165. doi: 10.1016/j.jep.2014.05.015.
- . . ‘Concentrated green tea extract induces severe acute hepatitis in a 63-year-old woman--a case report with pharmaceutical Analysis.’ Journal of Ethnopharmacology 155, Nr. 1.
- ‘Hydrolyzable tannins from hydroalcoholic extract from Poincianella pluviosa stem bark and its wound-healing properties: Phytochemical investigations and influence on in vitro cell physiology of human keratinocytes and dermal fibroblasts.’ Fitoterapia 99, Nr. null: 252–260. doi: 10.1016/j.fitote.2014.10.007. .
- . . ‘Extracts from Rhododendron ferrugineum Do Not Exhibit Grayanotoxin I: An Analytical Survey on Grayanotoxin I within the Genus Rhododendron.’ Planta Medica 80: 1321–1328. doi: 10.1055/s-0034-1383039.
- . . ‘Effective isolation protocol for secondary metabolites from Saffron: Semi-preparative scale preparation of crocin-1 and trans-crocetin.’ Fitoterapia 92: 290–295. doi: 10.1016/j.fitote.2013.11.014.
- . . ‘61st International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research - Book of abstracts (issue editors) .’ Planta Medica 79, Nr. 13: 1097–1288.
- „Traditional herbal drugs against uncomplicated urinary tract infections. In vitro investigations of their anti-adhesive effects against uropathogenic Escherichia coli.“ Zeitschrift für Phytotherapie 34, Nr. 5: 214–220. doi: 10.1055/s-0033-1349766. .
- „Eupatorium perfoliatum L.: New findings about an old medicinal plant.“ Zeitschrift für Phytotherapie 34, Nr. 2: 90–98. doi: 10.1055/s-0032-1331485. .
- ‘Antiadhesion as a functional concept for protection against uropathogenic Escherichia coli: In vitro studies with traditionally used plants with antiadhesive activity against uropathognic Escherichia coli.’ Journal of Ethnopharmacology 145, Nr. 2: 591–597. doi: 10.1016/j.jep.2012.11.035. .
- . . ‘Wound-healing plants from TCM: in vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes.’ Fitoterapia 84: 308–317. doi: 10.1016/j.fitote.2012.12.020.
- . . ‘Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect.’ Journal of Ethnopharmacology 141, Nr. 3: 848. doi: 10.1016/j.jep.2012.03.025.
- . . ‘Proteoglycans from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein.’ Glycobiology 22, Nr. 11: 1424–1439. doi: 10.1093/glycob/cws107.
- . . ‘Fast determination of N-phenylpropenoyl-L-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis.’ Food Chemistry 135: 1676–1964. doi: 10.1016/j.foodchem.2012.06.006.
- . . ‘Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications.’ Journal of Ethnopharmacology 138, Nr. 3: 641. doi: 10.1016/j.jep.2011.10.002.
- . . ‘Cyanogenesis in Higher Plants and Animals.’ In Encyclopedia of Life Sciences (ELS). John Wiley & Sons.
- ‘Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: Geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts.’ Phytomedicine 18, Nr. 7: 617–624. doi: 10.1016/j.phymed.2010.08.020. .
- . . ‘Ellagitannins from Phyllanthus muellerianus: geraniin stimulates keratinocytes differentiation and collagen synthesis of skin dermal fibroblasts - new concept for improved wound-healing.’ Planta Medica 76, Nr. 12: 1165–1166. doi: 10.1055/s-0030-1264188.
- . . ‘Phytochemical characterization of Rhododendron ferrugineum and in vitro assessment of an aqueous extract on cell toxicity.’ Planta Medica 76, Nr. 14: 1550–1557. doi: 10.1055/s-0029-1241016.
- . . Arzneipflanzen entdecken. (2. erweiterte Auflage). 2. Aufl. Münster: Selbstverlag / Eigenverlag.
- . . ‘Cyanogenic and non-cyanogenic pyridone glucosides from Acalypha indica (Euphorbiaceae).’ Phytochemistry 70, Nr. 2: 270–277. doi: 10.1016/j.phytochem.2008.12.011.
