Professor Dr. Uwe Karst
Professur für Analytische Chemie (Prof. Karst)
Corrensstr. 28/30
Research Foci
- Hyphenated techniques
- Nanoparticles
- Speciation Analysis
- Applied Atomic Spectroscopy
Further Affiliation at the University of Münster
CV
Academic Education
- Habilitation in Analytical Chemistry (Univ. of Muenster)
- Dr. rer. nat. (Univ. of Muenster, K. Cammann)
- Undergraduate studies of chemistry at the Westfälische-Wilhelms Universität Muenster
Positions
- Chair of Analytical Chemistry (Univ. of Muenster, Muenster)
- Chair of Analytical Chemistry (Univ. of Twente, Enschede)
- Independent research
- Postdoctoral researcher (Univ. of Colorado, Boulder, R.E. Sievers)
- Research associate (Univ. of North Carolina, Chapel Hill, R.M. Wightman)
Honors
- 2. Place at the 5th Nordic Conference on Plasma Spectrochemistry Poster Award Session 2010 – Royal Society of Chemistry
- 1. Place at the 5th Nordic Conference on Plasma Spectrochemistry Poster Award Session 2010 – Royal Society of Chemistry
- Fresenius-Preis – Gesellschaft Deutscher Chemiker (GDCh)
- 4th Nordic Conference on Plasma Spectrochemistry Poster Award 2008 – Norwegian Chemical Society - Division of Analytical Sciences
- Fachgruppenpreis der Fachgruppe Analytische Chemie – FG Analytische Chemie in der Gesellschaft Deutscher Chemiker (GDCh)
External Functions
- Elected member of the DFG Fachkollegium "Analytical Chemistry, Method Development"
- German Chemical Society (GDCh)
- German Society for Mass Spectrometry (DGMS)
- American Chemical Society (ACS)
Projects
In Process
- BACCARA – International Graduate School of Battery Chemistry, Characterization, Analysis, Recycling and Application ( – )
Individual Granted Project: Federal Ministry of Culture and Science of the Federal State of North Rhine-Westphalia, PowerCo SE - CRC 1450 - B02: Quantitative MRI of organ-specific vascular permeability and immune cell dynamics by combination with mass spectrometric imaging ( – )
Subproject in DFG-Joint Project Hosted at the University of Münster: DFG - Collaborative Research Centre | Project Number: SFB 1450/1, B02
Finished
- NanoBioQuant – NanoBioQuant - Quantifizierung von Nanomaterialien im Gewebe für die regulatorische Analytik und Entwicklung vin In-vitro-Methoden ( – )
participations in bmbf-joint project: Federal Ministry of Education and Research | Project Number: 03XP0213D - Multiscale Green Biology Münster - from molecule to ecosystem: Green knowledge for education, research and society in times of climate change ( – )
Internally at the University of Münster Funded Project: Uni Münster-internal funding - Topical Programs - EXC 1003 B1 - Formation and Properties of Epithelial and Endothelial Barriers ( – )
Subproject in DFG-Joint Project Hosted at the University of Münster: DFG - Cluster of Excellence | Project Number: EXC1003/1 - EXC 1003 A5 - Surface-Targeted Tracking of Individual Cells In Vivo ( – )
Subproject in DFG-Joint Project Hosted at the University of Münster: DFG - Cluster of Excellence | Project Number: EXC1003/1 - EU-NCL – European Nanomedicine Characterization Laboratory ( – )
participations in other joint project: French Alternative Energies and Atomic Energy Commission | Project Number: 654190 - LC/electrochemistry/mass spectrometry in (bio)analytical chemistry, drug metabolism and proteomics ( – )
Individual Granted Project: DFG - Individual Grants Programme | Project Number: KA 1093/7-2 - Laserablations-ICP-MS-Untersuchungen an Gewebecryoschnitten und MALDI/MS-Untersuchungen von Gewebecryoschnitten ( – )
Individual Granted Project: Bayer Schering Pharma AG - Artificial Kidney - Safety analysis and optimization of electrochemical dialysate regeneration ( – )
Individual Granted Project: Dutch Kidney Foundation - NanoBioDetect – NanoBioDetect - Nanopartikel im Gewebe: Detektion, Quantifizierung und Darstellung biologischer Effektmarker ( – )
