• Participation in “Cells in Motion”

    • Research interests: mechanisms controlling cell migration, cell-fate maintenance and organogenesis in the context of the live vertebrate embryo
    • Management Board member of the CiM-IMPRS Graduate Programme

  • News & views

  • Papers in the research focus “cell dynamics and imaging”

    2023

    Reichman-Fried M, Raz E. Bleb protrusions help cancer cells to cheat death. Nature 2023;615: 402-403. Abstract
    Tarbashevich K, Ermlich L, Wegner J, Pfeiffer J, Raz E. The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells. Front. Cell Dev. Biol. 2023;11Abstract
    Truszkowski L, Batur D, Long H, Tarbashevich K, Vos BE, Trappmann B, Raz E. Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo. Development 2023;150Abstract
    Westerich KJ, Reinecke S, Emich J, Wyrwoll MJ, Stallmeyer B, Meyer M, Oud MS, Fietz D, Pilatz A, Kliesch S, Reichman-Fried M, Tarbashevich K, Limon T, Stehling M, Friedrich C, Tuttelmann F, Raz E. Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos. Hum Reprod 2023;38: 655-670. Abstract
    Westerich KJ, Tarbashevich K, Schick J, Gupta A, Zhu M, Hull K, Romo D, Zeuschner D, Goudarzi M, Gross-Thebing T, Raz E. Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1. Dev Cell 2023;58: 1578-1592.e5. Abstract

    2022

    Kummer D, Steinbacher T, Tholmann S, Schwietzer MF, Hartmann C, Horenkamp S, Demuth S, Peddibhotla SSD, Brinkmann F, Kemper B, Schnekenburger J, Brandt M, Betz T, Liashkovich I, Kouzel IU, Shahin V, Corvaia N, Rottner K, Tarbashevich K, Raz E, Greune L, Schmidt MA, Gerke V, Ebnet K. A JAM-A-tetraspanin-alphavbeta5 integrin complex regulates contact inhibition of locomotion. J Cell Biol 2022;221Abstract
    Labbaf Z, Petratou K, Ermlich L, Backer W, Tarbashevich K, Reichman-Fried M, Luschnig S, Schulte-Merker S, Raz E. A robust and tunable system for targeted cell ablation in developing embryos. Dev Cell 2022;57: 2026-2040.e5. Abstract

    2021

    Marzano M, Herzmann S, Elsbroek L, Sanal N, Tarbashevich K, Raz E, Krahn MP, Rumpf S. AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila. Cell Rep 2021;37: 110024. Abstract
    Olguin-Olguin A, Aalto A, Maugis B, Boquet-Pujadas A, Hoffmann D, Ermlich L, Betz T, Gov NS, Reichman-Fried M, Raz E. Chemokine-biased robust self-organizing polarization of migrating cells in vivo. Proc Natl Acad Sci U S A 2021;118: e2018480118. Abstract

    2020

    Grimaldi C, Raz E. Germ cell migration-Evolutionary issues and current understanding. Semin Cell Dev Biol 2020;100: 152-159. Abstract
    Grimaldi C, Schumacher I, Boquet-Pujadas A, Tarbashevich K, Vos BE, Bandemer J, Schick J, Aalto A, Olivo-Marin J-C, Betz T, Raz E. E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow. Nat Commun 2020;11: 5397. Abstract
    Gross-Thebing S, Truszkowski L, Tenbrinck D, Sanchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Huwel J, Gaede F, Sasse R, Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Munoz A, Burger M, Raz E. Using migrating cells as probes to illuminate features in live embryonic tissues. Sci Adv 2020;6: eabc5546. Abstract
    Gross-Thebing T, Raz E. Dead end and Detour: The function of the RNA-binding protein Dnd in posttranscriptional regulation in the germline. Curr Top Dev Biol 2020;140: 181-208. Abstract
    Westerich KJ, Chandrasekaran KS, Gross-Thebing T, Kueck N, Raz E, Rentmeister A. Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos. Chem. Sci. 2020;11: 3089-3095. Abstract

    2019

    Goudarzi M, Boquet-Pujadas A, Olivo-Marin J-C, Raz E. Fluid dynamics during bleb formation in migrating cells in vivo. PLoS One 2019;14: e0212699. Abstract
    Lavi I, Goudarzi M, Raz E, Gov NS, Voituriez R, Sens P. Cellular Blebs and Membrane Invaginations Are Coupled through Membrane Tension Buffering. Biophys J 2019;117: 1485-1495. Abstract
    Skvortsova K, Tarbashevich K, Stehling M, Lister R, Irimia M, Raz E, Bogdanovic O. Retention of paternal DNA methylome in the developing zebrafish germline. Nat Commun 2019;10: 3054. Abstract

