International Encyclopedia of Human Geography

2009 Elsevier Ltd., Editors-in-Chief: Rob Kitchin and Nigel Thrift. ISBN: 978-0-08-044910-4

Including a detailled chapter on „Health and Medical Geography“.

The International Encyclopedia of Human Geography provides an authoritative and comprehensive source of information on the discipline of human geography and its constituent, and related, subject areas. The encyclopedia includes over 1,000 detailed entries on philosophy and theory, key concepts, methods and practices, biographies of notable geographers, and geographical thought and praxis in different parts of the world. This groundbreaking project covers every field of human geography and the discipline’s relationships to other disciplines, and is global in scope, involving an international set of contributors. Given its broad, inclusive scope and unique online accessibility, it is anticipated that the International Encyclopedia of Human Geography will become the major reference work for the discipline over the coming decades. The Encyclopedia will be available in both limited edition print and online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy.

Information Resources in Toxicology (Fourth Edition)

2009 Elsevier Inc. Edited by: Philip Wexler, Associate Editors and Steve G. Gilbert. ISBN: 978-0-12-373593-5

This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the „hot topics“ covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. . International in scope, with contributions from over 30 countries
. Numerous key references and relevant Web links
. Concise narratives about toxicologic sub-disciplines
. Valuable appendices such as the IUPAC Glossary of Terms in Toxicology
. Authored by experts in their respective sub-disciplines within toxicology

Genetic Diseases of the Kidney
Edited by: Richard P. Lifton, Stefan Somlo, Gerhard H. Giebisch and Donald W. Seldin
2009 Elsevier, ISBN: 978-0-12-449851-8

Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge.

Hayes‘ Handbook of Pesticide Toxicology (Third Edition)
Edited by: Robert Krieger, 2342 Seiten
2010 Elsevier , ISBN: 978-0-12-374367-1

Hayes‘ Handbook of Pesticide Toxicology (Third Edition) is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book’s tradition of serving as the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition.

Hematopathology: Morphology, Immunophenotype, Cytogenetics and Molecular Approaches
Author(s): Faramarz Naeim, M.D., FASCP, P. Nagesh Rao, Ph.D., FACMG,
and Wayne W. Grody, M.D., Ph.D., FACMG, FCAP, FASCP
2008 Elsevier , ISBN: 978-0-12-370607-2

This comprehensive, full color hematopathology reference book emphasizes immunophenotpic features, cytogenetic studies, and diagnostic molecular aspects. Hematopathology: Morphology, Immunophenotype, Cytogenetics and Molecular Approaches begins with introductions to morphologic evaluation of the hematopoietic tissues and principles of immunophenotyping, cytogenetics and molecular studies followed by chapters dedicated to different types of hematologic disorders. Each chapter starts with a basic overview of hematopathlogy followed by a comprehensive review of immunophenotypic, cytogenetic and molecular findings. The text is balanced with large numbers of full color images, graphs, charts, and tables to assist the reader in understanding these highly technical issues.

A History of Immunology (Second Edition)
Author(s): Arthur M. Silverstein
2009 Elsevier , ISBN: 978-0-12-370586-0

