The role of CSK in the regulation of immune cell recruitment and metabolism during acute kidney injury

Principal investigators: Verena Hörr, Andreas Margraf
Former principal investigator: Stefan Reuter
Project number: CRC 1450 C05
Project term: 01/2021–12/2028

Src-family kinases (SFKs) are central regulators of both immune cell functionality and metabolism. The c-terminal Src-Kinase CSK is an inhibitor of SFKs. Acute kidney injury (AKI) is a disease in which both immunoregulatory as well as metabolic alterations occur, evoking in organ failure. To understand the role of CSK in the setting of AKI, we will investigate different mouse models, integrating molecular analyses such as microscopy, flow cytometry, and sequencing, along with in vivo tracking of immune cells and metabolic changes using MRI.

Team

Principal investigators

Project members

Publications

The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.

2024

Nahardani A, Moradi S, Vo M, Reuter S, Hoerr V. 23Na Magnetic Resonance Imaging in Sepsis-Induced Acute Kidney Injury: A Preclinical Study 2024Abstract
Schache D, Peddi A, Nahardani A, Faber C, Hoerr V. Corrections for Rabi oscillations in cardiac chemical exchange saturation transfer MRI under the influence of very short preparation pulses. NMR Biomed 2024;37: e5081. Abstract
Schache D, Peddi A, Nahardani A, Faber C, Hoerr V. Corrections for Rabi oscillations in cardiac chemical exchange saturation transfer MRI under the influence of very short preparation pulses. NMR Biomed 2024;37: e5081. Abstract

2023

Hoffmann E, Schache D, Höltke C, Soltwisch J, Niland S, Krähling T, Bergander K, Grewer M, Geyer C, Groeneweg L, Eble JA, Vogl T, Roth J, Heindel W, Maus B, Helfen A, Faber C, Wildgruber M, Gerwing M, Hoerr V. Multiparametric chemical exchange saturation transfer MRI detects metabolic changes in breast cancer following immunotherapy. J Transl Med 2023;21: 577. Abstract
Lippe C, Schache D, Hoerr V. Book of Abstracts ESMRMB 2023 Online 39th Annual Scientific Meeting 4–7 October 2023. Magn Reson Mater Phy 2023;36: 1-328. Abstract
Zhao W-T, Herrmann K-H, Sibgatulin R, Nahardani A, Krämer M, Heitplatz B, van Marck V, Reuter S, Reichenbach JR, Hoerr V. Perfusion and T(2) Relaxation Time as Predictors of Severity and Outcome in Sepsis-Associated Acute Kidney Injury: A Preclinical MRI Study. J Magn Reson Imaging 2023;58: 1954-1963. Abstract

2022

Jehn U, Wiedmer N, Boeckel GR, Pavenstädt H, Thölking G, Reuter S. Fast Tacrolimus Metabolism Does Not Promote Post-Transplant Diabetes Mellitus after Kidney Transplantation. Int J Mol Sci 2022;23Abstract
Schache D, Bardin S, Ciobanu L, Faber C, Hoerr V. Ultrafast CEST line scanning as a method to quantify mutarotation kinetics. J Magn Reson 2022;342: 107270. Abstract
Schütte-Nütgen K, Edeling M, Kentrup D, Heitplatz B, Van Marck V, Zarbock A, Meersch-Dini M, Pavenstädt H, Reuter S. Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury. Am J Transplant 2022;22: 2548-2559. Abstract

2021

Buscher K, Heitplatz B, van Marck V, Song J, Loismann S, Rixen R, Hüchtmann B, Kurian S, Ehinger E, Wolf D, Ley K, Pavenstädt H, Reuter S. Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery. J Am Soc Nephrol 2021;32: 1933-1945. Abstract

2020

Margraf A, Germena G, Drexler HCA, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn PW, Haller H, Heitplatz B, Meyer Zu Brickwedde M, Moser M, Vestweber D, Zarbock A. The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil beta2-integrin LFA-1. Blood 2020;136: 2200-2205. Abstract

2019

Köhnke R, Kentrup D, Schütte-Nütgen K, Schäfers M, Schnöckel U, Hoerr V, Reuter S. Update on imaging-based diagnosis of acute renal allograft rejection. Am J Nucl Med Mol Imaging 2019;9: 110-126. Abstract
Margraf A, Ley K, Zarbock A. Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns. Trends Immunol 2019;40: 613-634. Abstract

2017

Kentrup D, Bovenkamp P, Busch A, Schuette-Nuetgen K, Pawelski H, Pavenstädt H, Schlatter E, Herrmann K-H, Reichenbach JR, Löffler B, Heitplatz B, Van Marck V, Yadav NN, Liu G, van Zijl PCM, Reuter S, Hoerr V. GlucoCEST magnetic resonance imaging in vivo may be diagnostic of acute renal allograft rejection. Kidney Int 2017;92: 757-764. Abstract
Krämer M, Motaal AG, Herrmann K-H, Löffler B, Reichenbach JR, Strijkers GJ, Hoerr V. Cardiac 4D phase-contrast CMR at 94 T using self-gated ultra-short echo time (UTE) imaging. J Cardiovasc Magn Reson 2017;19: 39. Abstract