• Participation in “Cells in Motion”

    • Research interests: cell physiology of synaptic transmission using high and super-resolution imaging techniques and electrophysiology; mechanisms of exo- and endocyosis, with particular emphasis on synaptic vesicle recycling
    • Supervisor in the CiM-IMPRS Graduate Programme

  • News & views

  • CiM Papers

    2024

    Singh A, Thale S, Leibner T, Lamparter L, Ricker A, Nusse H, Klingauf J, Galic M, Ohlberger M, Matis M. Dynamic interplay of microtubule and actomyosin forces drive tissue extension. Nat Commun 2024;15: 3198. Abstract

    2023

    Burmeister M, Fraunenstein A, Kahms M, Arends L, Gerwien H, Deshpande T, Kuhlmann T, Gross CC, Naik VN, Wiendl H, Klingauf J, Meissner F, Sorokin L. Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function. Sci Adv 2023;9: eadg0686. Abstract
    Ebrahimkutty M, Duan J, Nusse H, Klingauf J, Galic M. Negatively curved cellular membranes promote BAIAP2 signaling hub assembly. Nanoscale 2023;15: 6759-6769. Abstract
    Luik A-L, Hannocks M-J, Loismann S, Kapupara K, Cerina M, van der Stoel M, Tsytsyura Y, Glyvuk N, Nordenvall C, Klingauf J, Huveneers S, Meuth S, Jakobsson L, Sorokin L. Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication. Matrix Biol 2023;121: 56-73. Abstract

    2021

    Mancinelli G, Lamparter L, Nosov G, Saha T, Pawluchin A, Kurre R, Rasch C, Ebrahimkutty M, Klingauf J, Galic M. Dendrite tapering actuates a self-organizing signaling circuit for stochastic filopodia initiation in neurons. Proc Natl Acad Sci U S A 2021;118Abstract

    2020

    Begemann I, Keller U, Nüsse H, 1 Klingauf J, Galic M. Parallel Acquisition of Plasma Membrane Ultrastructure and Cytosolic Protein Localisation in Cultured Cells via Correlated Immunogold SEM. Cells 2020;9: 1329. Abstract

    2019

    Begemann I, Saha T, Lamparter L, Rathmann I, Grill D, Golbach L, Rasch C, Keller U, Trappmann B, Matis M, Gerke V, Klingauf J, Galic M. Mechanochemical self-organization determines search pattern in migratory cells. Nat. Phys. 2019;15: 848-857. Abstract
    Viplav A, Saha T, Huertas J, Selenschik P, Ebrahimkutty MP, Grill D, Lehrich J, Hentschel A, Biasizzo M, Mengoni S, Ahrends R, Gerke V, Cojocaru V, Klingauf J, Galic M. ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis. J Cell Sci 2019;132: pii: jcs226530. Abstract

    2018

    Kahms M, Klingauf J. Novel pH-Sensitive Lipid Based Exo-Endocytosis Tracers Reveal Fast Intermixing of Synaptic Vesicle Pools. Front Cell Neurosci 2018;12: 18. Abstract
    Lima AM, Wegner SV, Martins Cavaco AC, Estevao-Costa MI, Sanz-Soler R, Niland S, Nosov G, Klingauf J, Spatz JP, Eble JA. The spatial molecular pattern of integrin recognition sites and their immobilization to colloidal nanobeads determine alpha2beta1 integrin-dependent platelet activation. Biomaterials 2018;167: 107-120. Abstract
    Schuermann S, Steffes G, Manikowski D, Kastl P, Malkus U, Bandari S, Ohlig S, Ortmann C, Rebollido-Rios R, Otto M, Nusse H, Hoffmann D, Klambt C, Galic M, Klingauf J, Grobe K. Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing. Elife 2018;7: e33033. Abstract
    Singh A, Saha T, Begemann I, Ricker A, Nusse H, Thorn-Seshold O, Klingauf J, Galic M, Matis M. Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis. Nat Cell Biol 2018;20: 1126-1133. Abstract

    2017

    Bodzeta A, Kahms M, Klingauf J. The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery. Cell Rep 2017;20: 1348-1359. Abstract
    de Vries WC, Grill D, Tesch M, Ricker A, Nusse H, Klingauf J, Studer A, Gerke V, Ravoo BJ. Reversible Stabilization of Vesicles: Redox-Responsive Polymer Nanocontainers for Intracellular Delivery. Angew Chem Int Ed Engl 2017;56: 9603-9607. Abstract
    Di Russo J, Luik A-L, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker E NTP, Hellstrand P, Bhattachariya A, Albinsson S, Pincet F, Hallmann R, Sorokin L. Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J 2017;36: 183-201. Abstract
    Martineau M, Guzman RE, Fahlke C, Klingauf J. VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses. Nat Commun 2017;8: 2279. Abstract
    Shah B, Lutter D, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, Puschel AW. Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex. Cereb Cortex 2017;27: 1253-1269. Abstract

    2016

    Rajappa R, Gauthier-Kemper A, Boning D, Huve J, Klingauf J. Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression. Cell Rep 2016;14: 1369-1381. Abstract
    Saha T, Rathmann I, Viplav A, Panzade S, Begemann I, Rasch C, Klingauf J, Matis M, Galic M. Automated analysis of filopodial length and spatially resolved protein concentration via adaptive shape tracking. Mol Biol Cell 2016;27: 3616-3626. Abstract
    Shah B, Lutter D, Bochenek ML, Kato K, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, Adams RH, Puschel AW. C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development. PLoS One 2016;11: e0154174. Abstract

    2015

    Gauthier-Kemper A, Kahms M, Klingauf J. Restoring synaptic vesicles during compensatory endocytosis. Essays Biochem 2015;57: 121-134. Abstract
    Wedeking T, Lochte S, Birkholz O, Wallenstein A, Trahe J, Klingauf J, Piehler J, You C. Spatiotemporally Controlled Reorganization of Signaling Complexes in the Plasma Membrane of Living Cells. Small 2015;11: 5912-5918. Abstract

    2014

    Namadurai S, Balasuriya D, Rajappa R, Wiemhofer M, Stott K, Klingauf J, Edwardson JM, Chirgadze DY, Jackson AP. Crystal structure and molecular imaging of the Nav channel beta3 subunit indicates a trimeric assembly. J Biol Chem 2014;289: 10797-10811. Abstract

    2013

    Hoerr V, Tuchscherr L, Huve J, Nippe N, Loser K, Glyvuk N, Tsytsyura Y, Holtkamp M, Sunderkotter C, Karst U, Klingauf J, Peters G, Loffler B, Faber C. Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol 2013;11: 63. Abstract
    Hua Y, Woehler A, Kahms M, Haucke V, Neher E, Klingauf J. Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles. Neuron 2013;80: 343-349. Abstract