A key feature of cutaneous inflammatory diseases is the infiltration of myeloid cells into the skin. However, the role and crosstalk of subpopulations of myeloid cells, their interaction and the role of ROS stress in myeloid cell biology are largely unknown in the pathogenesis of inflammatory skin disorder s. We will combine novel nanocarrier-based approaches with functional and multiscale imaging techniques in mouse models of acute (allergic contact dermatitis) and chronic (systemic sclerosis) cutaneous inflammation to unravel molecular mechanisms of myeloid cell biology and of ROS-mediated processes in inflammatory and autoimmune skin diseases in vitro and in vivo.
| Chali SP, Westmeier J, Krebs F, Jiang S, Neesen FP, Uncuer D, Schelhaas M, Grabbe S, Becker C, Landfester K, Steinbrink K. Albumin nanocapsules and nanocrystals for efficient intracellular drug release. Nanoscale Horiz 2024;9: 1978-1989. Abstract
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| Frey M-L, Morsbach S, Domogalla M, Mailänder V, Steinbrink K, Landfester K. Process Control of Multistep Surface Functionalization on Hydroxyethyl Starch Nanocapsules Determines the Reproducibility of the Biological Efficacy. Biomacromolecules 2024;25: 7108-7122. Abstract
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| Heinl PV, Graulich E, Weigmann B, Wangorsch A, Ose R, Bellinghausen I, Khatri R, Raker VK, Scheurer S, Vieths S, Saloga J, Steinbrink K. IL-10-modulated dendritic cells from birch pollen- and hazelnut-allergic patients facilitate Treg-mediated allergen-specific and cross-reactive tolerance. Allergy 2024;79: 2826-2839. Abstract |
| Muecklich S, Shehzad K, Tiemann J, Li L, Leson S, Nelson PJ, Jennemann R, Klein M, Becker C, Sandhoff R, Steinbrink K, Raker VK. DKK3 Promotes Oxidative Stress‒Induced Fibroblast Activity. J Invest Dermatol 2023;143: 1088-1090.e2. Abstract
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| Silva-Vilches C, Bolduan V, Alabdullah M, Steinbrink K, Probst HC, Enk A, Mahnke K. Topical Application of Adenosine A(2)-Type Receptor Agonists Prevents Contact Hypersensitivity Reactions in Mice by Affecting Skin Dendritic Cells. J Invest Dermatol 2023;143: 408-418.e6. Abstract |
| Fleischer MI, Röhrig N, Raker VK, Springer J, Becker D, Ritz S, Bros M, Stege H, Haist M, Grabbe S, Haub J, Becker C, Reyda S, Disse J, Schmidt T, Mahnke K, Weiler H, Ruf W, Steinbrink K. Protease- and cell type-specific activation of protease-activated receptor 2 in cutaneous inflammation. J Thromb Haemost 2022;20: 2823-2836. Abstract
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| Frey M-L, Han S, Halim H, Kaltbeitzel A, Riedinger A, Landfester K, Lieberwirth I. Nanocarriers Made of Proteins: Intracellular Visualization of a Smart Biodegradable Drug Delivery System. Small 2022;18: e2106094. Abstract
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| Grabska-Zielińska S, Pin JM, Kaczmarek-Szczepańska B, Olewnik-Kruszkowska E, Sionkowska A, Monteiro FJ, Steinbrink K, Kleszczyński K. Scaffolds Loaded with Dialdehyde Chitosan and Collagen-Their Physico-Chemical Properties and Biological Assessment. Polymers (Basel) 2022;14Abstract
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| Hüppe N, Schunke J, Fichter M, Mailänder V, Wurm FR, Landfester K. Multicomponent encapsulation into fully degradable protein nanocarriers via interfacial azide-alkyne click reaction in miniemulsion allows the co-delivery of immunotherapeutics. Nanoscale Horiz 2022;7: 908-915. Abstract
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| Kaczmarek-Szczepańska B, Pin JM, Zasada L, Sonne MM, Reiter RJ, Slominski AT, Steinbrink K, Kleszczyński K. Assessment of Melatonin-Cultured Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials for Wound Healing. Antioxidants (Basel) 2022;11Abstract
