Hermann, Sven, Priv.-Doz. Dr. med.

Publikationen

2024

Hoffgen KS, Dabel J, Konken CP, Depke DA, Hermann S, Dorner W, Schelhaas S, Schafers M, Mootz HD. Combining poly-epitope MoonTags and labeled nanobodies for signal amplification in cell-specific PET imaging in vivo. Nucl Med Biol 2024;136-137: 108937. Abstract

Landau F, Hermann S, Schelhaas S, Schafers M, Niemann S, Faust A. 18F-labelled gentiobiose as potential PET-radiotracer for specific bacterial imaging: precursor synthesis, radiolabelling and in vitro evaluation. Nuklearmedizin 2024Abstract

Margeta R, Schelhaas S, Hermann S, Schafers M, Niemann S, Faust A. A novel radiolabelled salmochelin derivative for bacteria-specific PET imaging: synthesis, radiolabelling and evaluation. Chem Commun (Camb) 2024Abstract

Prasad VP, Wagner S, Keul P, Hermann S, Levkau B, Schafers M, Haufe G. Synthesis, radiosynthesis and biochemical evaluation of fluorinated analogues of sphingosine-1-phosphate receptor 3 specific antagonists using PET. Bioorg Med Chem 2024;104: 117697. Abstract

Sailaja STN Maisuls I Hepp A Brünink D Doltsinis N L Faust A Hermann S Strassert C A. Dual Emissive Zn(II) Naphthalocyanines: Synthesis, Structural and Photophysical Characterization with Theory-Supported Insights towards Soluble Coordination Compounds with Visible and Near-Infrared Emission. nt J Mol Sci 2024Abstract

2023

Cufe J, Gierse F, Schafers KP, Hermann S, Schafers MA, Backhaus P, Buther F. Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements. EJNMMI Res 2023;13: 86. Abstract

Galbiati A, Dorten P, Gilardoni E, Gierse F, Bocci M, Zana A, Mock J, Claesener M, Cufe J, Buther F, Schafers K, Hermann S, Schafers M, Neri D, Cazzamalli S, Backhaus P. Tumor-Targeted Interleukin 2 Boosts the Anticancer Activity of FAP-Directed Radioligand Therapeutics. J Nucl Med 2023Abstract

Jorch SK, McNally A, Berger P, Wolf J, Kaiser K, Chetrusca Covash A, Robeck S, Pastau I, Fehler O, Jauch-Speer S-L, Hermann S, Schafers M, Van Gorp H, Kanneganti A, Dehoorne J, Haerynck F, Penco F, Gattorno M, Chae JJ, Kubes P, Lamkanfi M, Wullaert A, Sperandio M, Vogl T, Roth J, Austermann J. Complex regulation of alarmins S100A8/A9 and secretion via Gasdermin-D pores exacerbates autoinflammation in Familial Mediterranean Fever. J Allergy Clin Immunol 2023Abstract

Roll W, Faust A, Hermann S, Schafers M. Infection Imaging: Focus on New Tracers?. J Nucl Med 2023;64: 59s-67s. Abstract

Tzolos E, Bing R, Andrews J, MacAskill MG, Tavares AAS, Macnaught G, Clark T, Mills NL, Fujisawa T, Nash J, Dey D, Slomka PJ, Koglin N, Stephens AW, Deutsch M-A, van Beek EJR, Williams MC, Hermann S, Hugenberg V, Dweck MR, Newby DE. Noninvasive In Vivo Coronary Artery Thrombus Imaging. JACC Cardiovasc Imaging 2023Abstract

von Wulffen M, Luehrmann V, Robeck S, Russo A, Fischer-Riepe L, van den Bosch M, van Lent P, Loser K, Gabrilovich DI, Hermann S, Roth J, Vogl T. S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis. Cell Rep 2023;42: 113006. Abstract

Wolf M, Joseph R, Austermann J, Scharrnbeck-Davis C, Hermann S, Roth J, Vogl T. S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of Leukocytes. Biomedicines 2023;11Abstract

2022

Backhaus P, Gierse F, Burg MC, Buther F, Asmus I, Dorten P, Cufe J, Roll W, Neri D, Cazzamalli S, Millul J, Mock J, Galbiati A, Zana A, Schafers KP, Hermann S, Weckesser M, Tio J, Wagner S, Breyholz H-J, Schafers M. Translational imaging of the fibroblast activation protein (FAP) using the new ligand [(68)Ga]Ga-OncoFAP-DOTAGA. Eur J Nucl Med Mol Imaging 2022;49: 1822-1832. Abstract

Barca C, Kiliaan AJ, Foray C, Wachsmuth L, Hermann S, Faber C, Schafers M, Wiesmann M, Jacobs AH, Zinnhardt B. A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor-Mediated Microglia Depletion in Experimental Stroke. J Nucl Med 2022;63: 446-452. Abstract