participations in bmbf-joint project: Federal Ministry of Education and Research | Project Number: 03X0146E - Studie zur Interaktion von biologischem Gewebe und Metallen ( – )
Individual Granted Project: German Academic Exchange Service | Project Number: 57219660 - Development of analytical methods for the evaluation of gadolinium species after in-vivo administration ( – )
Individual Granted Project: Guerbet SA - Aerosols and Imaging mass spectrometry ( – )
Individual Granted Project: DFG - Initiation of International Collaboration | Project Number: KA 1093/12-1 - EXC 1003 FF-2013-17 - Studying Cells in Motion by Complementary Magnetic Resonance and Mass Spectrometric Imaging ( – )
Subproject in DFG-Joint Project Hosted at the University of Münster: DFG - Cluster of Excellence - Fluoreszenzbasierte Analytik zur Sicherung von Warenketten ( – )
participations in bmbf-joint project: Federal Ministry of Education and Research | Project Number: 13N12012 - Investigation of the oxidative profile of chemicals by electrochemistry coupled to mass spectrometry ( – )
Individual Granted Project: Wirtschaft | Project Number: CH-2010-0836 - Molecules and Materials – NRW Research School "Molecules and Materials – A Common Design Principle" ( – )
Individual Granted Project: Federal Ministry of Culture and Science of the Federal State of North Rhine-Westphalia - FLEET - Flottenversuch Elektromobilität ( – )
participations in other joint project: Federal Ministry of Economic Affairs and Climate Action | Project Number: 0325071E - Third International Symposium on Metallomics, 15.-18.06.2011 ( – )
Scientific Event: DFG - International Scientific Events | Project Number: KA 1093/10
- BACCARA – International Graduate School of Battery Chemistry, Characterization, Analysis, Recycling and Application ( – )
Publications
- Rivas Aiello, .B., Kirse, T., Lavorato, .C., Maus, ., Maisuls, ., Kuberasivakumaran, ., Ostendorp, ., Hepp, ., Holtkamp, ., Winkler, .L., Karst, ., Wilde, ., Faber, ., Vericat, . and Strassert, .A., . Superparamagnetic Nanoparticles with Phosphorescent Complexes as Hybrid Contrast Agents: Integration of MRI and PLIM: SMALL SCIENCE, 2024 doi: 10.1002/smsc.202300145.
- Lefringhausen, ., Erbacher, ., Elinkmann, ., Karst, . and Müller, ., . Contiguous Silver(I)-Mediated Base Pairs of Imidazophenanthroline and Canonical Nucleobases in DNA Duplexes: Formation of Classical Duplexes versus Homodimer Formation: Bioconjugate Chemistry, 35, pp. 99–106. doi: 10.1021/acs.bioconjchem.3c00494.
- Kubot, ., Balke, ., Scholz, ., Wiemers-Meyer, ., Karst, ., Hayen, ., Hur, ., Winter, ., J, K. and Nowak, ., . High-Voltage Instability of Vinylene Carbonate (VC): Impact of Formed Poly-VC on Interphases and Toxicity: Advanced Science, 11(1), Article 2305282 doi: 10.1002/advs.202305282.
- Göldner, V., Speitling, M. and Karst, U., . Elucidation of the environmental reductive metabolism of the herbicide tritosulfuron assisted by electrochemistry and mass spectrometry: Chemosphere, 330, Article 138687 doi: 10.1016/j.chemosphere.2023.138687.
- Wagener, F., Naumann, N., Göldner, V., Görgens, C., Guddat, S., Karst, U. and Thevis, M., . Comparison of in vitro approaches for predicting the metabolism of the selective androgen receptor modulator RAD140: Analytical and Bioanalytical Chemistry, 415(23), pp. 5657 –5669. doi: 10.1007/s00216-023-04835-z.
- Göldner, V., Quach, L., Adhitama, E., Behrens, A., Junk, L., Winter, M., Placke, T., Glorius, F. and Karst, U., . Laser desorption/ionization-mass spectrometry for the analysis of interphases in lithium ion batteries: iScience, 26(9), Article 107517 doi: 10.1016/j.isci.2023.107517.
- Potęga, A., Göldner, V., Niehaves, E., Paluszkiewicz, E. and Karst, U., . Electrochemistry/mass spectrometry (EC/MS) for fast generation and identification of novel reactive metabolites of two unsymmetrical bisacridines with anticancer activity: Journal of Pharmaceutical and Biomedical Analysis, 235, Article 115607 doi: 10.1016/j.jpba.2023.115607.
