Research Foci
Mycotoxins
Process-induced contaminants
Formation and minimization of process contaminants such as furans, monochloropropanediols (MCPDs), glycidols and acrylamide
Instrumental analysis (HPLC-MS/MS, HPLC-HRMS, GC-MS)
Human biomonitoring
CV
Academic Education
- Dissertation (Prof. Dr. H.-U. Humpf), Lehrstuhl für Lebensmittelchemie der WWU Münster
- Kollegiat der International Research Training Group Münster/D - Nagoya/J (IRTG-MS/NG)
- Forschungsaufenthalt an der Nagoya University, Nagoya, Japan, Department of Chemistry (Prof. Dr. D. Uemura)
Positions
- Akademischer Rat am Institut für Lebensmittelchemie der WWU Münster, Leiter der Serviceeinheit "Instrumentelle Analytik und Spektroskopie"
- Post-Doc am Institut für Lebensmittelchemie der WWU Münster (Prof. Dr. H.-U. Humpf)
Honors
- Stockmeyer Wissenschaftspreis – Heinrich-Stockmeyer-Stiftung
External Functions
- Member of the editorial board of the journal "Mycotoxin Research"
- Mitglied der §64-LFGB Arbeitssgruppe "Mykotoxine" beim Bundesamt für Verbraucherschutz und Lebensmittelsicherheit
Publications
- . ‘Antagonistic properties against Fusarium sporotrichioides and glycosylation of HT-2 and T-2 toxins by selected Trichoderma strains.’ Scientific Reports 14, № 1. doi: 10.1038/s41598-024-55920-x.
- . ‘Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.’ Archives of Toxicology 98, № 4: 1081–1093. doi: 10.1007/s00204-024-03688-4.
- . ‘Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.’ Journal of Agricultural and Food Chemistry 72, № 6: 3150–3159. doi: 10.1021/acs.jafc.3c07465.
- . . ‘Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.’ Journal of Agricultural and Food Chemistry 72, № 6. doi: 10.1021/acs.jafc.3c07465.
- . . ‘Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.’ Archives of Toxicology 1. doi: 10.1007/s00204-024-03688-4.
- . . ‘Role of albumin in the metabolism and excretion of ochratoxin A.’ Mycotoxin Research 1. doi: 10.1007/s12550-024-00538-1.
- . . ‘Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.’ Archives of Toxicology 97, № 12: 3179–3196. doi: 10.1007/s00204-023-03607-z.
- . ‘Degradation products of aflatoxin M1 (AFM1) formed by high voltage atmospheric cold plasma (HVACP) treatment.’ Toxicon 230. doi: 10.1016/j.toxicon.2023.107160.
- . ‘Determination of furan and alkylfuran in breakfast cereals from the European market and their correlation with acrylamide levels.’ European Food Research and Technology 2023. doi: 10.1007/s00217-023-04374-y.
- . ‘Developments in mycotoxin analysis: an update for 2021-22.’ World Mycotoxin Journal 16, № 1: 3–24. doi: 10.3920/WMJ2022.2822.
- . ‘Maternal exposure to multiple mycotoxins and adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh.’ Archives of Toxicology 97, № 6: 1795–1812. doi: 10.1007/s00204-023-03491-7.
- . . ‘Mycotoxins in Serum and 24-h Urine of Vegans and Omnivores from the Risks and Benefits of a Vegan Diet (RBVD) Study.’ Molecular Nutrition and Food Research 66, № 6. doi: 10.1002/mnfr.202100874.
- . . ‘Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.’ Analytical Chemistry 94, № 10: 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- . . ‘Development and application of a competitive enzyme immunoassay for the detection of penitrem A in fungal mycelium: Evidence for frequent occurrence of multiple indole-containing mycotoxins in mouldy foods.’ Food Control 132: 108558. doi: 10.1016/j.foodcont.2021.108558.
- . ‘Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.’ Archives of Toxicology 96, № 11: 2967–2981. doi: 10.1007/s00204-022-03361-8.
- . ‘Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.’ Archives of Toxicology 96, № 12: 3349–3361. doi: 10.1007/s00204-022-03395-y.
- . ‘Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh.’ Archives of Toxicology 96, № 7: 2123–2138. doi: 10.1007/s00204-022-03288-0.
- . . ‘Analysis of mold and mycotoxins in naturally infested indoor building materials.’ Mycotoxin Research 2022. doi: 10.1007/s12550-022-00461-3.
- . ‘From the laboratory bench to the lecture hall: latest findings from mycotoxin research presented at the 43rd Mycotoxin Workshop.’ Mycotoxin Research 2022. doi: 10.1007/s12550-022-00462-2.