Barca C, Kiliaan AJ, Wachsmuth L, Foray C, Hermann S, Faber C, Schafers M, Wiesmann M, Zinnhardt B, Jacobs AH. Short-Term Colony-Stimulating Factor 1 Receptor Inhibition-Induced Repopulation After Stroke Assessed by Longitudinal (18)F-DPA-714 PET Imaging. J Nucl Med 2022;63: 1408-1414. Abstract

Foray C, Barca C, Winkeler A, Wagner S, Hermann S, Schafers M, Grauer OM, Zinnhardt B, Jacobs AH. Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI. J Nucl Med 2022;63: 1386-1393. Abstract

Honold L, Austrup M, Faust A, Konken CP, Schwegmann K, Zinnhardt B, Daniliuc CG, Haufe G, Schafers M, Kopka K, Hermann S. Towards Optimized Bioavailability of (99m)Tc-Labeled Barbiturates for Non-invasive Imaging of Matrix Metalloproteinase Activity. Mol Imaging Biol 2022;24: 434-443. Abstract

Russo A, Schurmann H, Brandt M, Scholz K, Matos ALL, Grill D, Revenstorff J, Rembrink M, von Wulffen M, Fischer-Riepe L, Hanley PJ, Hacker H, Prunster M, Sanchez-Madrid F, Hermann S, Klotz L, Gerke V, Betz T, Vogl T, Roth J. Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes. Adv Sci (Weinh) 2022: e2201505. Abstract

Schelhaas S, Frohwein LJ, Wachsmuth L, Hermann S, Faber C, Schafers KP, Jacobs AH. Voxel-Based Analysis of the Relation of 3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) PET and Diffusion-Weighted (DW) MR Signals in Subcutaneous Tumor Xenografts Does Not Reveal a Direct Spatial Relation of These Two Parameters. Mol Imaging Biol 2022;24: 359-364. Abstract

2021

Barca C, Foray C, Hermann S, Herrlinger U, Remory I, Laoui D, Schafers M, Grauer OM, Zinnhardt B, Jacobs AH. The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke). Front Immunol 2021;12: 787307. Abstract

Barca C, Kiliaan AJ, Foray C, Wachsmuth L, Hermann S, Faber C, Schaefers M, Wiesmann M, Jacobs AH, Zinnhardt B. A longitudinal PET/MR imaging study of colony stimulating factor-1 receptor-mediated microglia depletion in experimental stroke. J Nucl Med 2021Abstract

Barca C, Wiesmann M, Calahorra J, Wachsmuth L, Döring C, Foray C, Heiradi A, Hermann S, Peinado MÁ, Siles E, Faber C, Schäfers M, Kiliaan AJ, Jacobs AH, Zinnhardt B. Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes. Theranostics 2021;11: 4030-4049. Abstract

Depke DA, Konken CP, Rosner L, Hermann S, Schafers M, Rentmeister A. A novel (18)F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo. Chem Commun (Camb) 2021;57: 9850-9853. Abstract

Foray C, Valtorta S, Barca C, Winkeler A, Roll W, Müther M, Wagner S, Gardner ML, Hermann S, Schäfers M, Grauer OM, Moresco RM, Zinnhardt B, Jacobs AH. Imaging temozolomide-induced changes in the myeloid glioma microenvironment. Theranostics 2021;11: 2020-2033. Abstract

Merkes JM, Hasenbach A, Kiessling F, Hermann S, Banala S. Sensing Reactive Oxygen Species with Photoacoustic Imaging Using Conjugation-Extended BODIPYs. ACS Sens 2021;6: 4379-4388. Abstract

Wagner S, de Moura Gatti F, Silva DG, Ortiz Zacarias NV, Zweemer AJM, Hermann S, De Maria M, Koch M, Weiss C, Schepmann D, Heitman LH, Tschammer N, Kopka K, Junker A. Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors. ChemMedChem 2021;16: 640-645. Abstract

2020

Backhaus P, Buther F, Wachsmuth L, Frohwein L, Buchholz R, Karst U, Schafers K, Hermann S, Schafers M, Faber C. Toward precise arterial input functions derived from DCE-MRI through a novel extracorporeal circulation approach in mice. Magn Reson Med 2020;84: 1404-1415. Abstract

Barca C, Foray C, Hermann S, Doring C, Schafers M, Jacobs AH, Zinnhardt B. Characterization of the inflammatory post-ischemic tissue by full volumetric analysis of a multimodal imaging dataset. Neuroimage 2020: 117217. Abstract

Schwegmann K, Hohn M, Hermann S, Schafers M, Riemann B, Haufe G, Wagner S, Breyholz H-J. Optimizing the Biodistribution of Radiofluorinated Barbiturate Tracers for Matrix Metalloproteinase Imaging by Introduction of Fluorescent Dyes as Pharmacokinetic Modulators. Bioconjug Chem 2020Abstract

Tangherlini G, Borgel F, Schepmann D, Slocum S, Che T, Wagner S, Schwegmann K, Hermann S, Mykicki N, Loser K, Wunsch B. Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline-Based kappa-Opioid Receptor (KOR) Agonists Designed for PET Studies. Chemmedchem 2020;15: 1834-1853. Abstract