- Sommer, ., Becker, ., von Bremen-Kühne, ., Gotters, ., Quarles, ., Sperling, ., Kudla, . and Karst, ., . Analysis of the elemental species-dependent uptake of lanthanide complexes in Arabidopsis thaliana plants by LA-ICP-MS.: Chemosphere, 338, p. 139534–139534. doi: 10.1016/j.chemosphere.2023.139534.
- Göldner, ., Fangmeyer, . and Karst, ., . Development of an electrochemical flow-through cell for the fast and easy generation of isotopically labeled metabolite standards: Drug Testing and Analysis, 14(2), pp. 262–268. doi: 10.1002/dta.3175.
- Bücker, ., Funke, .K., Factor, ., Rasschaert, ., Robert, ., Sperling, . and Karst, ., . Combined speciation analysis and elemental bioimaging provide new insight into gadolinium retention in kidney: Metallomics, 14(3), p. mfac004. doi: 10.1093/mtomcs/mfac004.
- Buchholz, ., Krossa, ., Andersen, ., Holtkamp, ., Sperling, ., Karst, . and Tessem, ., . A simple preparation protocol for shipping and storage of tissue sections for laser ablation-inductively coupled plasma-mass spectrometry imaging: Metallomics, 14(3), p. mfac013. doi: 10.1093/mtomcs/mfac013.
- Reifschneider, ., Blaske, ., Vennemann, ., Köppen, ., Sperling, ., Karst, . and Wiemann, ., . Quantitative elemental bioimaging: an antibody-based double-labelling method to quantify the cell-specific distribution of silver nanoparticles in lung tissue sections: Journal of Analytical Atomic Spectrometry, 37, pp. 1084–1089. doi: 10.1039/d1ja00466b.
- Schwarz, ., Buchholz, ., Jawad, ., Hoesker, ., Terwesten-Solé, ., Karst, ., Linsen, ., Vogl, ., Hoerr, ., Wildgruber, . and Faber, ., . Fingerprints of Element Concentrations in Infective Endocarditis Obtained by Mass Spectrometric Imaging and t-Distributed Stochastic Neighbor Embedding: ACS Infectious Diseases, 8(2), pp. 360–372. doi: 10.1021/acsinfecdis.1c00485.
- von Bremen-Kühne, M., Ahmadi, H., Sperling, M., Krämer, U. and Karst, U., . Elemental bioimaging of Zn and Cd in leaves of hyperaccumulator Arabidopsis halleri using laser ablation-inductively coupled plasma-mass spectrometry and referencing strategies: Chemosphere, 305, Article 135267 doi: 10.1016/j.chemosphere.2022.135267.
- Sommer, K., Sperling, M. and Karst, U., . Species-dependent interaction of Gd-based contrast agents with humic substances: Chemosphere, 300, Article 134528 doi: 10.1016/j.chemosphere.2022.134528.
- Fingerhut, S., Rebecca, B., Bücker, P., Clasen, W., Sperling, M., Müller, K.-M., Rehkämper, J., Radbruch, A., Richter, H., Jeibmann, A. and Karst, U., . Gadolinium retention in the tunica media of arterial walls—a complementary study using elemental bioimaging and immunogold staining: Metallomics, 14(6), Article mfac029 doi: 10.1093/mtomcs/mfac029.
- Brungs, C., Schmid, R., Wolf, C., Berg, T., Korf, A., Heuckeroth, S., Hayen, H., van der Bent, S., Maijer, K., Rustemeyer, T. and Karst, U., . Tattoo Pigment Identification in Inks and Skin Biopsies of Adverse Reactions by Complementary Elemental and Molecular Bioimaging with Mass Spectral Library Matching: Analytical Chemistry, 94(8), pp. 3581–3589. doi: 10.1021/acs.analchem.1c04922.
- Seiffert, S.B., Vennemann, A., Nordhorn, I.D. and Kröger, S.W., . LA-ICP-MS and Immunohistochemical Staining with Lanthanide-Labeled Antibodies to Study the Uptake of CeO2 Nanoparticles by Macrophages in Tissue Sections: Chemical Research in Toxicology, 35(6), pp. 981–991. doi: 10.1021/acs.chemrestox.1c00433.