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| Micheva M, Baluschev S, Landfester K. Thermally activated delayed fluorescence in an optically accessed soft matter environment. J. Mater. Chem. C 2022;10: 4533-4545. Abstract
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| Scheib N, Tiemann J, Becker C, Probst HC, Raker VK, Steinbrink K. The Dendritic Cell Dilemma in the Skin: Between Tolerance and Immunity. Front Immunol 2022;13: 929000. Abstract
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| Shahneh F, Christian Probst H, Wiesmann SC, A-Gonzalez N, Ruf W, Steinbrink K, Raker VK, Becker C. Inflammatory Monocyte Counts Determine Venous Blood Clot Formation and Resolution. Arterioscler Thromb Vasc Biol 2022;42: 145-155. Abstract
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| Stegemann A, Raker V, Del Rey A, Steinbrink K, Böhm M. Expression of the alpha7 Nicotinic Acetylcholine Receptor Is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis. Neuroendocrinology 2022;112: 446-456. Abstract
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| Vasilev A, Kostadinov A, Kandinska M, Landfester K, Baluschev S. Tetrathienothiophene Porphyrin as a Metal-Free Sensitizer for Room-Temperature Triplet-Triplet Annihilation Upconversion. Front Chem 2022;10: 809863. Abstract |
| Grabska-Zielińska S, Sosik A, Malkowska A, Olewnik-Kruszkowska E, Steinbrink K, Kleszczyński K, Kaczmarek-Szczepańska B. The Characterization of Scaffolds Based on Dialdehyde Chitosan/Hyaluronic Acid. Materials (Basel) 2021;14Abstract
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| Heinrich E, Avlasevich Y, Landfester K, Baluschev S. How to Minimize Light-Organic Matter Interactions for All-Optical Sub-Cutaneous Temperature Sensing. ACS Omega 2021;6: 18860-18867. Abstract
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| Kaczmarek-Szczepańska B, Ostrowska J, Kozlowska J, Szota Z, Brozyna AA, Dreier R, Reiter RJ, Slominski AT, Steinbrink K, Kleszczyński K. Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing. Int J Mol Sci 2021;22Abstract |
| Frey M-L, Simon J, Brückner M, Mailänder V, Morsbach S, Landfester K. Bio-orthogonal triazolinedione (TAD) crosslinked protein nanocapsules affect protein adsorption and cell interaction. Polym. Chem. 2020;11: 3821-3830. Abstract
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| Iyisan B, Thiramanas R, Nazarova N, Avlasevich Y, Mailänder V, Baluschev S, Landfester K. Temperature Sensing in Cells Using Polymeric Upconversion Nanocapsules. Biomacromolecules 2020;21: 4469-4478. Abstract
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| Raker VK, Becker C, Landfester K, Steinbrink K. Targeted Activation of T Cells with IL-2-Coupled Nanoparticles. Cells 2020;9Abstract
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| Stegemann A, Flis D, Ziolkowski W, Distler JHW, Steinbrink K, Böhm M. The alpha7 Nicotinic Acetylcholine Receptor: A Promising Target for the Treatment of Fibrotic Skin Disorders. J Invest Dermatol 2020;140: 2371-2379. Abstract |
| Schmidt T, Lorenz N, Raker VK, Schmidgen MI, Mahnke K, Enk A, Roth J, Steinbrink K. Allergen-Specific Low Zone Tolerance Is Independent of MRP8/14-, TLR4-, TLR7-, and TLR9-Mediated Immune Processes. J Invest Dermatol 2018;138: 452-455. Abstract
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| Tonigold M, Simon J, Estupinan D, Kokkinopoulou M, Reinholz J, Kintzel U, Kaltbeitzel A, Renz P, Domogalla MP, Steinbrink K, Lieberwirth I, Crespy D, Landfester K, Mailänder V. Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona. Nat Nanotechnol 2018;13: 862-869. Abstract |