List of Photos Foreword: On History and Historians Preface to the Second Edition Preface to the First Edition PART ONE: INTELLECTUAL HISTORY 1. Theories of Acquired Immunity 2. Cellular vs. Humoral Immunity 3. Theories of Antibody Formation 4. The Generation of Diversity: The Germline/Somatic Mutation Debate 5. The Clonal Selection Theory Challenged: The Immunological Self 6. The Concept of Immunologic Specificity 7. Specificity Continued 8. Horror Autotoxicus: The Concept of Autoimmunity 9. Allergy and Immunopathology: The „Price“ of Immunity 10. Anti-Antibodies and Anti-Idiotypic Immunoregulation: 1899-1904 11. Transplantation and Immunogenetics PART TWO: SOCIAL HISTORY 12. Magic Bullets and Poisoned Arrows: The Uses of Antibodies 13. The Royal Experiment: 1721-22 14. The Languages of Immunologic Dispute 15. The Search for Cell-Bound Antibodies. On the Influence of Dogma 16. Natural‘ Antibodies and ‚Virgin‘ Lymphocytes: The Importance of Context 17. The Dynamics of Conceptual Change in Immunology 18. Immunology in Transition 1951-1972: The Role of International Meetings and Discipline Leaders 19. The Origin of Subdisciplines: (Ocular Immunology; Pediatric Immunology; Immunophysiology) 20. Immune Hemolysis: On the Heuristic Value of an Experimental System 21. Darwinism and Immunology: from Metchnikoff to Burnet 22. The End of Immunology? Appendix A1. The Calendar of Immunologic Progress Appendix A2. Seminal Discoveries Appendix A3. Important Books in Immunology, 1892 – 1968 Appendix B. Nobel Prize Highlights in Immunology Appendix C. Biographical Dictionary

HIV Prevention
A comprehensive approach
Edited by: Kenneth H. Mayer and Hank F. Pizer
2009 Elsevier, ISBN: 978-0-12-374235-3

Introduction I. Section I: Contexts and Principles: epidemiology, applied virology, microbiology, infectious disease and behavioural psychology applied to the design of AIDS prevention interventions Chapter 1: Current And Future Trends: Implications For Prevention Chapter 2. Biology of HIV Transmission Chapter 3: Principles and Theories of Behavior Applied to HIV Prevention II. Section II: Evidence-Based Prevention Interventions: programs for at-risk populations Chapter 4. Individual Interventions Chapter 5. Dyadic and Group Interventions Chapter 6. Structural Interventions in Societal Contexts Chapter 7: Voluntary Counselling and Testing Chapter 8: Interventions With Men Who Have Sex With Men Chapter 9. Interventions With Injecting Drug Users Chapter 10: Interventions With Sex Workers Chapter 11: Interventions With Youth in High Prevalence Areas Chapter 12: Interventions With Incarcerated and Institutionalized Persons Chapter 13. Preventing Perinatal Transmission III. Policy, Technology and Research: Biomedical technologies for prevention, testing and research Chapter 14. Harm Reduction and Public Health Chapter 15. STD Control for HIV Prevention Chapter 16 Using Antiretrovirals to Prevent HIV Transmission Chapter 17 Microbicides Chapter 18 Vaccines Chapter 19. Program Monitoring and Evaluation

Human Stem Cell Manual: A Laboratory Guide
Edited by: Jeanne F. Loring, Robin L. Wesselschmidt and Philip H. Schwartz
Elsevier: 2007, ISBN: 978-0-12-370465-8

Foreword by James Battey Foreword by Jeannie Fontana Preface Part I: Basic methods: Maintenance of stem cell cultures 1.Human Embryonic Stem Cell Culture 2.Feeder layers and feeder-free culture 3.Mouse Embryonic Fibroblast Feeder Cells 4.Cryopreservation of hESC Part II: Basic methods: Characterization of stem cells 5.Classical Cytogenetics: Karyotyping 6.Spectral Karyotyping and Fluorescent in situ Hybridization 7.Using SNP Genotyping to Identify Cell Lines, Determine Genomic Abnormalities and Monitor DNA Methylation Patterns 8.FACS/Cell sorting 9.Fluorescence Immunocytochemical Analysis of Stem Cells 10.Characterization of Stem Cells Using RT-PCR 11.Gene Expression Profiling of Stem Cells by Microarray 12.Teratomas produced from Human Embryonic Stem Cells Xenografted into Immunodeficient Mice 13.Generation of HESC-Derived Teratomas Part III: Differentiation of stem cells 14.?Embryoid Body? Formation and Neuroepithelia Differentiation 15.Motor Neuron and Dopamine Neuron Differentiation 16.Oligodendrocyte Differentiation from hESC 17.Cardiac 18.Hematopoietic Part IV: Genetic manipulation of stem cells 19.Genetic Manipulation of hESC: Lentivirus Vectors 20.Methods developed for mouse ES cells Part V: Advanced methods 21.Derivation of human ES cells 22.Neural Stem Cell Culture 23.Transplantation of stem cells 24.In vitro fertilization 25.Functional characterization-neural cells Part VI: Practical issues in establishing a human ES cell laboratory 26.Setting Up a Facility for hESC Research Part VII: Essays on stem cell biology 27.Intellectual Property: Owning the Stem Cell 28.Ethical Concerns for Stem Cell Research 29.Guidelines for hESC Research Oversight (ESCRO) Committees

