05.1998 – 06.1999

Postdoctoral Studies (biological mass spectrometry): Prof. Dr. J. Peter-Katalinic (Inst. f. Medizinische Physik und Biophysik); Centro Internationale di Servizi di Spettrometria di Massa (CISeSMa, Neapel, Consiglio Nationale delle Ricerche); Prof. Dr. Peter (Institut für Organische Chemie und Strukturanalytik der Universität Potsdam)

10.1994 – 02.1998

Ph. D. (H. J. Schäfer) WWU Münster: „Studien zur diastereselektiven Kupplung anodisch erzeugter Radikale in Hetero- und Homokupplungen“

10.1989 – 09.1994

Study of chemistry WWU Münster. Diploma (H. J. Schäfer) „Auxiliarkontrollierte Dimerisierung von 2-tert.-Butylmalonsäureamid- zu 2,3-Di-tert.-butylbernsteinsäurederivaten durch Kolbe-Elektrolyse“

since 07.2012

Head of mass spectrometry group at the Organisch-Chemischen Institut of the Westf. Wilhelms-Universität Münster

01. – 07.2012

Rep. head of mass spectrometry group at the Organisch-Chemischen Institut of the Westf. Wilhelms-Universität Münster

07.1999 – 12.2011

Head of mass spectrometry group (Universität Bielefeld, Fakultät für Chemie)

since 01.2017

Treasurer and Board Member of the Deutsche Gesellschaft für Massenspektrometrie e.V.

since 2005

Member of the ASMS - American Society for Mass Spectrometry

since 2004

Member of the DGMS - German Society for Mass Spectrometry

• 2023
• 2021
• 2020
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2011
• 2010
• 2009
• 2008
• 2007
• 2006
• 2005
• 2004
• 2003
• 2002
• 2001
• 2000
• 1995

2023

• Mo, Boris; Scharf, Birte; Gutheil, Christian; Letzel, Matthias C.; Hensel, Andreas. 2023. ‘Tamm-Horsfall protein in humane urine: sex-dependent differences in the excretion and N-glycosylation pattern.’ Scientific Reports 13, No. 1. doi: 10.1038/s41598-023-44650-1.

2021

• Fraschetti C., Letzel M. C., Paletta M., Mattay J., Crestoni M.E., Chiavarino B., Filippi A. 2021. ‘Unprotected Galactosamine as a Dynamic Key for a Cyclochiral Lock.’ Journal of The American Society for Mass Spectrometry 2021, No. 24: 736–743. doi: 10.1021/jasms.0c00437.

2020

• Watanabe, Kohei; Ueno, Atsushi; Tao, Xin; Skoch, Karel; Jie, Xiaoming; Vagin, Sergei; Rieger, Bernhard; Daniliuc, Constantin G.; Letzel, Matthias C.; Kehr, Gerald; Erker, Gerhard. 2020. ‘Reactions of an anionic chelate phosphane/borata-alkene ligand with [Rh(nbd)Cl]2, [Rh(CO)2Cl]2and [Ir(cod)Cl]2.’ Chemical science 11, No. 28. doi: 10.1039/d0sc02223c.
• Jansen, Dennis; Gramueller, Johannes; Niemeyer, Felix; Schaller, Torsten; Letzel, Matthias C.; Grimme, Stefan; Zhu, Hui; Gschwind, Ruth M.; Niemeyer, Jochen. 2020. ‘What is the role of acid-acid interactions in asymmetric phosphoric acid organocatalysis? A detailed mechanistic study using interlocked and non-interlocked catalysts.’ Chemical science 11, No. 17. doi: 10.1039/d0sc01026j.

2018

• Kuck D., Heitkamp S., Letzel M., Ahmed I., Krohn K. 2018. ‘Consecutive loss of two benzyl radicals from the [M + Na]+ adduct ions of pyrogallol tribenzyl ether and its derivatives.’ European Journal of Mass Spectrometry 24, No. 1: 23–32. doi: 10.1177/1469066717729300.

