Ruben Bierings (Erasmus Medical Center Rotterdam)

Exocytosis of Weibel-Palade bodies: how to unpack a vascular emergency kit

Host: Volker Gerke

Weibel-Palade bodies are unique secretory organelles of the endothelium that contain the hemostatic protein Von Willebrand factor together with a cocktail of inflammatory and angiogenic mediators. Exocytosis of Weibel-Palade bodies and release of their content into the vascular lumen upon vascular injury is a crucial step in hemostasis and directs leukocyte transmigration and blood vessel repair. Research in the Bierings lab revolves around the molecular mechanisms of Von Willebrand factor secretion, biogenesis and exocytosis of Weibel-Palade bodies and how defects in these process can give rise to bleeding abnormalities in patients. Ruben Bierings is an endothelial cell biologist and Associate Professor in the Department of Hematology of the Erasmus University Medical Center in Rotterdam (NL). He received his PhD from Utrecht University for his work on Von Willebrand factor secretion in endothelial cells (2007, thesis “Sorting out the Weibel-Palade body), which was carried out at CLB-Sanquin Research in Amsterdam. He completed postdoctoral research as an MRC Career Development Fellow (2007-2011) at the National Institute for Medical research (NIMR) in London (UK). Upon his return to the Netherlands he started his own lab, first at Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, but since 2018 at Erasmus MC. He serves as a co-chair of the International Society for Thombosis and Haemostasis (ISTH) Vascular Biology Scientific Standardization Subcommittee (SSC).

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