Publications

2024

Bredensteiner L, Ventura D, Rassek P, Schafers M, Bogemann M, Schindler P, Weckesser M, Rahbar K, Roll W. Determination of the optimal imaging protocol for [18F]PSMA-PET-CT for the detection of bone metastases in prostate cancer patients. Nuklearmedizin 2024Abstract

Höffgen KS, Dabel J, Konken CP, Depke DA, Hermann S, Dörner W, Schelhaas S, Schäfers M, Mootz HD. Combining poly-epitope MoonTags and labeled nanobodies for signal amplification in cell-specific PET imaging in vivo. Nucl Med Biol 2024;136-137: 108937. Abstract

Landau F, Hermann S, Schelhaas S, Schafers M, Niemann S, Faust A. 18F-labelled gentiobiose as potential PET-radiotracer for specific bacterial imaging: precursor synthesis, radiolabelling and in vitro evaluation. Nuklearmedizin 2024Abstract

Margeta R, Schelhaas S, Hermann S, Schäfers M, Niemann S, Faust A. A novel radiolabelled salmochelin derivative for bacteria-specific PET imaging: synthesis, radiolabelling and evaluation. Chem Commun (Camb) 2024Abstract

Prasad VP, Wagner S, Keul P, Hermann S, Levkau B, Schafers M, Haufe G. Synthesis, radiosynthesis and biochemical evaluation of fluorinated analogues of sphingosine-1-phosphate receptor 3 specific antagonists using PET. Bioorg Med Chem 2024;104: 117697. Abstract

Roll W, Bauer J, Dik A, Mueller C, Backhaus P, Rauber S, Zinnhardt B, Gallus M, Wimberley C, Kortvelyessy P, Schindler P, Stenzel W, Elger CE, Becker A, Lewerenz J, Wiendl H, Meuth SG, Schafers M, Melzer N. [(18)F]DPA-714-PET-MRI reveals pronounced innate immunity in human anti-LGI1 and anti-CASPR2 limbic encephalitis. J Neurol 2024Abstract

Roll W, Masthoff M, Kohler M, Rahbar K, Stegger L, Ventura D, Morgul H, Trebicka J, Schäfers M, Heindel W, Wildgruber M, Schindler P. Radiomics-Based Prediction Model for Outcome of Radioembolization in Metastatic Colorectal Cancer. Cardiovasc Intervent Radiol 2024;47: 462-471. Abstract

Ventura D, Dittmann M, Büther F, Schäfers M, Rahbar K, Hescheler D, Claesener M, Schindler P, Riemann B, Seifert R, Roll W. Diagnostic Performance of [(18)F]TFB PET/CT Compared with Therapeutic Activity [(131)I]Iodine SPECT/CT and [(18)F]FDG PET/CT in Recurrent Differentiated Thyroid Carcinoma. J Nucl Med 2024;65: 192-198. Abstract

2023

Bauer N, Maisuls I, Pereira da Graca A, Reinhardt D, Erapaneedi R, Kirschnick N, Schäfers M, Grashoff C, Landfester K, Vestweber D, Strassert CA, Kiefer F. Genetically encoded dual fluorophore reporters for graded oxygen-sensing in light microscopy. Biosens Bioelectron 2023;221: 114917. Abstract

Cufe J, Gierse F, Schäfers KP, Hermann S, Schäfers MA, Backhaus P, Büther F. Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements. EJNMMI Res 2023;13: 86. Abstract

Eilsberger F, Lapa C, Klasner B, Schafers MA, Luster M. [Hand in hand - the future of SPECT and PET imaging]. Nuklearmedizin 2023;62: 52-53. Abstract

Galbiati A, Dorten P, Gilardoni E, Gierse F, Bocci M, Zana A, Mock J, Claesener M, Cufe J, Büther F, Schäfers K, Hermann S, Schäfers M, Neri D, Cazzamalli S, Backhaus P. Tumor-Targeted Interleukin 2 Boosts the Anticancer Activity of FAP-Directed Radioligand Therapeutics. J Nucl Med 2023Abstract

Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstotz M, Kramer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Rauber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Gross CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schafers M, Melzer N. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis. Sci Adv 2023;9: eabq7595. Abstract

Jorch SK, McNally A, Berger P, Wolf J, Kaiser K, Chetrusca Covash A, Robeck S, Pastau I, Fehler O, Jauch-Speer S-L, Hermann S, Schäfers M, Van Gorp H, Kanneganti A, Dehoorne J, Haerynck F, Penco F, Gattorno M, Chae JJ, Kubes P, Lamkanfi M, Wullaert A, Sperandio M, Vogl T, Roth J, Austermann J. Complex regulation of alarmins S100A8/A9 and secretion via Gasdermin-D pores exacerbates autoinflammation in Familial Mediterranean Fever. J Allergy Clin Immunol 2023Abstract

Konken CP, Beutel B, Schinor B, Song J, Gerwien H, Korpos E, Burmeister M, Riemann B, Schafers M, Sorokin L, Haufe G. Influence of N-arylsulfonamido d-valine N-substituents on the selectivity and potency of matrix metalloproteinase inhibitors. Bioorg Med Chem 2023;90: 117350. Abstract

Ludwig N, Thörner-van Almsick J, Mersmann S, Bardel B, Niemann S, Chasan AI, Schäfers M, Margraf A, Rossaint J, Kahl BC, Zarbock A, Block H. Nuclease activity and protein A release of Staphylococcus aureus clinical isolates determine the virulence in a murine model of acute lung infection. Front. Immunol. 2023;14Abstract

Noto B, Eveslage M, Auf der Springe K, Exler A, Faldum A, Heindel W, Milachowski S, Roll W, Schafers M, Stegger L, Bauer J. Robustness of apparent diffusion coefficient-based lymph node classification for diagnosis of prostate cancer metastasis. Eur Radiol 2023Abstract

Paul Konken C, Beutel B, Schinor B, Song J, Gerwien H, Korpos E, Burmeister M, Riemann B, Schafers M, Sorokin L, Haufe G. Influence of N-arylsulfonamido d-valine N-substituents on the selectivity and potency of matrix metalloproteinase inhibitors. Bioorg Med Chem 2023;90: 117350. Abstract

Rassek P, Schafers M, Rahbar K, Backhaus P. [18F]-PSMA-1007-PET for evaluation of kidney function. Nuklearmedizin 2023;62: 244-251. Abstract

Roll W, Faust A, Hermann S, Schäfers M. Infection Imaging: Focus on New Tracers?. J Nucl Med 2023;64: 59s-67s. Abstract

Roll W, Müther M, Boning G, Delker A, Warneke N, Gildehaus F-J, Schäfers M, Stummer W, Zeidler R, Reulen H-J, Stegger L. First clinical experience with fractionated intracavitary radioimmunotherapy using [(177)Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study. EJNMMI Res 2023;13: 78. Abstract

Seifert R, Rasul S, Seitzer K, Eveslage M, Rahbar Nikoukar L, Kessel K, Schafers M, Yu J, Haug AR, Hacker M, Bogemann M, Bodei L, Morris MJ, Hofman MS, Rahbar K. A Prognostic Risk Score for Prostate Cancer Based on PSMA PET-derived Organ-specific Tumor Volumes. Radiology 2023: 222010. Abstract

Ventura D, Schindler P, Masthoff M, Gorlich D, Dittmann M, Heindel W, Schäfers M, Lenz G, Wardelmann E, Mohr M, Kies P, Bleckmann A, Roll W, Evers G. Radiomics of Tumor Heterogeneity in (18)F-FDG-PET-CT for Predicting Response to Immune Checkpoint Inhibition in Therapy-Naive Patients with Advanced Non-Small-Cell Lung Cancer. Cancers (Basel) 2023;15Abstract

Weber WA, Barthel H, Bengel F, Eiber M, Herrmann K, Schafers M. What Is Theranostics?. J Nucl Med 2023;64: 669-670. Abstract

2022

Backhaus P, Burg MC, Asmus I, Pixberg M, Büther F, Breyholz H-J, Yeh R, Weigel SB, Stichling P, Heindel W, Bobe S, Barth P, Tio J, Schäfers M. Initial Results of FAPI-PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer. J Nucl Med 2022Abstract

Backhaus P, Burg MC, Roll W, Büther F, Breyholz H-J, Weigel S, Heindel W, Pixberg M, Barth P, Tio J, Schäfers M. Simultaneous FAPI PET/MRI Targeting the Fibroblast-Activation Protein for Breast Cancer. Radiology 2022;302: 39-47. Abstract

Backhaus P, Gierse F, Burg MC, Büther F, Asmus I, Dorten P, Cufe J, Roll W, Neri D, Cazzamalli S, Millul J, Mock J, Galbiati A, Zana A, Schäfers KP, Hermann S, Weckesser M, Tio J, Wagner S, Breyholz H-J, Schäfers M. Translational imaging of the fibroblast activation protein (FAP) using the new ligand [(68)Ga]Ga-OncoFAP-DOTAGA. Eur J Nucl Med Mol Imaging 2022;49: 1822-1832. Abstract

Barca C, Griessinger CM, Faust A, Depke D, Essler M, Windhorst AD, Devoogdt N, Brindle KM, Schäfers M, Zinnhardt B, Jacobs AH. Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy. Pharmaceuticals 2022;15: 13.

Barca C, Kiliaan AJ, Foray C, Wachsmuth L, Hermann S, Faber C, Schafers M, Wiesmann M, Jacobs AH, Zinnhardt B. A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor-Mediated Microglia Depletion in Experimental Stroke. J Nucl Med 2022;63: 446-452. Abstract

Barca C, Kiliaan AJ, Wachsmuth L, Foray C, Hermann S, Faber C, Schafers M, Wiesmann M, Zinnhardt B, Jacobs AH. Short-Term Colony-Stimulating Factor 1 Receptor Inhibition-Induced Repopulation After Stroke Assessed by Longitudinal (18)F-DPA-714 PET Imaging. J Nucl Med 2022;63: 1408-1414. Abstract

Berdel AF, Ruhnke L, Angenendt L, Wermke M, Rollig C, Mikesch J-H, Scheller A, Hemmerle T, Matasci M, Wethmar K, Kessler T, Gerwing M, Hescheler D, Schafers M, Hartmann W, Altvater B, Rossig C, Bornhauser M, Lenz G, Stelljes M, Rueter B, Neri D, Berdel WE, Schliemann C. Using stroma-anchoring cytokines to augment ADCC: a phase 1 trial of F16IL2 and BI 836858 for posttransplant AML relapse. Blood Adv 2022;6: 3684-3696. Abstract

Bobe S, Beckmann D, Klump DM, Dierkes C, Kirschnick N, Redder E, Bauer N, Schäfers M, Erapaneedi R, Risse B, van de Pavert SA, Kiefer F. Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice. Front Cell Dev Biol 2022;10: 949896. Abstract

Follin M Chyzha R Sunga CH Breton D Maalmic J Chaminadea T Delagnes E Schaefers K Weinheimer C Yvon D Sharyy V. High resolution MCP-PMT Readout Using Transmission Lines. Nucl Instrum Method 2022Abstract

Foray C, Barca C, Winkeler A, Wagner S, Hermann S, Schäfers M, Grauer OM, Zinnhardt B, Jacobs AH. Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI. J Nucl Med 2022;63: 1386-1393. Abstract

Holzgreve A, Eilsberger F, Einspanner E, Kunz J, Sahin YA, Spreckelmeyer S, Luster M, Lapa C, Schafers M, Klasner B, Dgn Y. [The Youngsters of the German Society of Nuclear Medicine (Young DGN)]. Nuklearmedizin 2022;61: 290-292. Abstract

Honold L, Austrup M, Faust A, Konken CP, Schwegmann K, Zinnhardt B, Daniliuc CG, Haufe G, Schäfers M, Kopka K, Hermann S. Towards Optimized Bioavailability of (99m)Tc-Labeled Barbiturates for Non-invasive Imaging of Matrix Metalloproteinase Activity. Mol Imaging Biol 2022;24: 434-443. Abstract

Konken CP, Hessling K, Thale I, Schelhaas S, Dabel J, Maskri S, Bulk E, Budde T, Koch O, Schwab A, Schafers M, Wunsch B. Imaging of the calcium activated potassium channel 31 (KCa 31) in vivo using a senicapoc-derived positron emission tomography tracer. Arch Pharm (Weinheim) 2022: e2200388. Abstract

Noto B, Asmus I, Schafers M, Goerlich D, Riemann B. Predictors of anxiety and depression in differentiated thyroid cancer survivors: Results of a cross-sectional Study. Thyroid 2022Abstract

