Name: Syed Masood Husain
Diploma / M.Sc degree: Indian Istitute of Technology, Mumbai, India
(June 2004)
Title: Asymmetric Synthesis of 2-substituted 3-Benzoazepines

Abstract of Research Project

Substituted 3-Benzoazepines are found to be potent NMDA receptor antagonists. The NMDA receptor belongs to a group of excitatory inonotropic glutamate receptors. However overstimulation of NMDA receptors causes acute and chronic neurodegenerative disorders like excitotoxicity, epilepsy, Alzheimer’s or Parkinson’s disease.

In this project we intend to develop an asymmetric synthesis of 2-substituted 3-benzoazepines and their pharmacological properties will also be evaluated.




Publications

S. M. Husain, R. Fröhlich, D. Schepmann, B. Wünsch
Enantioselective Synthesis of a 2,2-Disubstituted Tetrahydro-3-benzazepines as Novel NMDA Receptor Antagonists
Z. Naturforsch. 65b (2010), 191–196.

S. M. Husain, M. T. Heim, D. Schepman, B. Wünsch
Asymmetric synthesis and σ-receptor affinity of enantionerically pure 1,4-disubstituted tetahydro-1H-3-benzazepines
Tetrahedron: Asymmetry 20 (2009), 1383-1392.

S. M. Husain, R. Fröhlich, B. Wünsch
Asymmetric Synthesis of Enantiomerically Pure 2-Substituted Tetrahydro-3-benzazepines and Their Affinity to Sigma Receptors
J. Org. Chem. 74 (2009), 2788–2793.

S. M. Husain, B. Wünsch
Synthesis of Phenylacetic Acids with (2-Oxoalkyl)Substituents in ortho Position from o-Phenylenediacetic Acids
Synthesis (2008), 2729-2732.

S. M. Husain, R. Fröhlich, B. Wünsch
A very short asymmetric aynthesis of enantiomerically pure methyl substituted tetrahydro-3-benzazepines
Tetrahedron: Asymmetry 19 (2008), 1613-1616.


Syed Masood Husain
eMail: Syed Masood Husain