Publications

• 2025

  Openy, J., Vega-Ces, S., Amrahova, G., Mestdach, E., Chi, C., Kissel, B., ‘t Hart, P.
  Single atom substitutions in backbone aromatic groups alter membrane permeability and biological activity of cyclic peptides
  ChemRxiv, 2025. https://doi.org/10.26434/chemrxiv-2025-pb6d3

  Pal, S., Gordijenko, I., Schmeing, S., Biswas, S., Akbulut, Y., Gasper, R., 't Hart, P.
  Stapled Peptides as Inhibitors of mRNA Deadenylation
  Angew. Chem. Int. Ed., 2025, 64(1), e202413911. https://doi.org/10.1002/anie.202413911

• 2024

  Schmeing, S.,  't Hart, P.
  Challenges in Therapeutically Targeting the RNA-Recognition Motif
  WIREs Interdisciplinary reviews: RNA, 2024, 15(6), e1877. https://doi.org/10.1002/wrna.1877

  Pal, S., ‘t Hart, P.
  Imbuing peptide libraries with drug-likeness
  Nat. Chem. Biol., 2024, 20(2), 140–141. https://doi.org/10.1038/s41589-023-01524-x

  Chang, J.Y., Neugebauer, C., Mues genannt Koers, A., ‘t Hart, P.
  Small molecule WDR5 inhibitors down-regulate lncRNA expression
  RSC Med. Chem., 2024, 15, 636. https://doi.org/10.1039/D3MD00605K

• 2023

  Chang, J.Y., Neugebauer, C., Schmeing, S., Amrahova, G., ‘t Hart, P.
  Macrocyclic peptides as inhibitors of WDR5–lncRNA interactions
  Chem. Commun., 2023, 59, 10656. https://doi.org/10.1039/D3CC03221C

  Schmeing, S., Amrahova, G., Bigler, K., Chang, J.Y., Openy, J., Pal, S., Posada, L., Gasper, R., 't Hart P.
  Rationally designed stapled peptides allosterically inhibit PTBP1 RNA-binding
  Chem. Sci., 2023, 14, 8269. https://doi.org/10.1039/D3SC00985H

  Pal, S., Openy, J., Krzyzanowski, A., Noisier, A., 't Hart, P.
  On-resin Photochemical Decarboxylative Arylation of Peptides
  Org. Lett., 2023, 26(14), 2795. https://doi.org/10.1021/acs.orglett.3c03070

  Nowacki, J., Malenica, M., Schmeing, S., Schiller, D., Buchmuller, B., Amrahova, G., ‘t Hart P.
  A translational repression reporter assay for the analysis of RNA-binding protein consensus sites
  RNA Biology, 2023, 20(1), 85. https://doi.org/10.1080/15476286.2023.2192553  

• 2022

  Krzyzanowski, A., Esser, L.M., Willaume, A., Prudent, R., Peter, C., ‘t Hart. P., Waldmann, H.
  Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors
  J. Med. Chem., 2022, 65(22), 15300. https://doi.org/10.1021/acs.jmedchem.2c01273

  Openy, J., Amrahova, G., Chang, J., Noisier, A., ‘t Hart, P.
  Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts
  Chem. Eur. J., 2023, 28(39), e202201121. https://doi.org/10.1002/chem.202201121

  Pal, S., 't Hart, P.
  RNA-Binding Macrocyclic Peptides
  Front Mol. Biosci., 2022, 9, 83060. https://doi.org/10.3389/fmolb.2022.883060

• 2021

  Krzyzanowski, A., Gasper, R., Adihou, H., ’t Hart, P., Waldmann, H.
  Biochemical Investigation of the Interaction of PICln, RioK1 and COPR5 with the PRMT5–MEP50 Complex
  ChemBioChem, 2021, 22(11), 1908. https://doi.org/10.1002/cbic.202100079

  ‘t Hart, P., Hommen, P., Noisier, A., Krzyzanowski, A., Schüler, D., Porfetye, A.T., Akbarzadeh, M., Vetter, I.R., Adihou, H., Waldmann, H.
  Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48
  Angew. Chem. Int. Ed., 2021, 60(4), 1813.  https://doi.org/10.1002/anie.202009749

