Single Molecule Biology

Author(s): Alex E. Knight
ISBN: 978-0-12-374227-8
Elsevier 2009

Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective. The contents of Single Molecule Biology are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Signal Transduction (Second Edition)

Author(s): Bastien D. Gomperts, IJsbrand M. Kramer and Peter E.R. Tatham
ISBN: 978-0-12-369441-6
Elsevier 2009

A reference on cellular-signalling processes, Signal Transduction (Second Edition) details the sources, key observations, and experiments that set the scene for recent and current scientific endeavor. Beginning with a historical overview, this book discusses how the concept of chemical messengers arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, and growth factors.

Signal Transduction second edition further examines more complex signalling cascades, emanating from classic receptors, as well as adhesion molecules, involved in processes such as vision, smell, inflammation, innate and adaptive immunity, glucose homeostasis, cell-fate decisions, cell differentiation, and cell transformation. This timely revision concludes with a discourse on the targeting of signal-transduction cascades in the treatment of cancer and the structure of protein domains key to the assembly of signalling complexes.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Stem Cells

Autoren: Christine Mummery, Ian Wilmut, Anja Van De Stolpe, Bernard Roelen
ISBN: 978-0-12-381535-4
Elsevier 2011

In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues of which everyone presumed were unable to regenerate in adults; these include particularly the heart and the brain. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson, diabetes and spinal cord lesions based on the use of stem cells and entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. As is often the case in science, many early claims turned out to be different from those expected. Embryonic stem cell therapies have not moved rapidly into clinical practice. Adult stem cells certainly have given certain degrees of success but not nearly to the extent that advocates would have wished for. Some claims of early successes in adult stem cell therapies have not been sustained in double-blinded, randomized clinical trials. Some claims are now close to routine therapy. Some of the claims not supported by evidence have nevertheless reached private clinical practice so that „stem cell tourism“ is beginning to reach exaggerated proportions. Stem Cells provides the reader background information on stem cells in a clear and well-organized manner. It provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. It distinguishes itself from the multiplicity of websites on the subject of stem cells by being scientifically, politically and ethically neutral, explaining pros and cons for stem cells of every sort with the intention of reaching a wide readership ranging from advanced students and patient advocacy groups to clinicians, specialists and early phase medics in training. By providing the background scientific and social information, it provides readers with the information they require to form their own opinions on the use of stem cells on the basis of facts rather than hype.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Science and the Media: Delgado’s Brave Bulls and the Ethics of Scientific Disclosure

Author(s): Peter J. Snyder, Linda C. Mayes and Dennis D. Spencer
ISBN: 978-0-12-373679-6
Elsevier 2009

Of great utility for every scientist faced with publicizing their discoveries via the media, Science and the Media addresses questions of responsibility for the balance and accuracy of scientific reporting, and attempts to be a guide for the scientist in their quest to inform the general public about their research in honest, truthful, and still interesting ways. Case studies by leading scholars in the fields of bioethics (pharmaceutical research (Declan Doogan, Senior VP Pfizer), medical journal editing (Jerome Kassirer, former editor of NEJM), science journalism, philosophy of science, history of medicine (John Warner, chair history of medicine Yale), public health (Ruth Katz, Dean public health, George Washington University), and philosophy of religion (Reverend Wesley Carr, former Dean of Westminster) illustrate positions and points of view and offer unique perspectives on the complex dance between science and the media.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

RNA Methodologies (Fourth Edition): A Laboratory Guide for Isolation and Characterization

Author(s): Robert E. Farrell, Jr., Ph.D
ISBN: 978-0-12-374727-3
Elsevier 2010

This is the fourth edition of the successful laboratory guide which has translated the rich story of riboneucleic acid for over fifteen years. RNA Methodologies 4e presents the latest collection of tested laboratory protocols for the isolation and characterization of eukaryotic and prokaryotic RNA with greater emphasis on transcript profiling, including quantification issues and elucidation of alternative transcription start sites. Collectively the chapters work together providing analysis with clear take-home lessons to assist researchers to understand RNA and to optimize time at the bench. The abundant use of flow charts, tables and graphs are especially helpful in the planning and implementation phases of a project and facilitate learning. 30% new material in this edition includes the addition of RNA isolation protocols including RNA isolation from tissue, expansion of PCR optimization analysis and RNA interference sections, the introduction of a new chapter dealing with the molecular biology of plants, and an expanded glossary.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research