Noto B, Roll W, Zinken L, Rischen R, Kerschke L, Evers G, Heindel W, Schäfers M, Büther F. Respiratory motion correction in F-18-FDG PET/CT impacts lymph node assessment in lung cancer patients. EJNMMI Res 2022;12: 61. Abstract

Rösner L, Konken CP, Depke DA, Rentmeister A, Schäfers M. Covalent labeling of immune cells. Curr Opin Chem Biol 2022;68: 102144. Abstract

Seifert R, Kersting D, Rischpler C, Sandach P, Ferdinandus J, Fendler WP, Rahbar K, Weckesser M, Umutlu L, Hanoun C, Huttmann A, Reinhardt HC, von Tresckow B, Herrmann K, Duhrsen U, Schafers M. Interim FDG-PET analysis to identify patients with aggressive non-Hodgkin lymphoma who benefit from treatment intensification: a post-hoc analysis of the PETAL trial. Leukemia 2022Abstract

Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, Spieker T, Tekath T, Velic A, Holtmeier R, Hermann J, Jankowski V, Meersch M, Vestweber D, Westphal M, Roth J, Schäfers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight 2022;7Abstract

Zana A, Galbiati A, Gilardoni E, Bocci M, Millul J, Sturm T, Stucchi R, Elsayed A, Nadal L, Cirillo M, Roll W, Stegger L, Asmus I, Backhaus P, Schäfers M, Neri D, Cazzamalli S. Fibroblast Activation Protein triggers release of drug payload from non-internalizing small molecule-drug conjugates in solid tumors. Clin Cancer Res 2022Abstract

2021

Axer A, Jumde RP, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch AKH, Gilmour R. Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design. Chem. Sci. 2021;12: 1286-1294. Abstract

Barca C, Foray C, Hermann S, Herrlinger U, Remory I, Laoui D, Schäfers M, Grauer OM, Zinnhardt B, Jacobs AH. The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke). Front Immunol 2021;12: 787307. Abstract

Barca C, Kiliaan AJ, Foray C, Wachsmuth L, Hermann S, Faber C, Schaefers M, Wiesmann M, Jacobs AH, Zinnhardt B. A longitudinal PET/MR imaging study of colony stimulating factor-1 receptor-mediated microglia depletion in experimental stroke. J Nucl Med 2021Abstract

Barca C, Wiesmann M, Calahorra J, Wachsmuth L, Döring C, Foray C, Heiradi A, Hermann S, Peinado MÁ, Siles E, Faber C, Schäfers M, Kiliaan AJ, Jacobs AH, Zinnhardt B. Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes. Theranostics 2021;11: 4030-4049. Abstract

Bautz J, Stypmann J, Reiermann S, Pavenstadt H-J, Suwelack B, Stegger L, Rahbar K, Reuter S, Schafers M. Prognostic implication of myocardial perfusion and contractile reserve in end-stage renal disease: A direct comparison of myocardial perfusion scintigraphy and dobutamine stress echocardiography. J Nucl Cardiol 2021Abstract

Brömmel K, Konken CP, Börgel F, Obeng-Darko H, Schelhaas S, Bulk E, Budde T, Schwab A, Schäfers M, Wünsch B. Synthesis and biological evaluation of PET tracers designed for imaging of calcium activated potassium channel 31 (K[sub:Ca]31) channels_in vivo_. RSC Adv. 2021;11: 30295-30304. Abstract

Depke DA, Konken CP, Rösner L, Hermann S, Schäfers M, Rentmeister A. A novel (18)F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo. Chem Commun (Camb) 2021;57: 9850-9853. Abstract

Foray C, Valtorta S, Barca C, Winkeler A, Roll W, Müther M, Wagner S, Gardner ML, Hermann S, Schäfers M, Grauer OM, Moresco RM, Zinnhardt B, Jacobs AH. Imaging temozolomide-induced changes in the myeloid glioma microenvironment. Theranostics 2021;11: 2020-2033. Abstract

Heinemann M, Hoffmann C, Hardes J, Guder W, Streitburger A, Gotte M, Welz TL, Jurgens H, Ranft A, Vieth V, Weckesser M, Schafers M, Stegger L, Dirksen U. Pain in survivors of Ewing sarcoma: Prevalence, associated factors and prediction of recurrence. Pediatr Blood Cancer 2021;68: e28801. Abstract

Karlas A, Masthoff M, Kallmayer M, Helfen A, Bariotakis M, Fasoula NA, Schäfers M, Seidensticker M, Eckstein H-H, Ntziachristos V, Wildgruber M. Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study. Ann Transl Med 2021;9: 36. Abstract

Kirschnick N, Drees D, Redder E, Erapaneedi R, Pereira da Graca A, Schäfers M, Jiang X, Kiefer F. Rapid methods for the evaluation of fluorescent reporters in tissue clearing and the segmentation of large vascular structures. iScience 2021;24: 102650. Abstract

Roll W, Evers G, Strotmann R, Albring J, Reicherts C, Noto B, Weckesser M, Lenz G, Schäfers M, Stelljes M. 18F-FDG-PET for the assessment of acute intestinal GvHD and prediction of response to immunosuppressive therapy. Transplantation and Cellular Therapy 2021Abstract

Roll W, Schindler P, Masthoff M, Strotmann R, Albring J, Reicherts C, Weckesser M, Noto B, Stelljes M, Schäfers M, Evers G. (18)F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD). BMC Cancer 2021;21: 1015. Abstract

Schliemann C, Kessler T, Berdel AF, Hemmerle T, Angenendt L, Altvater B, Rossig C, Mikesch J-H, Lenz G, Schafers M, Neri D, Stelljes M, Berdel WE. Phase I study of F16IL2 antibody-cytokine fusion with very low-dose araC in acute myeloid leukaemia relapse after allogeneic stem cell transplantation. Br J Haematol 2021;192: e148-e151. Abstract

Seifert R, Schafers MA, Heitplatz B, Kerschke L, Riemann B, Noto B. Minimal extrathyroid extension in papillary micro carcinoma of the thyroid is an independent risk factor for relapse through lymph node and distant metastases. J Nucl Med 2021: epub. Abstract

Stelljes M, Schafers M. From the inside: GVHD and glucose metabolism. Blood 2021;137: 11-12. Abstract

Weber M, Kersting D, Umutlu L, Schafers M, Rischpler C, Fendler WP, Buvat I, Herrmann K, Seifert R. Just another "Clever Hans"? Neural networks and FDG PET-CT to predict the outcome of patients with breast cancer. Eur J Nucl Med Mol Imaging 2021: epub. Abstract

Wenning C, Vrachimis A, Pavenstadt H-J, Reuter S, Schafers M. Coronary artery calcium burden, carotid atherosclerotic plaque burden, and myocardial blood flow in patients with end-stage renal disease: A non-invasive imaging study combining PET/CT and 3D ultrasound. J Nucl Cardiol 2021;28: 2660-2670. Abstract

2020

Backhaus P, Büther F, Wachsmuth L, Frohwein L, Buchholz R, Karst U, Schäfers K, Hermann S, Schäfers M, Faber C. Toward precise arterial input functions derived from DCE-MRI through a novel extracorporeal circulation approach in mice. Magn Reson Med 2020;84: 1404-1415. Abstract

Backhaus P, Roll W, Beuker C, Zinnhardt B, Seifert R, Wenning C, Eisenblätter M, Thomas C, Schmidt-Pogoda A, Strunk D, Wagner S, Faust A, Tüttelmann F, Röpke A, Jacobs AH, Stummer W, Wiendl H, Meuth SG, Schäfers M, Grauer O, Minnerup J. Initial experience with [(18)F]DPA-714 TSPO-PET to image inflammation in primary angiitis of the central nervous system. Eur J Nucl Med Mol Imaging 2020Abstract

Barca C, Foray C, Hermann S, Döring C, Schäfers M, Jacobs AH, Zinnhardt B. Characterization of the inflammatory post-ischemic tissue by full volumetric analysis of a multimodal imaging dataset. Neuroimage 2020: 117217. Abstract

Bengel F, Burchert W, Dörr R, Hacker M, Kaufmann P, Rischpler C, Schäfer W, Schäfers M, Silber S, Zimmermann R, Buechel R. Der Unterschied zwischen„Position“ und „Konsensus“ Zur Rolle der Nuklearkardiologie beikardialer Amyloidose. Kardiologe 2020Abstract

Büther F, Jones J, Seifert R, Stegger L, Schleyer P, Schäfers M. Clinical Evaluation of a Data-Driven Respiratory Gating Algorithm for Whole-Body PET with Continuous Bed Motion. J Nucl Med 2020;61: 1520-1527. Abstract

Dittmann M, Gonzalez Carvalho JM, Rahbar K, Schäfers M, Claesener M, Riemann B, Seifert R. Incremental diagnostic value of [(18)F]tetrafluoroborate PET-CT compared to [(131)I]iodine scintigraphy in recurrent differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 2020;47: 2639-2646. Abstract

Foray C, Barca C, Backhaus P, Schelhaas S, Winkeler A, Viel T, Schäfers M, Grauer O, Jacobs AH, Zinnhardt B. Multimodal Molecular Imaging of the Tumour Microenvironment. Adv Exp Med Biol 2020;1225: 71-87. Abstract

Kimm MA, Haas H, Stölting M, Kuhlmann M, Geyer C, Glasl S, Schäfers M, Ntziachristos V, Wildgruber M, Höltke C. Targeting Endothelin Receptors in a Murine Model of Myocardial Infarction Using a Small Molecular Fluorescent Probe. Mol Pharm 2020;17: 109-117. Abstract

Müther M, Roll W, Brokinkel B, Zinnhardt B, Sporns PB, Seifert R, Schäfers M, Weckesser M, Stegger L, Stummer W, Rahbar K. Response assessment of somatostatin receptor targeted radioligand therapies for progressive intracranial meningioma. Nuklearmedizin 2020;59: 348-355. Abstract

Noto B, Eveslage M, Pixberg M, Gonzalez Carvalho JM, Schäfers M, Riemann B, Kies P. Prevalence of hyperfunctioning thyroid nodules among those in need of fine needle aspiration cytology according to ATA 2015, EU-TIRADS, and ACR-TIRADS. Eur J Nucl Med Mol Imaging 2020;47: 1518-1526. Abstract

Pösse S, Büther F, Mannweiler D, Hong I, Jones J, Schäfers M, Schäfers KP. Comparison of two elastic motion correction approaches for whole-body PET/CT: motion deblurring vs gate-to-gate motion correction. EJNMMI Phys 2020;7Abstract

Rahbar K, Afshar-Oromieh A, Seifert R, Wagner S, Schäfers M, Bögemann M, Weckesser M. Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel?. World J Nucl Med 2020;19: 220-223. Abstract

Roll W, Müther M, Sporns PB, Zinnhardt B, Molina ES, Seifert R, Schäfers M, Weckesser M, Stegger L, Beule AG, Stummer W, Rahbar K. Somatostatin receptor targeted radioligand therapy in head and neck paraganglioma. World Neurosurg 2020Abstract

Schleupner MC, Riemann B, Schäfers M, Backhaus P, Vrachimis A. Impact of FDG-PET on therapy management and outcome of differentiated thyroid carcinoma patients with elevated thyroglobulin despite negative iodine scintigraphy. Nuklearmedizin 2020;59: 356-364. Abstract

Schwegmann K, Hohn M, Hermann S, Schafers M, Riemann B, Haufe G, Wagner S, Breyholz H-J. Optimizing the Biodistribution of Radiofluorinated Barbiturate Tracers for Matrix Metalloproteinase Imaging by Introduction of Fluorescent Dyes as Pharmacokinetic Modulators. Bioconjug Chem 2020Abstract

Seifert R, Herrmann K, Kleesiek J, Schafers M, Shah V, Xu Z, Chabin G, Grbic S, Spottiswoode B, Rahbar K. Semiautomatically Quantified Tumor Volume Using (68)Ga-PSMA-11 PET as a Biomarker for Survival in Patients with Advanced Prostate Cancer. J Nucl Med 2020;61: 1786-1792. Abstract

Seifert R, Kessel K, Schlack K, Weber M, Herrmann K, Spanke M, Fendler WP, Hadaschik B, Kleesiek J, Schafers M, Weckesser M, Boegemann M, Rahbar K. PSMA PET total tumor volume predicts outcome of patients with advanced prostate cancer receiving [(177)Lu]Lu-PSMA-617 radioligand therapy in a bicentric analysis. Eur J Nucl Med Mol Imaging 2020Abstract

