• Participation in “Cells in Motion”

    • Research interests: muscle cytoskeletal dynamics, biomolecular and cellular force measurements, atomic force microscopy, cardiomyocyte contractility and elasticity in health and disease, induced pluripotent stem cell-derived cardiomyocytes

  • Papers in the research focus “cell dynamics and imaging”

    2020

    Li Y, Hessel AL, Unger A, Ing D, Recker J, Koser F, Freundt JK, Linke WA. Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle. Elife 2020;9: e64107. Abstract
    Loescher CM, Breitkreuz M, Li Y, Nickel A, Unger A, Dietl A, Schmidt A, Mohamed BA, Kötter S, Schmitt JP, Krüger M, Krüger M, Toischer K, Maack C, Leichert LI, Hamdani N, Linke WA. Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx). Proc Natl Acad Sci U S A 2020;117: 24545-24556. Abstract
    Swist S, Unger A, Li Y, Voge A, von Frieling-Salewsky M, Skarlen A, Cacciani N, Braun T, Larsson L, Linke WA. Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin. Nat Commun 2020;11: 4479. Abstract

    2019

    Horsthemke M, Nutter LMJ, Bachg AC, Skryabin BV, Honnert U, Zobel T, Bogdan S, Stoll M, Seidl MD, Muller FU, Ravens U, Unger A, Linke WA, van Gorp PRR, de Vries AAF, Bahler M, Hanley PJ. A novel isoform of myosin 18A (Myo18Agamma) is an essential sarcomeric protein in mouse heart. J Biol Chem 2019;294: 7202-7218. Abstract