Name: Dr. Devendra Vyas
Diploma / M.Sc degree: University of Mumbai, India
(June 2006)

PhD Project:


Homepage: http://www.uni-muenster.de/Chemie.oc/research/oestreich/oe-welcome.html/members.html#DevendraVyas

Abstract of Research Project

Allylsilanes are widely used in stereoselective organic synthesis. Design and development of efficient catalytic asymmetric methods that furnished chiral allylsilanes in high enantiomeric purity would significantly expand the utility of these versatile nucleophiles.

A number of protocols for catalytic enantioselective synthesis of allylsilanes have been developed. Such transformation include hyrosilylation of 1,3-dienes, silylation of allylic chlorides, hydride addition to silyl-substituted allylic carbonates and silaboration of allenes. These processes, all Pd-catalysed, largely involved formation of C-Si or C-H bonds and deliver an array of synthetically useful allylsilanes in the racemic form.

In this research project, our aim is to develop an efficient method for enantioselective synthesis of a range of allylsilanes and to investigate their potential application in the synthetic organic chemistry.


Publications

L. B. Delvos, D. J. Vyas, M. Oestreich
Asymmetrische Synthese α-chiraler Allylsilane durch enantiokonvergente γ-selektive Kupfer(I)-katalysierte allylische Silylierung
Angew. Chem. 125 (2013), 4748 –4751.

D. J. Vyas, R. Fröhlich, M. Oestreich
Activation of the Si-B Linkage: Copper-Catalyzed Addition of Nucleophilic Silicon to Imines
Org Lett. 13(8) (2011), 2094-2097.

D. J. Vyas, M. Oestreich
Copper-Catalyzed Si-B Bond Activation in Branched-Selective Allylic Substitution of Linear Allylic Chlorides
Angew. Chem. Int. Ed. 49 (2010), 1–4.

D. J. Vyas, R. Fröhlich, M. Oestreich
Stereochemical Surprises in the Lewis Acid-Mediated Allylation of Isatins
J. Org. Chem. 75 (2010), 6720–6723.

D. J. Vyas, M. Oestreich
Expedient access to branched allylic silanes by copper-catalysed allylic substitution of linear allylic halides
Chem. Commun. 46 (2010), 568–570.


Devendra Vyas
eMail: Devendra Vyas