Name: Nugzar Ghavtadze
Diploma / M.Sc degree: Tbilisi State University, Georgia
(2003)
Title: Nitrogen-containing Intermediates in the Synthesis of New Five-membered Heterocyclic Systems

Abstract of Research Project

A new research in the field of synthesis of nitrogen containing heterocycles and their intermediates - aza-polyenyl cations - is proposed.
The main aim of my PhD thesis is broadening the scope of the applications of Aza-Nazarov cyclization reactions involving conjugated α- and γ-imino aldehydes and ketones. Furthermore, systems containing more than one nitrogen atom, giving possibility to offer variety of different heterocycles, will be investigated.
It’s also planed to carry out quantum-mechanical calculations on the investigated systems, in order to obtain useful information about important reaction intermediates and products.


Publications

N. Ghavtadze, R. Fröhlich, E.-U. Würthwein
Acid Mediated Electrocyclic Domino Transformations of 5,5-Disubstituted 1-Amino-1-azapenta-1,4-dien-3-ones into Dihydrospiroindenepyrazole and Dihydroindenodiazepine Derivatives
J. Org. Chem. (2009), 4584.

N. Ghavtadze, R. Fröhlich, E.-U. Würthwein
Cyclization Reactions of 1-Amino-5-trifluoromethyl-5-thienyl-1-aza-penta-1,4-dien-3-ones under Superelectrophilic Conditions - Synthesis of Novel Benzothiophenols, Cyclopentenols, and Dihydrodiazepinols
Eur. J. Org. Chem. (2009), 1228.

W. Uhl, T. Abel, A. Hepp, T. Nilges, F. Rogel, E.-U. Würthwein, N. Ghavtadze
The unique Decomposition Behaviour of the dimeric Dialkylaluminium Hydrazide [(Me₃C)₂Al-N(H)-N(H)-Me]₂ – Butane versus Ammonia Elimination
Inorganic Chemistry 48 (2009), 752.

N. Ghavtadze, R. Fröhlich, K. Bergander, E.-U. Würthwein
Superelectrophilic Intermediates in the Synthesis of Novel Indenol Derivatives via 1,5-Cyclization Reactions of 5-Aryl-1-aza-1,4-doen-3-ones
Synthesis 21 (2008), 3397.

N. Ghavtadze, R. Fröhlich, E.-U. Würthwein
2H-Pyrrole Derivatives from an Aza-Nazarov Reaction Cascade Involving Indole as the Neutral Leaving Group
Eur. J. Org. Chem. (2008), 3656; highlited in Synfacts 10 (2008), 1033.


Publications of research conducted prior to GSC-MS membership

E. O. Gogritchiani, E. A. Katsadze, N. G. Gavtadze, Sh. A. Samsoniya, H. Dürr
Indole derivatives. 143. Synthesis of photochromic 2-arylindole systems
Chemistry of Heterocyclic Compounds, Ed. Russ. 10(448) (2004), 1473.

Sh. A. Samsoniya, H. Dürr, E. O. Gogrichiani, E. A. Katsadze, N. G. Gavtadze
New derivatives of indole. Synthesis of photochromic 2-arylindole systems
Chemistry of Hetero­cyclic Compounds, Ed. Russ. 11(401) (2000), 1562-1563; Chemistry of Heterocyclic Com­pounds, Ed. Engl. 236(11) (2000), 1347.


Nugzar Ghavtadze
eMail: Nugzar Ghavtadze