Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases

Author(s): F. Javier Alvarez-Leefmans and Eric Delpire
ISBN: 978-0-12-374373-2
Elsevier 2009

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Nitric Oxide (Second Edition): Biology and Pathobiology
Edited by: Louise J. Ignarro
ISBN: 978-0-12-373866-0
Elsevier 2010

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide?s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Molecular Diagnostics: Techniques and Applications for the Clinical Laboratory

Edited by: Contributors, Wayne W. Grody, M.D., Ph.D., Robert M. Nakamura, M.D., Charles M. Strom, M.D., Ph.D., and Frederick L. Kiechle, MD, PhD.
ISBN: 978-0-12-369428-7
Elsevier 2010

Audience: Pathologists, laboratory technicians, geneticists, physicians, medical students, and other health care professionals involved in molecular testing.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Fundamentals of Toxicologic Pathology (Second Edition)

Author(s): Wanda M. Haschek, Colin G. Rousseaux and Matthew A. Wallig
ISBN: 978-0-12-370469-6
Elsevier 2009

CHAPTER ONE: Principles of Toxicology CHAPTER TWO: Manifestations of Toxic Cell Injury — Cell Injury/Death and Chemical Carcinogenesis CHAPTER THREE: Clinical Pathology CHAPTER FOUR: Nomenclature– Terminology for Morphologic Alterations CHAPTER FIVE: Techniques in Toxicologic Pathology CHAPTER SIX: Respiratory System CHAPTER SEVEN: Skin and Oral Mucosa CHAPTER EIGHT: Gastrointestinal Tract CHAPTER NINE: Liver CHAPTER TEN: Pancreas CHAPTER ELEVEN: Kidney and Lower Urinary Tract CHAPTER TWELVE: Cardiovascular and Skeletal Muscle Systems CHAPTER THIRTEEN: Bones CHAPTER FOURTEEN: Nervous System CHAPTER FIFTEEN: Immune System CHAPTER SIXTEEN: Hematopoietic System CHAPTER SEVENTEEN: Endocrine System CHAPTER EIGHTEEN: Male Reproduction CHAPTER NINETEEN: Female Reproduction CHAPTER TWENTY: Developmental Toxicology

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Natural Killer Cells: Basic Science and Clinical Application

Edited by: Michael T. Lotze and Angus W. Thomson
ISBN: 978-0-12-370454-2
Elsevier 2010

The Natural Killer [NK] Cell plays a critical role in regulating the innate and adaptive immune response to pathogens, injury and stress. Although originally portrayed as primarily a lytic cell, the NK cell has emerged as a cell capable of helper function, expansion, contraction, and accelerated memory responses – features similar to other adaptive immune cells. It is a professional accelerator of immunity, mediating dendritic cell maturation and its precursors critical for the origin and development of secondary lymph node structures. NK cells also play an essential role in mammalian placentation by regulating the quality of blood supply to the growing fetus. These characteristics place the NK cell in a unique position, with a major role in sculpting the host response to damage and injury. This volume is the first complete and authoritative reference to explore these emergent, exciting aspects of the NK cell, placing it at the center of damage/danger recognition and the response to stress. Natural Killer Cells details NK cell biology, the role of NK cells in regulating immunity through interactions with other cells and tissues, the participation of NK cells in disease and special topics in NK biology. [Amazon]

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Handbook of Epigenetics: The New Molecular and Medical Genetics

Edited by: Trygve Tollefsbol
ISBN: 978-0-12-375709-8
Elsevier 2011

Epigenetics is considered by many to be the „new genetics“ because the realization that many biological phenomena are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes that have opened up new paths for discovery. The biological processes impacted by epigenetics range from tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation to genomic imprinting and aging. The effects of epigenetics are vast and encompass lower organisms as well as humans. Aberrations of epigenetics influence many diseases involving but not limited to cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases. Clinical intervention is already in place for some of these disorders and many novel epigenetic therapies are on the horizon.

This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. [Amazon]

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Transfusion Medicine and Hemostasis Clinical and Laboratory Aspects

Edited by: Christopher D. Hillyer, MD, Beth H. Shaz, MD, James C. Zimring, MD, PhD, and Thomas C. Abshire, MD
ISBN: 978-0-12-374432-6
Elsevier 2009

Audience: Residents and fellows in hematology, transfusion medicine, pathology, and anesthesiology; practicing physicians in hematology, transfusion medicine, pathology, and anethesiology.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Therapist’s Guide to Posttraumatic Stress Disorder Intervention

Author(s): Sharon L. Johnson
ISBN: 978-0-12-374851-5
Elsevier 2009

Sharon Johnson is the author of the best selling Therapist’s Guide to Clinical Intervention now in its second edition. In this new book on PTSD, she lends her practical outline format to understanding PTSD assessment, treatment planning, and intervention. The book begins with a summary information on PTSD definition, and prevalence, assessment, and the evidence basis behind different treatment options. The book offers adjunctive skill building resources to supplement traditional therapy choices as well as forms for use in clinical practice. This clinician’s guide to diagnosing and treating PTSD is written in a concise format with much of the material in outline or bullet point format, allowing easy understanding of complex material for the busy therapist. The book includes a definition of the disorder, diagnostic criteria, the neurobiology of the disorder, tools and information for diagnosing clients, information on functional impairment, interventions, treatment planning, skill building, and additional clinician resources.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Therapist’s Guide to Positive Psychological Interventions

Author(s): Jeana L. Magyar-Moe, PhD
ISBN: 978-0-12-374517-0
Elsevier 2009

Positive psychology – essentially the scientific study of the strengths that enable individuals and communities to thrive – is a relatively new discipline that has experienced substantial growth in the last 5-10 years. Research suggests that the principles and theories from this area of study are highly relevant to the practice of counseling and psychotherapy, and positive psychology presents clinicians and patients with a much needed balance to the more traditional focus on pathology and the disease model of mental health. This book provides a comprehensive introduction to the best-researched positive psychological interventions. It emphasizes clinical application, providing a detailed view of how the research can be applied to patients. Covering the broaden-and-build theory, strengths-based therapy, mentoring modalities and more, the volume will provide numerous assessment tools, exercises and worksheets for use throughout the counseling and psychotherapy process.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.

Systems Biomedicine: Concepts and Perspectives

Edited by: Edison T. Liu and Douglas A. Lauffenburger
ISBN: 978-0-12-372550-9
Elsevier 2009

Systems biology is a critical emerging field that seeks to define the interactions of all biological components by examining underlying biochemical and genetic processes. It is a discipline that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine: Concepts and Perspectives is organized around foundations, computational modelling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon.

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Das obige Buch gehört zu den gut 1.000 dauerhaft von der ZB Med gekauften Online-Büchern des Elsevier-Verlags der Jahre 1995-2008, 2009 und 2010-2011, die in den folgenden Sachgebieten erschienen sind: Biochemistry, Genetics and Molecular Biology; Forensics; Immunology and Microbiology; Medicine and Dentistry; Neuroscience; Pharmacology, Toxicology and Pharmaceutical Science; Psychology.