Research Foci
- Biologische Systeme
- Zellkulturstudien
- Zelluläre Barrieren
- Lebensmittelinhaltsstoffe und ihre Biotransformation
CV
Academic Education
- Promotionsstudium (Dr. rer. nat.) unter Betreuung von Herrn Prof. Dr. Hans-Ulrich Humpf
- Studium Lebensmittelchemie (B. Sc./M. Sc.) WWU Münster
Positions
- Akademischer Rat am Institut für Lebensmittelchemie der WWU Münster
- Wissenschaftlicher Mitarbeiter am Institut für Lebensmittelchemie der WWU Münster
External Function
- Mitglied in der Gesellschaft Deutscher Chemiker GDCh und Lebensmittelchemischen Gesellschaft (LChG)
Teaching
- Seminar: Seminar Molecular Nutrition and Biosciences (Genetic Engineering and Biotechnology, Biochemical and Molecular Biological Analysis, Molecular Sensory) [128218]
[ - | | wöchentlich | Mi | LC 1 | Dr. Matthias Behrens] - Seminar: Seminar Molecular Nutrition and Biosciences (Genetic Engineering and Biotechnology, Biochemical and Molecular Biological Analysis, Molecular Sensory) [128220]
[ - | | wöchentlich | Mi | LC 1 | Dr. Matthias Behrens] - Seminar: Institutsseminar [128233]
(in cooperation with Dr. Benedikt Cramer, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ | wöchentlich | Do | Dr. Benedikt Cramer] - Seminar: Seminar Masterthesis [128229]
(in cooperation with Dr. Benedikt Cramer, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ - | | wöchentlich | Do | LC 3 | Dr. Benedikt Cramer] - Praktikum: Laboratory Course Chemistry and Analysis of Necessaries and Cosmetics [128224]
(in cooperation with Dr. Florian Hübner)
[wöchentlich | Dr. Florian Hübner] - Praktikum: Laboratory Course Biochemical and Molecular Biological Analysis [128221]
[n. V. | Dr. Matthias Behrens] - Seminar: Seminar Masterthesis [126230]
(in cooperation with Dr. Benedikt Cramer, Prof. Dr. Melanie Esselen, Prof. Dr. Hans-Ulrich Humpf, Dr. Florian Hübner) - Seminar: Institutsseminar [126233]
(in cooperation with Dr. Benedikt Cramer, Prof. Dr. Melanie Esselen, Prof. Dr. Hans-Ulrich Humpf, Dr. Florian Hübner) - Praktikum: Laboratory Course Food Microbiology [126217]
(in cooperation with UProf. Dr. Thorsten Kuczius) - Praktikum: Laboratory Course Food Toxicology [126224]
(in cooperation with Dr. Florian Hübner) - Vortrag: Vortrag zur Bachelorarbeit [126220]
(in cooperation with Dr. Benedikt Cramer, Dr. Michael Lange-Aperdannier, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
- Seminar: Seminar Molecular Nutrition and Biosciences (Genetic Engineering and Biotechnology, Biochemical and Molecular Biological Analysis, Molecular Sensory) [128218]
Publications
- . . ‘Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells.’ Molecular Nutrition and Food Research 68, № 6. doi: 10.1002/mnfr.202300639.
- . . ‘Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.’ Molecular Nutrition and Food Research 67, № 21: e2300052. doi: 10.1002/mnfr.202300052.
- . ‘Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.’ British Journal of Haematology 202, № 5: 1033–1048. doi: 10.1111/bjh.18939.
- . . ‘Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.’ Archives of Toxicology 97, № 12: 3179–3196. doi: 10.1007/s00204-023-03607-z.
- . . ‘Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.’ PLoS Pathogens 19, № 7: e1010986. doi: 10.1371/journal.ppat.1010986.
- . . ‘Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.’ Archives of Toxicology 96, № 11: 2983–2998. doi: 10.1007/s00204-022-03348-5.
- . . ‘Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.’ Food and Chemical Toxicology 164: 113006. doi: 10.1016/j.fct.2022.113006.
- . . ‘In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.’ Metabolites 12: 88. doi: 10.3390/metabo12010088.
- . ‘Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles.’ Biomaterials and Biosystems 5: 100032. doi: 10.1016/j.bbiosy.2021.100032.
- . . ‘In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.’ Metabolites 12, № 1: 88. doi: 10.3390/metabo12010088.
- ‘Studies on the formation of a protein corona on colloidal drug carriers.’ contributed to the EMBO practical course – targeted proteomics: Experimental design and data analysis., CRG – Centre de Regulació Genòmica, online, .
- ‘Nanoparticle matrix and incubation medium – main influencer of the protein corona?’ contributed to the DPhG Annual Meeting, Leipzig online, .
- . ‘Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.’ European journal of pharmaceutics and biopharmaceutics 163: 212–222.
- . . ‘Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone.’ Toxins 13, № 5: 327. doi: 10.3390/toxins13050327.
- . . ‘Govaniadine Evaluation of Cytotoxicity and Permeability in Cell Culture.’ Revista Brasileira de Farmacognosia 30, № 3: 374–380. doi: 10.1007/s43450-020-00066-w.
- . . ‘Intestinal Metabolism of α- and β‑Glucosylated Modified Mycotoxins T‑2 and HT‑2 Toxin in the Pig Cecum Model.’ Journal of Agricultural and Food Chemistry 68, № 19. doi: 10.1021/acs.jafc.0c00576.
- . ‘Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.’ PloS one 13(5). doi: 10.1371/journal.pone.0197406.
- . . ‘Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain.’ PloS one 10, № 11: 1–20. doi: 10.1371/journal.pone.0143640.
Dr. Matthias Behrens
Professur für Lebensmittelchemie (Prof. Humpf)