- Funke, ., Factor, ., Rasschaert, ., Lezius, ., Sperling, .K. and Robert, ., . Long-term Gadolinium Retention in the Healthy Rat Brain: Comparison between Gadopiclenol, Gadobutrol, and Gadodiamide: Radiology, 305(1), pp. 179–189. doi: 10.1148/radiol.212600.
- Bücker, ., Buzzi, ., Akeret, ., Mosberger, ., Richter, ., Sperling, ., Hugeslhofer, ., Schaer, . and Karst, ., . A model to visualize the fate of iron after intracranial hemorrhage using isotopic tracers and elemental bioimaging: Metallomics, 14(8), Article mfac057 doi: 10.1093/mtomcs/mfac057.
- Kader, ., Kaufmann, ., Mangarova, ., Moeckel, ., Brangsch, ., Adams, ., Zhao, ., Reimann, ., Saatz, ., Traub, ., Buchholz, ., Karst, ., Hamm, . and Makowski, ., . Iron Oxide Nanoparticles for Visualization of Prostate Cancer in MRI: Cancers, 14(12), Article 2909 doi: 10.3390/cancers14122909.
- Gerwing, ., Hoffmann, ., Kronenberg, ., Hansen, ., Masthoff, ., Helfen, ., Geyer, ., Wachsmuth, ., Höltke, ., Maus, ., Hoerr, ., Krähling, ., Hiddeßen, ., Heindel, ., Karst, ., Kimm, ., Schinner, ., Eisenblätter, ., Faber, . and Wildgruber, ., . Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer: Frontiers in Oncology, 12, Article 1000036 doi: 10.3389/fonc.2022.1000036.
- Lefringhausen, ., Seiffert, ., Erbacher, ., Karst, . and Müller, ., . Chiral-at-Metal Silver-Mediated Base Pairs: Metal-Centred Chirality versus DNA Helical Chirality: Chemistry - A European Journal, 29, Article e202202630 doi: 10.1002/chem.202202630.
- Bücker, ., Richter, ., Radbruch, ., Sperling, ., Brand, ., Holling, ., Van Marck, ., Paulus, ., Jeibman, . and Karst, ., . Deposition patterns of iatrogenic lanthanum and gadolinium in the human body depend on delivered chemical binding forms: Journal of Trace Elements in Medicine and Biology, 63(126665) doi: 10.1016/j.jtemb.2020.126665.
- Kader A, B.J., Reimann C, K.J., Mangarova DB, M.J., Adams LC, Z.J., Saatz J, T.h., Buchholz R, K.U. and Hamm B, M.M., . Visualization and Quantification of the Extracellular Matrix in Prostate Cancer Using an Elastin Specific Molecular Probe: Biology -Basel, 10(11), p. 1217. doi: 10.3390/biology10111217.
- Richter, ., Bücker, ., Martin, ., Dunker, ., Fingerhut, ., Xia, ., Karol, ., Sperling, ., Karst, ., Radbruch, . and Jeibmann, ., . Gadolinium Tissue Distribution in a Large-Animal Model after a Single Dose of Gadolinium-based Contrast Agents: Radiology, 301(3), pp. 637–642. doi: 10.1148/radiol.2021210553.
- Funke, .K., Sperling, . and Karst, ., . Weighted Linear Regression Improves Accuracy of Quantitative Elemental Bioimaging by Means of LA-ICP-MS: Analytical Chemistry, 93(
- Lefringhausen, ., Erbacher, ., Elinkmann, ., Karst, . and Müller, ., . Contiguous Silver(I)-Mediated Base Pairs of Imidazophenanthroline and Canonical Nucleobases in DNA Duplexes: Formation of Classical Duplexes versus Homodimer Formation: Bioconjugate Chemistry, 35, pp. 99–106. doi: 10.1021/acs.bioconjchem.3c00494.
- Rivas Aiello, .B., Kirse, T., Lavorato, .C., Maus, ., Maisuls, ., Kuberasivakumaran, ., Ostendorp, ., Hepp, ., Holtkamp, ., Winkler, .L., Karst, ., Wilde, ., Faber, ., Vericat, . and Strassert, .A., . Superparamagnetic Nanoparticles with Phosphorescent Complexes as Hybrid Contrast Agents: Integration of MRI and PLIM: SMALL SCIENCE, 2024 doi: 10.1002/smsc.202300145.