Dr. Ima Trempler

 

 

 

 

 

Completed project

Should I stay or should I go? Dopaminerge Modulation kognitiver Stabilität und Flexibilität

In daily life, it is of crucial importance to adjust our behavior to environmental changes without losing track of our action goals. On the one hand, we have to stabilize our predictions in the face of potential distracters. On the other hand, we need to adapt these stable predictions to altered circumstances. Recent physiological as well as neurocomputational models suggest that this balance between cognitive stability and flexibility is mediated by dopamine. Dopamine in the prefrontal cortex binding on so-called D1-receptors might be essential for stabilization of working memory (Durstewitz & Seamans, 2008). In contrast, dopamine acting on D2-receptors in the striatum possibly plays a considerable role for cognitive flexibility (Friston et al., 2012). Motor as well as cognitive dysfunctions resulting from dopaminergic decline in idiopathic Parkinson’s disease (IPD) may thus be described as specific impairments of cognitive stability and/or flexibility. In order to test this hypothesis, we investigate the explicit and implicit stabilization and flexibilization of prediction in patients with IPD (dopaminergic medication “on” and “off”) and healthy controls. Using a modified serial prediction task (sequence switch detection), we collect behavioral data (reaction times and error rates) as well as physiological measures (skin conductance responses (SCR), and BOLD functional Magnetic Resonance Imaging (fMRI)). In a further study, we examine the genotype dopamine catabolism’s (COMT-polymorphism) influence and that of dopamine receptor density (DRD2-polymorphism) on cognitive stability and flexibility in healthy subjects and patients.
References

Durstewitz, D. & Seamans, J. (2008). The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-o-methyltransferase genotypes and schizophrenia. Biol Psychiatry, 64, 739-749.

Friston, K. J., Shiner, T., FitzGerald, T., Galea, J. M., Adams, R., Brown, H., ... Bestmann, S. (2012). Dopamine, affordance and active inference. PLoS Comput Biol 8(1, e1002327.

Schubotz, R. I. & von Cramon D.Y. (2004). Anterior-posterior functional gradient within premotor fields: fMRI on memory-driven versus stimulus-driven sequencing. Neuroimage, 22 (1), 33.

Publications

Trempler, I., Ellen Binder, E., Reuter, M., Plieger, T., Isabel Standke, I., Mecklenbrauck, F., Kaltwasser, I., Meinert, S., Forstner, A.J., Noethen, M., Rietschel, M., Stürmer, S.,10, Dannlowski, U., Tittgemeyer, M., Lencer, R., Fink, G.R.,  Schubotz, R.I. (2022) Effects of DRD2/ANKK1 and COMT Val158Met Polymorphisms on Stabilization against and Adaptation to Unexpected Events, Cerebral Cortex, 2022, 00,1–18, doi.org/10.1093/cercor/bhac046.

Siestrup, S., Jainta., B., El-Sourani, N., Trempler, I., Wurm, M. F., Wolf, O. T., Cheng, S., & Schubotz, R. I. (2022) What happened when? Cerebral processing of modified structure and content in episodic cueing. Journal of Cognitive Neuroscience, in press

Jainta, B., Siestrup, S., El-Sourani, N., Trempler, I., Wurm, M.F., Werning, M., Cheng, S., Schubotz, R.I. (2021) Seeing what I did (not): Cerebral and behavioral effects of agency and perspective on episodic memory re-activation. Front. Behav. Neurosci. 15:793115. doi: 10.3389/fnbeh.2021.793115.

Standke, I., Trempler, I., Dannlowski, U., Schubotz, R.I., Lencer, R. (2021) Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders. NeuroImage: Clinical,  32:102855. doi: 10.1016/j.nicl.2021.102855

Hübner, A.M., Trempler, I., Gietmann, C., Schubotz, R.I. (2021) Interoceptive sensibility predicts the ability to infer others' emotional states. PLoS ONE 16(10): e0258089, doi.org/10.1371/journal.pone.0258089.

Pomp, J., Heins, N., Trempler, I., Kulvicius, T., Tamosiunaite, M., Mecklenbrauck, F., Wurm, M.F., Wörgötter, F., Schubotz, R.I. (2021) Touching events predict human action segmentation in brain and behavior. NeuroImage, 243 (2021) 118534, doi.org/10.1016/j.neuroimage.2021.118534

Heins, N., Pomp, J., Kluger, D.S., Vinbrüx, S., Trempler, I., Kohler, A., Kornysheva, K., Zentgraf, K., Raab, M., Schubotz, R.I. (2021) Surmising synchrony of sound and sight: Factors explaining variance of audiovisual integration in hurdling, tap dancing and drumming. PLoS ONE 16(7): e0253130

Schliephake, L.,Trempler, I., Roehe, M.A., Heins, N., Schubotz,R.I. (2021). Positive and negative prediction error signals to violated expectations of face and place stimuli distinctively activate FFA and PPA. NeuroImage, 236 (2021) 118028

Heins, N., Trempler, I., Zentgraf, K., Raab, M., Schubotz, R.I. (2020) Too late! Influence of temporal delay on the neural processing of one’s own incidental and intentional action-induced sounds. Frontiers in Neuroscience, 14:573970, doi.org/10.3389/fnins.2020.573970

Heins, N., Pomp, J., Kluger, D.S., Trempler, I., Zentgraf, K., Raab, M., Schubotz, R.I. (2020) Incidental or intentional? Different brain responses to one's own action sounds in hurdling vs. tap dancing. Frontiers in Neuroscience,14:483, doi.org/10.3389/fnins.2020.00483

Trempler, I., Bürkner, P.C., El-Sourani, N., Binder, E., Reker, P., Fink, G.R., Schubotz,R. I. (2020) Impaired context-sensitive adjustment of behaviour in Parkinson's disease patients tested on and off medication: an fMRI study. NeuroImage, 212, 116674, doi.org/10.1016/j.neuroimage.2020.116674

El-Sourani, N., Trempler, I., Wurm, M.F., Fink, G.R., Schubotz, R.I. (2019) Predictive Impact of Contextual Objects during Action Observation: Evidence from Functional Magnetic Resonance Imaging. Journal of Cognitive Neuroscience. 32(2), 326–337, doi.org/10.1162/jocn_a_01480