Seifert R, Seitzer K, Herrmann K, Kessel K, Schäfers M, Kleesiek J, Weckesser M, Boegemann M, Rahbar K. Analysis of PSMA expression and outcome in patients with advanced Prostate Cancer receiving 177Lu-PSMA-617 Radioligand Therapy. Theranostics 2020;10: 7812-7820. Abstract

Zinnhardt B, Müther M, Roll W, Backhaus P, Jeibmann A, Foray C, Barca C, Döring C, Tavitian B, Dolle F, Weckesser M, Winkeler A, Hermann S, Wagner S, Wiendl H, Stummer W, Jacobs AH, Schäfers M, Grauer OM. TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma. Neuro Oncol 2020;22: 1030-1043. Abstract

2019

Freundt JK, Frommeyer G, Spieker T, Wotzel F, Grotthoff JS, Stypmann J, Hempel G, Schafers M, Jacobs AH, Eckardt L, Lange PS. Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure. BMC Pharmacol Toxicol 2019;20: 16. Abstract

Kalinin DV, Agoglitta O, Van de Vyver H, Melesina J, Wagner S, Riemann B, Schäfers M, Sippl W, Löffler B, Holl R. Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies. Bioorg Med Chem 2019;27: 1997-2018. Abstract

Kessel K, Seifert R, Schafers M, Weckesser M, Schlack K, Boegemann M, Rahbar K. Second line chemotherapy and visceral metastases are associated with poor survival in patients with mCRPC receiving (177)Lu-PSMA-617. Theranostics 2019;9: 4841-4848. Abstract

Köhnke R, Kentrup D, Schütte-Nütgen K, Schäfers M, Schnöckel U, Hoerr V, Reuter S. Update on imaging-based diagnosis of acute renal allograft rejection. Am J Nucl Med Mol Imaging 2019;9: 110-126. Abstract

Kurch L, Hasenclever D, Kluge R, Georgi T, Tchavdarova L, Golombeck M, Sabri O, Eggert A, Brenner W, Sykora KW, Bengel FM, Rossig C, Korholz D, Schafers M, Feuchtinger T, Bartenstein P, Ammann RA, Krause T, Urban C, Aigner R, Gattenlohner S, Klapper W, Mauz-Korholz C. Only strongly enhanced residual FDG uptake in early response PET (Deauville 5 or qPET >/= 2) is prognostic in pediatric Hodgkin lymphoma: Results of the GPOH-HD2002 trial. Pediatr Blood Cancer 2019;66: e27539. Abstract

Roll W, Markwardt NA, Masthoff M, Helfen A, Claussen J, Eisenblätter M, Hasenbach A, Hermann S, Karlas A, Wildgruber M, Ntziachristos V, Schäfers M. Multispectral Optoacoustic Tomography of Benign and Malignant Thyroid Disorders: A Pilot Study. J Nucl Med 2019;60: 1461-1466. Abstract

Sibille L, Seifert R, Avramovic N, Vehren T, Spottiswoode B, Zuehlsdorff S, Schafers M. (18)F-FDG PET/CT Uptake Classification in Lymphoma and Lung Cancer by Using Deep Convolutional Neural Networks. Radiology 2019: 191114. Abstract

Zinnhardt B, Belloy M, Fricke IB, Orije J, Guglielmetti C, Hermann S, Wagner S, Schafers M, Van der Linden A, Jacobs AH. Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [(18)F]DPA-714 PET and MRI. Theranostics 2019;9: 1523-1537. Abstract

2018

Ahmadzadehfar H, Albers P, Bockisch A, Boegemann M, Bohme C, Burchert W, Dietlein M, Drzezga A, Fabry U, Feldmann G, Heidenreich A, Heinzel A, Herrmann K, Heyll A, Hohling C, Kreuzer C, Laufer D, Mengel R, Mottaghy FM, Muller H-W, Muller SC, Ost E, Rahbar K, Reifenhauser W, Schafers M, Schlenkhoff C, Schmidt M, Schmidt-Wolf I, Wildenhain C, Zimmer B, Essler M. [Lutetium-177-PSMA radioligand therapy : Consensus within the framework of GKV-funded care between the university hospitals in Aachen, Bonn, Dusseldorf, Essen, and Cologne and the MDK Nordrhein]. Urologe A 2018;57: 709-713. Abstract

Axer A, Hermann S, Kehr G, Clases D, Karst U, Fischer-Riepe L, Roth J, Fobker M, Schäfers M, Gilmour R, Faust A. Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design. ChemMedChem 2018;13: 241-250. Abstract

Backhaus P, Noto B, Avramovic N, Grubert LS, Huss S, Bögemann M, Stegger L, Weckesser M, Schäfers M, Rahbar K. Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives. Eur J Nucl Med Mol Imaging 2018;45: 860-877. Abstract

Becker A, Masthoff M, Claussen J, Ford SJ, Roll W, Burg M, Barth PJ, Heindel W, Schäfers M, Eisenblätter M, Wildgruber M. Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach. Eur Radiol 2018;28: 602-609. Abstract

Butsch V, Borgel F, Galla F, Schwegmann K, Hermann S, Schafers M, Riemann B, Wunsch B, Wagner S. Design, (Radio)Synthesis, and in Vitro and in Vivo Evaluation of Highly Selective and Potent Matrix Metalloproteinase 12 (MMP-12) Inhibitors as Radiotracers for Positron Emission Tomography. J Med Chem 2018;61: 4115-4134. Abstract

Duffy MJ, Planas O, Faust A, Vogl T, Hermann S, Schäfers M, Nonell S, Strassert CA. Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo. Photoacoustics 2018;9: 49-61. Abstract

Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, den Bosch M van, van Lent P, Spiekermann C, Hermann S, Vogl T, Schäfers M, Roth J. Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment_in vivo_. Theranostics 2018;8: 2407-2423. Abstract

Heinemann M, Ranft A, Langer T, Jurgens H, Kreyer J, Vieth V, Schafers M, Weckesser M, Simon T, Hassenpflug W, Corbacioglu S, Bielack S, Mayer-Steinacker R, Kuhne T, van den Berg H, Gelderblom H, Bauer S, Stegger L, Dirksen U. Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?. Pediatr Blood Cancer 2018;65: e27011. Abstract

Heming M, Gran S, Jauch S-L, Fischer-Riepe L, Russo A, Klotz L, Hermann S, Schäfers M, Roth J, Barczyk-Kahlert K. Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids. Front Immunol 2018;9: 893. Abstract

Hohn M, Chang M, Meisel JE, Frost E, Schwegmann K, Hermann S, Schäfers M, Riemann B, Haufe G, Breyholz HJ, Wagner S. Synthesis and preliminary in vitro and in vivo evaluation of thiirane-based slow binding MMP inhibitors as potential radiotracers for PET imaging. Chemistry Select 2018;3: 11729-11736. Abstract

Hugenberg V, Behrends M, Wagner S, Hermann S, Schafers M, Kolb HC, Szardenings K, Walsh JC, Gomez LF, Kopka K, Haufe G. Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on gamma-fluorinated alpha-sulfonylaminohydroxamic acid. EJNMMI Radiopharm Chem 2018;3: 10. Abstract

Konken CP, Haufe G, Brömmel K, Wünsch B, Schäfers M, Wagner S, Hugenberg V. Development of symmetric O-BODIPYs with different optical properties as building blocks for the synthesis of ligands for multimodal imaging. Dyes Pigment. 2018;158: 88-96. Abstract

Kurth J, Krause BJ, Schwarzenbock SM, Stegger L, Schafers M, Rahbar K. External radiation exposure, excretion, and effective half-life in (177)Lu-PSMA-targeted therapies. EJNMMI Res 2018;8: 32. Abstract

Lindner O, Bauersachs J, Bengel FM, Burchert W, Vom Dahl J, Dorr R, Hacker M, Kelm M, Rassaf T, Rischpler C, Schafer W, Schafers MA, Silber S, Zimmermann R. [Policy paper nuclear cardiology - update 2018 - Current status of clinical practice]. Nuklearmedizin 2018;57: 146-152. Abstract

Masthoff M, Helfen A, Claussen J, Roll W, Karlas A, Becker H, Gabriëls G, Riess J, Heindel W, Schäfers M, Ntziachristos V, Eisenblätter M, Gerth U, Wildgruber M. Multispectral optoacoustic tomography of systemic sclerosis. J Biophotonics 2018: e201800155. Abstract

Nensa F, Bamberg F, Rischpler C, Menezes L, Poeppel TD, la Fougere C, Beitzke D, Rasul S, Loewe C, Nikolaou K, Bucerius J, Kjaer A, Gutberlet M, Prakken NH, Vliegenthart R, Slart RHJA, Nekolla SG, Lassen ML, Pichler BJ, Schlosser T, Jacquier A, Quick HH, Schafers M, Hacker M. Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM). Eur Radiol 2018;28: 4086-4101. Abstract

Oertel M, Scobioala S, Kroeger K, Baehr A, Stegger L, Haverkamp U, Schafers M, Eich H-T. Worth a local treatment? - Analysis of modern radiotherapy concepts for oligometastatic prostate cancer. Radiat Oncol 2018;13: 185. Abstract

Rahbar K, Afshar-Oromieh A, Bogemann M, Wagner S, Schafers M, Stegger L, Weckesser M. (18)F-PSMA-1007 PET/CT at 60 and 120 minutes in patients with prostate cancer: biodistribution, tumour detection and activity kinetics. Eur J Nucl Med Mol Imaging 2018;45: 1329-1334. Abstract

Rahbar K, Afshar-Oromieh A, Seifert R, Wagner S, Schafers M, Bogemann M, Weckesser M. Diagnostic performance of (18)F-PSMA-1007 PET/CT in patients with biochemical recurrent prostate cancer. Eur J Nucl Med Mol Imaging 2018;45: 2055-2061. Abstract

Rahbar K, Boegemann M, Yordanova A, Eveslage M, Schäfers M, Essler M, Ahmadzadehfar H. PSMA targeted radioligandtherapy in metastatic castration resistant prostate cancer after chemotherapy, abiraterone and/or enzalutamide A retrospective analysis of overall survival. Eur J Nucl Med Mol Imaging 2018;45: 12-19. Abstract

Rahbar K, Bogeman M, Yordanova A, Eveslage M, Schafers M, Essler M, Ahmadzadehfar H. Delayed response after repeated (177)Lu-PSMA-617 radioligand therapy in patients with metastatic castration resistant prostate cancer. Eur J Nucl Med Mol Imaging 2018;45: 243-246. Abstract

Rahbar K, Weckesser M, Ahmadzadehfar H, Schäfers M, Stegger L, Bogemann M. Advantage of 18F-PSMA-1007 over 68Ga-PSMA-11 PET imaging for differentiation of local recurrence vs urinary tracer excretion. Eur J Nucl Med Mol Imaging 2018;45: 1076-1077. Abstract

Roll W, Riemann B, Schäfers M, Stegger L, Vrachimis A. 177Lu-DOTATATE Therapy in Radioiodine-refractory Differentiated Thyroid Cancer: A Single Center Experience. Clin Nucl Med 2018;43: e346-e351. Abstract

Roll W, Weckesser M, Poppelmann M, Schiborr M, Schäfers M, Rahbar K. 99mTc-MDP SPECT-CT and Ultrasound in the Diagnosis and Staging of Thyroid Metastasis From Osteosarcoma. Clin Nucl Med 2018;43: e109-e110. Abstract

Seifert R, Kuhlmann MT, Eligehausen S, Kiefer F, Hermann S, Schafers M. Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis. PLoS One 2018;13: e0204305. Abstract

Vigne J, Thackeray J, Essers J, Makowski M, Varasteh Z, Curaj A, Karlas A, Canet-Soulas E, Mulder W, Kiessling F, Schäfers M, Botnar R, Wildgruber M, Hyafil F. Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis. Mol Imaging Biol 2018;20: 869-887. Abstract

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest 2018;128: 1852-1866. Abstract

Völler T, Faust A, Roth J, Schäfers M, Vogl T, Hermann S. A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo. Mol Imaging Biol 2018;20: 407-416. Abstract

Zinnhardt B, Wiesmann M, Honold L, Barca C, Schäfers M, Kiliaan A, Jacobs AH. In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation. Theranostics 2018;8: 2603-2620. Abstract

Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Muller J, Seebohm G, Paul M, Schafers K, Stallmeyer B, Schafers M, Schulze-Bahr E. Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography. Heart 2018;104: 332-339. Abstract