• 2019

  ‘t Hart, P., Openy, J., Krzyzanowski, A., Adihou, H., Waldmann, H.
  Hot-Spot Guided Design of Macrocyclic Inhibitors of the LSD1-CoREST1 Interaction
  Tetrahedron, 2019, 75(48), 130685. https://doi.org/10.1016/j.tet.2019.130685

• 2017

  le Paige, U.B., Smits, B., ‘t Hart, P., Lefeber, F., Martin, N.I., van Ingen, H.
  Weak Coupling between Magnetically Inequivalent Spins: The Deceptively Simple, Complicated Spectrum of a13C-Labeled Trimethylated Amine
  Journal of Magnetic Resonance, 2017, 278, 96. https://doi.org/10.1016/j.jmr.2017.03.016

  ’t Hart, P., Wood, T.M., Tehrani, K.H.M.E., van Harten, R.M., Śleszyńska, M., Rentero Rebollo, I., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., Martin, N.I.
  De Novo Identification of Lipid II Binding Lipopeptides with Antibacterial Activity against Vancomycin-Resistant Bacteria
  Chem. Sci., 2017, 8(12), 7991. https://doi.org/10.1039/C7SC03413J

• 2016

  Kleijn, L.H.J., Oppedijk, S.F., ‘t Hart, P., van Harten, R.M., Martin-Visscher, L.A., Kemmink, J., Breukink, E., Martin, N.I., 2016.
  “Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action.”
  Journal of Medicinal Chemistry. 59(7):3569–74. https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00219

  ’t Hart, P., Oppedijk, S.F., Breukink, E., Martin, N.I., 2016.
  “New Insights into Nisin’s Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues.”
  Biochemistry. 55(1):232–37. https://pubs.acs.org/doi/10.1021/acs.biochem.5b01173

• 2015

  Koopmans, T., Wood, T.M., ’t Hart, P., Kleijn, L.H.J., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., Martin, N.I., 2015.
  “Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound.”
  Journal of the American Chemical Society. 137(29):9382–89. https://pubs.acs.org/doi/10.1021/jacs.5b04501

• 2014

  Mooney, C.A., Johnson, S.A., ’t Hart, P., Quarles van Ufford, L., de Haan, C.A.M., Moret, E.E., Martin. N.I., 2014.
  “Oseltamivir Analogues Bearing N-Substituted Guanidines as Potent Neuraminidase Inhibitors.”
  Journal of Medicinal Chemistry. 57(7):3154–60. https://pubs.acs.org/doi/10.1021/jm401977j

  ‘t Hart, P., Kleijn, L.H.J., de Bruin, G., Oppedijk, S.F., Kemmink, J., Martin, N.I., 2014.
  “A Combined Solid- and Solution-Phase Approach Provides Convenient Access to Analogues of the Calcium-Dependent Lipopeptide Antibiotics.”
  Organic & Biomolecular Chemistry. 12(6):913–18. https://pubs.rsc.org/en/content/articlehtml/2014/ob/c3ob42238k

• 2012

  ‘t Hart, P.*, Thomas, D.*, Van Ommeren, R., Lakowski, T.M., Frankel, A., Martin, N.I., 2012.
  “Analogues of the HIV-Tat Peptide Containing Nη-Modified Arginines as Potent Inhibitors of Protein Arginine N-Methyltransferases.”
  MedChemComm. 3(10). https://pubs.rsc.org/en/content/articlelanding/2012/md/c2md20161e

• 2011

  ’t Hart, P.*, Lakowski, T.M.*, Thomas, D., Frankel, A., Martin, N.I., 2011.
  “Peptidic Partial Bisubstrates as Inhibitors of the Protein Arginine N-Methyltransferases.”
  ChemBioChem. 12(9):1427–32. https://pubmed.ncbi.nlm.nih.gov/21560220/

• 2010

  Lakowski, T.M.*, ‘t Hart, P.*, Ahern, C.A., Martin, N.I., Frankel, A. 2010.
  “Nη-Substituted Arginyl Peptide Inhibitors of Protein Arginine N-Methyltransferases.”
  ACS Chemical Biology. 5(11):1053–63. https://pubmed.ncbi.nlm.nih.gov/20701328/

  *equal contribution