Jürgen Eirich

I studied chemistry and biochemistry and obtained my PhD in the field of chemical biology. I have been working in the field of mass spectrometry-based proteomics for several years now and have analysed samples from various organisms and origins. During a postdoctoral stay in Stockholm (Sweden), I was working on chemical and clinical proteomics, before joining the plant physiology and proteomics group at the University of Münster. My current research interest focuses on the analysis of post-translational modifications in plants to understand their function in stress response and other biological processes.

2024

Vogelsang Lara , Eirich Jürgen , Finkemeier Iris , Dietz Karl-Josef. 2024. ‘Specificity and dynamics of H2O2 detoxification by the cytosolic redox regulatory network as revealed by in vitro reconstitution.’ Redox Biology 2024. doi: 10.1016/j.redox.2024.103141.
Cosse, Maike; Rehders, Tanja; Eirich, Juergen; Finkemeier, Iris; Selinski, Jennifer. 2024. ‘Cysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD-dependent malate dehydrogenase.’ Physiologia Plantarum 176, Nr. 3. doi: 10.1111/ppl.14340.
Vogelsang, L.; Eirich, J.; Finkemeier, I.; Dietz, K.-J. 2024. ‘Thiol Redox Proteomics for Identifying Redox-Sensitive Cysteine Residues Within the Protein of Interest During Stress.’ Methods in Molecular Biology 2832: 99–113. doi: 10.1007/978-1-0716-3973-3_7.
Eirich Jürgen , Boyer Jean-Baptiste , Armbruster Laura , Ivanauskaite Aiste , Torre La De Carolina , Meinnel Thierry , Wirtz Markus , Mulo Paula , Finkemeier Iris , Giglione Carmela. 2024. ‘Light Changes Promote Distinct Responses of Plastid Protein Acetylation Marks.’ Molecular and Cellular Proteomics 2024. doi: 10.1016/j.mcpro.2024.100845.
Brünje Annika , Füßl Magdalena , Eirich Jürgen , Boyer Jean-Baptiste , Heinkow Paulina , Neumann Ulla , Konert Minna , Ivanauskaite Aiste , Seidel Julian , Ozawa Shin-Ichiro , Sakamoto Wataru , Meinnel Thierry , Schwarzer Dirk , Mulo Paula , Giglione Carmela , Finkemeier Iris. 2024. ‘The plastidial protein acetyltransferase GNAT1 forms a complex with GNAT2, yet their interaction is dispensable for state transitions.’ Molecular and Cellular Proteomics . doi: 10.1016/j.mcpro.2024.100850. [unknown status]
Armbruster Laura , Pożoga Marlena , Wu Zhongshou , Eirich Jürgen , Devendrakumar Thulasi Karen , Torre La De Carolina , Miklánková Pavlina , Huber Monika , Bradic Fabian , Poschet Gernot , Weidenhausen Jonas , Merker Sabine , Ruppert Thomas , Sticht Carsten , Sinning Irmgard , Finkemeier Iris , Li Xin , Hell Rüdiger , Wirtz Markus. 2024. ‘Nα-acetyltransferase NAA50 mediates plant immunity independent of the Nα-acetyltransferase A complex.’ Plant Physiology 2024. doi: 10.1093/plphys/kiae200.