Zinnhardt B, Muther M, Roll W, Backhaus P, Jeibmann A, Foray C, Barca C, Doring C, Tavitian B, Dolle F, Weckesser M, Winkeler A, Hermann S, Wagner S, Wiendl H, Stummer W, Jacobs AH, Schafers M, Grauer OM. TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma. Neuro Oncol 2020;22: 1030-1043. Abstract

2019

Luxan G, Stewen J, Diaz N, Kato K, Maney SK, Aravamudhan A, Berkenfeld F, Nagelmann N, Drexler HC, Zeuschner D, Faber C, Schillers H, Hermann S, Wiseman J, Vaquerizas JM, Pitulescu ME, Adams RH. Endothelial EphB4 maintains vascular integrity and transport function in adult heart. Elife 2019;8: e45863. Abstract

Roll W, Markwardt NA, Masthoff M, Helfen A, Claussen J, Eisenblatter M, Hasenbach A, Hermann S, Karlas A, Wildgruber M, Ntziachristos V, Schafers M. Multispectral Optoacoustic Tomography of Benign and Malignant Thyroid Disorders: A Pilot Study. J Nucl Med 2019;60: 1461-1466. Abstract

Zinnhardt B, Belloy M, Fricke IB, Orije J, Guglielmetti C, Hermann S, Wagner S, Schafers M, Van der Linden A, Jacobs AH. Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [(18)F]DPA-714 PET and MRI. Theranostics 2019;9: 1523-1537. Abstract

2018

Axer A, Hermann S, Kehr G, Clases D, Karst U, Fischer-Riepe L, Roth J, Fobker M, Schafers M, Gilmour R, Faust A. Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design. ChemMedChem 2018;13: 241-250. Abstract

Butsch V, Borgel F, Galla F, Schwegmann K, Hermann S, Schafers M, Riemann B, Wunsch B, Wagner S. Design, (Radio)Synthesis, and in Vitro and in Vivo Evaluation of Highly Selective and Potent Matrix Metalloproteinase 12 (MMP-12) Inhibitors as Radiotracers for Positron Emission Tomography. J Med Chem 2018;61: 4115-4134. Abstract

Duffy MJ, Planas O, Faust A, Vogl T, Hermann S, Schäfers M, Nonell S, Strassert CA. Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo. Photoacoustics 2018;9: 49-61. Abstract

Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, den Bosch M van, van Lent P, Spiekermann C, Hermann S, Vogl T, Schäfers M, Roth J. Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment_in vivo_. Theranostics 2018;8: 2407-2423. Abstract

Heming M, Gran S, Jauch S-L, Fischer-Riepe L, Russo A, Klotz L, Hermann S, Schafers M, Roth J, Barczyk-Kahlert K. Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids. Front Immunol 2018;9: 893. Abstract

Hohn M, Chang M, Meisel JE, Frost E, Schwegmann K, Hermann S, Schäfers M, Riemann B, Haufe G, Breyholz HJ, Wagner S. Synthesis and preliminary in vitro and in vivo evaluation of thiirane-based slow binding MMP inhibitors as potential radiotracers for PET imaging. Chemistry Select 2018;3: 11729-11736. Abstract

Hugenberg V, Behrends M, Wagner S, Hermann S, Schafers M, Kolb HC, Szardenings K, Walsh JC, Gomez LF, Kopka K, Haufe G. Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on gamma-fluorinated alpha-sulfonylaminohydroxamic acid. EJNMMI Radiopharm Chem 2018;3: 10. Abstract

Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith D-M, Fricke IB, Just N, Doblas S, Sinkus R, Doring C, Schafers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH. Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-(18)F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model. J Nucl Med 2018;59: 1063-1069. Abstract

Seifert R, Kuhlmann MT, Eligehausen S, Kiefer F, Hermann S, Schafers M. Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis. PLoS One 2018;13: e0204305. Abstract

Voeller T, Faust A, Roth J, Schafers M, Vogl T, Hermann S. A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo. Mol Imaging Biol 2018;20: 407-416. Abstract

Vogl T, Stratis A, Wixler V, Voller T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Frohling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schafers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, Konig S, Pap T, Roth J. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest 2018;128: 1852-1866. Abstract

2017

Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, Geraets IME, Coumans W, Luiken JJFP, Glatz JFC, Schafers M, Nicolay K, Faber C, Hermann S, Prompers JJ. Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovasc Res 2017;113: 1148-1160. Abstract

Fricke IB, Schelhaas S, Zinnhardt B, Viel T, Hermann S, Couillard-Despres S, Jacobs AH. In vivo bioluminescence imaging of neurogenesis - the role of the blood brain barrier in an experimental model of Parkinson's disease. Eur J Neurosci 2017;45: 975-986. Abstract

Grabner A, Schramm K, Silswal N, Hendrix M, Yanucil C, Czaya B, Singh S, Wolf M, Hermann S, Stypmann J, Di Marco GS, Brand M, Wacker MJ, Faul C. FGF23/FGFR4-mediated left ventricular hypertrophy is reversible. Sci Rep 2017;7: 1993. Abstract