2017

Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, Geraets IME, Coumans W, Luiken JJFP, Glatz JFC, Schafers M, Nicolay K, Faber C, Hermann S, Prompers JJ. Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovasc Res 2017;113: 1148-1160. Abstract

Brauer A, Grubert LS, Roll W, Schrader AJ, Schäfers M, Bögemann M, Rahbar K. 177Lu-PSMA-617 radioligand therapy and outcome in patients with metastasized castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging 2017;44: 1663-1670. Abstract

Breyholz H-J, Kopka K, Schafers M, Wagner S. Syntheses of Radioiodinated Pyrimidine-2,4,6-Triones as Potential Agents for Non-Invasive Imaging of Matrix Metalloproteinases. Pharmaceuticals (Basel) 2017;10Abstract

Hägerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schäfers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer PS, Kiefer F. VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations. JCI Insight 2017;2: e93424. Abstract

Hansen T, Weckesser M, Schafers M, Gunnemann A. [Uncommon manifestation of prostate cancer : Sister Mary Joseph's nodule]. Urologe A 2017;56: 50-53. Abstract

Hugenberg V, Wagner S, Kopka K, Schafers M, Schuit RC, Windhorst AD, Hermann S. Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation. J Med Chem 2017;60: 307-321. Abstract

Laukamp KR, Lindemann F, Weckesser M, Hesselmann V, Ligges S, Wölfer J, Jeibmann A, Zinnhardt B, Viel T, Schäfers M, Paulus W, Stummer W, Schober O, Jacobs AH. Multimodal Imaging of Patients With Gliomas Confirms[super:11]C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy. Molecular Imaging 2017;16: 153601211668765. Abstract

Mucke MM, Bettenworth D, Geyer C, Schwegmann K, Poremba C, Schäfers M, Domagk D, Höltke C, Lenz P. Targeting Mucosal Endothelin-A-Receptor Expression by Fluorescence Endoscopy is Feasible to Detect and Characterize Colitis-Associated Cancer in Mice. Inflamm Bowel Dis 2017;24: 111-122. Abstract

Noto B, Büther F, Auf der Springe K, Avramovic N, Heindel W, Schäfers M, Allkemper T, Stegger L. Impact of PET acquisition durations on image quality and lesion detectability in whole-body 68Ga-PSMA PET-MRI. EJNMMI Res 2017;7: 12. Abstract

Ortmeyer CP, Haufe G, Schäfers M, Wagner S, Schwegmann K, Hermann S, Hugenberg V. Development of 18F-fluorinated BODIPYs for multimodal imaging. J Label Compd Radiopharm 2017;60: 273. Abstract

Ortmeyer CP, Haufe G, Schwegmann K, Hermann S, Schafers M, Borgel F, Wunsch B, Wagner S, Hugenberg V. Synthesis and evaluation of a [18F]BODIPY-labeled caspase-inhibitor. Bioorg Med Chem 2017;25: 2167-2176. Abstract

Rahbar K, Ahmadzadehfar H, Kratochwil C, Haberkorn U, Schafers M, Essler M, Baum RP, Kulkarni HR, Schmidt M, Drzezga A, Bartenstein P, Pfestroff A, Luster M, Lutzen U, Marx M, Prasad V, Brenner W, Heinzel A, Mottaghy FM, Ruf J, Meyer PT, Heuschkel M, Eveslage M, Bogemann M, Fendler WP, Krause BJ. German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients. J Nucl Med 2017;58: 85-90. Abstract

Schulze AB, Heptner B, Kessler T, Baumgarten B, Stoica V, Mohr M, Wiewrodt R, Warneke V, Hartmann W, Wullenweber J, Schulke C, Schafers M, Wilmes D, Becker K, Schmidt LH, Groll AH, Berdel WE. Progressive Histoplasmosis with Hemophagocytic Lymphohistiocytosis and Epithelioid Cell Granulomatosis: A Case Report and Review of the Literature. Eur J Haematol 2017Abstract

Seifert R, Scherzinger A, Kiefer F, Hermann S, Jiang X, Schafers MA. Statistical Permutation-based Artery Mapping (SPAM): a novel approach to evaluate imaging signals in the vessel wall. BMC Med Imaging 2017;17: 36. Abstract

Sundermann B, Schroder J-B, Warnecke T, Heindel W, Schafers M, Weckesser M, Buerke B. Imaging Workup of Suspected Classical Paraneoplastic Neurological Syndromes: A Systematic Review and Retrospective Analysis of (18)F-FDG-PET-CT. Acad Radiol 2017;24: 1195-1202. Abstract

Thunemann M, Schörg BF, Feil S, Lin Y, Voelkl J, Golla M, Vachaviolos A, Kohlhofer U, Quintanilla-Martinez L, Olbrich M, Ehrlichmann W, Reischl G, Griessinger CM, Langer HF, Gawaz M, Lang F, Schäfers M, Kneilling M, Pichler BJ, Feil R. Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography. Nat Commun 2017;8: 444. Abstract

Zinnhardt B, Pigeon H, Theze B, Viel T, Wachsmuth L, Fricke IB, Schelhaas S, Honold L, Schwegmann K, Wagner S, Faust A, Faber C, Kuhlmann MT, Hermann S, Schäfers M, Winkeler A, Jacobs AH. Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake. Cancer Res 2017;77: 1831-1841. Abstract

2016

Ahmadzadehfar H, Essler M, Schafers M, Rahbar K. Radioligand therapy with 177Lu-PSMA-617 of metastatic prostate cancer has already been arrived in clinical use. Nucl Med Biol 2016;43: 835. Abstract

Angenendt L, Schliemann C, Lutz M, Rebber E, Schulze AB, Weckesser M, Stegger L, Schafers M, Groth C, Kessler T, Lenz G, Stelljes M, Berdel WE. Nivolumab in a patient with refractory Hodgkin's lymphoma after allogeneic stem cell transplantation. Bone Marrow Transplant 2016;51: 443-445. Abstract

Bailey DL, Pichler BJ, Guckel B, Barthel H, Beer AJ, Botnar R, Gillies R, Goh V, Gotthardt M, Hicks RJ, Lanzenberger R, la Fougere C, Lentschig M, Nekolla SG, Niederdraenk T, Nikolaou K, Nuyts J, Olego D, Riklund KA, Signore A, Schafers M, Sossi V, Suminski M, Veit-Haibach P, Umutlu L, Wissmeyer M, Beyer T. Combined PET/MRI: from Status Quo to Status Go Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tubingen, Germany. Mol Imaging Biol 2016;18: 637-650. Abstract

Bettenworth D, Mucke MM, Schwegmann K, Faust A, Poremba C, Schafers M, Domagk D, Lenz P. Endoscopy-guided orthotopic implantation of colorectal cancer cells results in metastatic colorectal cancer in mice. Clin Exp Metastasis 2016;33: 551-562. Abstract

Beutel B, Daniliuc CG, Riemann B, Schafers M, Haufe G. Fluorinated matrix metalloproteinases inhibitors-Phosphonate based potential probes for positron emission tomography. Bioorg Med Chem 2016;24: 902-909. Abstract

Büther F, Vehren T, Schäfers KP, Schäfers M. Impact of Data-driven Respiratory Gating in Clinical PET. Radiology 2016;281: 229-238. Abstract

Erapaneedi R, Belousov VV, Schäfers M, Kiefer F. A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. Embo J 2016;35: 102-113. Abstract

Faust A, Hermann S, Schäfers M, Höltke C. Optical imaging probes and their potential contribution to radiotracer development. Nuklearmedizin 2016;55: 51-62. Abstract

Galstyan A, Block D, Niemann S, Grüner MC, Abbruzzetti S, Oneto M, Daniliuc CG, Hermann S, Viappiani C, Schäfers M, Löffler B, Strassert CA, Faust A. Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry 2016;22: 5243-5252. Abstract

Galstyan A, Block D, Niemann S, Grüner MC, Abbruzzetti S, Oneto M, Daniliuc CG, Hermann S, Viappiani C, Schäfers M, Löffler B, Strassert CA, Faust A. Corrigendum: Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry 2016;22: 9051. Abstract

Galstyan A, Riehemann K, Schäfers M, Faust A. A combined experimental and computational study of the substituent effect on the photodynamic efficacy of amphiphilic Zn(ii)phthalocyanines. J. Mater. Chem. B 2016;4: 5683-5691. Abstract

Gerwien H, Hermann S, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer N, Opdenakker G, Wiendl H, Schäfers M, Sorokin L. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med 2016;8: 364ra152. Abstract

Geven EJW, van den Bosch MHJ, Di Ceglie I, Ascone G, Abdollahi-Roodsaz S, Sloetjes AW, Hermann S, Schafers M, van de Loo FAJ, van der Kraan PM, Koenders MI, Foell D, Roth J, Vogl T, van Lent PLEM. S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis. Arthritis Res Ther 2016;18: 247. Abstract

Hermann S, Kuhlmann MT, Starsichova A, Eligehausen S, Schafers K, Stypmann J, Tiemann K, Levkau B, Schafers M. Imaging Reveals the Connection Between Spontaneous Coronary Plaque Ruptures, Atherothrombosis, and Myocardial Infarctions in HypoE/SRBI-/- Mice. J Nucl Med 2016;57: 1420-1427. Abstract

Hugenberg V, Hermann S, Galla F, Schafers M, Wunsch B, Kolb HC, Szardenings K, Lebedev A, Walsh JC, Mocharla VP, Gangadharmath UB, Kopka K, Wagner S. Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability. Nucl Med Biol 2016;43: 424-437. Abstract

Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schafers M, Holl R. Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography. J Med Chem 2016;59: 9541-9559. Abstract

Keul P, van Borren MMGJ, Ghanem A, Muller FU, Baartscheer A, Verkerk AO, Stumpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot J-H, Alewijnse AE, Hermann S, Spijkers LJA, Hiller K-H, Herr D, Heusch G, Schafers M, Peters SLM, Chun J, Levkau B. Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. J Am Heart Assoc 2016;5: e003393. Abstract

Noto B, Vrachimis A, Schafers M, Stegger L, Rahbar K. Subacute Stroke Mimicking Cerebral Metastasis in 68Ga-PSMA-HBED-CC PET/CT. Clin Nucl Med 2016;41: e449-51. Abstract

O'Halloran PJ, Viel T, Murray DW, Wachsmuth L, Schwegmann K, Wagner S, Kopka K, Jarzabek MA, Dicker P, Hermann S, Faber C, Klasen T, Schafers M, O'Brien D, Prehn JHM, Jacobs AH, Byrne AT. Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers. Eur J Nucl Med Mol Imaging 2016;43: 1673-1683. Abstract

Rahbar K, Weckesser M, Huss S, Semjonow A, Breyholz H-J, Schrader AJ, Schafers M, Bogemann M. Correlation of Intraprostatic Tumor Extent with 68Ga-PSMA Distribution in Patients with Prostate Cancer. J Nucl Med 2016;57: 563-567. Abstract

Range FT, Kies P, Schafers KP, Breithardt G, Schober O, Wichter T, Schafers MA. Sex differences in absolute myocardial perfusion Non-invasive H2(15)O-PET in young healthy adults. Nuklearmedizin 2016;55: 196-202. Abstract

Reinartz G, Haverkamp U, Wullenkord R, Lehrich P, Kriz J, Büther F, Schäfers K, Schäfers M, Eich HT. 4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma : Determination of intra- and interfractional gastric motion. Strahlenther Onkol 2016;192: 322-332. Abstract

Schwegmann K, Bettenworth D, Hermann S, Faust A, Poremba C, Foell D, Schafers M, Domagk D, Lenz P. Detection of Early Murine Colorectal Cancer by MMP-2/-9-Guided Fluorescence Endoscopy. Inflamm Bowel Dis 2016;22: 82-91. Abstract

Vahle A-K, Hermann S, Schafers M, Wildner M, Kerem A, Ozturk E, Jure-Kunkel M, Franklin C, Lang S, Brandau S. Multimodal imaging analysis of an orthotopic head and neck cancer mouse model and application of anti-CD137 tumor immune therapy. Head Neck 2016;38: 542-549. Abstract

Vrachimis A, Burg MC, Wenning C, Allkemper T, Weckesser M, Schafers M, Stegger L. [(18)F]FDG PET/CT outperforms [(18)F]FDG PET/MRI in differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 2016;43: 212-220. Abstract

Vrachimis A, Honold L, Faust A, Hermann S, Schäfers M. New molecular probes of vascular inflammation. Q J Nucl Med Mol Imaging 2016;60: 194-204. Abstract

