Die Arbeitsgruppe befasst sich mit der Synthese und Charakterisierung neuer Cisplatin-Analoga mit tertiären Aminliganden sowie deren Test auf Antitumoraktivität. Untersucht werde die Wechselwirkungen dieser potentiellen Cytostatika mit Nucleosiden, methylierten Nucleobasen und DNA-Einzelstrang- sowie Doppelstrangfragmenten in Lösung und im Feststoff mit Hilfe der multinuclearen NMR-Spektroskopie und der Röntgenstrukturanalyse.

Veröffentlichungen

• S. Fakih, W. C. Tung, D. Eierhoff, C. Mock, B. Krebs
  "Dinuclear and Mononuclear Platinum(II) and Palladium(II) Complexes with modified 2,2´-Dipyridylamine Ligands Featuring a Cisplatin Analogous Structure Motif"
  Z. Anorg. Allg. Chem. 2005, 631, 1397.

• H. U. V. Gerth, A. Rompel, B. Krebs, J. Boos, C. Lanvers-Kaminsky
  "Cytotoxic effects of novel polyoxotungstates and a platinum compound on human cancer cell lines"
  Anti-Cancer Drugs 2005, 16, 101.

• T. Ludwig, S. Fakih, B. Krebs und H. Oberleitner
  "Platinum Complex Cytotoxity tested by the Electrical Resistance Breakdown Assay"
  Cellular Physiology and Biochemistry 2004, 14, 425.

• M. J. Rauterkus, B. Krebs
  "Fünfkernige Platin(II)-Makrocyklen mit Nucleobasen"
  Angew. Chem. 2004, 116, 1321
  "Pentanuclear Platinum(II) Macrocycles with Nucleobases"
  Angew. Chem. Int. Ed. 2004, 43, 1300

• B. Krebs, M. J. Rauterkus
  "A Cisplatin Analogue with 2,2´-Dipyridylketone Ligand: Cytotoxity and Interaction with DNA Constituents"
  J. Inorg. Biochem. 2003, 96, 171

• M. J. Rauterkus, I. Puscasu, S. Fakih und B. Krebs
  "Cisplatin Analogues with 2,2`-Dipyridylamine Ligands and their Reactions with DNA Nucleobases"
  Inorg. Chim. Acta 2003, 350, 355

• Michael J. Rauterkus, Ina Puscasu and Bernt Krebs
  "Head-to-Head and Head-to-Tail binding of a Pd(II)-methylthyminato complex: crystal structures and solution behaviour of a novel cisplatin analogue"
  Inorg. Chim. Acta 2002, 339, 438

• M. J. Rauterkus, I. Puscasu, C. Mock, G. Tallen, J. E. Wolff u. B. Krebs
  "Cytotoxity and X-ray structure analysis of novel cisplatin analogues"
  J. Inorg. Biochem. 2001, 86, 394

• C. Mock, I. Puscasu, M. J. Rauterkus, G. Tallen, J. E. A. Wolff u. B. Krebs
  "Novel Pt(II) anticancer agents and their Pd(II) analogues: syntheses, crystal structures, reactions with nucleobases and cytotoxicities"
  Inorg. Chim. Acta 2001, 319, 109

• I. Puscasu, C. Mock, M. Rauterkus, A. Röndigs, G. Tallen, S. Gangopadhyay, J. E. A. Wolff u. B. Krebs
  "Novel platinum(II) complexes with dipyridyl containing ligands and their products with the model nucleobases 1-methylthymine and 1-methyluracil"
  Z. Anorg. Allg. Chem. 2001, 627, 1292

• S. B. Gangopadhyay, A. Röndigs, B. Krebs u. J. E. A. Wolff
  "Cellular Accumulation Determines the Activity of Three Novel Platinum Agents"
  Anticancer Res. 2001, 21, 2039

• N. Moeller, B. S. Kangarloo, I. Puscasu, C. Mock, B. Krebs u. J. E. A. Wolff
  "Rational Design of Platinum Chemotherapeutic Drugs: Hydrophobicity increases Cytotoxity"
  Anticancer Res. 2000, 20, 4435

• Tallen G., Mock, C. Gangopadhyay, S. B. Kangarloo B. Krebs B., Wolff J. E. A.
  "Overcoming Cisplatin Resistance: Design of Novel Hydrophobic Platinum Platinum Compounds"
  Anticancer Res. 2000, 20, 445

• Tallen G., University of Calgary, AB, Canada; Mock C., University of Muenster, Germany; Gangopadhyay S., Calgary; Krebs B., Muenster; Wolff J. E. A., Calgary
  "Overcoming Cisplatin Resistance: Rational Design of New Platinum Agents"
  Medical & Pediatric Oncology 1999, 33, 139

• N. Paschke, A. Röndigs, H. Poppenborg, J. E. A. Wolff u. B. Krebs
  "Reaction of the diaqua(2-(pyridin-2yl)-2-oxazoline)platinum(II) and -palladium(II) dication with the model nucleobases 1-methylthymine and 1-methyluracil: Syntheses, spectroscopic properties and X-ray crystal structures"
  Inorg. Chim. Acta 1997, 264, 239

• S. Karentzopoulos, H. Engelking, B. Bremer, N. Paschke u. B. Krebs
  "First Example of a cis-Platinum-Analogue with Two Directly Bridged Imidazoles: Pt(mimim)Cl₂.Et₄NCl"
  Acta Cryst. 1997, C53, 172

• M. J. Bloemink, H. Engelking, S. Karentzopoulos, B. Krebs u. J. Reedijk
  "Synthesis, Crystal Structure, Antitumor Activity and DNA-Binding Properties of the New Active Pt Compound (Bis-(N-methylimidazol-2-yl)carbinol)dichloro-platinum(II), Lacking a NH Moity, and of the Inactive Analog (Bis(N-methyl-imidazol-2-yl)dichloroplatin(II)"
  Inorg. Chem. 1996, 35, 619

• H. Engelking u. B. Krebs
  "Dinuclear nucleobase-anion-bridged complexes of Pd(II) and Pt(II) with 1-methylimidazol-2-yl-pyridin-2-yl-ketone: synthesis, crystal structure and solutionbehavior"
  J. Chem. Soc. Dalton Trans. 1996, 2409

• M. J. Bloemink, H. Engelking, N. Gütschow, S. Karentzopoulos, B. Krebs u. J. Reedijk
  "The X-Ray Structure, Antitumor Activity and DNA-Binding Properties of the New Pt Bis-(imidazol-2-yl) Compounds Lacking a NH Moiety"
  J. Inorg. Biochem. 1995, 59, 222