- . . ‘An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana.’ Journal of Ethnopharmacology 125, Nr. 3: 393–403. doi: 10.1016/j.jep.2009.07.024.
- . . „Internet trade with kava preparations (Kava-Präparate im Internethandel).“ Deutsche Apotheker-Zeitung 148, Nr. 16: 1709–1710.
- ‘Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?’ Pharmazie 63, Nr. 1: 71–74. doi: 10.1691/ph.2008.7638. .
- . . ‘Evaluation of analytical markers characterising different drying methods of parsley leaves (Petroselinum crispum L.).’ Pharmazie 62, Nr. 12: 949–954. doi: 10.1691/ph.2007.12.7543.
- . . ‘Cyanogenesis in higher plants and animals.’ In Handbook of Plant Science Section Title: Plant Biochemistry, edited by , 1033–1035. John Wiley & Sons.
- . . ‘Qualitative determination of proanthocyanidin cleavage products after acid-catalyzed degradation in the presence of excess phloroglucinol by cyclodextrin-modified micellar electrokinetic chromatography.’ Pharmaceutical Biology 44, Nr. 4: 309–314. doi: 10.1080/13880200600716090.
- . . ‘Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis.’ Phytochemical Analysis 15, Nr. 3: 152–158. doi: 10.1002/pca.759.
- . . ‘New and Known Iridoid- and Phenylethanoid Glycosides from Harpagophytum procumbens and their in vitro Inhibition of Human Leukocyte Elastase.’ Planta Medica 69, Nr. 9: 820–825. doi: 10.1055/s-2003-43225.
- . . ‘Gynocardin and cyclopentenylglycine in Rawsonia lucida.’ Biochemical Systematics and Ecology 29, Nr. 2: 219–222. doi: 10.1016/S0305-1978(00)00048-X.
- . . ‘Cyanogenic Glycosides.’ In Naturally Occurring Glycosides, edited by , 147–191. Chichester: John Wiley & Sons.
- . . ‘Qualitative and quantitative micellar electrokinetic chromatography of kavalactones from dry extracts of Piper methysticum Forst. and commercial drugs.’ Journal of Chromatography A 848, Nr. 1-2: 457–464. doi: 10.1016/S0021-9673(99)00425-2.
- ‘Prunasin 6'-malonate from Lotononis fruticoides and Lotononis aft. falcata (Fabaceae).’ Biochemical Systematics and Ecology 27, Nr. 6: 607–612. doi: 10.1016/S0305-1978(98)00121-5. .
- . . ‘Nai habarala (Alocasia cucullata) fruits; analysed for potential hydrogen cyanide.’ Ceylon Medical Journal 42, Nr. 2: 110–111.
- . . ‘Leucine-derived nitrile glucosides in the Rosaceae and their systematic significance.’ Phytochemistry 41, Nr. 3: 779–785. doi: 10.1016/0031-9422(95)00661-3.
- Untersuchungen zur Cyanogenese höherer Pflanzen Dissertationsschrift, Universität Münster. .
- . . ‘Cyanoglucosides from Osmaronia cerasiformis (Rosaceae).’ Phytochemistry 37, Nr. 4: 1039–1043. doi: 10.1016/S0031-9422(00)89525-4.
- . . ‘4-Hydroxymandelonitrile glucosides, dhurrin in Suckleya suckleyana and taxiphyllin in Girgensohnia oppositiflora (Chenopodiaceae).’ Phytochemistry 33, Nr. 4: 847–850. doi: 10.1016/0031-9422(93)85288-3.
- ‘Cyanoglucosides from Osmaronia cerasiformis.’ Contributed to the Gesellschaft für Arzneipflanzenforschung (GA) 31.8.1993 bis zum 4.9.1993, Düsseldorf. .
Wissenschaftlicher Vortrag
- Lechtenberg, Matthias; Hensel, Andreas (): „Brokkoli – immer eine zuverlässige Quelle für Glucoraphanin und Sulforaphan?“ Lebensmittelchemische Gesellschaft (Fachgruppe in der GDCh): Arbeitstagung 2024 des Regionalverbandes NRW (Lebensmittelchemische Gesellschaft der GdCh), Münster, .