2017

• Thierbach, Sven; Birmes, Franziska S.; Letzel, Matthias C.; Hennecke, Ulrich; Fetzner, Susanne. 2017. ‘Chemical Modification and Detoxification of the Pseudomonas aeruginosa Toxin 2-Heptyl-4-hydroxyquinoline N-Oxide by Environmental and Pathogenic Bacteria.’ ACS Chemical Biology 12, No. 9: 2305–2312. doi: 10.1021/acschembio.7b00345.
• Thierbach S., Birmes F., Letzel M., Hennecke U., Fetzner S. 2017. ‘Chemical Modification and Detoxification of the Pseudomonas aeruginosa Toxin 2-Heptyl-4-hydroxyquinoline N-Oxide by Environmental and Pathogenic Bacteria.’ ACS Chemical Biology 12, No. 9: 2305–2312. doi: 10.1021/acschembio.7b00345.
• Tesch M, Kudruk S, Letzel M, Studer A. 2017. ‘Orthogonal Click Postfunctionalization of Alternating Copolymers Prepared by Nitroxide-Mediated Polymerization.’ Chemistry - A European Journal 23, No. 25: 5915–5919. doi: 10.1002/chem.201605639.
• Letzel M C, Schäfer H-J, Fröhlich R. 2017. ‘Diastereoselective anodic hetero- and homo-coupling of menthol-, 8-methylmenthol- and 8-phenylmenthol-2-alkylmalonates.’ Beilstein Journal of Organic Chemistry 13, No. null: 33–42. doi: 10.3762/bjoc.13.5.

2016

• Hickert S., Cramer B., Letzel M., Humpf H.-U. 2016. ‘Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging of ochratoxin A and fumonisins in mold-infected food.’ Rapid Communications in Mass Spectrometry 30, No. 23: 2508–2516. doi: 10.1002/rcm.7733.
• Elghamry I., El-Ayaan U., Youssef M., Al-Shihry S., Letzel M., Mattay J. 2016. ‘Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products.’ Chemical Monthly / Monatshefte für Chemie 2016: 1–6. doi: 10.1007/s00706-016-1765-z.
• Mitra R., Thiele M., Octa-Smolin F., Letzel M., Niemeyer J. 2016. ‘A bifunctional chiral [2]catenane based on 1,1′-binaphthyl-phosphates.’ Chemical communications 52, No. 35: 5977–5980. doi: 10.1039/c6cc01980c.

2015

• Radunsky C, Kösters J, Letzel MC, Yogendra S, Schwickert C, Manck S, Sarkar B, Pöttgen R, Weigand JJ, Neugebauer J, Müller J. 2015. ‘Dioxygen Activation by an in situ Reduced Cu^II Hydrazone Complex.’ European Journal of Inorganic Chemistry 2015: 4006–4012. doi: 10.1002/ejic.201500556.
• Volkenhoff A., Weiler A., Letzel M., Stehling M., Klämbt C., Schirmeier S. 2015. ‘Glial glycolysis is essential for neuronal survival in drosophila.’ Cell Metabolism 22, No. 3: 437–447. doi: 10.1016/j.cmet.2015.07.006.
• Tesch M., Hepperle J., Klaasen H., Letzel M., Studer A. 2015. ‘Alternating copolymerization by nitroxide-mediated polymerization and subsequent orthogonal functionalization.’ Angewandte Chemie - International Edition 54, No. 17: 5054–5059. doi: 10.1002/anie.201412206.
• Kuck D., Heitkamp S., Sproß J., Letzel M., Ahmed I., Krohn K., Parker R., Wang Y., Robbins V., Ames W., Schettler P., Hark R. 2015. ‘Consecutive losses of two benzyl radicals from the [M+Na]⁺ adduct ions of di- and tri(benzyloxy)benzenes under ESI/CID conditions.’ International Journal of Mass Spectrometry 377, No. 1: 23–38. doi: 10.1016/j.ijms.2014.06.013.

2014

• Kuck D., Salameh L., Onwuka K., Letzel M. 2014. ‘Unidirectional triple hydrogen rearrangement in the radical cations of electron-rich 3-aryl-1-propanols: Further evidence and limitation.’ European Journal of Mass Spectrometry 20, No. 1: 51–61. doi: 10.1255/ejms.1239.
• Pirkl A., Meier M., Popkova Y., Letzel M., Schnapp A., Schiller J., Dreisewerd K. 2014. ‘Analysis of free fatty acids by ultraviolet laser desorption ionization mass spectrometry using insect wings as hydrophobic sample substrates.’ Analytical Chemistry 86, No. 21: 10763–10771. doi: 10.1021/ac5020047.