    2018

    Malhotra D, Shin J, Solnica-Krezel L, Raz E. Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. Elife 2018;7: e33574. Abstract
    Pfeiffer J, Tarbashevich K, Bandemer J, Palm T, Raz E. Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90. Dev Biol 2018;436: 84-93. Abstract

    2017

    Cao J, Ehling M, März S, Seebach J, Tarbashevich K, Sixta T, Pitulescu ME, Werner A-C, Flach B, Montanez E, Raz E, Adams RH, Schnittler H. Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nat Commun 2017;8Abstract
    Goudarzi M, Tarbashevich K, Mildner K, Begemann I, Garcia J, Paksa A, Reichman-Fried M, Mahabaleshwar H, Blaser H, Hartwig J, Zeuschner D, Galic M, Bagnat M, Betz T, Raz E. Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Dev Cell 2017;43: 577-587.e5. Abstract
    Gross-Thebing T, Yigit S, Pfeiffer J, Reichman-Fried M, Bandemer J, Ruckert C, Rathmer C, Goudarzi M, Stehling M, Tarbashevich K, Seggewiss J, Raz E. The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation. Developmental Cell 2017;43: 704-715.e5. Abstract
    Horner F, Meissner R, Polali S, Pfeiffer J, Betz T, Denz C, Raz E. Holographic optical tweezers-based in vivo manipulations in zebrafish embryos. J Biophotonics 2017;10: 1492-1501. Abstract

    2016

    Otten ABC, Theunissen TEJ, Derhaag JG, Lambrichs EH, Boesten IBW, Winandy M, van Montfoort APA, Tarbashevich K, Raz E, Gerards M, Vanoevelen JM, van den Bosch BJC, Muller M, Smeets HJM. Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells. Cell Rep 2016;16: 622-630. Abstract
    Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, Meyen D, Biundo A, Leidel SA, Peyrieras N, Gov NS, Keller PJ, Raz E. Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nat Commun 2016;7: 11288. Abstract

    2015

    Bussmann J, Raz E. Chemokine-guided cell migration and motility in zebrafish development. Embo J 2015;34: 1309-1318. Abstract
    Goudarzi M, Mildner K, Babatz F, Riedel D, Klambt C, Zeuschner D, Raz E. Correlative Light and Electron Microscopy of Rare Cell Populations in Zebrafish Embryos Using Laser Marks. Zebrafish 2015;12: 470-473. Abstract
    Meyen D, Tarbashevich K, Banisch TU, Wittwer C, Reichman-Fried M, Maugis B, Grimaldi C, Messerschmidt E-M, Raz E. Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo. Elife 2015;4: e05279. Abstract
    Paksa A, Raz E. Zebrafish germ cells: motility and guided migration. Curr Opin Cell Biol 2015;36: 80-85. Abstract
    Stanganello E, Hagemann AIH, Mattes B, Sinner C, Meyen D, Weber S, Schug A, Raz E, Scholpp S. Filopodia-based Wnt transport during vertebrate tissue patterning. Nat Commun 2015;6: 5846. Abstract
    Tarbashevich K, Reichman-Fried M, Grimaldi C, Raz E. Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Curr Biol 2015;25: 1096-1103. Abstract

    2014

    Gross-Thebing T, Paksa A, Raz E. Simultaneous high-resolution detection of multiple transcripts combined with localization of proteins in whole-mount embryos. BMC Biol 2014;12: 55. Abstract
    Hartwig J, Tarbashevich K, Seggewiss J, Stehling M, Bandemer J, Grimaldi C, Paksa A, Gross-Thebing T, Meyen D, Raz E. Temporal control over the initiation of cell motility by a regulator of G-protein signaling. Proc Natl Acad Sci U S A 2014;111: 11389-11394. Abstract
    Reichman-Fried M, Raz E. Small proteins, big roles: The signaling protein Apela extends the complexity of developmental pathways in the early zebrafish embryo. Bioessays 2014;36: 741-745. Abstract
    Xu C, Hasan SS, Schmidt I, Rocha SF, Pitulescu ME, Bussmann J, Meyen D, Raz E, Adams RH, Siekmann AF. Arteries are formed by vein-derived endothelial tip cells. Nat Commun 2014;5: 5758. Abstract

    2013

    Goudarzi M, Strate I, Paksa A, Lagendijk A-K, Bakkers J, Raz E. On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling. Nat Genet 2013;45: 1264-1265. Abstract
    Paluch EK, Raz E. The role and regulation of blebs in cell migration. Curr Opin Cell Biol 2013;25: 582-590. Abstract