Vrachimis A, Stegger L, Wenning C, Noto B, Burg MC, Konnert JR, Allkemper T, Heindel W, Riemann B, Schafers M, Weckesser M. [(68)Ga]DOTATATE PET/MRI and [(18)F]FDG PET/CT are complementary and superior to diffusion-weighted MR imaging for radioactive-iodine-refractory differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 2016;43: 1765-1772. Abstract

Vrachimis A, Weckesser M, Schafers M, Stegger L. Imaging of differentiated thyroid carcinoma: (124)I-PET/MRI may not be superior to (124)I-PET/CT. Eur J Nucl Med Mol Imaging 2016;43: 1183-1184. Abstract

2015

Ahmadzadehfar H, Rahbar K, Kurpig S, Bogemann M, Claesener M, Eppard E, Gartner F, Rogenhofer S, Schafers M, Essler M. Early side effects and first results of radioligand therapy with (177)Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: a two-centre study. EJNMMI Res 2015;5: 114. Abstract

Angenendt L, Kerkhoff A, Wiebe S, Mikesch J-H, Rudat A, Wotzel F, Wenning C, Schliemann C, Kessler T, Schafers M, Wardelmann E, Stelljes M, Berdel WE. Remissions of different quality following rituximab, tocilizumab and rituximab, and allogeneic stem cell transplantation in a patient with severe idiopathic multicentric Castleman's disease. Ann Hematol 2015;94: 1241-1243. Abstract

Bailey DL, Pichler BJ, Guckel B, Barthel H, Beer AJ, Bremerich J, Czernin J, Drzezga A, Franzius C, Goh V, Hartenbach M, Iida H, Kjaer A, la Fougere C, Ladefoged CN, Law I, Nikolaou K, Quick HH, Sabri O, Schafer J, Schafers M, Wehrl HF, Beyer T. Combined PET/MRI: Multi-modality Multi-parametric Imaging Is Here: Summary Report of the 4th International Workshop on PET/MR Imaging; February 23-27, 2015, Tubingen, Germany. Mol Imaging Biol 2015;17: 595-608. Abstract

Behrends M, Wagner S, Kopka K, Schober O, Schafers M, Kumbhar S, Waller M, Haufe G. New matrix metalloproteinase inhibitors based on gamma-fluorinated alpha-aminocarboxylic and alpha-aminohydroxamic acids. Bioorg Med Chem 2015;23: 3809-3818. Abstract

Faust A, Völler T, Busch F, Schäfers M, Roth J, Hermann S, Vogl T. Development and evaluation of a non-peptidic ligand for the molecular imaging of inflammatory processes using S100A9 (MRP14) as a novel target. Chem Commun (Camb) 2015;51: 15637-15640. Abstract

Junker A, Kokornaczyk AK, Zweemer AJM, Frehland B, Schepmann D, Yamaguchi J, Itami K, Faust A, Hermann S, Wagner S, Schafers M, Koch M, Weiss C, Heitman LH, Kopka K, Wunsch B. Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists. Org Biomol Chem 2015;13: 2407-2422. Abstract

Limpachayaporn P, Schafers M, Haufe G. Isatin sulfonamides: potent caspases-3 and -7 inhibitors, and promising PET and SPECT radiotracers for apoptosis imaging. Future Med Chem 2015;7: 1173-1196. Abstract

Maier TM, Schober O, Gerss J, Gorlich D, Wenning C, Schaefers M, Riemann B, Vrachimis A. Differentiated thyroid cancer patients more than 60 years old paradoxically show an increased life expectancy. J Nucl Med 2015;56: 190-195. Abstract

Reilmann R, Lippross V, Holzner E, Gigengack F, Bohlen S, Kugel H, Deppe M, Osada N, Lucke M, Riess O, Nguyen HP, Von Horsten S, Schafers K, Schafers M, Jacobs AH, Hermann S. FDG muPET Fails to Detect a Disease-Specific Phenotype in Rats Transgenic for Huntington's Disease - A 15 Months Follow-up Study. J Huntingtons Dis 2015;4: 37-47. Abstract

Santschi N, Wagner S, Daniliuc C, Hermann S, Schafers M, Gilmour R. Synthesis of 2-[(18) F]Fluoro-2-deoxyisosorbide 5-mononitrate and Assessment of Its in vivo Biodistribution as Determined by Dynamic Positron Emission Tomography (PET). ChemMedChem 2015;10: 1724-1732. Abstract

Schilson SS, Keul P, Shaikh RS, Schafers M, Levkau B, Haufe G. Synthesis of new ligands for targeting the S1P1 receptor. Bioorg Med Chem 2015;23: 1011-1026. Abstract

Schliemann C, Gutbrodt KL, Kerkhoff A, Pohlen M, Wiebe S, Silling G, Angenendt L, Kessler T, Mesters RM, Giovannoni L, Schafers M, Altvater B, Rossig C, Grunewald I, Wardelmann E, Kohler G, Neri D, Stelljes M, Berdel WE. Targeting interleukin-2 to the bone marrow stroma for therapy of acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation. Cancer Immunol Res 2015;3: 547-556. Abstract

Shaikh RS, Keul P, Schäfers M, Levkau B, Haufe G. New fluorinated agonists for targeting the sphingosin-1-phosphate receptor 1 (S1P1). Bioorganic & Medicinal Chemistry Letters 2015;25: 5048-5051. Abstract

Shaikh RS, Schilson SS, Wagner S, Hermann S, Keul P, Levkau B, Schafers M, Haufe G. Synthesis and evaluation of fluorinated fingolimod (FTY720) analogues for sphingosine-1-phosphate receptor molecular imaging by positron emission tomography. J Med Chem 2015;58: 3471-3484. Abstract

Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schafers M, Korner H, Opdenakker G, Hallmann R, Sorokin L. Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Cell Rep 2015;10: 1040-1054. Abstract

Waldmann CM, Hermann S, Faust A, Riemann B, Schober O, Schafers M, Haufe G, Kopka K. Novel fluorine-18 labeled 5-(1-pyrrolidinylsulfonyl)-7-azaisatin derivatives as potential PET tracers for in vivo imaging of activated caspases in apoptosis. Bioorg Med Chem 2015;23: 5734-5739. Abstract

Wenning C, Vrachimis A, Dell Aquila A, Penning A, Stypmann J, Schafers M. Inhomogeneous myocardial stress perfusion in SPECT studies predicts future allograft dysfunction in heart transplant recipients. EJNMMI Res 2015;5: 51. Abstract

Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz H-J, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab 2015;35: 1711-1721. Abstract

2014

Alsibai W, Hahnenkamp A, Eisenblätter M, Riemann B, Schäfers M, Bremer C, Haufe G, Höltke C. Fluorescent Non-peptidic RGD Mimetics with High Selectivity for alphaVbeta3 vs alphaIIbbeta3 Integrin Receptor: Novel Probes for in Vivo Optical Imaging. J Med Chem 2014;57: 9971-9982. Abstract

Biesemann N, Mendler L, Wietelmann A, Hermann S, Schafers M, Kruger M, Boettger T, Borchardt T, Braun T. Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res 2014;115: 296-310. Abstract

Heindel W, Gubitz R, Vieth V, Weckesser M, Schober O, Schafers M. The diagnostic imaging of bone metastases. Dtsch Arztebl Int 2014;111: 741-747. Abstract

Limpachayaporn P, Wagner S, Kopka K, Schober O, Schafers M, Haufe G. Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis. J Med Chem 2014;57: 9383-9395. Abstract

Lindner O, Burchert W, Schafers M, Schaefer W. [Myocardial perfusion scintigraphy 2012 in Germany Results of the 6th Query]. Nuklearmedizin 2014;53: 13-18. Abstract

Paul M, Kies P, Schafers M, Schulze-Bahr E. Cardiac sympathetic innervation in a patient with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 2014;11: 1490-1491. Abstract

Pawelski H, Schnockel U, Kentrup D, Grabner A, Schafers M, Reuter S. SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection. Biomed Res Int 2014;2014: 874785. Abstract

Persigehl T, Ring J, Bremer C, Heindel W, Holtmeier R, Stypmann J, Claesener M, Hermann S, Schafers M, Zerbst C, Schliemann C, Mesters RM, Berdel WE, Schwoppe C. Non-invasive monitoring of tumor-vessel infarction by retargeted truncated tissue factor tTF-NGR using multi-modal imaging. Angiogenesis 2014;17: 235-246. Abstract

Prasad VP, Wagner S, Keul P, Hermann S, Levkau B, Schafers M, Haufe G. Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography. Bioorg Med Chem 2014;22: 5168-5181. Abstract

Schäfers KP, Bolwin K, Büther F, Hermann S, Jacobs AH, Kösters T, Kuhlmann M, Schäfers M, Viel T. High-Resolution Small Animal Imaging. In: Comprehensive Biomedical Physics 2014;Elsevier, Oxford: 181-211. Abstract

Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith D-M, Hermann S, Wagner S, Kuhlmann MT, Muller-Tidow C, Kopka K, Schober O, Schafers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AH. Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-18F-Fluorothymidine PET and Diffusion-Weighted MR Imaging. J Nucl Med 2014;55: 983-988. Abstract

Tucci S, Flogel U, Hermann S, Sturm M, Schafers M, Spiekerkoetter U. Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice. Biochim Biophys Acta 2014;1842: 677-685. Abstract

Vahle A-K, Domikowsky B, Schwöppe C, Krähling H, Mally S, Schäfers M, Hermann S, Shahin V, Haier J, Schwab A, Stock C. Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility. Int J Oncol 2014;44: 78-90. Abstract

van Duijnhoven SMJ, Robillard MS, Hermann S, Kuhlmann MT, Schafers M, Nicolay K, Grull H. Imaging of MMP activity in postischemic cardiac remodeling using radiolabeled MMP-2/9 activatable peptide probes. Mol Pharm 2014;11: 1415-1423. Abstract

Vogl T, Eisenblätter M, Völler T, Zenker S, Hermann S, van Lent P, Faust A, Geyer C, Petersen B, Roebrock K, Schäfers M, Bremer C, Roth J. Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun 2014;5: 4593. Abstract

Wenning C, Kloth C, Kuhlmann MT, Jacobs AH, Schober O, Hermann S, Schafers MA. Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Atherosclerosis 2014;234: 276-282. Abstract

2013

Bettenworth D, Reuter S, Hermann S, Weckesser M, Kerstiens L, Stratis A, Nowacki TM, Ross M, Lenze F, Edemir B, Maaser C, Pap T, Koschmieder S, Heidemann J, Schäfers M, Lugering A. Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation. J Nucl Med 2013;54: 748-755. Abstract

Büther F, Ernst I, Hamill J, Eich HT, Schober O, Schäfers M, Schäfers KP. External radioactive markers for PET data-driven respiratory gating in positron emission tomography. Eur J Nucl Med Mol Imaging 2013;40: 602-614. Abstract

Diepenbrock S, Hermann S, Schäfers M, Kuhlmann M, Hinrichs K. Comparative Visualization of Tracer Uptake in In Vivo Small Animal PET/CT Imaging of the Carotid Arteries. Comput Graph Forum 2013;32: 241-250. Abstract

Grabner A, Kentrup D, Edemir B, Sirin Y, Pavenstadt H, Schlatter E, Schober O, Schafers M, Schnockel U, Reuter S. PET with 18F-FDG-labeled T lymphocytes for diagnosis of acute rat renal allograft rejection. J Nucl Med 2013;54: 1147-1153. Abstract

Grabner A, Kentrup D, Schnockel U, Gabriels G, Schroter R, Pavenstadt H, Schober O, Schlatter E, Schafers M, Reuter S. Non-invasive imaging of acute allograft rejection after rat renal transplantation using 18F-FDG PET. J Vis Exp 2013: e4240. Abstract

Grabner A, Kentrup D, Schnöckel U, Schäfers M, Reuter S. Non-Invasive Diagnosis of Acute Renal Allograft Rejection - Special Focus on Gamma Scintigraphy and Positron Emission Tomography 2013: chapter 4. Abstract

Hahnenkamp A, Schäfers M, Bremer C, Höltke C. Design and Synthesis of Small-Molecule Fluorescent Photoprobes Targeted to Aminopeptdase N (APN/CD13) for Optical Imaging of Angiogenesis. Bioconjug Chem 2013;24: 1027-1038. Abstract

Hugenberg V, Riemann B, Hermann S, Schober O, Schafers M, Szardenings K, Lebedev A, Gangadharmath U, Kolb H, Walsh J, Zhang W, Kopka K, Wagner S. Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation. J Med Chem 2013;56: 6858-6870. Abstract

