Name: Anil Kumar Podichetty
Diploma / M.Sc degree: Osmania University, Hyderabad, India
(April 2000)
Title: Development of fast methods to transform medicinally relevant compounds to their fluorinated analogues.
Homepage:
www.uni-muenster.de/Chemie.oc/research/hau/personen/podichetty.htm
Abstract of Research Project
Organic Chemistry is a field of enormous complexity. The fact, which makes it such a fascinating field to
pursue is that it is still largely unexplored. One of the greatest challenges in organic chemistry is the
synthesis of physiologically active compounds, so that the ever increasing demand for selective synthetic drugs is met.
Introduction of fluorine substituent into a bioactive compound is a powerful tool to enhance its pharmacological activity
as shown by many examples. Several widely used synthetic drugs contain fluorine as a substituent, viz, Ciprofloxacin,
Norfloxacin, Efavirenz, Pantoprazole, etc. Introduction of a fluorine atom changes the reactivity and the biological
activity of a molecule. Though fluorine is isosteric to the hydroxyl group, fluorinated compounds do not undergo
the same metabolic processes. Also, the lipophilicity of a molecule can be enhanced so that the drug easily
passes the blood-brain barrier.
The main aim of my research project is to selectively introduce the 18F isotope into biologically
relevant compounds, so that they are in turn used for evaluation of a variety of human diseases by Positron
Emission Tomography (PET Imaging). The above is a diagnostic examination that involves the acquisition of physiologic
images based on the detection of radiation from the emission of positrons from the administered 18F
labelled substance.
Publications
A. K. Podichetty, S. Wagner, A. Faust, M. Schäfers, O. Schober, K. Kopka, G. Haufe
Fluorinated isatin derivatives. Part 3: New Side-Chain Fluoro-Functionalized Pyrrolidinyl Sulfonyl Isatins as Potent Caspase-3 and -7 Inhibitors
Future Med. Chem. 1 (2009), 969-989.
A. K. Podichetty, S. Wagner, S. Schröer, A. Faust, M. Schäfers, O. Schober, K. Kopka, G. Haufe
Fluorinated Isatin Derivatives. Part 2: New N-Substituted 5-Pyrrolidinylsulfonyl Isatins as Potential Tools for Molecular Imaging of Caspases in Apoptosis
J. Med. Chem. 52(11) (2009), 3484-3495.
A. K. Podichetty, A. Faust, K. Kopka, S. Wagner, O. Schober, M. Schäfers, G. Haufe
Fluorinated Isatin Derivatives. Part 1: Synthesis of new N-Substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors
Bioorg. Med. Chem. 17(7) (2009), 2680-2688.
Anil Kumar Podichetty
eMail: Anil Kumar Podichetty
|
|