Tailored coordination compounds as multimodal labels for multiscale imaging of mesenteric pathogen transport
Principal investigator: Stefanie Bobe, Cristian A. Strassert
Project number: CRC 1450 A02
Project term: 01/2021–12/2028
We will elucidate the role of capillary mesenteric lymph vessels in peritoneal lymph drainage and inflammatory disease progression. Hence, the coordination-chemical concepts established in the first funding period will be implemented towards small molecules as functional labels. Their biodistribution profiles will be tuned by the amphiphilicity or by specific targeting units; since the chelator can remain invariant, no modification of the localization is expected upon exchange of the central cation. Thus, multiple orthogonal readouts arising from a single label will be used to visualize the early pathogen transport of Y. pseudotuberculosis in mice bridging the gap between different scales and modalities.
Team
Principal investigator
Publications
The names of the principal investigators in our network have been bolded. Publications released prior to 2021, when funding for our network commenced, represent previous project-related work.
2024
| Ezquerra Riega SD, Gutierrez Suburu ME, Rodríguez HB, Lantaño B, Kleinschmidt M, Marian CM, Strassert CA. A case-study on the photophysics of chalcogen-substituted zinc(II) phthalocyanines. Chemistry – A European Journal 2024
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| Kirse TM, Maisuls I, Cappellari MV, Niehaves E, Kösters J, Hepp A, Karst U, Wolcan E, Strassert CA. Neutral and Cationic Re(I) Complexes with Pnictogen-Based Coligands and Tunable Functionality: From Phosphorescence to Photoinduced CO Release. Inorg Chem 2024;63: 4132-4151. Abstract
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| Kirse TM, Maisuls I, Denofrio MP, Hepp A, Cabrerizo FM, Strassert CA. Functional Pt(II) and Re(I) Complexes with CO- and β Carboline-Based Coligands: From Time-Resolved Photoluminescence Spectroscopy and Evaluation of 1O2 Photosensitization Efficiency toward in vitro (Photo)cytotoxicity. Organometallics 2024
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| Rivas Aiello MB, Kirse TM, Lavorato GC, Maus B, Maisuls I, Kuberasivakumaran S, Ostendorp S, Hepp A, Holtkamp M, Winkler EL, Karst U, Wilde G, Faber C, Vericat C, Strassert CA. Superparamagnetic Nanoparticles with Phosphorescent Complexes as Hybrid Contrast Agents: Integration of MRI and PLIM. Small Science 2024Abstract
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| Sailaja STN, Maisuls I, Hepp A, Brünink D, Doltsinis NL, Faust A, Hermann S, Strassert CA. Dual Emissive Zn(II) Naphthalocyanines: Synthesis, Structural and Photophysical Characterization with Theory-Supported Insights towards Soluble Coordination Compounds with Visible and Near-Infrared Emission. nt J Mol Sci 2024Abstract |
2023
| Bauer N, Maisuls I, Pereira da Graca A, Reinhardt D, Erapaneedi R, Kirschnick N, Schäfers M, Grashoff C, Landfester K, Vestweber D, Strassert CA, Kiefer F. Genetically encoded dual fluorophore reporters for graded oxygen-sensing in light microscopy. Biosens Bioelectron 2023;221: 114917. Abstract
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| Kirse TM, Maisuls I, Spierling L, Hepp A, Kösters J, Strassert CA. One Dianionic Luminophore with Three Coordination Modes Binding Four Different Metals: Toward Unexpectedly Phosphorescent Transition Metal Complexes. Adv Sci (Weinh) 2023: e2306801. Abstract
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| Thale I, Maskri S, Grey L, Todesca LM, Budde T, Maisuls I, Strassert CA, Koch O, Schwab A, Wünsch B. Imaging of K(Ca) 31 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes. ChemMedChem 2023;18: e202200551. Abstract
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| Theiss T, Buss S, Maisuls I, López-Arteaga R, Brünink D, Kösters J, Hepp A, Doltsinis NL, Weiss EA, Strassert CA. Room-Temperature Phosphorescence from Pd(II) and Pt(II) Complexes as Supramolecular Luminophores: The Role of Self-Assembly, Metal-Metal Interactions, Spin-Orbit Coupling, and Ligand-Field Splitting. J Am Chem Soc 2023Abstract |
