A hallmark of cutaneous autoimmune diseases is the infiltration of myeloid cells into the skin and affected organs. However, the role of subpopulations of myeloid cells, in particular of inflammatory and patrolling monocytes, and their crosstalk with platelets remains largely unknown in the pathogenesis of systemic Lupus erythematosus (SLE) and systemic sclerosis (SSc).
To decipher molecular mechanisms (1, 2, 3) of myeloid cell and platelet function (4), their interaction and the role of ROS-mediated processes, we will combine novel nanocapsule-based approaches with multiscale imaging techniques in mouse models of SSc and SLE (5).
The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.
2023
Muecklich S, Shehzad K, Tiemann J, Li L, Leson S, Nelson PJ, Jennemann R, Klein M, Becker C, Sandhoff R, Steinbrink K, Raker VK. DKK3 Promotes Oxidative Stress‒Induced Fibroblast Activity. J Invest Dermatol 2023;143: 1088-1090.e2. Abstract
Silva-Vilches C, Bolduan V, Alabdullah M, Steinbrink K, Probst HC, Enk A, Mahnke K. Topical Application of Adenosine A(2)-Type Receptor Agonists Prevents Contact Hypersensitivity Reactions in Mice by Affecting Skin Dendritic Cells. J Invest Dermatol 2023;143: 408-418.e6. Abstract
2022
Fleischer MI, Rohrig N, Raker VK, Springer J, Becker D, Ritz S, Bros M, Stege H, Haist M, Grabbe S, Haub J, Becker C, Reyda S, Disse J, Schmidt T, Mahnke K, Weiler H, Ruf W, Steinbrink K. Protease- and cell type-specific activation of protease-activated receptor 2 in cutaneous inflammation. J Thromb Haemost 2022;20: 2823-2836. Abstract
Frey M-L, Han S, Halim H, Kaltbeitzel A, Riedinger A, Landfester K, Lieberwirth I. Nanocarriers Made of Proteins: Intracellular Visualization of a Smart Biodegradable Drug Delivery System. Small 2022;18: e2106094. Abstract
Grabska-Zielinska S, Pin JM, Kaczmarek-Szczepanska B, Olewnik-Kruszkowska E, Sionkowska A, Monteiro FJ, Steinbrink K, Kleszczynski K. Scaffolds Loaded with Dialdehyde Chitosan and Collagen-Their Physico-Chemical Properties and Biological Assessment. Polymers (Basel) 2022;14Abstract
Huppe N, Schunke J, Fichter M, Mailander V, Wurm FR, Landfester K. Multicomponent encapsulation into fully degradable protein nanocarriers via interfacial azide-alkyne click reaction in miniemulsion allows the co-delivery of immunotherapeutics. Nanoscale Horiz 2022;7: 908-915. Abstract
Kaczmarek-Szczepanska B, Pin JM, Zasada L, Sonne MM, Reiter RJ, Slominski AT, Steinbrink K, Kleszczynski K. Assessment of Melatonin-Cultured Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials for Wound Healing. Antioxidants (Basel) 2022;11Abstract
Micheva M, Baluschev S, Landfester K. Thermally activated delayed fluorescence in an optically accessed soft matter environment. J. Mater. Chem. C 2022;10: 4533-4545. Abstract
Scheib N, Tiemann J, Becker C, Probst HC, Raker VK, Steinbrink K. The Dendritic Cell Dilemma in the Skin: Between Tolerance and Immunity. Front Immunol 2022;13: 929000. Abstract
Shahneh F, Christian Probst H, Wiesmann SC, A-Gonzalez N, Ruf W, Steinbrink K, Raker VK, Becker C. Inflammatory Monocyte Counts Determine Venous Blood Clot Formation and Resolution. Arterioscler Thromb Vasc Biol 2022;42: 145-155. Abstract
Stegemann A, Raker V, Del Rey A, Steinbrink K, Bohm M. Expression of the alpha7 Nicotinic Acetylcholine Receptor Is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis. Neuroendocrinology 2022;112: 446-456. Abstract
Vasilev A, Kostadinov A, Kandinska M, Landfester K, Baluschev S. Tetrathienothiophene Porphyrin as a Metal-Free Sensitizer for Room-Temperature Triplet-Triplet Annihilation Upconversion. Front Chem 2022;10: 809863. Abstract
2021
Grabska-Zielinska S, Sosik A, Malkowska A, Olewnik-Kruszkowska E, Steinbrink K, Kleszczynski K, Kaczmarek-Szczepanska B. The Characterization of Scaffolds Based on Dialdehyde Chitosan/Hyaluronic Acid. Materials (Basel) 2021;14Abstract
Heinrich E, Avlasevich Y, Landfester K, Baluschev S. How to Minimize Light-Organic Matter Interactions for All-Optical Sub-Cutaneous Temperature Sensing. ACS Omega 2021;6: 18860-18867. Abstract
Kaczmarek-Szczepanska B, Ostrowska J, Kozlowska J, Szota Z, Brozyna AA, Dreier R, Reiter RJ, Slominski AT, Steinbrink K, Kleszczynski K. Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing. Int J Mol Sci 2021;22Abstract
2020
Frey M-L, Simon J, Brückner M, Mailänder V, Morsbach S, Landfester K. Bio-orthogonal triazolinedione (TAD) crosslinked protein nanocapsules affect protein adsorption and cell interaction. Polym. Chem. 2020;11: 3821-3830. Abstract
Iyisan B, Thiramanas R, Nazarova N, Avlasevich Y, Mailander V, Baluschev S, Landfester K. Temperature Sensing in Cells Using Polymeric Upconversion Nanocapsules. Biomacromolecules 2020;21: 4469-4478. Abstract
Raker VK, Becker C, Landfester K, Steinbrink K. Targeted Activation of T Cells with IL-2-Coupled Nanoparticles. Cells 2020;9Abstract
Stegemann A, Flis D, Ziolkowski W, Distler JHW, Steinbrink K, Bohm M. The alpha7 Nicotinic Acetylcholine Receptor: A Promising Target for the Treatment of Fibrotic Skin Disorders. J Invest Dermatol 2020;140: 2371-2379. Abstract
Schmidt T, Lorenz N, Raker VK, Schmidgen MI, Mahnke K, Enk A, Roth J, Steinbrink K. Allergen-Specific Low Zone Tolerance Is Independent of MRP8/14-, TLR4-, TLR7-, and TLR9-Mediated Immune Processes. J Invest Dermatol 2018;138: 452-455. Abstract
Tonigold M, Simon J, Estupinan D, Kokkinopoulou M, Reinholz J, Kintzel U, Kaltbeitzel A, Renz P, Domogalla MP, Steinbrink K, Lieberwirth I, Crespy D, Landfester K, Mailander V. Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona. Nat Nanotechnol 2018;13: 862-869. Abstract
2017
Haeberle S, Raker V, Haub J, Kim YO, Weng S-Y, Yilmaz OK, Enk A, Steinbrink K, Schuppan D, Hadaschik EN. Regulatory T cell deficient scurfy mice exhibit a Th2/M2-like inflammatory response in the skin. J Dermatol Sci 2017;87: 285-291. Abstract
2016
Frick SU, Domogalla MP, Baier G, Wurm FR, Mailander V, Landfester K, Steinbrink K. Interleukin-2 Functionalized Nanocapsules for T Cell-Based Immunotherapy. ACS Nano 2016;10: 9216-9226. Abstract
