Prof. Dr. Melanie Esselen

• 2024
• 2023
• 2022
• 2021
• 2020
• 2019
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2011
• 2010
• 2009
• 2008
• 2007
• 2006
• 2005

2024

• Hassan, R., Gerdemann, A., Cramer, B., Hobloss, Z., Myllys, M., González, D., Albrecht, W., Veerkamp, J., Friebel, A., Hoehme, S., Esselen, M., Degen, G., Humpf, H., Hengstler, J., and Ghallab, A. 2024. “Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.” Archives of Toxicology, № 98 (4): 1081–1093. doi: 10.1007/s00204-024-03688-4.
• Muschiol, Elisabeth, Louisa, Tölke, Lechtenfeld, Christian, Nowak, Sascha, and Esselen, Melanie. 2024. “P13-16 Studies on the toxicology of electrolyte additives – mechanisms and changes during cycling.” Toxicology Letters, № 399 (2): S215–S2156. doi: 10.1016/j.toxlet.2024.07.532.

2023

• Gerdemann, A, Cramer, B, Degen, GH, Veerkamp, J, Günther, G, Albrecht, W, Behrens, M, Esselen, M, Ghallab, A, Hengstler, JG, and Humpf, H-U. 2023. “Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.” Archives of Toxicology, № 97 (12): 3179–3196. doi: 10.1007/s00204-023-03607-z.
• Muschiol, Elisabeth, Lechtenfeld, Christian-Timo, and Esselen, Melanie. 2023. “In vitro Mutagenicity of Sulfur-Containing Additives.” contributed to the Baccara Power Day, Münster
• Gerdemann, A, Broenhorst, M, Behrens, M, Humpf, HU, and Esselen, M. 2023. “Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.” Molecular Nutrition and Food Research, № 67 (21): e2300052–e2300052. doi: 10.1002/mnfr.202300052.
• Kleinehr, J, Schöfbänker, M, Daniel, K, Günl, F, Mohamed, FF, Janowski, J, Brunotte, L, Boergeling, Y, Liebmann, M, Behrens, M, Gerdemann, A, Klotz, L, Esselen, M, Humpf, HU, Ludwig, S, and Hrincius, ER. 2023. “Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.” PLoS Pathogens, № 19 (7): e1010986–e1010986. doi: 10.1371/journal.ppat.1010986.

2022

• Hahn, M, Lindemann, V, Behrens, M, Mulac, D, Langer, K, Esselen, M, and Humpf, HU. 2022. “Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro.” PloS one, № 17 (6): e0269486–e0269486. doi: 10.1371/journal.pone.0269486.
• Müller, L, Keuter, L, Bücksteeg, D, Uebel, T, Wilken, M, Schürmann, L, Behrens, M, Humpf, H, and Esselen, M. 2022. “Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.” Food and Chemical Toxicology, № 164: 113006. doi: 10.1016/j.fct.2022.113006.
• Kubot, Maximilian, Frankenstein, Lars, Muschiol, Elisabeth, Klein, Sven, Esselen, Melanie, Winter, Martin, Nowak, Sascha, and Kasnatscheew, Johannes. 2022. “Lithium Difluorophosphate Electrolyte Additive: a Boon for good High Voltage Li Ion Batteries, but a Bane for high Thermal Stability and low Toxicity: Towards a Synergistic Dual-Additive Approach with Fluoroethylene Carbonate to Circumvent this Dilemma.” ChemSusChem, № 16 (6) e202202189. doi: 10.1002/cssc.202202189.
• Gerdemann, A, Behrens, M, Esselen, M, and Humpf, HU. 2022. “Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.” Archives of Toxicology, № 96 (11): 2983–2998. doi: 10.1007/s00204-022-03348-5.
• Alfke, J, and Esselen, M. 2022. “Cellular Uptake of Epigallocatechin Gallate in Comparison to Its Major Oxidation Products and Their Antioxidant Capacity In Vitro.” Antioxidants, № 11 (9) doi: 10.3390/antiox11091746.
• Maisuls, I., Boisten, F., Hebenbrock, M., Alfke, J., Schürmann, L., Jasper-Peter, B., Hepp, A., Esselen, M., Müller, J., and Strassert, C.A. 2022. “Monoanionic C^N^N Luminophores and Monodentate C-Donor Co-Ligands for Phosphorescent Pt(II) Complexes: A Case Study Involving Their Photophysics and Cytotoxicity.” Inorganic Chemistry, № 61 (24): 9195–9204. doi: 10.1021/acs.inorgchem.2c00753.
• Alfke, Julian, Kampermann, Uta, and Esselen, Melanie. 2022. “HPLC-MS/MS Quantification of Flavan-3-ols, Xanthines, and Epigallocatechin-3-Gallate Oxidation Products in Tea Samples and New Insights into Their Cytotoxicity.” ACS Food Science & Technology, № 2 (5): 925–935. doi: 10.1021/acsfoodscitech.2c00065.
• Gerhard, MN, Schymanski, D, Ebner, I, Esselen, M, Stahl, T, and Humpf, HU. 2022. “Can the presence of additives result in false positive errors for microplastics in infant feeding bottles?” Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, № 39 (1): 185–197. doi: 10.1080/19440049.2021.1989498.