2013

• Letzel M., Barth D., Kuck D., Grützmacher H., Kim S., Yim M., Choe J. 2013. ‘Unimolecular reactions of gaseous picoline radical cations. A new experimental and computational study.’ International Journal of Mass Spectrometry 336, No. null: 1–16. doi: 10.1016/j.ijms.2012.11.005.
• Rozhenko A., Schoeller W., Letzel M., Decker B., Mattay J. 2013. ‘Anion-π interactions in adducts of anionic guests with octahydroxy-pyridine[4]arene: Theoretical and experimental elucidation.’ New Journal of Chemistry 37, No. 2: 356–365. doi: 10.1039/c2nj40670e.

2012

• Amick A., Hoegg E., Harrison S., Houston K., Hark R., Reingold I., Barth D., Letzel M., Kuck D. 2012. ‘Site-specific hydrogen exchange and hydrogen transfer processes preceding the fragmentation of long-lived radical cations of ethyl dihydrocinnamate and related arylalkanoates.’ International Journal of Mass Spectrometry null, No. null: 206–215. doi: 10.1016/j.ijms.2012.01.005.
• Fraschetti C., Letzel M., Paletta M., Mattay J., Speranza M., Filippi A., Aschi M., Rozhenko A. 2012. ‘Cyclochiral resorcin[4]arenes as effective enantioselectors in the gas phase.’ Journal of Mass Spectrometry 47, No. 1: 72–78. doi: 10.1002/jms.2028.
• Fraschetti C., Letzel M., Filippi A., Speranza M., Mattay J. 2012. ‘Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system.’ Beilstein Journal of Organic Chemistry 8, No. null: 539–550. doi: 10.3762/bjoc.8.62.

2011

• Botta B., Fraschetti C., D'Acquarica I., Sacco F., Mattay J., Letzel M., Speranza M. 2011. ‘Unprecedented gas-phase chiroselective logic gates.’ Organic and Biomolecular Chemistry 9, No. 6: 1717–1719. doi: 10.1039/c0ob00664e.
• Kuck D., Matthias C., Barth D., Letzel M. 2011. ‘Isomerization of the constituents of ion/neutral complexes during the fragmentation of protonated dialkyl-substituted 1,3-diphenylpropanes.’ International Journal of Mass Spectrometry 306, No. null: 167–174. doi: 10.1016/j.ijms.2010.10.007.
• Kuck D., Grützmacher H., Barth D., Heitkamp S., Letzel M. 2011. ‘The role of ion/neutral complexes in the fragmentation of N-benzyl-(alkylpyridinium) ions.’ International Journal of Mass Spectrometry 306, No. null: 159–166. doi: 10.1016/j.ijms.2010.10.006.

2010

• Krohn K., Ahmed I., John M., Letzel M., Kuck D. 2010. ‘Stereoselective synthesis of benzylated prodelphinidins and their diastereomers with use of the mitsunobu reaction in the preparation of their gallocatechin precursors.’ European Journal of Organic Chemistry null, No. 13: 2544–2554. doi: 10.1002/ejoc.201000053.

2009

• Botta B., Fraschetti C., D'Acquarica I., Speranza M., Novara F., Mattay J., Letzel M. 2009. ‘Gas-Phase enantioselectivity of chiral N-Linked peptidoresorc[4]arene isomers toward dipeptides.’ Journal of Physical Chemistry A 113, No. 52: 14625–14629. doi: 10.1021/jp904374h.
• Böcker S., Letzel M., Lipták Z., Pervukhin A. 2009. ‘SIRIUS: Decomposing isotope patterns for metabolite identification.’ Bioinformatics 25, No. 2: 218–224. doi: 10.1093/bioinformatics/btn603.
• Botta B., Fraschetti C., Novara F., Tafi A., Sacco F., Mannina L., Sobolev A., Mattay J., Letzel M., Speranza M. 2009. ‘Interactions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: A dynamic, kinetic, and spectroscopic study.’ Organic and Biomolecular Chemistry 7, No. 9: 1798–1806. doi: 10.1039/b900735k.
• Sekiguchi O., Meyer V., Letzel M., Kuck D., Uggerud E. 2009. ‘Energetics and reaction mechanisms for the competitive losses of H 2, CH4 and C2H4 from protonated methylbenzenes-implications to the methanol-to-hydrocarbons (MTH) process.’ European Journal of Mass Spectrometry 15, No. 2: 167–181. doi: 10.1255/ejms.953.