Limpachayaporn P, Riemann B, Kopka K, Schober O, Schäfers M, Haufe G. Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem 2013;64C: 562-578. Abstract

Limpachayaporn P, Schäfers M, Schober O, Kopka K, Haufe G. Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents. Bioorg Med Chem 2013;21: 2025-2036. Abstract

Limpachayaporn P, Wagner S, Kopka K, Hermann S, Schäfers M, Haufe G. Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography. J Med Chem 2013;56: 4509-4520. Abstract

Lindner O, Burchert W, Hacker M, Schaefer W, Schmidt M, Schober O, Schwaiger M, vom Dahl J, Zimmermann R, Schafers M. [Myocardial perfusion scintigraphy - short form of the German guideline]. Nuklearmedizin 2013;52: 51-63; quiz N22. Abstract

Stegger L, Schülke C, Wenning C, Rahbar K, Kies P, Schober O, Schäfers M. Cardiac PET/MRI. Curr Cardiovasc Imaging Rep 2013: 1-10. Abstract

Steingräber AK, Schelhaas S, Faust A, Jacobs AH, Schäfers M, Goerge T. Molecular imaging reveals time course of MMP activity in acute cutaneous vasculitis in vivo. Exp Dermatol 2013;22: 730-735. Abstract

Viel T, Schelhaas S, Wagner S, Wachsmuth L, Schwegmann K, Kuhlmann M, Faber C, Kopka K, Schafers M, Jacobs AH. Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging. PLoS One 2013;8: e67911. Abstract

Waschkau B, Faust A, Schäfers M, Bremer C. Performance of a new fluorescence-labeled MMP inhibitor to image tumor MMP activity in vivo in comparison to an MMP-activatable probe. Contrast Media Mol Imaging 2013;8: 1-11. Abstract

Wenning C, Lange PS, Schülke C, Vrachimis A, Mönnig G, Schober O, Eckardt L, Schafers M. Pulmonary vein isolation in patients with paroxysmal atrial fibrillation is associated with regional cardiac sympathetic denervation. EJNMMI Res 2013;3: 81. Abstract

Wenning C, Rahbar K, Vrachimis A, Schober O, Schäfers M, Stegger L. Myocardial perfusion imaging and coronary calcium scoring with a two-slice SPECT/CT system: can the attenuation map be calculated from the calcium scoring CT scan?. Eur J Nucl Med Mol Imaging 2013;40: 1069-1076. Abstract

2012

Bertrand J, Nitschke Y, Fuerst M, Hermann S, Schäfers M, Sherwood J, Nalesso G, Ruether W, Rutsch F, Dell'Accio F, Pap T. Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice. Ann Rheum Dis 2012;71: 1249-1253. Abstract

Büther K, Compeer MG, De Mey JG, Schober O, Schäfers M, Bremer C, Riemann B, Höltke C. Assessment of Endothelin-A Receptor Expression in Subcutaneous and Orthotopic Thyroid Carcinoma Xenografts in Vivo Employing Optical Imaging Methods. Endocrinology 2012;153: 2907-2918. Abstract

Claesener M, Breyholz H-J, Hermann S, Faust A, Wagner S, Schober O, Schäfers M, Kopka K. Efficient synthesis of a fluorine-18 labeled biotin derivative. Nucl Med Biol 2012;39: 1189-1194. Abstract

Hermann S, Starsichova A, Waschkau B, Kuhlmann M, Wenning C, Schober O, Schäfers M. Non-FDG imaging of atherosclerosis: Will imaging of MMPs assess plaque vulnerability?. J Nucl Cardiol 2012;19: 609-617. Abstract

Hugenberg V, Breyholz H-J, Riemann B, Hermann S, Schober O, Schäfers M, Gangadharmath U, Mocharla V, Kolb H, Walsh J, Zhang W, Kopka K, Wagner S. A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. J Med Chem 2012;55: 4714-4727. Abstract

Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S, Schäfers M. Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice. J Vis Exp 2012: 3308. Abstract

Paul M, Rahbar K, Gerss J, Kies P, Schober O, Schäfers K, Breithardt G, Schulze-Bahr E, Wichter T, Schäfers M. Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy. Eur J Nucl Med Mol Imaging 2012;39: 416-420. Abstract

Paulis LE, Geelen T, Kuhlmann MT, Coolen BF, Schäfers M, Nicolay K, Strijkers GJ. Distribution of lipid-based nanoparticles to infarcted myocardium with potential application for MRI-monitored drug delivery. J Control Release 2012;162: 276-285. Abstract

Rahbar K, Seifarth H, Schäfers M, Stegger L, Hoffmeier A, Spieker T, Tiemann K, Maintz D, Scheld HH, Schober O, Weckesser M. Differentiation of malignant and benign cardiac tumors using 18F-FDG PET/CT. J Nucl Med 2012;53: 856-863. Abstract

Schrigten D, Breyholz HJ, Wagner S, Hermann S, Schober O, Schäfers M, Haufe G, Kopka K. A new generation of radiofluorinated pyrimidine-2,4,6-triones as MMP-targeted radiotracers for positron emission tomography. J Med Chem 2012: 223-232. Abstract

Szymanski MK, Kruizinga S, Tio RA, Willemsen AT, Schäfers MA, Stegger L, Dierckx RA, Hillege HL, Slart RH. Use of gated (13)N-NH(3) micro-PET to examine left ventricular function in rats. Nucl Med Biol 2012;39: 724-729. Abstract

Vrachimis A, Hermann S, Mathe D, Schober O, Schäfers M. Systematic evaluation of 99mTc-tetrofosmin versus 99mTc-sestamibi to study murine myocardial perfusion in small animal SPECT/CT. EJNMMI Res 2012;2: 21. Abstract

Wenning C, Stypmann J, Papavassilis P, Sindermann J, Schober O, Hoffmeier A, Scheld HH, Stegger L, Schäfers M. Left ventricular dilation and functional impairment assessed by gated SPECT are indicators of cardiac allograft vasculopathy in heart transplant recipients. J Heart Lung Transplant 2012;31: 719-728. Abstract

2011

Baumann A, Faust A, Law MP, Kuhlmann MT, Kopka K, Schäfers M, Karst U. Metabolite identification of a radiotracer by electrochemistry coupled to liquid chromatography with mass spectrometric and radioactivity detection. Anal Chem 2011;83: 5415-5421. Abstract

Bunk EC, Stelzer S, Hermann S, Schäfers M, Schlatt S, Schwamborn JC. Cellular organization of adult neurogenesis in the Common Marmoset. Aging Cell 2011;10: 28-38. Abstract

Grabner A, Schnöckel U, Kentrup D, Schäfers M, Reuter S. Strategies for Non-Invasive Molecular Imaging of Acute Allograft Rejection by Gamma Scintigraphy and Positron Emission Tomography. Curr Radiopharm 2011;4(1): 10-23. Abstract

Herzberg S, Rahbar K, Stegger L, Schäfers M, Dugas M. Concept and implementation of a computer-based reminder system to increase completeness in clinical documentation. Int J Med Inform 2011;80: 351-358. Abstract

Kentrup D, Reuter S, Schnöckel U, Grabner A, Edemir B, Pavenstadt H, Schober O, Schäfers M, Schlatter E, Bussemaker E. Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury. PLoS One 2011;6: e26419. Abstract

Kies P, Paul M, Gerss J, Stegger L, Monnig G, Schober O, Wichter T, Schäfers M, Schulze-Bahr E. Impaired cardiac sympathetic innervation in symptomatic patients with long QT syndrome. Eur J Nucl Med Mol Imaging 2011;38: 1899-1907. Abstract

Lindner O, Burchert W, Bengel FM, Zimmermann R, Vom Dahl J, Schäfers M. Myocardial perfusion scintigraphy in Germany in 2009: utilization and state of the practice. Eur J Nucl Med Mol Imaging 2011;38: 1485-1492. Abstract

Lindner O, Burchert W, Schäfers M. [High radiation exposure by myocardial scintigraphy: Is there a dosage problem?]. Dtsch Med Wochenschr 2011;136: 600. Abstract

Michel K, Büther K, Law MP, Wagner S, Schober O, Hermann S, Schäfers M, Riemann B, Höltke C, Kopka K. Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography. J Med Chem 2011;54: 939-948. Abstract

Paul M, Wichter T, Kies P, Gerss J, Wollmann C, Rahbar K, Eckardt L, Breithardt G, Schober O, Schulze-Bahr E, Schäfers M. Cardiac Sympathetic Dysfunction in Genotyped Patients with Arrhythmogenic Right Ventricular Cardiomyopathy and Risk of Recurrent Ventricular Tachyarrhythmias. J Nucl Med 2011;52: 1559-65. Abstract

Seidler DG, Mohamed NA, Bocian C, Stadtmann A, Hermann S, Schäfers K, Schäfers M, Iozzo RV, Zarbock A, Götte M. The role for decorin in delayed-type hypersensitivity. J Immunol 2011;187: 6108-6119. Abstract

Waerzeggers Y, Monfared P, Viel T, Faust A, Kopka K, Schäfers M, Tavitian B, Winkeler A, Jacobs A. Specific biomarkers of receptors, pathways of inhibition and targeted therapies: pre-clinical developments. Br J Radiol 2011;84 Spec No 2: S168-78. Abstract

Wagner S, Faust A, Breyholz H-J, Schober O, Schäfers M, Kopka K. The MMP inhibitor (R)-2-(N-benzyl-4-(2-[18F]fluoroethoxy)phenylsulphonamido)-N-hydroxy-3-met hylbutanamide: Improved precursor synthesis and fully automated radiosynthesis. Appl Radiat Isot 2011;69: 862-868. Abstract

Wagner S, Hugenberg V, Breyholz HJ, Faust A, Schober O, Schäfers M, Kopka K. Highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamic acids: synthesis, in vitro evaluation and 18F-radiolabelling. J Label Compd Radiopharm 2011;54: 150.

Wenning C, Stegger D, Hermann S, Schober O, Schäfers M. F-18-FDG Imaging for Atherosclerotic Plaque Characterization. Curr Cardiovasc Imaging Rep 2011;4: 190-198. Abstract

2010

Bovens S, Schulze Elfringhoff A, Kaptur M, Reinhardt D, Schäfers M, Lehr M. 1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A(2)alpha: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability. J Med Chem 2010;53: 8298–8308. Abstract

Breyholz HJ, Wagner S, Faust A, Riemann B, Höltke C, Hermann S, Schober O, Schäfers M, Kopka K. Radiofluorinated pyrimidine-2,4,6-triones as molecular probes for noninvasive MMP-targeted imaging. ChemMedChem 2010;5: 777-789. Abstract

Buscher K, Judenhofer MS, Kuhlmann MT, Hermann S, Wehrl HF, Schäfers KP, Schäfers M, Pichler BJ, Stegger L. Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI. J Nucl Med 2010;51: 1277-1284. Abstract

Büther F, Ernst I, Dawood M, Kraxner P, Schäfers M, Schober O, Schäfers KP. Detection of respiratory tumour motion using intrinsic list mode-driven gating in positron emission tomography. Eur J Nucl Med Mol Imaging 2010;37: 2315-2327. Abstract

Dawood M, Brune C, Büther F, Jiang X, Burger M, Schober O, Schäfers M, Schäfers KP. A continuity equation based optical flow method for cardiac motion correction in 3 D PET data. Lect Notes Comput Sc 2010;6326: 88-97. Abstract

Drews A, Bovens S, Roebrock K, Sunderkotter C, Reinhardt D, Schäfers M, van der Velde A, Schulze Elfringhoff A, Fabian J, Lehr M. 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. J Med Chem 2010;53: 5165-5178. Abstract

Fabritz L, Damke D, Emmerich M, Kaufmann SG, Theis K, Blana A, Fortmuller L, Laakmann S, Hermann S, Aleynichenko E, Steinfurt J, Volkery D, Riemann B, Kirchhefer U, Franz MR, Breithardt G, Carmeliet E, Schäfers M, Maier SKG, Carmeliet P, Kirchhof P. Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3. Cardiovasc Res 2010;87: 60-72. Abstract

Flotats A, Carrio I, Agostini D, Le Guludec D, Marcassa C, Schäfers M, Somsen GA, Unlu M, Verberne HJ. Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology. Eur J Nucl Med Mol Imaging 2010;37: 1802-1812. Abstract

Hugenberg V, Wagner S, Kopka K, Schober O, Schäfers M, Haufe G. Synthesis of geminal difluorides by oxidative desulfurization-difluorination of alkyl aryl thioethers with halonium electrophiles in the presence of fluorinating reagents and its application for 18F-radiolabeling. J Org Chem 2010;75: 6086-6095. Abstract

Korb A, Hillmann A, Burgis S, Kollias G, Hermann S, Schäfers M, Pap T, Weide T, Gessner A, Pavenstadt H. The TRAF6 binding molecule p62/SQSTM1 is a critical regulator of inflammatory bone destruction. Ann Rheum Dis 2010;69: A19-A19.

