In this project, we aim at a novel multimodal imaging approach using BODIPY-based nanostructures to investigate endothelial permeability upon inflammatory stimuli in vivo. The tunable size (ranging from few nanometers to several micrometers) and shape (spherical, 1D, 2D) of the nanostructures will allow for a quantitative assessment of endothelial barrier function using the entire range of multiscale imaging modalities applied in this CRC (1, 2).
We will evaluate our BODIPY-based approach in inflammatory pathologies associated with changes in endothelial permeability such as ischemia-reperfusion (I/R; heart, kidney) and sepsis (3).
The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.
Accepted for publication
Hoffmann E*, Masthoff M*, Kunz W, Seidensticker M, Schliemann Christoph, Faber C, Wildgruber M. Multiparametric magnetic resonance imaging for characterization of the tumor microenvironment – going beyond size. Nature Reviews Clinical Oncology: accepted for publication.
2024
Wilken E, Havlas A, Masthoff M, Moussavi A, Boretius S, Faber C. Radial compressed sensing imaging improves the velocity detection limit of single cell tracking time-lapse MRI. Magn Reson Med 2024;91: 1449-1463. Abstract
2023
Armstrong M, Wilken E, Freppon F, Masthoff M, Faber C, Xiao D. Dynamic cell tracking using time-lapse MRI with variable temporal resolution Cartesian sampling. Magn Reson Med 2023;90: 2443-2453. Abstract
Baumer N, Ogi S, Borsdorf L, Yamaguchi S, Fernandez G. Amphiphile desymmetrisation-induced steric relief governs self-assembly pathways in aqueous media. Chem Commun (Camb) 2023;59: 8937-8940. Abstract
Hoffmann E, Gerwing M, Krahling T, Hansen U, Kronenberg K, Masthoff M, Geyer C, Holtke C, Wachsmuth L, Schinner R, Hoerr V, Heindel W, Karst U, Eisenblatter M, Maus B, Helfen A, Faber C, Wildgruber M. Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy. Breast Cancer Res 2023;25: 56. Abstract
Hoffmann E, Gerwing M, Niland S, Niehoff R, Masthoff M, Geyer C, Wachsmuth L, Wilken E, Holtke C, Heindel WL, Hoerr V, Schinner R, Berger P, Vogl T, Eble JA, Maus B, Helfen A, Wildgruber M, Faber C. Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI. J Immunother Cancer 2023;11Abstract
Holtke C, Enders L, Stolting M, Geyer C, Masthoff M, Kuhlmann MT, Wildgruber M, Helfen A. Detection of Early Endothelial Dysfunction by Optoacoustic Tomography. Int J Mol Sci 2023;24Abstract
Manha Veedu R, Niemeyer N, Baumer N, Kartha Kalathil K, Neugebauer J, Fernandez G. Sterically Allowed H-type Supramolecular Polymerizations. Angew Chem Int Ed Engl 2023;62: e202314211. Abstract
2022
Gerwing M, Hoffmann E, Kronenberg K, Hansen U, Masthoff M, Helfen A, Geyer C, Wachsmuth L, Höltke C, Maus B, Hoerr V, Krähling T, Hiddeßen L, Heindel W, Karst U, Kimm MA, Schinner R, Eisenblätter M, Faber C, Wildgruber M. Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer. Front. Oncol. 2022;12Abstract
Helmers I, Hossain MS, Baumer N, Wesarg P, Soberats B, Shimizu LS, Fernandez G. Anti-cooperative Self-Assembly with Maintained Emission Regulated by Conformational and Steric Effects. Angew Chem Int Ed Engl 2022;61: e202200390. Abstract
Matern J, Fernández Z, Bäumer N, Fernández G. Erweiterung des Spektrums metastabiler Spezies in der durch H‐Bindungen gesteuerten supramolekularen Polymerisation. Angewandte Chemie 2022;134Abstract
Matern J, Fernandez Z, Fernandez G. Exploiting halido ligands to control nucleation pathways and Ptcdots, three dots, centeredPt interactions in supramolecular co-polymerizations. Chem Commun (Camb) 2022;58: 12309-12312. Abstract
Matern J, Maisuls I, Strassert CA, Fernandez G. Luminescence and Length Control in Nonchelated d(8) -Metallosupramolecular Polymers through Metal-Metal Interactions. Angew Chem Int Ed Engl 2022;61: e202208436. Abstract
2021
