Prof. Steiner: Research and teaching

  • Research Areas

    Formulierung von anspruchsvollen pharmazeutischen Wirkstoffen (u.a. schwer wasserlösliche Wirkstoffe)

    Herstellung von Wirkstoffnanopartikeln und nanopartikuläre Lipidträgersysteme mittels verschiedener Technologien

    Einarbeitung von nanopartikulären Systemen in orodispersible und mukoadhäsive Formen

    2D-Druck von wirkstoffhaltigen Tinten auf geeignete Trägersysteme

  • CV

    Education

    Promotion zum Dr.-Ing. an der Technischen Universität Braunschweig
    Studienabschluss zum Dipl.-Ing. an der Technischen Universität Braunschweig

    Positions

    Universitätsprofessur für Pharmazeutische Technologie, Universität Münster / Stiftungsprofessur der Rottendorf Stiftung
    Juniorprofessur für Pharmazeutische Technologie, Universität Tübingen
    Wissenschaftliche Mitarbeiterin (PostDoc) am Institut für Pharmazeutische Technologie und Biopharmazie, Technische Universität Braunschweig
    Senior Formulation Scientist & Project Manager, NextPharma GmbH
    Wissenschaftliche Mitarbeiterin am Institut für Partikeltechnik, Technische Universität Braunschweig

  • Publications

    • Steiner, Denise; Meyer, Alexander; Immohr, Laura Isabell; Pein-Hackelbusch, Miriam. . ‘Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.’ Pharmaceutics 16: 658. doi: 10.3390/pharmaceutics16050658.

    • Koehler, Jonas K.; Schmager, Stefanie; Bender, Valentin; Steiner, Denise; Massing Ulrich. . ‘Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation.’ Pharmaceuticals 16: 1519. doi: https://doi.org/10.3390/ph16111519.
    • Steiner, Denise.; Tidau, Marius.; Finke, Jan Henrik. . ‘Embedding of poorly water-soluble drugs in orodispersible films - Comparison of five formulation strategies.’ Pharmaceutics 15, No. 17: 1–22. doi: 10.3390/pharmaceutics15010017.

    • Steiner, Denise; Schumann, Leonie V.; Bunjes, Heike. . ‘Processing of lipid nanodispersions into solid powders by spray drying.’ Pharmaceutics 14, No. 11: 1–17. doi: doi.org/10.3390/pharmaceutics14112464.

    • Steiner, Denise; Emmendörffer, Jakob F.; Bunjes, Heike. . ‘Orodispersible films: A delivery platform for solid lipid nanoparticles?’ Pharmaceutics 13, No. 12: 1–17. doi: doi.org/10.3390/pharmaceutics13122162.
    • Steiner, Denise; Bunjes, Heike. . ‘Influence of process and formulation parameters on the preparation of solid lipid nanoparticles by dual centrifugation.’ International Journal of Pharmaceutics: X 3: 1–11. doi: doi.org/10.1016/j.ijpx.2021.100085.

    • Steiner, Denise; Finke, Jan Henrik; Kwade, Arno. . ‘SOFTs – Structured orodispersible film templates.’ European journal of pharmaceutics and biopharmaceutics 137: 209–217. doi: https://doi.org/10.1016/j.ejpb.2019.03.001.
    • Steiner, Denise; Finke, Jan Henrik; Kwade, Arno. . ‘Model-based description of disintegration time and dissolution rate of nanoparticle-loaded orodispersible films.’ European Journal of Pharmaceutical Sciences 132: 18–26. doi: https://doi.org/10.1016/j.ejps.2019.02.029.

    • Steiner, Denise; Finke, Jan Henrik; Kwade, Arno. . ‘Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication.’ European journal of pharmaceutics and biopharmaceutics 126: 149–158. doi: http://dx.doi.org/10.1016/j.ejpb.2017.04.014.
    • Speer, Isabell; Steiner, Denise; Thabet, Yasmin; Breitkreutz, Jörg; Kwade, Arno. . ‘Comparative study on disintegration methods for oral film preparations.’ European journal of pharmaceutics and biopharmaceutics 132: 50–61. doi: https://doi.org/10.1016/j.ejpb.2018.09.005.