2023

Giese Jonas , Eirich Jürgen , Walther Dirk , Zhang Youjun , Lassowskat Ines , Fernie R. Alisdair , Elsässer Marlene , Maurino G. Veronica , Schwarzländer Markus , Finkemeier Iris. 2023. ‘The interplay of post‐translational protein modifications in Arabidopsis leaves during photosynthesis induction.’ The Plant journal 116, Nr. 4: 1172–1193. doi: 10.1111/tpj.16406.
Hartmann Philipp , Bohdan Kostiantyn , Hommrich Moritz , Juliá Fabio , Vogelsang Lara , Eirich Jürgen , Zangl Rene , Farès Christophe , Jacobs Beatrice Julia , Mukhopadhyay Dwaipayan , Mengeler Marie Johanna , Vetere Alessandro , Sterling Sophie Marie , Hinrichs Heike , Becker Stefan , Morgner Nina , Schrader Wolfgang , Finkemeier Iris , Dietz Karl-Josef , Griesinger Christian , Ritter Tobias. 2023. ‘Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation.’ Nature Chemistry 2023. doi: 10.1038/s41557-023-01388-7.
Eirich J.; Köhl K.; Jahns P.; Finkemeier I.; Armbruster U.; Kramer D.M.; von Bismarck T.; Korkmaz K.; Ruß J.; Skurk K.; Kaiser E.; Correa Galvis V.; Cruz J.A.; Strand D.D. 2023. ‘Light acclimation interacts with thylakoid ion transport to govern the dynamics of photosynthesis in Arabidopsis.’ New Phytologist 237, Nr. 1: 160–176. doi: 10.1111/nph.18534.
Eirich J.; Sindlinger J.; Schön S.; Schwarzer D.; Finkemeier I. 2023. ‘Peptide CoA conjugates for in situ proteomics profiling of acetyltransferase activities.’ Methods in Enzymology 684: 209–252. doi: 10.1016/bs.mie.2022.09.005.
Tilak P.; Kotnik F.; Née G.; Seidel J.; Sindlinger J.; Heinkow P.; Eirich J.; Schwarzer D.; Finkemeier I. 2023. ‘Proteome-wide lysine acetylation profiling to investigate the involvement of histone deacetylase HDA5 in the salt stress response of Arabidopsis leaves.’ The Plant journal 115, Nr. 1: 275–292. doi: 10.1111/tpj.16206.
Bismarck von Thekla , Korkmaz Kübra , Ruß Jeremy , Skurk Kira , Kaiser Elias , Galvis Correa Viviana , Cruz A. Jeffrey , Strand D. Deserah , Köhl Karin , Eirich Jürgen , Finkemeier Iris , Jahns Peter , Kramer M. David , Armbruster Ute. 2023. ‘Light acclimation interacts with thylakoid ion transport to govern the dynamics of photosynthesis in Arabidopsis.’ New Phytologist 2022. doi: 10.1111/nph.18534.
Jethva, Jay; Lichtenauer, Sophie; Schmidt-Schippers, Romy; Steffen-Heins, Anja; Poschet, Gernot; Wirtz, Markus; van Dongen, Joost T.; Eirich, Juergen; Finkemeier, Iris; Bilger, Wolfgang; Schwarzländer, Markus; Sauter, Margret. 2023. ‘Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.’ New Phytologist 238, Nr. 1. doi: 10.1111/nph.18657.
Länger Marie Zoe , Baur Moritz , Korša Ana , Eirich Jürgen , Lindeza Sofia Ana , Zanchi Caroline , Finkemeier Iris , Kurtz Joachim. 2023. ‘Differential proteome profiling of bacterial culture supernatants reveals candidates for the induction of oral immune priming in the red flour beetle.’ Biology Letters 19, Nr. 11. doi: 10.1098/rsbl.2023.0322.
Keller JM; Frieboes MJ; Jödecke L; Kappel S; Wulff N; Rindfleisch T; Sandoval-Ibanez O; Gerlach I; Thiele W; Bock R; Eirich J; Finkemeier I; Schünemann D; Zoschke R; Schöttler MA; Armbruster U. 2023. ‘Eukaryote-specific assembly factor DEAP2 mediates an early step of photosystem II assembly in Arabidopsis.’ Plant Physiology 2023. doi: 10.1093/plphys/kiad446.