Hugenberg V, Wagner S, Kopka K, Schafers M, Schuit RC, Windhorst AD, Hermann S. Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation. J Med Chem 2017;60: 307-321. Abstract

Ortmeyer CP, Haufe G, Schäfers M, Wagner S, Schwegmann K, Hermann S, Hugenberg V. Development of 18F-fluorinated BODIPYs for multimodal imaging. J Label Compd Radiopharm 2017;60: 273. Abstract

Ortmeyer CP, Haufe G, Schwegmann K, Hermann S, Schafers M, Borgel F, Wunsch B, Wagner S, Hugenberg V. Synthesis and evaluation of a [18F]BODIPY-labeled caspase-inhibitor. Bioorg Med Chem 2017;25: 2167-2176. Abstract

Seifert R, Scherzinger A, Kiefer F, Hermann S, Jiang X, Schafers MA. Statistical Permutation-based Artery Mapping (SPAM): a novel approach to evaluate imaging signals in the vessel wall. BMC Med Imaging 2017;17: 36. Abstract

Van de Vyver H, Bovenkamp PR, Hoerr V, Schwegmann K, Tuchscherr L, Niemann S, Kursawe L, Grosse C, Moter A, Hansen U, Neugebauer U, Kuhlmann MT, Peters G, Hermann S, Loffler B. A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection: Noninvasive Imaging of Biofilm Development in Vivo. Am J Pathol 2017;187: 268-279. Abstract

Wiesmann M, Zinnhardt B, Reinhardt D, Eligehausen S, Wachsmuth L, Hermann S, Dederen PJ, Hellwich M, Kuhlmann MT, Broersen LM, Heerschap A, Jacobs AH, Kiliaan AJ. A specific dietary intervention to restore brain structure and function after ischemic stroke. Theranostics 2017;7: 493-512. Abstract

Zinnhardt B, Pigeon H, Theze B, Viel T, Wachsmuth L, Fricke IB, Schelhaas S, Honold L, Schwegmann K, Wagner S, Faust A, Faber C, Kuhlmann MT, Hermann S, Schafers M, Winkeler A, Jacobs AH. Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake. Cancer Res 2017;77: 1831-1841. Abstract

2016

Faust A, Hermann S, Schafers M, Holtke C. Optical imaging probes and their potential contribution to radiotracer development. Nuklearmedizin 2016;55: 51-62. Abstract

Fricke IB, Viel T, Worlitzer MM, Collmann FM, Vrachimis A, Faust A, Wachsmuth L, Faber C, Dolle F, Kuhlmann MT, Schafers K, Hermann S, Schwamborn JC, Jacobs AH. 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. Eur J Neurosci 2016;43: 1352-1365. Abstract

Galstyan A, Block D, Niemann S, Gruner MC, Abbruzzetti S, Oneto M, Daniliuc CG, Hermann S, Viappiani C, Schafers M, Loffler B, Strassert CA, Faust A. Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry 2016;22: 5243-5252. Abstract

Galstyan A, Block D, Niemann S, Gruner MC, Abbruzzetti S, Oneto M, Daniliuc CG, Hermann S, Viappiani C, Schafers M, Loffler B, Strassert CA, Faust A. Corrigendum: Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry 2016;22: 9051. Abstract

Gerwien H, Hermann S, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer N, Opdenakker G, Wiendl H, Schafers M, Sorokin L. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med 2016;8: 364ra152. Abstract

Geven EJW, van den Bosch MHJ, Di Ceglie I, Ascone G, Abdollahi-Roodsaz S, Sloetjes AW, Hermann S, Schafers M, van de Loo FAJ, van der Kraan PM, Koenders MI, Foell D, Roth J, Vogl T, van Lent PLEM. S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis. Arthritis Res Ther 2016;18: 247. Abstract

Hermann S, Kuhlmann MT, Starsichova A, Eligehausen S, Schafers K, Stypmann J, Tiemann K, Levkau B, Schafers M. Imaging Reveals the Connection Between Spontaneous Coronary Plaque Ruptures, Atherothrombosis, and Myocardial Infarctions in HypoE/SRBI-/- Mice. J Nucl Med 2016;57: 1420-1427. Abstract

Hugenberg V, Hermann S, Galla F, Schafers M, Wunsch B, Kolb HC, Szardenings K, Lebedev A, Walsh JC, Mocharla VP, Gangadharmath UB, Kopka K, Wagner S. Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability. Nucl Med Biol 2016;43: 424-437. Abstract

Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schafers M, Holl R. Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography. J Med Chem 2016;59: 9541-9559. Abstract

Keul P, van Borren MMGJ, Ghanem A, Muller FU, Baartscheer A, Verkerk AO, Stumpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot J-H, Alewijnse AE, Hermann S, Spijkers LJA, Hiller K-H, Herr D, Heusch G, Schafers M, Peters SLM, Chun J, Levkau B. Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. J Am Heart Assoc 2016;5: e003393. Abstract