2008

• Letzel M., Grützmacher H., Stein D., Grützmacher H. 2008. ‘Trends in the reactions of gaseous phenyl pnictogen radical cations C 6H5EH2̇+ (E = N, P, As).’ Dalton Transactions null, No. 25: 3282–3291. doi: 10.1039/b801970c.
• König H., Marsmann H., Letzel M. 2008. ‘Thioether Functionalized Octasilsesquioxanes.’ In Organosilicon Chemistry I: From Molecules to Materials, edited by Auner Norbert, Weis Johann, 425–428. John Wiley & Sons. doi: 10.1002/9783527620777.ch69d.
• Igoli J., Onyiriuka S., Letzel M., Nwaji M., Gray A. 2008. ‘Cassane diterpenoids from Lonchocarpus laxiflorus.’ Natural Product Communications 3, No. 1: 5–10.
• Schröder T., Brodbeck R., Letzel M., Mix A., Schnatwinkel B., Tonigold M., Volkmer D., Mattay J. 2008. ‘A self-assembling metallosupramolecular cage based on cavitand-terpyridine subunits.’ Tetrahedron Letters 49, No. 41: 5939–5942. doi: 10.1016/j.tetlet.2008.07.143.
• Letzel M., Schäfer C., Novara F., Speranza M., Rozhenko A., Schoeller W., Mattay J. 2008. ‘A kinetic study of guest displacement reactions on a host-guest complex with a photoswitchable calixarene.’ Journal of Mass Spectrometry 43, No. 11: 1553–1564. doi: 10.1002/jms.1464.

2007

• Botta B., D'Acquarica I., Nevola L., Sacco F., Lopez Z., Zappia G., Fraschetti C., Speranza M., Tafi A., Caporuscio F., Letzel M., Mattay J. 2007. ‘Bis(diamido)-bridged basket resorcin[4]arenes as enantioselective receptors for amino acids and amines.’ European Journal of Organic Chemistry null, No. 36: 5995–6002. doi: 10.1002/ejoc.200700829.

2006

• Schäfer C., Decker B., Letzel M., Novara F., Eckel R., Ros R., Anselmetti D., Mattay J. 2006. ‘On the way to supramolecular photochemistry at the single-molecule level.’ Pure and Applied Chemistry 78, No. 12: 2247–2259. doi: 10.1351/pac200678122247.
• Letzel M., Kirchhoff D., Grützmacher H., Stein D., Grützmacher H. 2006. ‘Isomerization and fragmentation reactions of gaseous phenylarsane radical cations and phenylarsanyl cations. A study by tandem mass spectrometry and theoretical calculations.’ Dalton Transactions null, No. 16: 2008–2016. doi: 10.1039/b514312h.
• Svelle S., Bjørgen M., Kolboe S., Kuck D., Letzel M., Olsbye U., Sekiguchi O., Uggerud E. 2006. ‘Intermediates in the methanol-to-hydrocarbons (MTH) reaction: A gas phase study of the unimolecular reactivity of multiply methylated benzenium cations.’ Catalysis Letters 109, No. null: 25–35. doi: 10.1007/s10562-006-0052-8.
• Rozhenko A., Schoeller W., Letzel M., Decker B., Agena C., Mattay J. 2006. ‘Calixarenes as hosts for ammonium cations: A quantum chemical study and mass-spectrometric investigations.’ Chemistry - A European Journal 12, No. 35: 8995–9000. doi: 10.1002/chem.200501520.
• Böcker S., Letzel M., Lipták Z., Pervukhin A. 2006. ‘Decomposing metabolomic isotope patterns.’ Contributed to the 6th International Workshop on Algorithms in Bioinformatics, WABI 2006, Zurich, che.
• Sekiguchi O., Letzel M., Kuck D., Uggerud E. 2006. ‘The unimolecular dissociation of protonated glyoxylic acid: Structure and dynamics of a step-by-step process.’ International Journal of Mass Spectrometry null, No. null: 177–184. doi: 10.1016/j.ijms.2005.12.041.

2005

• Schulte T, Siegenthaler KO, Luftmann H, Letzel M, Studer A. 2005. ‘Nitroxide-mediated polymerization of N-isopropylacrylamide: Electrospray ionization mass spectrometry, matrix-assisted laser desorption ionization mass spectrometry, and multiple-angle laser light scattering studies on nitroxide-terminated poly-N-isopropylacrylamides.’ Macromolecules 38, No. 16: 6833–6840. doi: 10.1021/ma050343n.
• Rozhenko A., Schoeller W., Letzel M., Decker B., Agena C., Mattay J. 2005. ‘Conformational features of calix[4]arenes with alkali metal cations: A quantum chemical investigation with density functional theory.’ Journal of Molecular Structure: THEOCHEM 732, No. null: 7–20. doi: 10.1016/j.theochem.2005.06.041.