- . ‘Developments in mycotoxin analysis: an update for 2020-2021.’ World Mycotoxin Journal 15, № 1: 3–25. doi: 10.3920/WMJ2021.2752.
- . . ‘Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).’ Mycotoxin Research 37, № 4: 275–278. doi: 10.1007/s12550-021-00439-7.
- . . ‘Phase II metabolism of asarone isomers in vitro and in humans using HPLC-MS/MS and HPLC-QToF/MS.’ Foods 10, № 9: 2032. doi: 10.3390/foods10092032.
- . . ‘Determination of urinary mycotoxin biomarkers using a sensitive online solid phase extraction‐uhplc‐ms/ms method.’ Toxins 13, № 6. doi: 10.3390/toxins13060418.
- . . ‘Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine.’ Mycotoxin Research 37, № 2: 129–140. doi: 10.1007/s12550-021-00423-1.
- . . ‘Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney.’ Archives of Toxicology 95, № 6: 2163–2177. doi: 10.1007/s00204-021-03073-5.
- . . ‘Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 69, № 2: 776–782. doi: 10.1021/acs.jafc.0c05513.
- . . ‘Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry Online ahead of print. doi: 10.1021/acs.jafc.0c05513.
- . . ‘Developments in mycotoxin analysis: An update for 2018-19.’ World Mycotoxin Journal 13, № 1: 3–24. doi: 10.3920/WMJ2019.2535.
- . . ‘Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics.’ Mycotoxin Research 36, № 2: 193–206. doi: 10.1007/s12550-019-00381-9.
- . . ‘Artificial vs natural Stachybotrys infestation—Comparison of mycotoxin production on various building materials.’ Indoor Air 30, № 6: 1268–1282. doi: 10.1111/ina.12705.
- . . ‘Occurrence of the ochratoxin A degradation product 2′R-ochratoxin a in coffee and other food: An update.’ Toxins 11, № 6: 329. doi: 10.3390/toxins11060329.
- . . ‘Matrix binding of T-2 toxin: structure elucidation of reaction products and indications on the fate of a relevant food-borne toxin during heating.’ Mycotoxin Research 35, № 3: 261–270. doi: 10.1007/s12550-019-00350-2.
- . . ‘Human Study on the Kinetics of 2′R-Ochratoxin A in the Blood of Coffee Drinkers.’ Molecular Nutrition and Food Research 63, № 4: 1801026. doi: 10.1002/mnfr.201801026.
- . . Thermal reactions and the formation of degradation products of T-2 and HT-2 toxin during processing of oats. Washington, D.C.: American Chemical Society. doi: 10.1021/bk-2019-1306.ch007.
- . . ‘Identification of ochratoxin-N-acetyl-L-cysteine as a new ochratoxin A metabolite and potential biomarker in human urine.’ Mycotoxin Research 2020, № 36: 1–10. doi: 10.1007/s12550-019-00360-0.
- . . ‘Exploring secondary metabolite profiles of stachybotrys spp. By LC-MS/MS.’ Toxins 11, № 3: 133. doi: 10.3390/toxins11030133.
- . . ‘Developments in mycotoxin analysis: An update for 2017-2018.’ World Mycotoxin Journal 12, № 1: 3–29. doi: 10.3920/WMJ2018.2398.
- . . ‘Interaction of ochratoxin A and its thermal degradation product 2'R-ochratoxin A with human serum albumin.’ Toxins 10, № 7. doi: 10.3390/toxins10070256.
- . . ‘Glucosylation of T-2 and HT-2 toxins using biotransformation and chemical synthesis: Preparation, stereochemistry, and stability.’ Mycotoxin Research 34, № 3: 159–172. doi: 10.1007/s12550-018-0310-9.
- . . ‘Detection of the Cytotoxic Penitrems A-F in Cheese from the European Single Market by HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 66, № 5: 1264–1269. doi: 10.1021/acs.jafc.7b06001.
- . . ‘Interaction of 2'R-ochratoxin A with serum albumins: Binding site, effects of site markers, thermodynamics, species differences of albumin-binding, and influence of albumin on its toxicity in MDCK cells.’ Toxins 10, № 9. doi: 10.3390/toxins10090353.
- . . ‘Developments in mycotoxin analysis: An update for 2016-2017.’ World Mycotoxin Journal 11, № 1: 5–32. doi: 10.3920/WMJ2017.2250.
- . . ‘Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants.’ Journal of Agricultural and Food Chemistry 66, № 1: 315–322. doi: 10.1021/acs.jafc.7b05580.
- . . ‘Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells.’ Toxins 10, № 9: 353. doi: 10.3390/toxins10090353.
- . ‘Interaction of Ochratoxin A and Its Thermal Degradation Product 2′R-Ochratoxin A with Human Serum Albumin.’ Toxins 10, № 7: 256. doi: 10.3390/toxins10070256.