2022
| Backhaus P, Burg MC, Asmus I, Pixberg M, Büther F, Breyholz H-J, Yeh R, Weigel SB, Stichling P, Heindel W, Bobe S, Barth P, Tio J, Schäfers M. Initial Results of FAPI-PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer. J Nucl Med 2022Abstract
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| Bäumer N, Tiemann J, Scheller A, Meyer T, Wittmann L, Suburu MEG, Greune L, Peipp M, Kellmann N, Gumnior A, Brand C, Hartmann W, Rossig C, Müller-Tidow C, Neri D, Strassert CA, Rüter C, Dersch P, Lenz G, Koeffler HP, Berdel WE, Bäumer S. Targeted siRNA nanocarrier: a platform technology for cancer treatment. Oncogene 2022;41: 2210-2224. Abstract
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| Kirse TM, Lüke J, Maisuls I, Hepp A, Strassert CA. Comparison of Phosphorescent Pt(II) Complexes with C;N;N vs N;N;N Chelators and Caffeine-Based NHC-co-ligands(1). Photochem Photobiol 2022Abstract
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| Maisuls I, Kirse TM, Hepp A, Kösters J, Wolcan E, Strassert CA. Rhenium(I) Complexes with Neutral Monodentate Coligands and Monoanionic 2-(1,2,4-Triazol-5-yl)pyridine-Based Chelators as Bidentate Luminophores with Tunable Color and Photosensitized Generation of (1)O(2): An Integrated Case Study Involving Photophysics and Theory. Inorg Chem 2022;61: 13775-13791. Abstract
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| Matern J, Maisuls I, Strassert CA, Fernández G. Luminescence and Length Control in Nonchelated d(8) -Metallosupramolecular Polymers through Metal-Metal Interactions. Angew Chem Int Ed Engl 2022;61: e202208436. Abstract |
2021
| Maisuls I, Singh J, Salto IP, Steiner ST, Kirse TM, Niemann S, Strassert CA, Faust A. Conjugated Pt(II) Complexes as Luminescence-Switch-On Reporters Addressing the Microenvironment of Bacterial Biofilms. Inorg Chem 2021;60: 11058-11069. Abstract
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| Maisuls I, Wang C, Gutierrez Suburu ME, Wilde S, Daniliuc C-G, Brünink D, Doltsinis NL, Ostendorp S, Wilde G, Kösters J, Resch-Genger U, Strassert CA. Ligand-controlled and nanoconfinement-boosted luminescence employing Pt(ii) and Pd(ii) complexes: from color-tunable aggregation-enhanced dual emitters towards self-referenced oxygen reporters. Chem Sci 2021;12: 3270-3281. Abstract |
2019
| Proetto MT, Sanning J, Peterlechner M, Thunemann M, Stegemann L, Sadegh S, Devor A, Gianneschi NC, Strassert CA. Phosphorescent Pt(ii) complexes spatially arrayed in micellar polymeric nanoparticles providing dual readout for multimodal imaging. Chem Commun (Camb) 2019;55: 501-504. Abstract
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| Ren J, Cnudde M, Brünink D, Buss S, Daniliuc CG, Liu L, Fuchs H, Strassert CA, Gao H-Y, Doltsinis NL. On-Surface Reactive Planarization of Pt(II) Complexes. Angew Chem Int Ed Engl 2019;58: 15396-15400. Abstract |
2018
| Delcanale P, Galstyan A, Daniliuc CG, Grecco HE, Abbruzzetti S, Faust A, Viappiani C, Strassert CA. Oxygen-Insensitive Aggregates of Pt(II) Complexes as Phosphorescent Labels of Proteins with Luminescence Lifetime-Based Readouts. ACS Appl Mater Interfaces 2018;10: 24361-24369. Abstract
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| Duffy MJ, Planas O, Faust A, Vogl T, Hermann S, Schäfers M, Nonell S, Strassert CA. Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo. Photoacoustics 2018;9: 49-61. Abstract
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| Grüner MC, Niemann S, Faust A, Strassert CA. Axially Decorated Si(IV) -phthalocyanines Bearing Mannose- or Ammonium-conjugated Siloxanes: Comparative Bacterial Labeling and Photodynamic Inactivation. Photochem Photobiol 2018;94: 890-899. Abstract
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| Wilde S, Ma D, Koch T, Bakker A, Gonzalez-Abradelo D, Stegemann L, Daniliuc CG, Fuchs H, Gao H, Doltsinis NL, Duan L, Strassert CA. Toward Tunable Electroluminescent Devices by Correlating Function and Submolecular Structure in 3D Crystals, 2D-Confined Monolayers, and Dimers. ACS Appl Mater Interfaces 2018;10: 22460-22473. Abstract |