2004

• Mehdizadeh A., Letzel M., Klaes M., Agena C., Mattay J. 2004. ‘Chiral discrimination on the host-guest complexation of resorc[4]arenes with quarternary amines.’ European Journal of Mass Spectrometry 10, No. 5: 649–655. doi: 10.1255/ejms.675.
• Oley M., Letzel M., Ragg H. 2004. ‘Inhibition of furin by serpin Spn4A from Drosophila melanogaster.’ FEBS Letters 577, No. null: 165–169. doi: 10.1016/j.febslet.2004.10.003.
• Letzel M., Decker B., Rozhenko A., Schoeller W., Mattay J. 2004. ‘Encapsulated guest molecules in the dimer of octahydroxypyridine[4]arene.’ Journal of the American Chemical Society 126, No. 31: 9669–9674. doi: 10.1021/ja049128x.

2003

• Leitão E., Bittencourt V., Haido R., Valente A., Peter-Katalinic J., Letzel M., de Souza L., Barreto-Bergter E. 2003. ‘β-Galactofuranose-containing O-linked oligosaccharides present in the cell wall peptidogalactomannan of Aspergillus fumigatus contain immunodominant epitopes.’ Glycobiology 13, No. 10: 681–692. doi: 10.1093/glycob/cwg089.

2002

• Bahrke S., Einarsson J., Gislason J., Haebel S., Letzel M., Peter-Katalinić J., Peter M. 2002. ‘Sequence analysis of chitooligosaccharides by matrix-assisted laser desorption ionization postsource decay mass spectrometry.’ Biomacromolecules 3, No. 4: 696–704. doi: 10.1021/bm020010n.
• Müller A., Diemann E., Shah S., Kuhlmann C., Letzel M. 2002. ‘Soccer-playing metal oxide giant spheres: A first step towards patterning structurally well defined nano-object collectives.’ Chemical communications null, No. 5: 440–441.
• Letzel M., Agena C., Mattay J. 2002. ‘Investigation of homo- and heterodimer alkali metal cation complexes of resorc[4]arenes by electrospray ionization mass spectrometry.’ Journal of Mass Spectrometry 37, No. 1: 63–68. doi: 10.1002/jms.247.
• Letzel M., Grützmacher H., Fürst T., Mayer K., Wiegrebe W. 2002. ‘Functional group migration in benzaldoxime-O-n-propyl ether radical cation.’ International Journal of Mass Spectrometry 217, No. null: 153–168. doi: 10.1016/S1387-3806(02)00571-7.

2001

• Hollah P, Hausberg M, Kosch M, Barenbrock M, Letzel M, Schlatter E, Rahn KH. 2001. ‘A novel assay for determination of diadenosine polyphosphates in human platelets: studies in normotensive subjects and in patients with essential hypertension.’ Journal of Hypertension 19, No. 2: 237–245. doi: 10.1097/00004872-200102000-00010.
• Letzel M., Agena C., Mattay J. 2001. ‘Letter: Calibration of electrospray mass spectrometers with rccc-2,8,14,20-tetra-n-octyl-5,11,17,23- tetrahydroxyresorc[4]arene in the high mass range up to m/z 6000.’ European Journal of Mass Spectrometry 7, No. 1: 35–38.

2000

• Letzel Matthias C., Synstad B., Eijsink V.G. H. , Peter-Katalinić Jasna, Peter Martin G. 2000. ‘Libraries of chito-oligosaccharides of mixed acetylation patterns and their interactions with chitinases.’ In Advan. Chitin Science 2000, Vol. IV, edited by Peter G., Muzzarelli R.A.A., Domard A., 545–552. Potsdam: unbekannt / n.a. / unknown.

1995

• Schäfer H. J., Klotz-Berendes B., Letzel M., Zielinski C., Schoo N., Lohl T. Höweler U. 1995. ‘Diastereoselective and Enantioselective Conversions at the Anode and the Cathode.’ In Novel Trends in Electroorganic Synthesis, edited by Torii Sigeru, 149–154. Okayama.