    • Göke, Katrina; Lorenz, Thomas; Repanas, Alexandros; Schneider, Frederic; Steiner, Denise; Baumann Knut; Bunje, Heike; Dietzel, Andreas; Finke, Jan H.; Glasmacher, Birgit; Kwade, Arno. . ‘Novel strategies for the formulation and processing of poorly watersoluble drugs.’ European journal of pharmaceutics and biopharmaceutics 126: 40–56. doi: http://dx.doi.org/10.1016/j.ejpb.2017.05.008.
    • Steiner, Denise; Finke, Jan Henrik; Kwade, Arno. . ‘Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness.’ Chemie Ingenieur Technik 89: 1034–1040. doi: 10.1002/cite.201600139.
    • Erfinder: Steiner, Denise; Kwade, Arno. . Deutsche (DE102017103346 A1) und internationale Patentanmeldung (WO 2018/149983A1), Titel: "Structured orodispersible films".

    • Steiner, Denise; Finke, Jan Henrik; Kwade, Arno. . ‘Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill.’ International Journal of Pharmaceutics 511: 804–813. doi: http://dx.doi.org/10.1016/j.ijpharm.2016.07.058.
    • Steiner, Denise; Finke, Jan Henrik; Breitung-Faes, Sandra; Kwade, Arno. . ‘Breakage, temperature dependency and contamination of Lactose during ball milling in ethanol.’ Advanced Powder Technology 27: 1700–1709. doi: http://dx.doi.org/10.1016/j.apt.2016.05.034.

  • Supervised Doctoral Studies

    Scholten, Julia MarieEinbettung von wirkstoffhaltigen Lipidanodispersionen in orodispersible Filme
    Klein, IsabelleSprühtrocknung und Weiterverarbeitung von wirkstoffhaltigen Lipidnanodispersionen zu orodispersiblen Tabletten
    Hellmund, NicoFormulierung und Charakterisierung von lipidhaltigen, mucoadhäsiven Arzneiformen
    Mahlberg, Lena2D-Druck von Nanodispersionen auf strukturierte orodispersible Formen

  • Scientific Talks

    • Steiner, Denise (): ‘Embedding of lipid nanodispersions in ODFs’. 7th APV Winter Conference: ODx and MBx - orodispersible and mucoadhesive buccal formulations: Novel technologies, new products, future opportunities, Innsbruck, .
    • Steiner, Denise (): ‘Evaluation of drying behaviour and temperature exposure of lipid nanodispersions during spray drying ’. International Congress on Particle Technology, Nürnberg, .
    • Steiner, Denise (): „Wirkstoff Meets Lipid - Nanopartikuläre Lipidträgersysteme eingebettet in feste Matrizes“. DPhG-Vortrag Regionalgruppe Südbaden, Freiburg, .
    • Steiner, Denise (): ‘Processing of lipid nanodispersions into solid formulations by spray drying’. 13. World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Rotterdam, .
    • Steiner, Denise (): ‘Embedding solid lipid nanoparticles in orodispersible films - A feasibility study’. 4. Braunschweig International Symposium on Pharmaceutical Engineering Research, Braunschweig, .
    • Steiner, Denise; Finke, Jan (): ‘Instant preparations for orodispersible films’. 3. APV Winterkonferenz zum Thema “Individualized Medicines for oral use – visions and challenges”, Innsbruck, .
    • Steiner, Denise (): ‘Individualized medication with poorly water-soluble APIs – Instant ODFs’. 2. Europeance Conference on Pharmaceutics, Krakau, .
    • Steiner, Denise (): ‘Loading nanoparticular suspensions on drug-free orodispersible films’. International Congress on Particle Technology, Nürnberg, .
    • Steiner, Denise (): ‘Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill’. 1. Symposium on Pharmaceutical Engineering Research, Braunschweig, .
    • Steiner, Denise (): ‘Stirred media milling of an organic model compound in ethanol’. 6. International Congress on Pharmaceutical Engineering, Graz, .

  • Teaching

    Seminar:

    "Qualitätssicherung bei Herstellung und Prüfung von Arzneimitteln"

Staff

Dissertation, MSc