2021

• Müller, L, Schütte, LRF, Bücksteeg, D, Alfke, J, Uebel, T, and Esselen, M. 2021. “Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells.” Archives of Toxicology, № 95 (12): 3787–3802. doi: 10.1007/s00204-021-03162-5.
• Hermes, Lena, Römermann, Jannis, Cramer, Benedikt, and Esselen, Melanie. 2021. “Phase II metabolism of asarone isomers in vitro and in humans using HPLC-MS/MS and HPLC-QToF/MS.” Foods, № 10 (9): 2032. doi: 10.3390/foods10092032.
• Lünne, F, Köhler, J, Stroh, C, Müller, L, Daniliuc, CG, Mück-Lichtenfeld, C, Würthwein, EU, Esselen, M, Humpf, HU, and Kalinina, SA. 2021. “Insights into Ergochromes of the Plant Pathogen <i>Claviceps purpurea</i>.” Journal of Natural Products, № 84 (10): 2630–2643. doi: 10.1021/acs.jnatprod.1c00264.
• Müller, L, Weever, F, Hübner, F, Humpf, HU, and Esselen, M. 2021. “Characterization of Oligomeric Proanthocyanidin-Enriched Fractions from <i>Aronia melanocarpa</i> (Michx.) Elliott via High-Resolution Mass Spectrometry and Investigations on Their Inhibitory Potential on Human Topoisomerases.” Journal of Agricultural and Food Chemistry, № 69 (37): 11053–11064. doi: 10.1021/acs.jafc.1c04761.
• Alfke, J, Kampermann, U, Kalinina, S, and Esselen, M. 2021. “Isolation and structural elucidation of dimeric epigallocatechin-3-gallate autoxidation products and their antioxidant capacity.” European Food Research and Technology, № 247: 2961–2975. doi: 10.1007/s00217-021-03846-3.
• Hermes, L, Römermann, J, Cramer, B, and Esselen, M. 2021. “Quantitative Analysis of β-Asarone Derivatives in <i>Acorus calamus</i> and Herbal Food Products by HPLC-MS/MS.” Journal of Agricultural and Food Chemistry, № 69 (2): 776–782. doi: 10.1021/acs.jafc.0c05513.
• Hermes, L, Römermann, J, Cramer, B, and Esselen, M. 2021. “Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC-MS/MS.” Journal of Agricultural and Food Chemistry, № Online ahead of print doi: 10.1021/acs.jafc.0c05513.

2020

• Hermes, L, Haupenthal, S, Uebel, T, and Esselen, M. 2020. “DNA double strand break repair as cellular response to genotoxic asarone isomers considering phase I metabolism.” Food and Chemical Toxicology, № 2020 doi: 10.1016/j.fct.2020.111484.
• Uebel, T, Hermes, L, Haupenthal, S, Müller, L, and Esselen, M. 2020. “α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation.” Journal of Applied Toxicology, № 2020: 1–14. doi: 10.1002/jat.4112.

2019

• Schultheis, J, Beckmann, D, Mulac, D, Müller, L, Esselen, M, and Düfer, M. 2019. “Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance.” Oxidative medicine and cellular longevity, № 2019 doi: 10.1155/2019/7518510.
• Uebel, T, Wilken, M, Vu, Chi H, and Esselen, M. 2019. “In vitro combinatory cytotoxicity of hepatocarcinogenic asarone isomers and flavonoids.” Toxicology in Vitro, № 60: 19–26. doi: 10.1016/j.tiv.2019.04.029.

