Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient

Authors

  • Liam Chen Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA

DOI:

https://doi.org/10.17879/freeneuropathology-2021-3388

Keywords:

SARS-CoV-2, COVID-19, Acute disseminated encephalomyelitis (ADEM), Acute hemorrhagic leukoencephalitis (AHLE), Acute necrotizing encephalopathy of childhood (ANEC), Demyelinating

Abstract

Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leukoencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management.

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Published

2021-07-12

How to Cite

Chen, L. (2021). Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient. Free Neuropathology, 2, 19. https://doi.org/10.17879/freeneuropathology-2021-3388

Issue

Vol. 2 (2021)

Section

Case Reports

License

Papers are published open access under the Creative Commons BY 4.0 license. This license lets others distribute, remix, adapt, and build upon your work, even commercially, as long as they credit you for the original creation. Data included in the article are made available under the CC0 1.0 Public Domain Dedication waiver, unless otherwise stated, meaning that all copyrights are waived.