Law MP, Schäfers K, Kopka K, Wagner S, Schober O, Schäfers M. Molecular imaging of cardiac sympathetic innervation by 11C-mHED and PET: from man to mouse?. J Nucl Med 2010;51: 1269-1276. Abstract

Law MP, Wagner S, Kopka K, Renner C, Pike VW, Schober O, Schäfers M. Preclinical evaluation of an 18F-labelled beta1-adrenoceptor selective radioligand based on ICI 89,406. Nucl Med Biol 2010;37: 517-526. Abstract

Lindner O, Burchert W, Bengel FM, Zimmermann R, Vom Dahl J, Schäfer W, Schober O, Schäfers M. [Myocardial perfusion scintigraphy 2008 in Germany - results of the fourth query]. Nuklearmedizin 2010;49: 65-72. Abstract

Lucignani G, Schäfers M. PET, CT and MRI characterisation of the atherosclerotic plaque. Eur J Nucl Med Mol Imaging 2010;37: 2398-2402. Abstract

Range FT, Wenning C, Rahbar K, Schober O Schäfers M. Nuclear medicine imaging of the heart and large vessels - State of the art. Zeitschrift für Herz-, Thorax- und Gefäßchirurgie 2010;24: 169-184. Abstract

Reuter S, Schnöckel U, Edemir B, Schröter R, Kentrup D, Pavenstädt H, Schober O, Schlatter E, Gabriels G, Schäfers M. Potential of noninvasive serial assessment of acute renal allograft rejection by 18F-FDG PET to monitor treatment efficiency. J Nucl Med 2010;51: 1644-1652. Abstract

Schäfers M, Schober O, Hermann S. Matrix-metalloproteinases as imaging targets for inflammatory activity in atherosclerotic plaques. J Nucl Med 2010;51: 663-666. Abstract

Schnöckel U, Hermann S, Stegger L, Law M, Kuhlmann M, Schober O, Schäfers K, Schäfers M. Small-animal PET: a promising, non-invasive tool in pre-clinical research. Eur J Pharm Biopharm 2010;74: 50-54. Abstract

Tiemann K, Stypmann J, Landeta F, Wiebe S, Schäfers M, Schober O, Weckesser M, Rahbar K. Three-dimensional echocardiography and 153Sm-EDTMP SPECT/CT in extensive cardiac metastases from osteosarcoma. Eur J Nucl Med Mol Imaging 2010;37: 2406. Abstract

Tsotsalas MM, Kopka K, Luppi G, Wagner S, Law MP, Schäfers M, De Cola L. Encapsulating (111)In in nanocontainers for scintigraphic imaging: synthesis, characterization, and in vivo biodistribution. ACS Nano 2010;4: 342-348. Abstract

Waerzeggers Y, Rahbar K, Riemann B, Weckesser M, Schäfers M, Hesselmann V, Niederstadt T, Willich N, Stummer W, Paulus W, Schober O, Jacobs AH. PET in the diagnosis and management of patients with brain metastasis: Current role and future perspectives. Cancer Biomark 2010;7: 219-233. Abstract

2009

Büther F, Dawood M, Stegger L, Wübbeling F, Schäfers M, Schober O, Schäfers KP. List mode-driven cardiac and respiratory gating in PET. J Nucl Med 2009;50: 674-681. Abstract

Dawood M, Büther F, Schober O, Schäfers M, Schäfers KP. Wieviele respiratorische Gates? Einfluss der Anzahl an Gates auf atemgetriggerte PET Aufnahmen. Nuklearmedizin 2009;48: A23.

Dawood M, Büther F, Stegger L, Jiang X, Schober O, Schäfers M, Schäfers KP. Optimal number of respiratory gates in positron emission tomography: a cardiac patient study. Med Phys 2009;36: 1775-1784. Abstract

Faust A, Hermann S, Wagner S, Haufe G, Schober O, Schäfers M, Kopka K. Molecular imaging of apoptosis in vivo with scintigraphic and optical biomarkers - a status report. Anticancer Agents Med Chem 2009;9: 968-985. Abstract

Faust A, Waschkau B, Waldeck J, Höltke C, Breyholz H-J, Wagner S, Kopka K, Schober O, Heindel W, Schäfers M, Bremer C. Synthesis and evaluation of a novel hydroxamate based fluorescent photoprobe for imaging of matrix metalloproteinases. Bioconjug Chem 2009;20: 904-912. Abstract

Höltke C, Faust A, Breyholz H-J, Kopka K, Schober O, Riemann B, Bremer C, Schäfers M, Wagner S. Non-invasive approaches to visualize the endothelin axis in vivo using state-of-the-art molecular imaging modalities. Mini Rev Med Chem 2009;9: 1580-1595. Abstract

Höltke C, Law MP, Wagner S, Kopka K, Faust A, Breyholz H-J, Schober O, Bremer C, Riemann B, Schäfers M. PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies. Bioorg Med Chem 2009;17: 7197-7208. Abstract

Höltke C, Waldeck J, Kopka K, Heindel W, Schober O, Schäfers M, Bremer C. Biodistribution of a nonpeptidic fluorescent endothelin A receptor imaging probe. Mol Imaging 2009;8: 27-34. Abstract

Kato K, Schober O, Ikeda M, Schäfers M, Ishigaki T, Kies P, Naganawa S, Stegger L. Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT. Eur J Nucl Med Mol Imaging 2009;36: 1622-1628. Abstract

Kopka K, Faust A, Hermann S, Kuhlmann M, Wagner S, Klohs J, Schober O, Wunder A, Schäfers M. 18F-Labeled Isatin as putative biomarker for the specific imaging of activated caspases in apoptosis. J Labelled Comp Radiopharm 2009;52: S39-S39.

Lindner O, Burchert W, Bengel FM, Zimmermann R, vom Dahl J, Schafer W, Schober O, Schäfers M. [Myocardial perfusion scintigraphy 2007 in Germany - results of the query and current status]. Nuklearmedizin 2009;48: 131-137. Abstract

Podichetty AK, Faust A, Kopka K, Wagner S, Schober O, Schäfers M, Haufe G. Fluorinated isatin derivatives Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors. Bioorg Med Chem 2009;17: 2680-2688. Abstract

Podichetty AK, Wagner S, Faust A, Schäfers M, Schober O, Kopka K, Haufe G. Fluorinated isatin derivatives Part 3 New side-chain fluoro-functionalized pyrrolidinyl sulfonyl isatins as potent caspase-3 and -7 inhibitors. Future Med Chem 2009;1: 969-989. Abstract

Podichetty AK, Wagner S, Kopka K, Schröer S Faust A Schäfers M, Schober O, Haufe G. New N-Substituted 5-Pyrrolidinylsulfonyl Isatins as Potential Tools for Imaging of Caspases in Apoptosis by Positron Emission Tomography. J Med Chem 2009;52: 3484-3495.

Podichetty AK, Wagner S, Schroer S, Faust A, Schäfers M, Schober O, Kopka K, Haufe G. Fluorinated isatin derivatives Part 2 New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis. J.Med.Chem. 2009;52: 3484-3495. Abstract

Range FT, Paul M, Schäfers KP, Acil T, Kies P, Hermann S, Schober O, Breithardt G, Wichter T, Schäfers MA. Myocardial perfusion in nonischemic dilated cardiomyopathy with and without atrial fibrillation. J Nucl Med 2009;50: 390-396. Abstract

Reuter S, Schnockel U, Edemir B, Kanzog A, Schroter R, Neugebauer U, Pavenstadt H, Schober O, Schäfers M, Schlatter E, Gabriels G. FDG-Positron Emission Tomography in Diagnosis and Therapy Follow-Up of Acute Rat Renal Allograft Rejection. Am J Transplant 2009;9: 554-555.

Reuter S, Schnöckel U, Schroter R, Schober O, Pavenstädt H, Schäfers M, Gabriels G, Schlatter E. Non-invasive imaging of acute renal allograft rejection in rats using small animal F-FDG-PET. PLoS One 2009;4: e5296. Abstract

Ropinski T, Hermann S, Reich R, Schäfers M, Hinrichs K. Multimodal vessel visualization of mouse aorta PET/CT scans. IEEE Trans Vis Comput Graph 2009;15: 1515-1522. Abstract

Schäfers M, Bengel F, Bull U, Burchert W, Kies P, Kluge R, Krause BJ, Lindner O, Nienaber C, Nowak B, Schafer W, Schober O, Schwaiger M, Silber S, Vom Dahl J, Zimmermann R. [Position paper nuclear cardiology: update 2008]. Nuklearmedizin 2009;48: 71-78. Abstract

Stegger L, Heijman E, Schäfers KP, Nicolay K, Schäfers MA, Strijkers GJ. Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI. J Nucl Med 2009;50: 132-138. Abstract

Stelljes M, Hermann S, Kohler G, Silling G, Berdel WE, Schober O, Schäfers M, Kienast J. Noninvasive assessment of intestinal graft-versus-host disease activity by molecular imaging with 18F-fluorodeoxyglucose positron emission tomography. Bone Marrow Transplant 2009;43: S15-S15.

Wagner S, Breyholz H-J, Höltke C, Faust A, Schober O, Schäfers M, Kopka K. A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies. Appl Radiat Isot 2009;67: 606-610. Abstract

Wagner S, Breyholz H, Schäfers M, Schober O, Kopka K. 18F-Labeled pyrimidine-2,4,6-triones as potential probes for imaging activated MMPS. J Labelled Comp Radiopharm 2009;52: S40-S40.

Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 2009;29: 14177-14184. Abstract

2008

Faust A, Waschkau B, Waldeck J, Höltke C, Breyholz H-J, Wagner S, Kopka K, Heindel W, Schäfers M, Bremer C. Synthesis and evaluation of a novel fluorescent photoprobe for imaging matrix metalloproteinases. Bioconjug Chem 2008;19: 1001-1008. Abstract

Kobbert C, Mollmann C, Schäfers M, Hermann S, Baba HA, Hoffmeier A, Breithardt G, Scheld HH, Weissen-Plenz G, Sindermann JR. Transgenic model of cardiac rhabdomyosarcoma formation. J Thorac Cardiovasc Surg 2008;136: 1178-1186. Abstract

Kopka K, Hermann S, Faust A, Kuhlmann M, Wagner S, Breyholz HJ, Schober O, Schäfers M. Imaging of the "roads to ruin": 18F-labelled isatin as potential tracer for the molecular visualisation of activated caspases in apoptosis. Q J Nucl Med Mol Imaging 2008;52: 21-22.

Law MP, Wagner S, Kopka K, Pike VW, Schober O, Schäfers M. Are [O-methyl-11C]derivatives of ICI 89,406 beta1-adrenoceptor selective radioligands suitable for PET?. Eur J Nucl Med Mol Imaging 2008;35: 174-185. Abstract

Levkau B, Schäfers M, Wohlschlaeger J, von Wnuck Lipinski K, Keul P, Hermann S, Kawaguchi N, Kirchhof P, Fabritz L, Stypmann J, Stegger L, Flogel U, Schrader J, Fischer JW, Hsieh P, Ou YL, Mehrhof F, Tiemann K, Ghanem A, Matus M, Neumann J, Heusch G, Schmid KW, Conway EM, Baba HA. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation 2008;117: 1583-1593. Abstract

Riemann B, Schäfers KP, Schober O, Schäfers M. Small animal PET in preclinical studies: opportunities and challenges. Q J Nucl Med Mol Imaging 2008;52: 215-221.