2022

Sinha Neha , Eirich Jürgen , Finkemeier Iris , Grimm Bernhard. 2022. ‘Glutamate 1-semialdehyde aminotransferase is connected to GluTR by GluTR-binding protein and contributes to the rate-limiting step of 5-aminolevulinic acid synthesis.’ The Plant cell 34. doi: 10.1093/plcell/koac237.
Giese J; Eirich J; Post F; Schwarzländer M; Finkemeier I. 2022. ‘Mass Spectrometry-Based Quantitative Cysteine Redox Proteome Profiling of Isolated Mitochondria Using Differential iodoTMT Labeling.’ Methods in Molecular Biology 2363: 215–234. doi: 10.1007/978-1-0716-1653-6_16.
Balparda M, Elsässer M, Badia MB, Giese J, Bovdilova A, Hüdig M, Reinmuth L, Eirich J, Schwarzländer M, Finkemeier I, Schallenberg-Rüdinger M, Maurino VG. 2022. ‘Acetylation of conserved lysines fine-tunes mitochondrial malate dehydrogenase activity in land plants.’ The Plant journal 109, Nr. 1: 92–111. doi: 10.1111/tpj.15556.
Leister D.; Kramer K.; Finkemeier I.; Nickelsen J.; Füßl M.; König A.C.; Eirich J.; Hartl M.; Kleinknecht L.; Bohne A.V.; Harzen A. 2022. ‘Dynamic light- and acetate-dependent regulation of the proteome and lysine acetylome of Chlamydomonas.’ The Plant journal 109, Nr. 1: 261–277. doi: 10.1111/tpj.15555.
Sinha N.; Eirich J.; Finkemeier I.; Grimm B. 2022. ‘Glutamate 1-semialdehyde aminotransferase is connected to GluTR by GluTR-binding protein and contributes to the rate-limiting step of 5-aminolevulinic acid synthesis.’ The Plant cell 34, Nr. 11: 4623–4640. doi: 10.1093/plcell/koac237.
Sindlinger J.; Schön S.; Eirich J.; Kirchgäßner S.; Finkemeier I.; Schwarzer D. 2022. ‘Investigating Peptide-Coenzyme A Conjugates as Chemical Probes for Proteomic Profiling of N-Terminal and Lysine Acetyltransferases.’ ChemBioChem 23, Nr. 17. doi: 10.1002/cbic.202200255.
Nickelsen J.; Bohne A.V.; Neusius D.; Kleinknecht L.; Teh J.T.; Ostermeier M.; Kelterborn S.; Eirich J.; Hegemann P.; Finkemeier I. 2022. ‘Lysine acetylation regulates moonlighting activity of the E2 subunit of the chloroplast pyruvate dehydrogenase complex in Chlamydomonas.’ The Plant journal 111, Nr. 6: 1780–1800. doi: 10.1111/tpj.15924.
Giese J.; Eirich J.; Post F.; Schwarzländer M.; Finkemeier I. 2022. ‘Mass Spectrometry–Based Quantitative Cysteine Redox Proteome Profiling of Isolated Mitochondria Using Differential iodoTMT Labeling.’ Methods in Molecular Biology 2363: 215–234. doi: 10.1007/978-1-0716-1653-6_16.
Magdalena Füßl, Ann-Christine König, Jürgen Eirich, Markus Hartl, Laura Kleinknecht, Alexandra-Viola Bohne, Anne Harzen, Katharina Kramer, Dario Leister, Jörg Nickelsen, Iris Finkemeier. 2022. ‘Dynamic light‐ and acetate‐dependent regulation of the proteome and lysine acetylome of Chlamydomonas.’ The Plant journal 109, Nr. 1: 261–277. doi: 10.1111/tpj.15555.
Neusius D.; Kleinknecht L.; Teh J.T.; Ostermeier M.; Kelterborn S.; Eirich J.; Hegemann P.; Finkemeier I.; Bohne A.V.; Nickelsen J. 2022. ‘Lysine acetylation regulates moonlighting activity of the E2 subunit of the chloroplast pyruvate dehydrogenase complex in Chlamydomonas.’ The Plant journal 111, Nr. 6: 1780–1800. doi: 10.1111/tpj.15924.
Zhou H.; Zhang F.; Zhai F.; Su Y.; Zhou Y.; Ge Z.; Tilak P.; Eirich J.; Finkemeier I.; Fu L.; Li Z.; Yang J.; Shen W.; Yuan X.; Xie Y. 2022. ‘Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling.’ Molecular Plant 15, Nr. 4: 651–670. doi: 10.1016/j.molp.2021.11.006.
Linnenbrügger, L; Doering, L; Lansing, H; Fischer, K; Eirich, J; Finkemeier, I; von Schaewen, A. 2022. ‘Alternative splicing of Arabidopsis G6PD5 recruits NADPH-producing OPPP reactions to the endoplasmic reticulum.’ Frontiers in Plant Science 13: 909624. doi: 10.3389/fpls.2022.909624.
Dr. Julia Sindlinger, Stefan Schön, Dr. Jürgen Eirich, Dr. Sören Kirchgäßner, Prof. Dr. Iris Finkemeier, Prof. Dr. Dirk Schwarzer. 2022. ‘Investigating Peptide‐Coenzyme A Conjugates as Chemical Probes for Proteomic Profiling of N‐Terminal and Lysine Acetyltransferases.’ ChemBioChem 23. doi: 10.1002/cbic.202200255.

