Beteiligung an „Cells in Motion“
- Forschungsinteressen: cell mechanics, cell motility, cancer cell invasion, 3D organoid and tumour models, zebrafish development, soft matter physics, microscopy development, optical tweezers and UV microablation, traction force microscopy, non-equilibrium physics in living systems, mechanics of transmigration, actin based force generation, quantitative modelling of active living systems
- Cells-in-Motion-Professor für Zellmechanik
News & Themen
Publikationen im Forschungsschwerpunkt „Zelldynamik und Bildgebung“
alle Publikationen von Timo Betz
2022
Kummer D, Steinbacher T, Tholmann S, Schwietzer MF, Hartmann C, Horenkamp S, Demuth S, Peddibhotla SSD, Brinkmann F, Kemper B, Schnekenburger J, Brandt M, Betz T, Liashkovich I, Kouzel IU, Shahin V, Corvaia N, Rottner K, Tarbashevich K, Raz E, Greune L, Schmidt MA, Gerke V, Ebnet K. A JAM-A-tetraspanin-alphavbeta5 integrin complex regulates contact inhibition of locomotion. J Cell Biol 2022;221Abstract Russo A, Schurmann H, Brandt M, Scholz K, Matos ALL, Grill D, Revenstorff J, Rembrink M, von Wulffen M, Fischer-Riepe L, Hanley PJ, Hacker H, Prunster M, Sanchez-Madrid F, Hermann S, Klotz L, Gerke V, Betz T, Vogl T, Roth J. Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes. Adv Sci (Weinh) 2022: e2201505. Abstract 2021
Olguin-Olguin A, Aalto A, Maugis B, Boquet-Pujadas A, Hoffmann D, Ermlich L, Betz T, Gov NS, Reichman-Fried M, Raz E. Chemokine-biased robust self-organizing polarization of migrating cells in vivo. Proc Natl Acad Sci U S A 2021;118: e2018480118. Abstract 2020
Grimaldi C, Schumacher I, Boquet-Pujadas A, Tarbashevich K, Vos BE, Bandemer J, Schick J, Aalto A, Olivo-Marin J-C, Betz T, Raz E. E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow. Nat Commun 2020;11: 5397. Abstract Gross-Thebing S, Truszkowski L, Tenbrinck D, Sanchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Huwel J, Gaede F, Sasse R, Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Munoz A, Burger M, Raz E. Using migrating cells as probes to illuminate features in live embryonic tissues. Sci Adv 2020;6: eabc5546. Abstract 2018
Ahmed WW, Fodor E, Almonacid M, Bussonnier M, Verlhac M-H, Gov N, Visco P, van Wijland F, Betz T. Active Mechanics Reveal Molecular-Scale Force Kinetics in Living Oocytes. Biophys J 2018;114: 1667-1679. Abstract Wallmeyer B, Trinschek S, Yigit S, Thiele U, Betz T. Collective Cell Migration in Embryogenesis Follows the Laws of Wetting. Biophys J 2018;114: 213-222. Abstract 2017
Attieh Y, Clark AG, Grass C, Richon S, Pocard M, Mariani P, Elkhatib N, Betz T, Gurchenkov B, Vignjevic DM. Cancer-associated fibroblasts lead tumor invasion through integrin-beta3-dependent fibronectin assembly. J Cell Biol 2017;216: 3509-3520. Abstract Goudarzi M, Tarbashevich K, Mildner K, Begemann I, Garcia J, Paksa A, Reichman-Fried M, Mahabaleshwar H, Blaser H, Hartwig J, Zeuschner D, Galic M, Bagnat M, Betz T, Raz E. Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Dev Cell 2017;43: 577-587.e5. Abstract Horner F, Meissner R, Polali S, Pfeiffer J, Betz T, Denz C, Raz E. Holographic optical tweezers-based in vivo manipulations in zebrafish embryos. J Biophotonics 2017;10: 1492-1501. Abstract Peuhu E, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attie Y, Silva K, Betz T, Sundberg J, Salmi M, Deugnier MA, Eliceiri K, Ivaska J. SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. EMBO J 2017;36: 165-182. Abstract 2016
Caorsi V, Lemiere J, Campillo C, Bussonnier M, Manzi J, Betz T, Plastino J, Carvalho K, Sykes C. Cell-sized liposome doublets reveal active tension build-up driven by acto-myosin dynamics. Soft Matter 2016;12: 6223-6231. Abstract Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventela S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen P-L, Joensuu H, Grenman R, Ivaska J. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun 2016;7: 12237. Abstract Kopanska KS, Alcheikh Y, Staneva R, Vignjevic D, Betz T, Engler AJ. Tensile Forces Originating from Cancer Spheroids Facilitate Tumor Invasion. PLoS ONE 2016;11: e0156442. Abstract Turlier H, Fedosov DA, Audoly B, Auth T, Gov NS, Sykes C, Joanny J-F, Gompper G, Betz T. Equilibrium physics breakdown reveals the active nature of red blood cell flickering. Nat Phys 2016;12: 513-519. Abstract Valentino F, Sens P, Lemiere J, Allard A, Betz T, Campillo C, Sykes C. Fluctuations of a membrane nanotube revealed by high-resolution force measurements. Soft Matter 2016;12: 9429-9435. Abstract 2015
Garate F, Betz T, Pertusa M, Bernal R. Time-resolved neurite mechanics by thermal fluctuation assessments. Phys Biol 2015;12: 066020. Abstract