2018

• Hermes, L, Haupenthal, S, and Esselen, M. 2018. “DNA repair mechanisms involved in cellular response of to genotoxic asarone isomers.” contribution to the DGDR-Jahrestagung, Karlsruhe
• Hermes, L, Haupenthal, S, and Esselen, M. 2018. “Genotoxic asarone isomers influence DNA strand break repair.” contribution to the 46th EEMGS/30th GUM meeting, Potsdamm
• Zielinski, A, and Esselen, M. 2018. “Genotoxic Properties of Prostaglandins and Cyclopentenone Prostaglandines derived from Arachidonic Acid.” contribution to the 46th EEMGS/30th GUM meeting, Potsdamm
• Zielinski, A, and Esselen, M. 2018. “Gentoxische Effekte von Prostaglandinen und Cyclopentenonprostaglandinen aus Arachidonsäure.” contribution to the LChG Regionalverband NRW, Arbeitstagung 2018, Essen
• Müller, L, Uebel, T, and Esselen, M. 2018. “Einfluss von Alkenylbenzenen auf die Expression von Phase II-Enzymen in humanen Leberkarzinomzellen.” contribution to the LChG Regionalverband NRW Arbeitstagung, Essen
• Pöppelmann, T, Alfke, J, and Esselen, M. 2018. “Einfluss von (-)-Epigallocatechin-3-gallat auf Histondeactylasen und apoptoseassoziierter Enzyme in humanen Kolonkarzinomzellen.” contribution to the 47. Deutscher Lebensmittelchemikertag, Berlin
• Jagels, A, Hövelmann, Y, Zielinski, A, Esselen, M, Köhler, J, Hübner, F, and Humpf, HU. 2018. “Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp.” Mycotoxin Res., № 34: 179–185.
• Krug, I, Behrens, M, Esselen, M, and Humpf, HU. 2018. “Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.” PloS one, № 13(5) doi: 10.1371/journal.pone.0197406.

2017

• Groh, IAM, and Esselen, M. 2017. “The Alkenylbenzene Methyleugenol and Selected Oxidative Metabolites Affect the DNA-Damage Signaling Pathway and Induce Apoptosis in Human Colon Tumor HT29 Cells.” Food Toxicol., № 2017: 267–265.
• Haupenthal, S, Berg, K, Gründken, M, Vallicotti, S, Hemgesberg, M, Sak, K, Schrenk, D, and Esselen, M. 2017. “In vitro genotoxicity of carcinogenic asarone isomers.” Food and Function, № 2017 doi: 10.1039/c6fo01701k.
• Pöppelmann, T, and Esselen, M. 2017. “(-)-Epigallocatechin-3- gallate (EGCG) acts as a modulator of post-translational protein modifications of histone deacetylases.” contribution to the Frühjahrstagung, Deutsche Gesellschaft für Pharmakologie und Toxikologie, Heidelberg
• Pöppelmann, T, and Esselen, M. 2017. “(-)-Epigallocatechingallat als Modulator post-translationaler Proteinmodifikationen von Histondeacetylasen in vitro.” contribution to the Regionalverbandes NRW LChG, Münster
• Esselen, M, and Schrenk, D. 2017. “Other Process-Generated Toxicants in Foods.” in CHEMICAL CONTAMINANTS AND RESIDUES IN FOOD, edited by D Schrenk and A Cartus. Oxford: Woodhead Publishing Limited.

2016

• Haupenthal, S, Uebel, T, and Esselen, M. 2016. “Angriffspunkt DNA - Zelluläre Schadensantwort auf natürliche Lebensmittelkanzerogene.” Labor and More, № 06.16
• Uebel, T, Vu, Chi H, and Esselen, M. 2016. “Development of a long-term cytotoxicity in vitro cell model using naturally occurring alkenylbenzenes.” contribution to the Industriesymposium FoChIn, Münster
• Zielinski, A, and Esselen, M. 2016. “Zytotoxizität von langkettigen, mehrfach ungesättigten Fettsäuren und ihren oxidativen Metaboliten.” contribution to the GDCh, LChG "Deutscher Lebensmittelchemikertag", München, Deutschland
• Pöppelmann, T, and Esselen, M. 2016. “(-)-Epigallocatechingallat als Modulator post-translationaler Proteinmodifikation von Histondeacetylasen.” contribution to the GDCh - LChG "Deutscher Lebensmittelchemikertag", München, Deutschland
• Uebel, T, Haupenthal, S, Groh, IAM, and Esselen, M. 2016. “Profiling DNA damage response concerning cellular gene and protein phosphorylation status after phenylpropene incubation.” contribution to the Symposium „DNA damage response, genetic instability and cancer“, Mainz
• Zielinski, Alexa, Morten, Solecki Gergely, and Esselen, Melanie. 2016. “Zelluläre Wirkmechanismen von nicht enzymatischen Oxidationsprodukten von mehrfach ungesättigten Fettsäuren (PUFA).” contribution to the Arbeitstagung des Regionalverbands Nordrhein-Westfalen der Lebensmittelchemischen Gesellschaft, Mönchengladbach
• Pöppelmann, Tobias, Maria, Groh Isabel Anna, and Esselen, Melanie. 2016. “Einfluss von (-)-Epigallocatechingallat auf die SUMO- und HDAC-Expressionin vitro.” contribution to the Arbeitstagung des Regionalverbands Nordrhein-Westfalen der Lebensmittelchemischen Gesellschaft, Mönchengladbach