O'Halloran PJ, Viel T, Murray DW, Wachsmuth L, Schwegmann K, Wagner S, Kopka K, Jarzabek MA, Dicker P, Hermann S, Faber C, Klasen T, Schafers M, O'Brien D, Prehn JHM, Jacobs AH, Byrne AT. Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers. Eur J Nucl Med Mol Imaging 2016;43: 1673-1683. Abstract

Schelhaas S, Held A, Baumer N, Viel T, Hermann S, Muller-Tidow C, Jacobs AH. Preclinical Evidence That 3'-Deoxy-3'-[18F]Fluorothymidine PET Can Visualize Recovery of Hematopoiesis after Gemcitabine Chemotherapy. Cancer Res 2016;76: 7089-7095. Abstract

Schelhaas S, Held A, Wachsmuth L, Hermann S, Honess DJ, Heinzmann K, Smith D-M, Griffiths JR, Faber C, Jacobs AH. Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer. Cancer Res 2016;76: 7096-7105. Abstract

Schwegmann K, Bettenworth D, Hermann S, Faust A, Poremba C, Foell D, Schafers M, Domagk D, Lenz P. Detection of Early Murine Colorectal Cancer by MMP-2/-9-Guided Fluorescence Endoscopy. Inflamm Bowel Dis 2016;22: 82-91. Abstract

Vahle A-K, Hermann S, Schafers M, Wildner M, Kerem A, Ozturk E, Jure-Kunkel M, Franklin C, Lang S, Brandau S. Multimodal imaging analysis of an orthotopic head and neck cancer mouse model and application of anti-CD137 tumor immune therapy. Head Neck 2016;38: 542-549. Abstract

Vrachimis A, Honold L, Faust A, Hermann S, Schafers M. New molecular probes of vascular inflammation. Q J Nucl Med Mol Imaging 2016;60: 194-204. Abstract

2015

Faust A, Voller T, Busch F, Schafers M, Roth J, Hermann S, Vogl T. Development and evaluation of a non-peptidic ligand for the molecular imaging of inflammatory processes using S100A9 (MRP14) as a novel target. Chem Commun (Camb) 2015;51: 15637-15640. Abstract

Junker A, Kokornaczyk AK, Zweemer AJM, Frehland B, Schepmann D, Yamaguchi J, Itami K, Faust A, Hermann S, Wagner S, Schafers M, Koch M, Weiss C, Heitman LH, Kopka K, Wunsch B. Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists. Org Biomol Chem 2015;13: 2407-2422. Abstract

Reilmann R, Lippross V, Holzner E, Gigengack F, Bohlen S, Kugel H, Deppe M, Osada N, Lucke M, Riess O, Nguyen HP, Von Horsten S, Schafers K, Schafers M, Jacobs AH, Hermann S. FDG muPET Fails to Detect a Disease-Specific Phenotype in Rats Transgenic for Huntington's Disease - A 15 Months Follow-up Study. J Huntingtons Dis 2015;4: 37-47. Abstract

Santschi N, Wagner S, Daniliuc C, Hermann S, Schafers M, Gilmour R. Synthesis of 2-[(18) F]Fluoro-2-deoxyisosorbide 5-mononitrate and Assessment of Its in vivo Biodistribution as Determined by Dynamic Positron Emission Tomography (PET). ChemMedChem 2015;10: 1724-1732. Abstract

Shaikh RS, Schilson SS, Wagner S, Hermann S, Keul P, Levkau B, Schafers M, Haufe G. Synthesis and evaluation of fluorinated fingolimod (FTY720) analogues for sphingosine-1-phosphate receptor molecular imaging by positron emission tomography. J Med Chem 2015;58: 3471-3484. Abstract

Waldmann CM, Hermann S, Faust A, Riemann B, Schober O, Schafers M, Haufe G, Kopka K. Novel fluorine-18 labeled 5-(1-pyrrolidinylsulfonyl)-7-azaisatin derivatives as potential PET tracers for in vivo imaging of activated caspases in apoptosis. Bioorg Med Chem 2015;23: 5734-5739. Abstract

Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz H-J, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab 2015;35: 1711-1721. Abstract

2014

Biesemann N, Mendler L, Wietelmann A, Hermann S, Schafers M, Kruger M, Boettger T, Borchardt T, Braun T. Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res 2014;115: 296-310. Abstract

Persigehl T, Ring J, Bremer C, Heindel W, Holtmeier R, Stypmann J, Claesener M, Hermann S, Schafers M, Zerbst C, Schliemann C, Mesters RM, Berdel WE, Schwoppe C. Non-invasive monitoring of tumor-vessel infarction by retargeted truncated tissue factor tTF-NGR using multi-modal imaging. Angiogenesis 2014;17: 235-246. Abstract

Prasad VP, Wagner S, Keul P, Hermann S, Levkau B, Schafers M, Haufe G. Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography. Bioorg Med Chem 2014;22: 5168-5181. Abstract

Schäfers KP, Bolwin K, Büther F, Hermann S, Jacobs AH, Kösters T, Kuhlmann M, Schäfers M, Viel T. High-Resolution Small Animal Imaging. In: Comprehensive Biomedical Physics 2014;Elsevier, Oxford: 181-211. Abstract

Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith D-M, Hermann S, Wagner S, Kuhlmann MT, Muller-Tidow C, Kopka K, Schober O, Schafers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AH. Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-18F-Fluorothymidine PET and Diffusion-Weighted MR Imaging. J Nucl Med 2014;55: 983-988. Abstract

Tucci S, Flogel U, Hermann S, Sturm M, Schafers M, Spiekerkoetter U. Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice. Biochim Biophys Acta 2014;1842: 677-685. Abstract

Vahle A-K, Domikowsky B, Schwöppe C, Krähling H, Mally S, Schäfers M, Hermann S, Shahin V, Haier J, Schwab A, Stock C. Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility. Int J Oncol 2014;44: 78-90. Abstract

van Duijnhoven SMJ, Robillard MS, Hermann S, Kuhlmann MT, Schafers M, Nicolay K, Grull H. Imaging of MMP activity in postischemic cardiac remodeling using radiolabeled MMP-2/9 activatable peptide probes. Mol Pharm 2014;11: 1415-1423. Abstract

Vogl T, Eisenblatter M, Voller T, Zenker S, Hermann S, van Lent P, Faust A, Geyer C, Petersen B, Roebrock K, Schafers M, Bremer C, Roth J. Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun 2014;5: 4593. Abstract

Wenning C, Kloth C, Kuhlmann MT, Jacobs AH, Schober O, Hermann S, Schafers MA. Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Atherosclerosis 2014;234: 276-282. Abstract

2013

Bettenworth D, Reuter S, Hermann S, Weckesser M, Kerstiens L, Stratis A, Nowacki TM, Ross M, Lenze F, Edemir B, Maaser C, Pap T, Koschmieder S, Heidemann J, Schäfers M, Lugering A. Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation. J Nucl Med 2013;54: 748-755. Abstract

Diepenbrock S, Hermann S, Schäfers M, Kuhlmann M, Hinrichs K. Comparative Visualization of Tracer Uptake in In Vivo Small Animal PET/CT Imaging of the Carotid Arteries. Comput Graph Forum 2013;32: 241-250. Abstract

Gigengack F, Ruthotto L, Jiang X, Modersitzki J, Burger M, Hermann S, Schäfers KP. Atlas-Based Whole-Body PET-CT Segmentation using a Passive Contour Distance. Lect Notes Comput Sc 2013;7766: 82-92. Abstract

Hermann S, Pichler B, Kotzerke J. [Preclinical research Seal of approval translational medicine]. Nuklearmedizin 2013;52: N53-4. Abstract

Hugenberg V, Riemann B, Hermann S, Schober O, Schafers M, Szardenings K, Lebedev A, Gangadharmath U, Kolb H, Walsh J, Zhang W, Kopka K, Wagner S. Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation. J Med Chem 2013;56: 6858-6870. Abstract

Limpachayaporn P, Wagner S, Kopka K, Hermann S, Schäfers M, Haufe G. Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography. J Med Chem 2013;56: 4509-4520. Abstract

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PLEM, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V. Doxycycline-induced expression of transgenic human tumor necrosis factor alpha in adult mice results in psoriasis-like arthritis. Arthritis Rheum 2013;65: 2290-2300. Abstract

2012

Bertrand J, Nitschke Y, Fuerst M, Hermann S, Schäfers M, Sherwood J, Nalesso G, Ruether W, Rutsch F, Dell'Accio F, Pap T. Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice. Ann Rheum Dis 2012;71: 1249-1253. Abstract

Claesener M, Breyholz H-J, Hermann S, Faust A, Wagner S, Schober O, Schäfers M, Kopka K. Efficient synthesis of a fluorine-18 labeled biotin derivative. Nucl Med Biol 2012;39: 1189-1194. Abstract

Gigengack F, Ruthotto L, Kösters T, Jiang X, Modersitzki J, Burger M, Hermann S, Schäfers KP. Atlas-Based Segmentation Using Passive Contours. IEEE NSS/MIC 2012: 3015-3016.

Hermann S, Starsichova A, Waschkau B, Kuhlmann M, Wenning C, Schober O, Schäfers M. Non-FDG imaging of atherosclerosis: Will imaging of MMPs assess plaque vulnerability?. J Nucl Cardiol 2012;19: 609-617. Abstract

Hugenberg V, Breyholz H-J, Riemann B, Hermann S, Schober O, Schäfers M, Gangadharmath U, Mocharla V, Kolb H, Walsh J, Zhang W, Kopka K, Wagner S. A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. J Med Chem 2012;55: 4714-4727. Abstract

Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S, Schäfers M. Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice. J Vis Exp 2012: 3308. Abstract

Schrigten D, Breyholz HJ, Wagner S, Hermann S, Schober O, Schäfers M, Haufe G, Kopka K. A new generation of radiofluorinated pyrimidine-2,4,6-triones as MMP-targeted radiotracers for positron emission tomography. J Med Chem 2012: 223-232. Abstract