- . ‘In vitro biosynthesis of 3-mercaptolactate by lactate dehydrogenases.’ Enzyme and Microbial Technology 108, № null: 1–10. doi: 10.1016/j.enzmictec.2017.08.005.
- . . ‘Auranthine, a Benzodiazepinone from Penicillium aurantiogriseum: Refined Structure, Absolute Configuration, and Cytotoxicity.’ Journal of Natural Products 81, № 10: 2177–2186. doi: 10.1021/acs.jnatprod.8b00187.
- . ‘Enniatin B and ochratoxin A in the blood serum of workers from the waste management setting.’ Mycotoxin Research 34, № 2: 85–90. doi: 10.1007/s12550-017-0302-1.
- . ‘Alternaria toxins in South African sunflower seeds: cooperative study.’ Mycotoxin Research 33, № 4: 309–321. doi: 10.1007/s12550-017-0290-1.
- . ‘Applications of High-Performance Liquid Chromatography-Mass Spectrometry Techniques for the Analysis of Chemical Contaminants and Residues in Food.’ In Chemical Contaminants and Residues in Food: Second Edition, edited by , 51–66. Amsterdam: Elsevier. doi: 10.1016/B978-0-08-100674-0.00003-5.
- . ‘Detection of the tremorgenic mycotoxin paxilline and its desoxy analog in ergot of rye and barley: a new class of mycotoxins added to an old problem.’ Analytical and Bioanalytical Chemistry 409, № 21: 5101–5112. doi: 10.1007/s00216-017-0455-y.
- . ‘Impact of Mechanical and Thermal Energies on the Degradation of T-2 and HT-2 Toxins during Extrusion Cooking of Oat Flour.’ Journal of Agricultural and Food Chemistry 65, № 20: 4177–4183. doi: 10.1021/acs.jafc.7b01484.
- . ‘Influence of environmental factors on the production of penitrems A–F by Penicillium crustosum.’ Toxins 9, № 7. doi: 10.3390/toxins9070210.
- . ‘Multi-mycotoxin analysis using dried blood spots and dried serum spots.’ Analytical and Bioanalytical Chemistry 409, № 13: 3369–3382. doi: 10.1007/s00216-017-0279-9.
- . ‘Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study.’ Mycotoxin Research 33, № 1: 79–91. doi: 10.1007/s12550-016-0263-9.
- . ‘Evidence of ochratoxin A conjugates in urine samples from infants and adults.’ Mycotoxin Research 33, № 1: 39–47. doi: 10.1007/s12550-016-0261-y.
- . ‘Localization of ergot alkaloids in sclerotia of Claviceps purpurea by matrix-assisted laser desorption/ionization mass spectrometry imaging.’ Analytical and Bioanalytical Chemistry 409, № 5: 1221–1230. doi: 10.1007/s00216-016-0047-2.
- . ‘Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging of ochratoxin A and fumonisins in mold-infected food.’ Rapid Communications in Mass Spectrometry 30, № 23: 2508–2516. doi: 10.1002/rcm.7733.
- . ‘Determination of exposure to the alternaria mycotoxin tenuazonic acid and its isomer allo-tenuazonic acid in a German population by stable isotope dilution HPLC-MS3 .’ Journal of Agricultural and Food Chemistry 64, № 34: 6641–6647. doi: 10.1021/acs.jafc.6b02735.
- . ‘Analysis of ochratoxin A in dried blood spots - Correlation between venous and finger-prick blood, the influence of hematocrit and spotted volume.’ Journal of Chromatography B 1020, № null: 158–164. doi: 10.1016/j.jchromb.2016.03.026.
- . ‘Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach.’ Mycotoxin Research 32, № 1: 7–18. doi: 10.1007/s12550-015-0233-7.
- . ‘Detection and Quantitative Analysis of the Non-cytotoxic allo-Tenuazonic Acid in Tomato Products by Stable Isotope Dilution HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 63, № 50: 10879–10884. doi: 10.1021/acs.jafc.5b04812.
- . ‘A new approach using micro HPLC-MS/MS for multi-mycotoxin analysis in maize samples.’ Mycotoxin Research 31, № 2: 109–115. doi: 10.1007/s12550-015-0221-y.
- . ‘A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach.’ Mycotoxin Research 31, № 3: 127–136. doi: 10.1007/s12550-015-0223-9.
- . ‘Biomonitoring using dried blood spots: Detection of ochratoxin A and its degradation product 2'R-ochratoxin A in blood from coffee drinkers*.’ Molecular Nutrition and Food Research 59, № 9: 1837–1843. doi: 10.1002/mnfr.201500220.
