• Participation in “Cells in Motion”

    • Research interests: matrix-dependent morphogen release and transport, in vivo visualization of dynamic matrix biosynthesis, “pre-patterning” and turnover, development of matrix-modification-specific and morphogen-specific nanobodies for in vivo visualization of matrix modifications and morphogen gradients, plasma membrane cholesterol-dependent cellular patterning, morphogen-regulated cellular compartmentalization

  • Papers in the research focus “cell dynamics and imaging”

    2020

    Macchi M, Magalon K, Zimmer C, Peeva E, El Waly B, Brousse B, Jaekel S, Grobe K, Kiefer F, Williams A, Cayre M, Durbec P. Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production. Elife 2020;9: e51735. Abstract

    2018

    Schuermann S, Steffes G, Manikowski D, Kastl P, Malkus U, Bandari S, Ohlig S, Ortmann C, Rebollido-Rios R, Otto M, Nusse H, Hoffmann D, Klambt C, Galic M, Klingauf J, Grobe K. Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing. Elife 2018;7: e33033. Abstract

    2016

    Jakobs P, Schulz P, Ortmann C, Schurmann S, Exner S, Rebollido-Rios R, Dreier R, Seidler DG, Grobe K. Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells. Sci Rep 2016;6: 26435. Abstract

    2015

    Ortmann C, Pickhinke U, Exner S, Ohlig S, Lawrence R, Jboor H, Dreier R, Grobe K. Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans. J Cell Sci 2015;128: 2374-2385. Abstract

    2014

    Xu Y, Pektor S, Balkow S, Hemkemeyer SA, Liu Z, Grobe K, Hanley PJ, Shen L, Bros M, Schmidt T, Bahler M, Grabbe S. Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb. J Immunol 2014;192: 3559-3568. Abstract