2021

Uflewski M, Mielke S, Corre GV, vo BT, Chen X, Tietz E, Ruß J, Luzarowski M, Sokolowska E, Skirycz A, Eirich J, Finkemeier I, Schöttler MA, Armbruster U. 2021. ‘Functional characterization of protonantiport regulation in the thylakoid membrane.’ Plant Physiology 187. doi: 10.1093/plphys/kiab135.
Eirich J.; Skirycz A.; Schöttler M.A.; Finkemeier I.; Armbruster U.; Uflewski M.; Mielke S.; Galvis V.C.; von Bismarck T.; Chen X.; Tietz E.; Ruß J.; Luzarowski M.; Sokolowska E. 2021. ‘Functional characterization of proton antiport regulation in the thylakoid membrane.’ Plant Physiology 187, Nr. 4: 2209–2229. doi: 10.1093/plphys/kiab135.
Rugen N.; Schaarschmidt F.; Eirich J.; Finkemeier I.; Braun H.P.; Eubel H. 2021. ‘Protein interaction patterns in Arabidopsis thaliana leaf mitochondria change in dependence to light.’ Biochimica et Biophysica Acta - Bioenergetics 1862, Nr. 8. doi: 10.1016/j.bbabio.2021.148443.
Rose J.; Müller B.; Groscurth S.; Giese J.; Eirich J.; Finkemeier I.; Twyman R.M.; Prüfer D.; Noll G.A. 2021. ‘The functionality of plant mechanoproteins (forisomes) is dependent on the dual role of conserved cysteine residues.’ International Journal of Biological Macromolecules 193: 1332–1339. doi: 10.1016/j.ijbiomac.2021.10.192.
Giovannucci T.A.; Salomons F.A.; Haraldsson M.; Elfman L.H.M.; Wickström M.; Young P.; Lundbäck T.; Eirich J.; Altun M.; Jafari R.; Gustavsson A.L.; Johnsen J.I.; Dantuma N.P. 2021. ‘Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound.’ Cell Death and Disease 12, Nr. 10. doi: 10.1038/s41419-021-04191-9.
Rugen N.; Schaarschmidt F.; Eirich J.; Finkemeier I.; Braun H.P.; Eubel H. 2021. ‘Protein interaction patterns in Arabidopsis thaliana leaf mitochondria change in dependence to light.’ Biochimica et Biophysica Acta - Bioenergetics 1862, Nr. 8. doi: 10.1016/j.bbabio.2021.148443.
Rose J.; Müller B.; Groscurth S.; Giese J.; Eirich J.; Finkemeier I.; Twyman R.M.; Prüfer D.; Noll G.A. 2021. ‘The functionality of plant mechanoproteins (forisomes) is dependent on the dual role of conserved cysteine residues.’ International Journal of Biological Macromolecules 193: 1332–1339. doi: 10.1016/j.ijbiomac.2021.10.192.

