Name: Dr. Eugen Werwein
Diploma / M.Sc degree: Westfälische Wilhelms-Universität Münster, Germany
(May 2008)

PhD Project: The role of the transcription factor B-Myb in the regulation of the cell cycle


Homepage: http://www.uni-muenster.de/Chemie.bc/staff/bc-staff.html

Abstract of Research Project

"Omnus cellula e cellula"
Rudolf Virchow

In order to divide cells have to perform a process called the cell cycle. The progress of the cell cycle is striktly regulated, since the disregulation may lead to genetic damage and tumor formation. The control of cell proliferation is closely linked to the regulation of transcription. B-Myb is a member of the Myb family of transcription factors. The B-Myb gene is widely expressed in all dividing cells suggesting its universal role during the cell cycle. Consistent with this is the fact that B-Myb knock out mice die early in development. To extent our knowledge of the function of B-Myb, in my PhD thesis I am analyzing the precise mechanism by which B-Myb regulates the progression of the cell cycle.



Publications

E. Werwein, T. Schmedt, H. Hoffmann, C. Usadel, N. Obermann, J. D. Singer, K. H. Klempnauer
B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1)
Cell Cycle 11(21) (2012), 4047-58.


Eugen Werwein
eMail: Eugen Werwein