Aurelio Teleman (DKFZ)

Identification of a therapeutic target for NF2

Host: Christian Klämbt / Anna Ziegler

Neurofibromatosis Type II (NFII) is a genetic condition caused by loss of the NF2 gene, resulting in activation of the YAP/TAZ pathway and recurrent growth of benign tumors from Schwann cells, the glia of the peripheral nervous system. Unfortunately, few pharmacological options are available for NFII. We undertook a genome-wide CRISPR/Cas9 screen to search for synthetic-lethal genes that, when inhibited, cause death of NF2 mutant Schwann cells but not NF2 wildtype cells. I will report on progress we made in this direction to identify a therapeutic target for NF2.

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