- . ‘Beitrag eines Acrylamid-Niacin-Adduktes zur Reduzierung des Acrylamid-Gehaltes im Lebensmittel .’ präsentiert auf der Deutscher Lebensmittelchemikertag, Karlsruhe, .
- . . ‘Structure elucidation and in vitro cytotoxicity of ochratoxin α amide, a new degradation product of ochratoxin A.’ Mycotoxin Research 31, № 2: 83–90. doi: 10.1007/s12550-014-0218-y.
- . . ‘Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach.’ Molecular Nutrition and Food Research 58, № 12: 2368. doi: 10.1002/mnfr.201400406.
- . . ‘Matrix binding of ochratoxin A during roasting.’ Journal of Agricultural and Food Chemistry 61, № 51: 12737. doi: 10.1021/jf403984x.
- . . ‘H2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid.’ European Journal of Mass Spectrometry 19, № 5: 350. doi: 10.1255/ejms.1243.
- . . ‘HPLC-MS/MS-analysis of Mycotoxins: Current applications and future perspectives.’ Journal of Plant Pathology 1, № SUPPL: S1.39.
- . . ‘Large-scale synthesis of isotopically labeled 13C 2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products.’ Journal of Agricultural and Food Chemistry 61, № 1: 120. doi: 10.1021/jf305138k.
- . ‘Wavelength-dependent degradation of ochratoxin and citrinin by light in vitro and in vivo and its implications on Penicillium.’ Toxins 4, № 12: 1535–1551. doi: 10.3390/toxins4121535.
- . ‘In vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity.’ Planta Medica 78, № 18: 1939–1941. doi: 10.1055/s-0032-1327876.
- . ‘Intestinal metabolism of T-2 toxin in the pig cecum model.’ Mycotoxin Research 28, № 3: 191–198. doi: 10.1007/s12550-012-0134-y.
- . ‘Applications of HPLC-MS techniques for the analysis of chemical contaminants and residues in food.’ In Chemical Contaminants and Residues in Food, edited by , 62–78. Amsterdam: Elsevier. doi: 10.1533/9780857095794.1.62.
- . ‘Analysis of the Fusarium mycotoxin moniliformin in cereal samples using 13C 2-moniliformin and high-resolution mass spectrometry.’ Journal of Agricultural and Food Chemistry 60, № 14: 3586–3591. doi: 10.1021/jf300323d.
- . . ‘Systematic approach for structure elucidation of polyphenolic compounds using a bottom-up approach combining ion trap experiments and accurate mass measurements.’ Journal of Agricultural and Food Chemistry 60, № 45: 11274. doi: 10.1021/jf3030369.
- . ‘Re-examination of the anion derivatives of isoflavones by radical fragmentation in negative electrospray ionization tandem mass spectrometry: Experimental and computational studies.’ Rapid Communications in Mass Spectrometry 25, № 14: 2020–2026. doi: 10.1002/rcm.5075.
- . ‘Impact of physicochemical parameters on the decomposition of deoxynivalenol during extrusion cooking of wheat grits.’ Journal of Agricultural and Food Chemistry 59, № 23: 12480–12485. doi: 10.1021/jf2038604.
- . . ‘Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers.’ Bioorganic & Medicinal Chemistry 18, № 1: 343–357. doi: 10.1016/j.bmc.2009.10.050.
- . . ‘Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.’ Molecular Nutrition and Food Research 53, № 9: 1123–1133. doi: 10.1002/mnfr.200800584.
- . . ‘Identification and in vitro cytotoxicity of ochratoxin a degradation products formed during coffee roasting.’ Journal of Agricultural and Food Chemistry 56, № 14: 5673–5681. doi: 10.1021/jf801296z.
- . . ‘Stable isotope dilution analysis of the Fusarium mycotoxin zearalenone.’ Journal of Agricultural and Food Chemistry 55, № 21: 8353–8358. doi: 10.1021/jf0717283.
- . . ‘Thermal degradation of the Fusarium mycotoxin deoxynivalenol.’ Journal of Agricultural and Food Chemistry 54, № 17: 6445–6451. doi: 10.1021/jf061008g.
- . . ‘New Monascus metabolites: Structure elucidation and toxicological properties studied with immortalized human kidney epithelial cells.’ Molecular Nutrition and Food Research 50, № 3: 314–321. doi: 10.1002/mnfr.200500229.
- . . ‘Stable isotope dilution analysis of the Fusarium mycotoxins deoxynivalenol and 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 50, № 3: 251–260. doi: 10.1002/mnfr.200500230.
- . . ‘Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 49, № 12: 1151–1153. doi: 10.1002/mnfr.200500153.
Dr. Benedikt Cramer
Professur für Lebensmittelchemie (Prof. Humpf)