Vrachimis A, Hermann S, Mathe D, Schober O, Schäfers M. Systematic evaluation of 99mTc-tetrofosmin versus 99mTc-sestamibi to study murine myocardial perfusion in small animal SPECT/CT. EJNMMI Res 2012;2: 21. Abstract

2011

Bunk EC, Stelzer S, Hermann S, Schäfers M, Schlatt S, Schwamborn JC. Cellular organization of adult neurogenesis in the Common Marmoset. Aging Cell 2011;10: 28-38. Abstract

Michel K, Büther K, Law MP, Wagner S, Schober O, Hermann S, Schäfers M, Riemann B, Höltke C, Kopka K. Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography. J Med Chem 2011;54: 939-948. Abstract

Seidler DG, Mohamed NA, Bocian C, Stadtmann A, Hermann S, Schäfers K, Schäfers M, Iozzo RV, Zarbock A, Götte M. The role for decorin in delayed-type hypersensitivity. J Immunol 2011;187: 6108-6119. Abstract

2010

Breyholz HJ, Wagner S, Faust A, Riemann B, Höltke C, Hermann S, Schober O, Schäfers M, Kopka K. Radiofluorinated pyrimidine-2,4,6-triones as molecular probes for noninvasive MMP-targeted imaging. ChemMedChem 2010;5: 777-789. Abstract

Buscher K, Judenhofer MS, Kuhlmann MT, Hermann S, Wehrl HF, Schäfers KP, Schäfers M, Pichler BJ, Stegger L. Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI. J Nucl Med 2010;51: 1277-1284. Abstract

Fabritz L, Damke D, Emmerich M, Kaufmann SG, Theis K, Blana A, Fortmuller L, Laakmann S, Hermann S, Aleynichenko E, Steinfurt J, Volkery D, Riemann B, Kirchhefer U, Franz MR, Breithardt G, Carmeliet E, Schäfers M, Maier SKG, Carmeliet P, Kirchhof P. Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3. Cardiovasc Res 2010;87: 60-72. Abstract

Korb A, Hillmann A, Burgis S, Kollias G, Hermann S, Schäfers M, Pap T, Weide T, Gessner A, Pavenstadt H. The TRAF6 binding molecule p62/SQSTM1 is a critical regulator of inflammatory bone destruction. Ann Rheum Dis 2010;69: A19-A19.

Schäfers M, Schober O, Hermann S. Matrix-metalloproteinases as imaging targets for inflammatory activity in atherosclerotic plaques. J Nucl Med 2010;51: 663-666. Abstract

Schnöckel U, Hermann S, Stegger L, Law M, Kuhlmann M, Schober O, Schäfers K, Schäfers M. Small-animal PET: a promising, non-invasive tool in pre-clinical research. Eur J Pharm Biopharm 2010;74: 50-54. Abstract

2009

Faust A, Hermann S, Wagner S, Haufe G, Schober O, Schäfers M, Kopka K. Molecular imaging of apoptosis in vivo with scintigraphic and optical biomarkers - a status report. Anticancer Agents Med Chem 2009;9: 968-985. Abstract

Kopka K, Faust A, Hermann S, Kuhlmann M, Wagner S, Klohs J, Schober O, Wunder A, Schäfers M. 18F-Labeled Isatin as putative biomarker for the specific imaging of activated caspases in apoptosis. J Labelled Comp Radiopharm 2009;52: S39-S39.

Range FT, Paul M, Schäfers KP, Acil T, Kies P, Hermann S, Schober O, Breithardt G, Wichter T, Schäfers MA. Myocardial perfusion in nonischemic dilated cardiomyopathy with and without atrial fibrillation. J Nucl Med 2009;50: 390-396. Abstract

Ropinski T, Hermann S, Reich R, Schäfers M, Hinrichs K. Multimodal vessel visualization of mouse aorta PET/CT scans. IEEE Trans Vis Comput Graph 2009;15: 1515-1522. Abstract

Stelljes M, Hermann S, Kohler G, Silling G, Berdel WE, Schober O, Schäfers M, Kienast J. Noninvasive assessment of intestinal graft-versus-host disease activity by molecular imaging with 18F-fluorodeoxyglucose positron emission tomography. Bone Marrow Transplant 2009;43: S15-S15.

Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 2009;29: 14177-14184. Abstract

2008

Kobbert C, Mollmann C, Schäfers M, Hermann S, Baba HA, Hoffmeier A, Breithardt G, Scheld HH, Weissen-Plenz G, Sindermann JR. Transgenic model of cardiac rhabdomyosarcoma formation. J Thorac Cardiovasc Surg 2008;136: 1178-1186. Abstract

Kopka K, Hermann S, Faust A, Kuhlmann M, Wagner S, Breyholz HJ, Schober O, Schäfers M. Imaging of the "roads to ruin": 18F-labelled isatin as potential tracer for the molecular visualisation of activated caspases in apoptosis. Q J Nucl Med Mol Imaging 2008;52: 21-22.