Schäfers M. The future of molecular imaging in the clinic needs a clear strategy and a multidisciplinary effort. Basic Res Cardiol 2008;103: 200-202. Abstract

Schnöckel U, Reuter S, Stegger L, Schlatter E, Schäfers KP, Hermann S, Schober O, Gabriels G, Schäfers M. Dynamic 18F-fluoride small animal PET to noninvasively assess renal function in rats. Eur J Nucl Med Mol Imaging 2008;35: 2267-2274. Abstract

Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Schäfers M, Kummer MP, Klockgether T, Heneka MT. Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. J Neuroinflammation 2008;5: 38. Abstract

Stegger L, Schäfers M, Weckesser M, Schober O. EANM-ESR white paper on multimodality imaging. Eur J Nucl Med Mol Imaging 2008;35: 677-680. Abstract

Stelljes M, Hermann S, Albring J, Kohler G, Loffler M, Franzius C, Poremba C, Schlosser C, Volkmann S, Opitz C, Bremer C, Kucharzik T, Silling G, Schober O, Berdel WE, Schäfers M, Kienast J. Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography. Blood 2008;111: 2909-2918. Abstract

von Wallbrunn A, Waldeck J, Höltke C, Zuhlsdorf M, Mesters R, Heindel W, Schäfers M, Bremer C. In vivo optical imaging of CD13/APN-expression in tumor xenografts. J Biomed Opt 2008;13: 011007. Abstract

Waldeck J, Hager F, Höltke C, Lanckohr C, von Wallbrunn A, Torsello G, Heindel W, Theilmeier G, Schäfers M, Bremer C. Fluorescence reflectance imaging of macrophage-rich atherosclerotic plaques using an alphavbeta3 integrin-targeted fluorochrome. J Nucl Med 2008;49: 1845-1851. Abstract

2007

Breyholz HJ, Wagner S, Levkau B, Schober O, Schäfers M, Kopka K. A 18F-radiolabeled analogue of CGS 27023A as a potential agent for assessment of matrix-metalloproteinase activity in vivo. Q J Nucl Med Mol Imaging 2007;51: 24-32. Abstract

Büther F, Stegger L, Dawood M, Range F, Schäfers M, Fischbach R, Wichter T, Schober O, Schäfers KP. Effective methods to correct contrast agent-induced errors in PET quantification in cardiac PET/CT. J Nucl Med 2007;48: 1060-1068. Abstract

Faust A, Wagner S, Law MP, Hermann S, Schnöckel U, Keul P, Schober O, Schäfers M, Levkau B, Kopka K. The nonpeptidyl caspase binding radioligand (S)-1-(4-(2-[18F]Fluoroethoxy)-benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)s ulfonyl]isatin ([18F]CbR) as potential positron emission tomography-compatible apoptosis imaging agent. Q J Nucl Med Mol Imaging 2007;51: 67-73. Abstract

Hartung D, Schäfers M, Fujimoto S, Levkau B, Narula N, Kopka K, Virmani R, Reutelingsperger C, Hofstra L, Kolodgie F D, Petrov A, Narula J. Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions. Eur J Nucl Med Mol Imaging 2007;34: 1-8.

Höltke C, von Wallbrunn A, Kopka K, Schober O, Heindel W, Schäfers M, Bremer C. A fluorescent photoprobe for the imaging of endothelin receptors. Bioconjug Chem 2007;18: 685-694. Abstract

Höltke C, Wagner S, Breyholz HJ, Faust A, Law MP, Schäfers M, Kopka K. Developement, synthesis and in vitro evaluation of novel et-a receptor pet-radioligands based on pd 156707. J Labelled Comp Radiopharm 2007;50: 258.

Kirchhof P, Klimas J, Fabritz L, Zwiener M, Jones LR, Schäfers M, Hermann S, Boknik P, Schmitz W, Breithardt G, Kirchhefer U, Neumann J. Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin. J Mol Cell Cardiol 2007;42: 962-971. Abstract

Kopka K, Breyholz H J, Wagner S, Brandau W, Hermann S, Schober O, Levkau B, Bremcer C, Schäfers M. Radioiodinated pyrimidine-2,4,6-triones as model probes for the in vivo molecular imaging of activated mmps. J Labelled Comp Radiopharm 2007;50: 310.

Lang N, Hermann S, Hold S, Mienkina M, Stegger L, Stypmann J, Schober O, Schäfers M, Schäfers KP, Schmitz G. Hybrid 3D Sono/PET in a mouse. Eur J Nucl Med Mol Imaging 2007;34: 1706-1707. Abstract

Range FT, Schäfers M, Acil T, Schäfers KP, Kies P, Paul M, Hermann S, Brisse B, Breithardt G, Schober O, Wichter T. Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation. Eur Heart J 2007;28: 2223-2230. Abstract

Schäfers M. Molekulare kardiovaskuläre Bildgebung. Nuklearmediziner 2007;30: 57-63. Abstract

Stegger L, Lipke CSA, Kies P, Nowak B, Schober O, Buell U, Schäfers M, Schaefer WM. Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: validation of an elastic surface model approach in comparison to cardiac magnetic resonance imaging, 4D-MSPECT and QGS. Eur J Nucl Med Mol Imaging 2007;34: 900-909. Abstract

Stegger L, Schäfers K, Kopka K, Wagner S, Hermann S, Kies P, Law M, Schober O, Schäfers M. Molecular cardiovascular imaging using scintigraphic methods. Eur Radiol 2007;17: 1422-1432. Abstract

von Wallbrunn A, Höltke C, Zuhlsdorf M, Heindel W, Schäfers M, Bremer C. In vivo imaging of integrin alpha v beta 3 expression using fluorescence-mediated tomography. Eur J Nucl Med Mol Imaging 2007;34: 745-754. Abstract

Wagner S, Breyholz H-J, Law MP, Faust A, Höltke C, Schroer S, Haufe G, Levkau B, Schober O, Schäfers M, Kopka K. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem 2007;50: 5752-5764. Abstract

Wagner S, Breyholz HJ, Law MP, Faust A, Hoeltke C, Schober O, Schäfers M, Kopka K. Fluorinated derivatives of the potent matrix metalloproteinase inhibitors CGS 25966 and CGS 27023A: (Radio)syntheses and in vitro evaluation. J Label Compd Radiopharm 2007;50: 62.

2006

Höltke C, Law MP, Wagner S, Breyholz H-J, Kopka K, Bremer C, Levkau B, Schober O, Schäfers M. Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ET(A) receptor radioligands. Bioorg Med Chem 2006;14: 1910-1917. Abstract

Kirchhof P, Fabritz L, Zwiener M, Witt H, Schäfers M, Zellerhoff S, Paul M, Athai T, Hiller K-H, Baba HA, Breithardt G, Ruiz P, Wichter T, Levkau B. Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation 2006;114: 1799-1806. Abstract

Kopka K, Faust A, Keul P, Wagner S, Breyholz H-J, Höltke C, Schober O, Schäfers M, Levkau B. 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis. J Med Chem 2006;49: 6704-6715. Abstract

Schäfers KP, Lang N, Stegger L, Schober O, Schäfers M. Gated listmode acquisition with the quadHIDAC animal PET to image mouse hearts. Z Med Phys 2006;16: 60-66. Abstract

Stegger L, Hoffmeier A-N, Schäfers KP, Hermann S, Schober O, Schäfers MA, Theilmeier G. Accurate noninvasive measurement of infarct size in mice with high-resolution PET. J Nucl Med 2006;47: 1837-1844. Abstract

Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation 2006;114: 1403-1409. Abstract

Wagner S, Breyholz H-J, Faust A, Höltke C, Levkau B, Schober O, Schäfers M, Kopka K. Molecular imaging of matrix metalloproteinases in vivo using small molecule inhibitors for SPECT and PET. Curr Med Chem 2006;13: 2819-2838. Abstract

Wagner S, Law MP, Riemann B, Pike VW, Breyholz H-J, Höltke C, Faust A, Renner C, Schober O, Schäfers M, Kopka K. Synthesis of an 18F-labelled high affinity β1-adrenoceptor PET radioligand based on ICI 89,406. J Label Compd Radiopharm 2006;49: 177-195. Abstract

2005

Breyholz HJ, Schäfers M, Wagner S, Höltke C, Faust A, Rabeneck H, Levkau B, Schober O, Kopka K. C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging. J Med Chem 2005;48: 3400-3409. Abstract

Schäfers KP, Reader AJ, Kriens M, Knoess C, Schober O, Schäfers M. Performance evaluation of the 32-module quadHIDAC small-animal PET scanner. J.Nucl.Med. 2005;46: 996-1004. Abstract

Stegger L, Schäfers KP, Flogel U, Livieratos L, Hermann S, Jacoby C, Keul P, Conway EM, Schober O, Schrader J, Levkau B, Schäfers M. Monitoring left ventricular dilation in mice with PET. J.Nucl.Med. 2005;46: 1516-1521.

Wagner S, Law MP, Riemann B, Pike VW, Breyholz H-J, Höltke C, Faust A, Schober O, Schäfers M, Kopka K. Synthesis of (R)- and (S)-[O-methyl-11C]N-[2-[3-(2-cyano-phenoxy)-2-hydroxy-propylamino]-ethyl]-N′-(4-methoxy-phenyl)-urea as candidate high affinity β1-adrenoceptor PET radioligands. J Label Compd Radiopharm 2005;48: 721-733. Abstract

2004

Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, Schulze-Bahr E, Rimoldi O, Breithardt G, Schober O, Camici PG. Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Circulation 2004;110: 3017-3022. Abstract

Kopka K, Breyholz HJ, Wagner S, Law MP, Riemann B, Schroer S, Trub M, Guilbert B, Levkau B, Schober O, Schäfers M. Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo. Nucl Med Biol 2004;31: 257-267. Abstract

Levkau B, Hermann S, Theilmeier G, van der Giet M, Chun J, Schober O, Schäfers M. High-density lipoprotein stimulates myocardial perfusion in vivo. Circulation 2004;110: 3355-3359. Abstract

Nofer JR, van der Giet M, Tolle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Godecke A, Ishii I, Kleuser B, Schäfers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J.Clin.Invest. 2004;113: 569-581. Abstract

Schäfers M, Riemann B, Kopka K, Breyholz HJ, Wagner S, Schäfers KP, Law MP, Schober O, Levkau B. Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo. Circulation 2004;109: 2554-2559. Abstract

2002

Wichter T, Matheja P, Eckardt L, Kies P, Schäfers KP, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M. Cardiac autonomic dysfunction in Brugada syndrome. Circulation 2002;105: 702-706. Abstract

1998

Schäfers M, Dutka D, Rhodes CG, Lammertsma AA, Hermansen F, Schober O, Camici PG. Myocardial presynaptic and postsynaptic autonomic dysfunction in hypertrophic cardiomyopathy. Circ Res 1998;82: 57-62. Abstract

Schäfers M, Lerch H, Wichter T, Rhodes CG, Lammertsma AA, Borggrefe M, Hermansen F, Schober O, Breithardt G, Camici PG. Cardiac sympathetic innervation in patients with idiopathic right ventricular outflow tract tachycardia. J Am Coll Cardiol 1998;32: 181-186. Abstract

Patents

Faust A, Hermann S, Roth J, Schäfers M, Vogl T. Quinolone-3-carboxamide compounds and their use in diagnosis. WO 2016067238 A1; publication date: 06/05/2016. PCT/IB2015/058348; publication date: 06/05/2016.

Chen G, Gangadharmath UB, Kasi D, Kolb HC, Liu C, Sinha A, Szardenings AK, Walsh JC, Wang E, Yu C, Zhang W, Kopka K, Haufe G, Schäfers M, Hugenberg V, Wagner S, Hermann S, Breyholz H-J, Faust A. Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof. EP 2644601; 02/10/2013.

Haufe G, Schilson S, Keul P, Levkau B, Schäfers M. New ligands for targeting of S1P receptors for in vivo imaging and treatment of diseases. EP 2559683; 20/02/2013. WO 2013/026765; 28/02/2013. EP 2744776; 25/06/2014.

Haufe G, Hermann S, Hugenberg V, Kolb H, Kopka K, Wagner S, Schäfers M. Compounds with matrix-metalloproteinase inhibitory activity. WO 2013/010573; publication date: 24/01/2013.

Behrends M, Breyholz H-J, Hermann S, Haufe G, Hugenberg V, Kolb H, Kopka K, Wagner S, Schäfers M. Compounds with matrix-metalloproteinase inhibitory activity. EP 2520573; publication date: 07/11/2012.

Bremer C, Höltke C, Kopka K, Schäfers M. A fluorescent photoprobe for the imaging of endothelin receptors. WO 2007/028599; 15/03/2007. EP 1931392; 18/06/2008.

Kopka K, Levkau B, Schäfers M. 5-Pyrrolidinylsulfonyl isatin derivatives. WO 2006/074799; 20/07/2006. EP 1841759; 10/10/2007.

Research Areas

CV

Education

Positions

Honors

External Functions

Appointment