2015

• Haupenthal, S, Vallicotti, S, and Hemgesberg, Mand Esselen M. 2015. “The alkaline comet assay as a method to investigate the DNA strand breaking effect of phenylpropanoids in mammalian cells.” contribution to the CAW 2015 - 11th International Comet Assay Workshop, Antwerpen doi: 10.3389/conf.fgene.2015.01.00037.
• Haben, Melina, Cramer, Benedikt, Hickert, Sebastian, Eisenbrand, Gerhard, and Esselen, Melanie. 2015. “Beitrag eines Acrylamid-Niacin-Adduktes zur Reduzierung des Acrylamid-Gehaltes im Lebensmittel.” in Lebensmittelchmie
• Haben, Melina, Eisenbrand, Gerhard, and Esselen, Melanie. 2015. “Impact of an acrylamide-niacin adduct on the cellular redox status of human colon carcinoma cells.” in Naunyn-Schmiedeberg's Archives of Pharmacology
• Kerstin, Berg, Melanie, Esselen, and Dieter, Schrenk. 2015. “Determination of the mutagenicity of α- , β-and γ-asarone.” in Naunyn-Schmiedeberg's Archives of Pharmacology
• Haupenthal, Sabrina, Maria, Groh Isabel Anna, Berg, Kerstin, Schrenk, Dieter, and Esselen, Melanie. 2015. “DNA-damaging effects of phenylpropanoids in hamster lung fibroblast V79 cells.” in Naunyn-Schmiedeberg's Archives of Pharmacology Springer.
• Uebel, Thomas, Heyer, Melanie, Vallicotti, Sabrina, Esselen, and Melanie. 2015. “Phenylpropanoids induce oxidative DNA strand breaks in mammalian cells.” in Naunyn-Schmiedeberg's Archives of Pharmacology Springer.
• Groh, I., Rudakovski, O., Gründken, M., Schroeter, A., Marko, D., and Esselen, M. 2015. “Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases.” Archives of Toxicology, № null (null) doi: 10.1007/s00204-015-1625-3.

2014

• Esselen, M. 2014. “Trendbericht Lebensmittelchemie 2013: Natürliche kanzerogene Lebensmittelinhaltsstoffe aus der Klasse der Phenylpropanoide.” Nachrichten aus der Chemie, № 03/2014
• Esselen, M, and Barth, S. 2014. “Food-Borne Topoisomerase Inhibitors: Risk or Benefit.” in Advances in Molecular Toxicology, edited by JC Fishbein and JM Heilman.

2013

• Groh, IA, Chen, C, Lüske, C, Cartus, AT, and Esselen, M. 2013. “Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells.” Journal of Nutrition and Metabolism, № 2013: 821082. doi: 10.1155/2013/821082.
• Esselen, M, Barth, SW, Winkler, S, Baechler, S, Briviba, K, Watzl, B, Skrbek, S, and Marko, D. 2013. “Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats.” Carcinogenesis, № 34 (4): 835–40. doi: 10.1093/carcin/bgs398.
• Solecki, GM, Groh, IA, Kajzar, J, Haushofer, C, Scherhag, A, Schrenk, D, and Esselen, M. 2013. “Genotoxic properties of cyclopentenone prostaglandins and the onset of glutathione depletion.” Chemical Research in Toxicology, № 26 (2): 252–61. doi: 10.1021/tx300435p.

2012

• Esselen, M, and Schrenk, D. 2012. “Toxicants in foods generated by non-thermal processes.” in Chemical contaminants and residues in food, edited by Schrenk Dieter.
• Groh, IA, Cartus, AT, Vallicotti, S, Kajzar, J, Merz, KH, Schrenk, D, and Esselen, M. 2012. “Genotoxic potential of methyleugenol and selected methyleugenol metabolites in cultured Chinese hamster V79 cells.” Food and Function, № 3 (4): 428–36. doi: 10.1039/c2fo10221h.