Levkau B, Schäfers M, Wohlschlaeger J, von Wnuck Lipinski K, Keul P, Hermann S, Kawaguchi N, Kirchhof P, Fabritz L, Stypmann J, Stegger L, Flogel U, Schrader J, Fischer JW, Hsieh P, Ou YL, Mehrhof F, Tiemann K, Ghanem A, Matus M, Neumann J, Heusch G, Schmid KW, Conway EM, Baba HA. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation 2008;117: 1583-1593. Abstract

Schnöckel U, Reuter S, Stegger L, Schlatter E, Schäfers KP, Hermann S, Schober O, Gabriels G, Schäfers M. Dynamic 18F-fluoride small animal PET to noninvasively assess renal function in rats. Eur J Nucl Med Mol Imaging 2008;35: 2267-2274. Abstract

Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Schäfers M, Kummer MP, Klockgether T, Heneka MT. Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. J Neuroinflammation 2008;5: 38. Abstract

Stelljes M, Hermann S, Albring J, Kohler G, Loffler M, Franzius C, Poremba C, Schlosser C, Volkmann S, Opitz C, Bremer C, Kucharzik T, Silling G, Schober O, Berdel WE, Schäfers M, Kienast J. Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography. Blood 2008;111: 2909-2918. Abstract

2007

Faust A, Wagner S, Law MP, Hermann S, Schnöckel U, Keul P, Schober O, Schäfers M, Levkau B, Kopka K. The nonpeptidyl caspase binding radioligand (S)-1-(4-(2-[18F]Fluoroethoxy)-benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)s ulfonyl]isatin ([18F]CbR) as potential positron emission tomography-compatible apoptosis imaging agent. Q J Nucl Med Mol Imaging 2007;51: 67-73. Abstract

Kirchhof P, Klimas J, Fabritz L, Zwiener M, Jones LR, Schäfers M, Hermann S, Boknik P, Schmitz W, Breithardt G, Kirchhefer U, Neumann J. Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin. J Mol Cell Cardiol 2007;42: 962-971. Abstract

Kopka K, Breyholz H J, Wagner S, Brandau W, Hermann S, Schober O, Levkau B, Bremcer C, Schäfers M. Radioiodinated pyrimidine-2,4,6-triones as model probes for the in vivo molecular imaging of activated mmps. J Labelled Comp Radiopharm 2007;50: 310.

Lang N, Hermann S, Hold S, Mienkina M, Stegger L, Stypmann J, Schober O, Schäfers M, Schäfers KP, Schmitz G. Hybrid 3D Sono/PET in a mouse. Eur J Nucl Med Mol Imaging 2007;34: 1706-1707. Abstract

Range FT, Schäfers M, Acil T, Schäfers KP, Kies P, Paul M, Hermann S, Brisse B, Breithardt G, Schober O, Wichter T. Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation. Eur Heart J 2007;28: 2223-2230. Abstract

Stegger L, Schäfers K, Kopka K, Wagner S, Hermann S, Kies P, Law M, Schober O, Schäfers M. Molecular cardiovascular imaging using scintigraphic methods. Eur Radiol 2007;17: 1422-1432. Abstract

2006

Stegger L, Hoffmeier A-N, Schäfers KP, Hermann S, Schober O, Schäfers MA, Theilmeier G. Accurate noninvasive measurement of infarct size in mice with high-resolution PET. J Nucl Med 2006;47: 1837-1844. Abstract

Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation 2006;114: 1403-1409. Abstract

2005

Stegger L, Schäfers KP, Flogel U, Livieratos L, Hermann S, Jacoby C, Keul P, Conway EM, Schober O, Schrader J, Levkau B, Schäfers M. Monitoring left ventricular dilation in mice with PET. J.Nucl.Med. 2005;46: 1516-1521.

2004

Levkau B, Hermann S, Theilmeier G, van der Giet M, Chun J, Schober O, Schäfers M. High-density lipoprotein stimulates myocardial perfusion in vivo. Circulation 2004;110: 3355-3359. Abstract

Patente

Faust A, Hermann S, Roth J, Schäfers M, Vogl T. Quinolone-3-carboxamide compounds and their use in diagnosis. WO 2016067238 A1; publication date: 06/05/2016. PCT/IB2015/058348; publication date: 06/05/2016.

Chen G, Gangadharmath UB, Kasi D, Kolb HC, Liu C, Sinha A, Szardenings AK, Walsh JC, Wang E, Yu C, Zhang W, Kopka K, Haufe G, Schäfers M, Hugenberg V, Wagner S, Hermann S, Breyholz H-J, Faust A. Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof. EP 2644601; 02/10/2013.

Haufe G, Hermann S, Hugenberg V, Kolb H, Kopka K, Wagner S, Schäfers M. Compounds with matrix-metalloproteinase inhibitory activity. WO 2013/010573; publication date: 24/01/2013.

Behrends M, Breyholz H-J, Hermann S, Haufe G, Hugenberg V, Kolb H, Kopka K, Wagner S, Schäfers M. Compounds with matrix-metalloproteinase inhibitory activity. EP 2520573; publication date: 07/11/2012.

Forschungsschwerpunkte

Vita

Akademische Ausbildung

Beruflicher Werdegang

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Mitgliedschaften und Aktivitäten in Gremien