2020

Armbruster L, Linster E, Boyer J, Brünje A, Eirich J, Stephan I, Bienvenut WV, Weidenhausen J, Meinnel T, Hell R, Sinning I, Finkemeier I, Giglione C, Wirtz M. 2020. ‘NAA50 is an enzymatically active Nα-acetyltransferase that is crucial for development and regulation of stress responses.’ Plant Physiology 183, Nr. 4: 1502–1516. doi: 10.1104/pp.20.00222.
Sinning I.; Hell R.; Giglione C.; Finkemeier I.; Wirtz M.; Armbruster L.; Linster E.; Boyer J.B.; Brünje A.; Eirich J.; Stephan I.; Bienvenut W.V.; Weidenhausen J.; Meinnel T. 2020. ‘NAA50 is an enzymatically active Na-acetyltransferase that is crucial for development and regulation of stress responses1[OPEN].’ Plant Physiology 183, Nr. 4: 1502–1516. doi: 10.1104/pp.20.00222.
Meineke B.; Heimgärtner J.; Eirich J.; Landreh M.; Elsässer S.J. 2020. ‘Site-Specific Incorporation of Two ncAAs for Two-Color Bioorthogonal Labeling and Crosslinking of Proteins on Live Mammalian Cells.’ Cell Reports 31, Nr. 12. doi: 10.1016/j.celrep.2020.107811.
Bienvenut WV, Brünje A, Boyer J, Mühlenbeck JS, Bernal G, Lassowskat I, Dian C, Linster E, Dinh TV, Koskela MM, Jung V, Seidel J, Schyrba LK, Ivanauskaite A, Eirich J, Hell R, Schwarzer D, Mulo P, Wirtz M, Meinnel T, Giglione C, Finkemeier I. 2020. ‘Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation.’ Molecular Systems Biology 16, Nr. 7: e9464. doi: 10.15252/msb.20209464.

2019

Le P.; Nodwell M.; Eirich J.; Sieber S. 2019. ‘A Chemical Proteomic Analysis of Illudin-Interacting Proteins.’ Chemistry - A European Journal 25, Nr. 54: 12644–12651. doi: 10.1002/chem.201902919.

2018

Srinivas V, Lebrette H, Lundin D, Kutin Y, Sahlin M, Lerche M, Eirich J, Branca RM, Cox N, Sjöberg B, others. 2018. ‘Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens.’ Nature 563, Nr. 7731: 416–420. doi: 10.1038/s41586-018-0653-6.
Maugeri P.T.; Griese J.J.; Branca R.M.; Miller E.K.; Smith Z.R.; Eirich J.; Högbom M.; Shafaat H.S. 2018. ‘Driving Protein Conformational Changes with Light: Photoinduced Structural Rearrangement in a Heterobimetallic Oxidase.’ Journal of the American Chemical Society 140, Nr. 4: 1471–1480. doi: 10.1021/jacs.7b11966.

2014

Eirich J, Braig S, Schyschka L, Servatius P, Hoffmann J, Hecht S, Fulda S, Zahler S, Antes I, Kazmaier U, others. 2014. ‘A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells.’ Angewandte Chemie International Edition 53, Nr. 47: 12960–12965. doi: 10.1002/anie.201406577.
Eirich J, Sieber SA. 2014. ‘Naturstoffe und ihre zellulären Angriffsziele.’ Nachrichten aus der Chemie 62, Nr. 7: 743–747.
Eirich J, Braig S, Schyschka L, Servatius P, Hoffmann J, Hecht S, Fulda S, Zahler S, Antes I, Kazmaier U, others. 2014. ‘Eine niedermolekulare Verbindung inhibiert die Proteindisulfidisomerase und sensibilisiert Krebszellen für die Chemotherapie.’ Angewandte Chemie 126, Nr. 47: 13174–13179.
Eirich J.; Sieber S.A. 2014. „Natural substances and their cellular targets Naturstoffe und ihre zellulären Angriffsziele.“ Nachrichten aus der Chemie 62, Nr. 7: 743–747. doi: 10.1002/nadc.201490249.

2012

Eirich J, Burkhart JL, Ullrich A, Rudolf GC, Vollmar A, Zahler S, Kazmaier U, Sieber SA. 2012. ‘Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy.’ Molecular BioSystems 8, Nr. 8: 2067–2075. doi: 10.1039/c2mb25144b.

2011

Eirich J, Orth R, Sieber SA. 2011. ‘Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells.’ Journal of the American Chemical Society 133, Nr. 31: 12144–12153. doi: 10.1021/ja2039979.

2009

Trindler C, Manetto A, Eirich J, Carell T. 2009. ‘A new ground state single electron donor for excess electron transfer studies in DNA.’ Chemical communications 24, Nr. 24: 3583–3584. doi: 10.1039/b906180k.