Author(s): Robert M. Rydzewski
ISBN: 978-0-08-046617-0
Elsevier 2008

Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Quantitative EEG, Event-Related Potentials and Neurotherapy

Author(s): Juri D. Kropotov
ISBN: 978-0-12-374512-5
Elsevier 2009

While the brain is ruled to a large extent by chemical neurotransmitters, it is also a bioelectric organ. The collective study of Quantitative ElectroEncephaloGraphs (QEEG-the conversion of brainwaves to digital form to allow for comparison between neurologically normative and dysfunctional individuals), Event Related Potentials (ERPs – electrophysiological response to stimulus) and Neurotherapy (the process of actually retraining brain processes to) offers a window into brain physiology and function via computer and statistical analyses of traditional EEG patterns, suggesting innovative approaches to the improvement of attention, anxiety, mood and behavior. Quantitative EEG, Event-Related Potentials and Neurotherapy provides detailed description of the various EEG rhythms and ERPs, the conventional analytic methods such as spectral analysis, and the emerging method utilizing QEEG and ERPs. This research is then related back to practice and all existing approaches in the field of Neurotherapy – conventional EEG-based neurofeedback, brain-computer interface, transcranial Direct Current Stimulation, and Transcranial Magnetic Stimulation – are covered in full. Additionally, software for EEG analysis is provided on a companion web site so that the theory can be practically utilized on the spot, and a database of the EEG algorithms described in the book can be combined with algorithms uploaded by the user in order to compare dysfunctional and normative data. While it does not offer the breadth provided by an edited work, this volume does provide a level of depth and detail that a single author can deliver, as well as giving readers insight into the personl theories of one of the preeminent leaders in the field.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Neuromodulation

Edited by: Elliot S. Krames,
P. Hunter Peckham and Ali R. Rezai
ISBN: 978-0-12-374248-3
Elsevier 2009, 556 Seiten

Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs.
The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices.
All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Pharmacology: Principles and Practice

Edited by: Miles Hacker, William Messer and Kenneth Bachmann
Elsevier 2008, 608 Seiten. ISBN: 978-0-12-369521-5

Pharmacology: Principles and Practice meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

The Prefrontal Cortex (Fourth Edition)

Author(s): Joaquín M. Fuster, MD, PHD
ISBN: 978-0-12-373644-4
424 Seiten, Elsevier 2009

This is the fourth edition of The Prefrontal Cortex (Fourth Edition), the undisputed classic on the prefrontal cortex, the principal „executive“ structure of the brain. Because of its role in such cognitive functions as working memory, planning, and decision-making, the prefrontal cortex is critically involved in the organization of behavior, language, and reasoning. Prefrontal dysfunction lies at the foundation of several psychotic and neurodegenerative disorders, including schizophrenia and dementia.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Posttraumatic Stress Disorder Scientific and Professional Dimensions
Author(s): Julian D. Ford
Elsevier 2009, ISBN: 978-0-12-374462-3

Posttraumatic Stress Disorder will be the first comprehensive text in the rapidly growing field of psychological trauma and posttraumatic stress disorder. According to the NIMH, approximately 5.2 million American adults already suffer from post traumatic stress disorder. Caused by everything from combat experience to violent personal assaults to natural disasters and accidents, the incidence of PTSD has already reached epidemic proportions. The profound impact of psychological trauma and the need for proactive and scientifically-based approaches to timely prevention and evidence based treatment is unarguable and mental health programs are seeing a significant rise in the number of PTSD courses offered and services required. As a result, scholars, researchers, educators, clinicians, and trainees in the health care and human and social services need a concise and comprehensive source of authoritative information on psychological trauma and posttraumatic stress. This volume will offer a foundational understanding of the field as well cover key controversies, the influence of culture and gender, and describe state-of-the-art research and clinical methodologies in down-to-earth terms. Clinical case studies will be used liberally.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases
Author(s): F. Javier Alvarez-Leefmans and Eric Delpire
Elsevier 2009, ISBN: 978-0-12-374373-2

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. Physiology and Pathology of Chloride Transporters and Channels in the Nervous System is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008 und 2009, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.