Gerwing M, Krahling T, Schliemann C, Harrach S, Schwoppe C, Berdel AF, Klein S, Hartmann W, Wardelmann E, Heindel WL, Lenz G, Berdel WE, Wildgruber M. Multiparametric Magnetic Resonance Imaging for Immediate Target Hit Assessment of CD13-Targeted Tissue Factor tTF-NGR in Advanced Malignant Disease. Cancers (Basel) 2021;13Abstract
Helmers I, Ghosh G, Albuquerque RQ, Fernandez G. Pathway and Length Control of Supramolecular Polymers in Aqueous Media via a Hydrogen Bonding Lock. Angew Chem Int Ed Engl 2021;60: 4368-4376. Abstract
Karlas A, Masthoff M, Kallmayer M, Helfen A, Bariotakis M, Fasoula NA, Schafers M, Seidensticker M, Eckstein H-H, Ntziachristos V, Wildgruber M. Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study. Ann Transl Med 2021;9: 36. Abstract
Masthoff M, Freppon FN, Zondler L, Wilken E, Wachsmuth L, Niemann S, Schwarz C, Fredrich I, Havlas A, Block H, Gerwing M, Helfen A, Heindel W, Zarbock A, Wildgruber M, Faber C. Resolving immune cells with patrolling behaviour by magnetic resonance time-lapse single cell tracking. EBioMedicine 2021;73: 103670. Abstract
Matarranz B, Fernández G. BODIPY dyes: Versatile building blocks to construct multiple types of self-assembled structures 2021;2Abstract
Matarranz B, Ghosh G, Kandanelli R, Sampedro A, Kartha KK, Fernandez G. Understanding the role of conjugation length on the self-assembly behaviour of oligophenyleneethynylenes. Chem Commun (Camb) 2021;57: 4890-4893. Abstract
2020
Gerwing M, Kocman V, Stolting M, Helfen A, Masthoff M, Roth J, Barczyk-Kahlert K, Greune L, Schmidt MA, Heindel W, Faber C, Konig S, Wildgruber M, Eisenblatter M. Tracking of Tumor Cell-Derived Extracellular Vesicles In Vivo Reveals a Specific Distribution Pattern with Consecutive Biological Effects on Target Sites of Metastasis. Mol Imaging Biol 2020;22: 1501-1510. Abstract
Helmers I, Shen B, Kartha KK, Albuquerque RQ, Lee M, Fernandez G. Impact of Positional Isomerism on Pathway Complexity in Aqueous Media. Angew Chem Int Ed Engl 2020;59: 5675-5682. Abstract
2019
Helfen A, Masthoff M, Claussen J, Gerwing M, Heindel W, Ntziachristos V, Eisenblatter M, Kohler M, Wildgruber M. Multispectral Optoacoustic Tomography: Intra- and Interobserver Variability Using a Clinical Hybrid Approach. J Clin Med 2019;8Abstract
Masthoff M, Buchholz R, Beuker A, Wachsmuth L, Kraupner A, Albers F, Freppon F, Helfen A, Gerwing M, Holtke C, Hansen U, Rehkamper J, Vielhaber T, Heindel W, Eisenblatter M, Karst U, Wildgruber M, Faber C. Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining (57)Fe-Based MRI and Mass Spectrometry. Nano Lett 2019;19: 7908-7917. Abstract
2018
Becker A, Masthoff M, Claussen J, Ford SJ, Roll W, Burg M, Barth PJ, Heindel W, Schafers M, Eisenblatter M, Wildgruber M. Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach. Eur Radiol 2018;28: 602-609. Abstract
Masthoff M, Gran S, Zhang X, Wachsmuth L, Bietenbeck M, Helfen A, Heindel W, Sorokin L, Roth J, Eisenblatter M, Wildgruber M, Faber C. Temporal window for detection of inflammatory disease using dynamic cell tracking with time-lapse MRI. Sci Rep 2018;8: 9563. Abstract
Masthoff M, Helfen A, Claussen J, Karlas A, Markwardt NA, Ntziachristos V, Eisenblatter M, Wildgruber M. Use of Multispectral Optoacoustic Tomography to Diagnose Vascular Malformations. JAMA Dermatol 2018;154: 1457-1462. Abstract
Masthoff M, Helfen A, Claussen J, Roll W, Karlas A, Becker H, Gabriels G, Riess J, Heindel W, Schafers M, Ntziachristos V, Eisenblatter M, Gerth U, Wildgruber M. Multispectral optoacoustic tomography of systemic sclerosis. J Biophotonics 2018: e201800155. Abstract
Sampedro A, Ramos-Torres A, Schwoppe C, Muck-Lichtenfeld C, Helmers I, Bort A, Diaz-Laviada I, Fernandez G. Hierarchical Self-Assembly of BODIPY Dyes as a Tool to Improve the Antitumor Activity of Capsaicin in Prostate Cancer. Angew Chem Int Ed Engl 2018;57: 17235-17239. Abstract
2017
Rödle A, Lambov M, Mück-Lichtenfeld C, Stepanenko V, Fernández G. Cooperative nanoparticle H-type self-assembly of a bolaamphiphilic BODIPY derivative in aqueous medium. Polymer 2017;128: 317-324. Abstract
