Scientific fields of interest

Scientific work:

  • > 175 Scientific works (including submitted)
  • > 300 Scientific abstracts (congress contribution)
  • > 220 Lectures and seminars
  • 11 books (edited or major contributions)
  • Databank (www.parkinson-datenbank.de)

Scientific fields of interests at present:

  • Impact of subtypes of adenosine receptors in diabetes (testing of newly synthetized adenosine receptor agonists and antagonists of Prof. Dr. C. E. Müller, Bonn)
  • Effects of angiotensin II and its degradation products (capillary electrophoresis, HPLC-MS) on fibroblasts and 3T3 fat cells with respect to angiotensin IV/IRAP receptors
  • Plant extracts with spasmolytic (ileum, trachea), antiemetic, endocrine (antidiabetic) effects and the mechanisms of action
  • Plant extracts with effects on ciliary clearance and the involved mechanism including cytoprotection Ciliary activity of the BEAS-2B cells and cytoprotection mechanisms

Scientific fields of interests in the past:

  • Mechanism of insulin secretion
  • Receptors in islets of Langerhans/INS-1 cells/Rin-m5F cells for insulin, opioids, ANP, cholecystokinin, sulphonylureas, GRP, subtypes of muscarinic receptors, activin A
  • Insulin secretion coupling, 2nd messengers, ion fluxes (Ca+, K+), tyrosine kinase, PKC; knock out of G-proteins by antibodies introduced to cells by electroporation
  • Mechanism of receptor desensitization (PKC-isoforms, G-protein mRNA and -proteins)
  • Diadenosine polyphosphates as pathophysiological agents in diabetes
  • RAR-, RXR- and PPARgamma-Agonisten