© Uni Münster

Research Topic

The important question as to ‘how cells make tissues’ is the central research interest in my laboratory. Much of our work is focusing on the vertebrate cardiovascular system, in which blood vessels need to integrate precisely into very different tissue environments, acquire organ-specific functional specialization, and retain plasticity allowing them to adapt to changing local requirements and cues.

We make use of a powerful combination of inducible and cell type-specific genetic approaches in mice, confocal and two-photon microscopy, immunohistochemistry, cell/tissue culture, biochemistry, RNA and scRNA sequencing, and molecular biology to study the angiogenic growth of blood vessels, the interactions between different cell types forming the vessel wall, and the communication between blood vessels and the surrounding tissue. An example of the latter is the regulation of bone-forming cells and hematopoietic stem cells by blood vessels and specific capillary subtypes in the skeletal system. 

More information can be found here:
MPI Münster
Researchgate

Selected Publications

  • Stewen J., Kruse K., Godoi-Filip A.T., Zenia, Jeong H.W., Adams S., Berkenfeld F., Stehling M., Red-Horse K., Adams R.H.*, Pitulescu M.E.* (2024). Eph-ephrin signaling couples endothelial cell sorting and arterial specification. Nature Communications, 15(1):2539. doi: 10.1038/s41467-024-46300-0.
  • Bixel M.G., Sivaraj K.K., Timmen M., Mohanakrishnan V., Aravamudhan A., Adams S., Koh B.I., Jeong H.W., Kruse K., Stange R., Adams R.H. (2024). Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration. Nature Communications, 15(1):4575. doi: 10.1038/s41467-024-48579-5.
  • Sivaraj K.K., Dharmalingam B., Mohanakrishnan V., Jeong H.W., Kato K., Schröder S., Adams S., Koh G.Y., Adams R.H. (2020). YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. Elife, 9:e50770. doi: 10.7554/eLife.50770.   
  • Luxán G., Stewen J., Díaz N., Kato K., Maney S.K., Aravamudhan A., Berkenfeld F., Nagelmann N., Drexler H.C., Zeuschner D., Faber C., Schillers H., Hermann S., Wiseman J., Vaquerizas J.M., Pitulescu M.E.*, Adams R.H.*. (2019). Endothelial EphB4 maintains vascular integrity and transport function in adult heart. Elife, 8:e45863. doi: 10.7554/eLife.45863.
  • Chen Q., Liu Y., Jeong H.W., Stehling M., Dinh V.V., Zhou B., Adams R.H.*. (2019). Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Cell Stem Cell, 25(6):768-783.e6. doi: 10.1016/j.stem.2019.10.006.

* corresponding author