2011

• Esselen, M, Boettler, U, Teller, N, Bachler, S, Hutter, M, Rufer, CE, Skrbek, S, and Marko, D. 2011. “Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase I and II poisons in colon carcinoma cells.” Journal of Agricultural and Food Chemistry, № 59 (13): 6966–73. doi: 10.1021/jf200379c.
• Esselen, M, Fritz, J, Hutter, M, Teller, N, Baechler, S, Boettler, U, Marczylo, TH, Gescher, AJ, and Marko, D. 2011. “Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.” Molecular Nutrition and Food Research, № 55 Suppl 1: S143–53. doi: 10.1002/mnfr.201000315.

2010

• Barth, SW, Briviba, K, Watzl, B, Jäger, N, Marko, D, and Esselen, M. 2010. “In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats.” Biotechnology Journal, № 5 (3): 321–7. doi: 10.1002/biot.200900174.

2009

• Pelka, J, Gehrke, H, Esselen, M, Türk, M, Crone, M, Bräse, S, Muller, T, Blank, H, Send, W, Zibat, V, Brenner, P, Schneider, R, Gerthsen, D, and Marko, D. 2009. “Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity.” Chemical Research in Toxicology, № 22 (4): 649–59. doi: 10.1021/tx800354g.
• Esselen, M, Fritz, J, Hutter, M, and Marko, D. 2009. “Delphinidin modulates the DNA-damaging properties of topoisomerase II poisons.” Chemical Research in Toxicology, № 22 (3): 554–64. doi: 10.1021/tx800293v.

2008

• Fritz, J, Roth, M, Holbach, P, Esselen, M, and Marko, D. 2008. “Impact of delphinidin on the maintenance of DNA integrity in human colon carcinoma cells.” Journal of Agricultural and Food Chemistry, № 56 (19): 8891–6. doi: 10.1021/jf801522x.
• Fridrich, D, Teller, N, Esselen, M, Pahlke, G, and Marko, D. 2008. “Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.” Molecular Nutrition and Food Research, № 52 (7): 815–22. doi: 10.1002/mnfr.200800026.

2007

• Kern, M, Fridrich, D, Reichert, J, Skrbek, S, Nussher, A, Hofem, S, Vatter, S, Pahlke, G, Rüfer, C, and Marko, D. 2007. “Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid.” Molecular Nutrition and Food Research, № 51 (9): 1163–72. doi: 10.1002/mnfr.200700004.
• Kern, M, Pahlke, G, Balavenkatraman, KK, Böhmer, FD, and Marko, D. 2007. “Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells.” Journal of Agricultural and Food Chemistry, № 55 (13): 4999–5006. doi: 10.1021/jf063158x.
• Fridrich, D, Kern, M, Pahlke, G, Volz, N, Will, F, Dietrich, H, and Marko, D. 2007. “Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells.” Molecular Nutrition and Food Research, № 51 (5): 594–601. doi: 10.1002/mnfr.200600189.
• Fridrich, D, Kern, M, Fritz, J, Pahlke, G, Köhler, N, Winterhalter, P, and Marko, D. 2007. “The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins.” Molecular Nutrition and Food Research, № 51 (2): 192–200. doi: 10.1002/mnfr.200600186.

2006

• Kern, M, Pahlke, G, Ngiewih, Y, and Marko, D. 2006. “Modulation of key elements of the Wnt pathway by apple polyphenols.” Journal of Agricultural and Food Chemistry, № 54 (19): 7041–6. doi: 10.1021/jf0606611.
• Pahlke, G, Ngiewih, Y, Kern, M, Jakobs, S, Marko, D, and Eisenbrand, G. 2006. “Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells.” Journal of Agricultural and Food Chemistry, № 54 (19): 7075–82. doi: 10.1021/jf0612530.
• Fritz, J, Kern, M, Pahlke, G, Vatter, S, and Marko, D. 2006. “Biological activities of malvidin, a red wine anthocyanidin.” Molecular Nutrition and Food Research, № 50 (4-5): 390–5. doi: 10.1002/mnfr.200500228.

2005

• Kern, M, Tjaden, Z, Ngiewih, Y, Puppel, N, Will, F, Dietrich, H, Pahlke, G, and Marko, D. 2005. “Inhibitors of the epidermal growth factor receptor in apple juice extract.” Molecular Nutrition and Food Research, № 49 (4): 317–28. doi: 10.1002/mnfr.200400086.