Hyaluronan in Cancer Biology
Elsevier: 2009, Edited by: Robert Stern
ISBN: 978-0-12-374178-3

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. Hyaluronan in Cancer Biology offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.

Handbook of the Neuroscience of Language
Author(s): Brigitte Stemmer and Harry A. Whitaker
2008 Elsevier Ltd., ISBN: 978-0-08-045352-1

In the last ten years the neuroscience of language has matured as a field. Ten years ago, neuroimaging was just being explored for neurolinguistic questions, whereas today it constitutes a routine component. At the same time there have been significant developments in linguistic and psychological theory that speak to the neuroscience of language. The Handbook of the Neuroscience of Language consolidates those advances into a single reference. The Handbook of the Neuroscience of Language provides a comprehensive overview of this field. Divided into five sections, section one discusses methods and techniques including clinical assessment approaches, methods of mapping the human brain, and a theoretical framework for interpreting the multiple levels of neural organization that contribute to language comprehension. Section two discusses the impact imaging techniques (PET, fMRI, ERPs, electrical stimulation of language cortex, TMS) have made to language research. Section three discusses experimental approaches to the field, including disorders at different language levels in reading as well as writing and number processing. Additionally, chapters here present computational models, discuss the role of mirror systems for language, and cover brain lateralization with respect to language. Part four focuses on language in special populations, in various disease processes, and in developmental disorders. The book ends with a listing of resources in the neuroscience of language and a glossary of items and concepts to help the novice become acquainted with the field. Editors Stemmer & Whitaker prepared this book to reflect recent developments in neurolinguistics, moving the book squarely into the cognitive neuroscience of language and capturing the developments in the field over the past 7 years.

Handbook of Neuro-Oncology NeuroImaging
Author(s): Herbert B. Newton, M.D., FAAN, and Ferenc A. Jolesz, M.D., Ph.D.
2008 Elsevier Ltd., ISBN: 978-0-12-370863-2

Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive, single-source books that summarize the current literature and future trends of neuroimaging in neuro-oncology. Handbook of Neuro-Oncology NeuroImaging covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging

Handbook of Exposure Therapies
Edited by: David C.S. Richard and Dean Lauterbach
2007 Elsevier Inc., ISBN: 978-0-12-587421-2

Exposure Therapy refers to any clinical intervention in which a client directly confronts a source of fear. Since high levels of anxiety can not be maintained indefinitely, repeated exposure leads to decreased anxiety. This type of treatment is effective with phobias, post traumatic stress disorder, obsessive compulsive disorders, panic, generalized anxiety, and several other disorders. It’s also been found to be effective in helping to treat substance abuse. Although exposure-based treatments have been extensively researched and reported in the literature, there is no single comprehensive treatment of exposure therapies. Writings tend to be limited to larger pieces on treating specific disorders or types of patients. A comprehensive book on the use of these treatments across patient disorders will be of great use to practitioners. Handbook of Exposure Therapies is divided into three sections: Foundation, Applications, and Issues. Foundation chapters considers theoretical and assessment issues. Applications chapters will discuss research literature on each disorder having been proven to be successfully treated with exposure therapy. Issue chapters will discuss liability issues, false memory syndrome, and the use of computers and virtual reality in exposure therapy.